Verfügbarkeit: Endocrine pathophysiology

Endocrine pathophysiology: a concise guide to the physical exam

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Bibliographische Detailangaben
Hauptverfasser:	Manni, Andrea (VerfasserIn), Quarde, Akuffo (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Cham Springer [2020]
Schlagworte:	Endocrinology Endocrinology Pathophysiologie Endokrinopathie Endokrine Drüse
Online-Zugang:	Inhaltsverzeichnis Klappentext
Beschreibung:	XVII, 200 Seiten Illustrationen
ISBN:	9783030498719

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Datensatz im Suchindex

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adam_text	Contents 1 Pituitary Gland Signs............................................................................... 1.1 Cushing’s Disease.............................................................................. 1.1.1 Proximal Myopathy................................................................ 1.1.2 Fat Maldistribution.................................................................. 1.1.3 Striae and Skin Atrophy.......................................................... 1.1.4 Facial Plethora........................................................................ 1.1.5 Hirsutism................................................................................ 1.1.6 Hypertension.......................................................................... 1.1.7 Fragility Fractures.................................................................. 1.1.8 Hyperpigmentation................................................................ 1.2 Acromegaly........................................................................................ 1.2.1 Acanthosis Nigricans.............................................................. 1.2.2 Frontal Bossing and Prognathism.......................................... 1.2.3 Acrochordons and Other Skin Manifestations....................... 1.2.4 Colonic Polyps........................................................................ 1.2.5 Tinel’s Sign (Carpal Tunnel Syndrome)................................ 1.2.6 Hypertension.......................................................................... 1.3 Prolactinoma...................................................................................... 1.3.1 Hypogonadism........................................................................ 1.3.2 Gynecomastia and Galactorrhea............................................ 1.3.3 Bitemporal Hemianopsia........................................................ 1.4 Adult Growth Hormone Deficiency.................................................... 1.4.1 Abnormal Body Composition................................................ 1.5 Growth Hormone Insensitivity (Laron-Type Dwarfism)................... 1.5.1 Short Stature............................................................................ 1.5.2 Obesity.................................................................................... 1.5.3 Small Genitalia........................................................................ 1.6 Central Diabetes Insipidus................................................................. 1.6.1 Dehydration due to Polyuria and Polydipsia......................... References.................................................................................................... 1 1 1 3 4 4 5 6 6 7 8 8 9 9 10 11 11 12 12 12 13 14 14 16 16 16 17 18 18 21 2 Thyroid Gland Signs................................................................................. 2.1 Hashimoto’s Thyroiditis..................................................................... 2.1.1 Queen Anne’s Sign................................................................. 27 27 27 xi xii Contents 2.1.2 Bradycardia.......................................................................... 2.1.3 Pericardial and Pleural Effusions......................................... 2.1.4 Dry Skin................................................................................ 2.1.5 Macroglossia........................................................................ 2.1.6 Hyporeflexia.......................................................................... 2.1.7 Proximal Myopathy.............................................................. 2.1.8 Galactorrhea.......................................................................... 2.2 Graves’ Disease................................................................................. 2.2.1 Thyroid Eye Disease............................................................ 2.2.2 Prétibial Myxedema.............................................................. 2.2.3 Thyroid Acropachy.............................................................. 2.2.4 Onycholysis.......................................................................... 2.2.5 Periodic Paralysis.................................................................. 2.2.6 Thyroid Bruit and Thrill........................................................ 2.2.7 Tachycardia.......................................................................... 2.2.8 Gynecomastia........................................................................ 2.2.9 Lymphadenopathy................................................................ 2.2.10 Change in Body Composition (Weight Loss)...................... 2.3 Euthyroid Goiter with Thoracic Outlet Syndrome............................ 2.3.1 Pemberton’s Sign.................................................................. 2.3.2 Other Compressive Signs (Superior Vena Cava Syndrome, Phrenic Nerve Paralysis)...................................................... 2.4 Resistance to ThyroidHormone....................................................... 2.4.1 Goiter.................................................................................... 2.4.2 Short Stature........................................................................... 2.5 Medullary Thyroid Cancer................................................................. 2.5.1 Facial Flushing and Other Clinical Features of Neuroendocrine Origin........................................................ 2.5.2 Cervical Mass......................................................................... References................................................................................................... 3 28 28 29 29 30 30 30 32 32 34 34 35 35 36 36 37 37 38 39 39 40 42 42 42 44 44 44 45 Adrenal Gland Signs................................................................................. 51 3.1 Primary Adrenal Insufficiency........................................................... 51 3.1.1 Postural Hypotension............................................................ 51 3.1.2 Hyperpigmentation.............................................................. 53 3.2 Primary Hyperaldosteronism............................................................. 55 3.2.1 Hypertension........................................................................ 55 3.2.2 Muscle Weakness.................................................................. 57 3.2.3 Atrial Fibrillation.................................................................. 57 3.2.4 Dehydration.......................................................................... 57 3.3 Pseudohypoaldosteronism................................................................. 60 3.3.1 Cardiac Arrest due toLife-Threatening Hyperkalemia......... 60 3.3.2 Cutaneous Manifestations (Folliculitis and Atopic Dermatitis)................................................................ 60 Contents xiii 3.4 Familial Glucocorticoid Deficiency................................................... 3.4.1 Hyperpigmentation................................................................ 3.4.2 Hypoglycemia........................................................................ 3.5 Pheochromocytomas and Other Paraganglioma Syndromes............. 3.5.1 Hypertension.......................................................................... 3.5.2 Hypotension............................................................................ 3.5.3 Generalized Hyperhidrosis...................................................... 3.5.4 Cardiogenic Shock.................................................................. 3.6 Nonclassic Congenital Adrenal Hyperplasia (NCCAH)................... 3.6.1 Clinical Hyperandrogenism (Acne and Hirsutism)............... 3.6.2 Testicular Adrenal Rest Tumors............................................. 3.6.3 Signs of Insulin Resistance (Skin Tags and Acanthosis Nigricans)........................................................... References.................................................................................................... 61 61 61 63 63 65 66 66 67 67 68 4 Pancreatic Gland Signs.............................................................................. 4.1 Diabetes Mellitus................................................................................ 4.1.1 Acanthosis Nigricans.............................................................. 4.1.2 Diabetic Dermopathy.............................................................. 4.1.3 Acrochordons (Skin Tags)...................................................... 4.1.4 Necrobiosis Lipoidica Diabeticorum..................................... 4.1.5 Lipodystrophy Due to Insulin Injections............................... 4.1.6 Diabetic Retinopathy on Direct Ophthalmoscopy................. 4.1.7 The Diabetic Foot.................................................................. 4.2 Rabson-Mendenhall Syndrome (Type A Insulin Resistance)........... 4.2.1 Acanthosis Nigricans.............................................................. 4.3 Glucagonoma...................................................................................... 4.3.1 Necrolytic Migratory Erythema............................................. 4.4 Carcinoid Syndrome.......................................................................... 4.4.1 Cutaneous Flushing................................................................ 4.4.2 Diarrhea.................................................................................. 4.4.3 Bronchospasm........................................................................ 4.4.4 Cardiac Valvular Lesions........................................................ 4.4.5 Other Cutaneous Manifestations (Pellagra)........................... 4.5 VIPoma.............................................................................................. 4.5.1 Dehydration Due to Extrarenai Losses.................................. References................................................................................................... 77 77 77 78 78 78 79 81 83 86 86 88 88 89 89 90 91 92 92 94 94 97 5 Parathyroid Gland and Musculoskeletal Signs........................................ 103 5.1 Hyperparathyroidism........................................................................... 103 5.1.1 Acute Abdomen.........................................................................103 5.1.2 Fragility Fractures.................................................................... 104 5.1.3 Band Keratopathy/Cataracts.....................................................104 5.1.4 Hypertension.............................................................................105 68 71 Contents xiv 5.2 Hypoparathyroidism............................................................................109 5.2.1 Trousseau’s Sign and Chvostek Sign in the Setting of Hypocalcemia......................................................... 109 5.2.2 Seizures.................................................................................... 109 5.2.3 Hypotension............................................................................. HO 5.2.4 Papilledema............................................................................. 110 5.3 Pseudohypoparathyroidism................................................................. Ill 5.3.1 Short Stature.............................................................................. Ill 5.3.2 Obesity...................................................................................... 112 5.3.3 Brachydactyly.......................................................................... 112 5.3.4 Dental Manifestations.............................................................. 113 5.4 Paget’s Disease of Bone........................................................................114 5.4.1 Fractures and Bone Deformity.................................................. 114 5.4.2 Congestive Heart Failure.......................................................... 115 5.4.3 Sensorineural Hearing Loss...................................................... 115 5.5 Hereditary Vitamin D-ResistantRickets Type 2 (HVDRR-II).......... 116 5.5.1 Rickets.......................................................................................116 5.6 X-Linked Hypophosphatémie Rickets.................................................. 117 5.6.1 Short Stature............................................................................... 117 5.6.2 Dental Abscess...........................................................................119 References..................................................................................................... 120 6 Reproductive Organ Signs...............................................................................127 6.1 6.2 6.3 6.4 6.5 Turner’s Syndrome............................................................................... 127 6.1.1 Short Stature............................................................................. 127 6.1.2 Webbed Neck and Lymphedema............................................. 129 6.1.3 Hypertension........................................................................... 129 6.1.4 Melanocytic Nevi..................................................................... 130 6.1.5 Sexual Infantilism.................................................................. 130 Polycystic Ovarian Syndrome............................................................131 6.2.1 Hirsutism................................................................................ 131 6.2.2 Acanthosis Nigricans.............................................................. 132 6.2.3 Acne........................................................................................ 132 6.2.4 Obesity.................................................................................... 132 Male Hypogonadism.......................................................................... 134 6.3.1 Decreased Testicular Volume.................................................. 134 6.3.2 Gynecomastia.......................................................................... 135 6.3.3 Loss of Height or Fragility Fractures...................................... 137 6.3.4 Change in Body Composition................................................ 138 Menopause.......................................................................................... 139 6.4.1 Vaginal Dryness...................................................................... 139 6.4.2 Fragility Fractures...................................................................139 6.4.3 Change in Body Composition................................................ 140 Estrogen Resistance............................................................................ 141 6.5.1 Tall Stature...............................................................................141 6.5.2 Acanthosis Nigricans...............................................................141 Contents XV Complete Androgen Insensitivity........................................................ 142 6.6.1 Abnormalities of the External andInternal Genitalia............ 142 6.6.2 Normal Breast Tissue Development........................................ 142 References...................................................................................................... 144 6.6 7 Signs in Disorders of Lipid Metabolism and Obesity............................. 151 7.1 Signs in Disorders of Lipid Metabolism............................................ 151 7.1.1 Corneal Arcus........................................................................... 151 7.1.2 Xanthomas and Xanthelasma................................................... 152 7.1.3 Skin Crease (Frank’s Sign)..................................................... 153 7.1.4 Lipemia Retinalis..................................................................... 153 7.2 Congenital Leptin Deficiency............................................................. 160 7.2.1 Obesity...................................................................................... 160 7.3 Proopiomelanocortin (POMC) Deficiency........................................ 161 7.3.1 Triad of Obesity, Adrenal Insufficiency, and Reddish Hair............................................................... 161 7.4 Lipodystrophy Syndromes................................................................... 163 7.4.1 Atrophy of Adipose Tissue....................................................... 163 7.4.2 Hepatomegaly.......................................................................... 163 References...................................................................................................... 165 8 Eponymous Terms and Selected Historical Figures in Endocrinology....................................................................171 8.1 Eponyms Related to the Pituitary Gland............................................. 171 8.1.1 Wolfram Syndrome (DIDMOAD)........................................ 171 8.1.2 Histiocytosis X......................................................................... 172 8.2 Eponyms Related to the Thyroid Gland............................................ 172 8.2.1 Pendred’s Syndrome............................................................. 172 8.3 Eponyms Related to the Adrenal Glands............................................. 174 8.3.1 Carney Dyad or Carney-Stratakis Syndrome.......................... 174 8.3.2 Allgrove Syndrome.............................................................. 175 8.4 Eponyms Related to the Pancreas....................................................... 175 8.4.1 Kussmaul’s Breathing (Diabetic Ketoacidosis)...................... 175 8.4.2 Somogyi Effect....................................................................... 175 8.5 Eponyms Related to the Parathyroid Glands and Bone Metabolism..................................................................................176 8.5.1 Albers-Schönberg Disease....................................................... 176 8.5.2 McCune-Albright Syndrome................................................... 177 8.6 Miscellaneous Eponyms..................................................................... 177 8.7 A Brief Account of Selected Historical Figures in Endocrinology..................................................................... 177 8.7.1 Harvey Cushing (1869-1939).............................................. 177 8.7.2 Hakaru Hashimoto (1881-1934)........................................... 178 8.7.3 Thomas Addison (1793-1860).............................................. 179 8.7.4 Fuller Albright (1900-1969)................................................. 179 8.7.5 Jerome W. Conn (1907-1994)................................................. 180 xvi Contents 8.7.6 Frederick Banting (1891-1941).............................................. 180 8.7.7 Robert Graves (1797-1853)..................................................... 181 8.7.8 Edward Kendall (1888-1972)................................................. 181 References........................................................................................................... 182 Appendix............................................................................................................. 187 Index..................................................................................................................... 193 Andrea Manni · Akuffo Guarde Endocrine Pathophysiology A Concise Guide to the Physical Exam this practical guide presents a concise approach to exploring endo crine pathophysiology through the physical exam, emphasizing com mon clinical signs in endocrinology that can be elicited through inspection, palpation, percussion or auscultation. The established and proposed mechanisms underlying these physical signs are highlight ed, allowing students, residents and trainees to better appreciate endo crine pathophysiology at the bedside. The text is organized sensibly to facilitate quick and efficient review by medical trainees. Major diseases in endocrinology are grouped by organ systems - pituitary, thyroid, adrenal, and so on. Specific physical examination findings in each primary endocrine disease are reviewed and grouped under the categories of clinical features and pathophysi ology, followed by related clinical and pathophysiology pearls. A brief description of the clinical finding is followed by a summary of the pathophysiologic mechanisms underlying the stated clinical finding. Relevant normal physiology and pathophysiology are reviewed where applicable, to facilitate learning. There are numerous texts on the pathophysiologic basis of diagnostic and laboratory findings in endocrinology. There is, however, no dedi cated text to address questions that might be asked by trainees. Endo crine Pathophysiology satisfies this need in the literature.
adam_txt	Contents 1 Pituitary Gland Signs. 1.1 Cushing’s Disease. 1.1.1 Proximal Myopathy. 1.1.2 Fat Maldistribution. 1.1.3 Striae and Skin Atrophy. 1.1.4 Facial Plethora. 1.1.5 Hirsutism. 1.1.6 Hypertension. 1.1.7 Fragility Fractures. 1.1.8 Hyperpigmentation. 1.2 Acromegaly. 1.2.1 Acanthosis Nigricans. 1.2.2 Frontal Bossing and Prognathism. 1.2.3 Acrochordons and Other Skin Manifestations. 1.2.4 Colonic Polyps. 1.2.5 Tinel’s Sign (Carpal Tunnel Syndrome). 1.2.6 Hypertension. 1.3 Prolactinoma. 1.3.1 Hypogonadism. 1.3.2 Gynecomastia and Galactorrhea. 1.3.3 Bitemporal Hemianopsia. 1.4 Adult Growth Hormone Deficiency. 1.4.1 Abnormal Body Composition. 1.5 Growth Hormone Insensitivity (Laron-Type Dwarfism). 1.5.1 Short Stature. 1.5.2 Obesity. 1.5.3 Small Genitalia. 1.6 Central Diabetes Insipidus. 1.6.1 Dehydration due to Polyuria and Polydipsia. References. 1 1 1 3 4 4 5 6 6 7 8 8 9 9 10 11 11 12 12 12 13 14 14 16 16 16 17 18 18 21 2 Thyroid Gland Signs. 2.1 Hashimoto’s Thyroiditis. 2.1.1 Queen Anne’s Sign. 27 27 27 xi xii Contents 2.1.2 Bradycardia. 2.1.3 Pericardial and Pleural Effusions. 2.1.4 Dry Skin. 2.1.5 Macroglossia. 2.1.6 Hyporeflexia. 2.1.7 Proximal Myopathy. 2.1.8 Galactorrhea. 2.2 Graves’ Disease. 2.2.1 Thyroid Eye Disease. 2.2.2 Prétibial Myxedema. 2.2.3 Thyroid Acropachy. 2.2.4 Onycholysis. 2.2.5 Periodic Paralysis. 2.2.6 Thyroid Bruit and Thrill. 2.2.7 Tachycardia. 2.2.8 Gynecomastia. 2.2.9 Lymphadenopathy. 2.2.10 Change in Body Composition (Weight Loss). 2.3 Euthyroid Goiter with Thoracic Outlet Syndrome. 2.3.1 Pemberton’s Sign. 2.3.2 Other Compressive Signs (Superior Vena Cava Syndrome, Phrenic Nerve Paralysis). 2.4 Resistance to ThyroidHormone. 2.4.1 Goiter. 2.4.2 Short Stature. 2.5 Medullary Thyroid Cancer. 2.5.1 Facial Flushing and Other Clinical Features of Neuroendocrine Origin. 2.5.2 Cervical Mass. References. 3 28 28 29 29 30 30 30 32 32 34 34 35 35 36 36 37 37 38 39 39 40 42 42 42 44 44 44 45 Adrenal Gland Signs. 51 3.1 Primary Adrenal Insufficiency. 51 3.1.1 Postural Hypotension. 51 3.1.2 Hyperpigmentation. 53 3.2 Primary Hyperaldosteronism. 55 3.2.1 Hypertension. 55 3.2.2 Muscle Weakness. 57 3.2.3 Atrial Fibrillation. 57 3.2.4 Dehydration. 57 3.3 Pseudohypoaldosteronism. 60 3.3.1 Cardiac Arrest due toLife-Threatening Hyperkalemia. 60 3.3.2 Cutaneous Manifestations (Folliculitis and Atopic Dermatitis). 60 Contents xiii 3.4 Familial Glucocorticoid Deficiency. 3.4.1 Hyperpigmentation. 3.4.2 Hypoglycemia. 3.5 Pheochromocytomas and Other Paraganglioma Syndromes. 3.5.1 Hypertension. 3.5.2 Hypotension. 3.5.3 Generalized Hyperhidrosis. 3.5.4 Cardiogenic Shock. 3.6 Nonclassic Congenital Adrenal Hyperplasia (NCCAH). 3.6.1 Clinical Hyperandrogenism (Acne and Hirsutism). 3.6.2 Testicular Adrenal Rest Tumors. 3.6.3 Signs of Insulin Resistance (Skin Tags and Acanthosis Nigricans). References. 61 61 61 63 63 65 66 66 67 67 68 4 Pancreatic Gland Signs. 4.1 Diabetes Mellitus. 4.1.1 Acanthosis Nigricans. 4.1.2 Diabetic Dermopathy. 4.1.3 Acrochordons (Skin Tags). 4.1.4 Necrobiosis Lipoidica Diabeticorum. 4.1.5 Lipodystrophy Due to Insulin Injections. 4.1.6 Diabetic Retinopathy on Direct Ophthalmoscopy. 4.1.7 The Diabetic Foot. 4.2 Rabson-Mendenhall Syndrome (Type A Insulin Resistance). 4.2.1 Acanthosis Nigricans. 4.3 Glucagonoma. 4.3.1 Necrolytic Migratory Erythema. 4.4 Carcinoid Syndrome. 4.4.1 Cutaneous Flushing. 4.4.2 Diarrhea. 4.4.3 Bronchospasm. 4.4.4 Cardiac Valvular Lesions. 4.4.5 Other Cutaneous Manifestations (Pellagra). 4.5 VIPoma. 4.5.1 Dehydration Due to Extrarenai Losses. References. 77 77 77 78 78 78 79 81 83 86 86 88 88 89 89 90 91 92 92 94 94 97 5 Parathyroid Gland and Musculoskeletal Signs. 103 5.1 Hyperparathyroidism. 103 5.1.1 Acute Abdomen.103 5.1.2 Fragility Fractures. 104 5.1.3 Band Keratopathy/Cataracts.104 5.1.4 Hypertension.105 68 71 Contents xiv 5.2 Hypoparathyroidism.109 5.2.1 Trousseau’s Sign and Chvostek Sign in the Setting of Hypocalcemia. 109 5.2.2 Seizures. 109 5.2.3 Hypotension. HO 5.2.4 Papilledema. 110 5.3 Pseudohypoparathyroidism. Ill 5.3.1 Short Stature. Ill 5.3.2 Obesity. 112 5.3.3 Brachydactyly. 112 5.3.4 Dental Manifestations. 113 5.4 Paget’s Disease of Bone.114 5.4.1 Fractures and Bone Deformity. 114 5.4.2 Congestive Heart Failure. 115 5.4.3 Sensorineural Hearing Loss. 115 5.5 Hereditary Vitamin D-ResistantRickets Type 2 (HVDRR-II). 116 5.5.1 Rickets.116 5.6 X-Linked Hypophosphatémie Rickets. 117 5.6.1 Short Stature. 117 5.6.2 Dental Abscess.119 References. 120 6 Reproductive Organ Signs.127 6.1 6.2 6.3 6.4 6.5 Turner’s Syndrome. 127 6.1.1 Short Stature. 127 6.1.2 Webbed Neck and Lymphedema. 129 6.1.3 Hypertension. 129 6.1.4 Melanocytic Nevi. 130 6.1.5 Sexual Infantilism. 130 Polycystic Ovarian Syndrome.131 6.2.1 Hirsutism. 131 6.2.2 Acanthosis Nigricans. 132 6.2.3 Acne. 132 6.2.4 Obesity. 132 Male Hypogonadism. 134 6.3.1 Decreased Testicular Volume. 134 6.3.2 Gynecomastia. 135 6.3.3 Loss of Height or Fragility Fractures. 137 6.3.4 Change in Body Composition. 138 Menopause. 139 6.4.1 Vaginal Dryness. 139 6.4.2 Fragility Fractures.139 6.4.3 Change in Body Composition. 140 Estrogen Resistance. 141 6.5.1 Tall Stature.141 6.5.2 Acanthosis Nigricans.141 Contents XV Complete Androgen Insensitivity. 142 6.6.1 Abnormalities of the External andInternal Genitalia. 142 6.6.2 Normal Breast Tissue Development. 142 References. 144 6.6 7 Signs in Disorders of Lipid Metabolism and Obesity. 151 7.1 Signs in Disorders of Lipid Metabolism. 151 7.1.1 Corneal Arcus. 151 7.1.2 Xanthomas and Xanthelasma. 152 7.1.3 Skin Crease (Frank’s Sign). 153 7.1.4 Lipemia Retinalis. 153 7.2 Congenital Leptin Deficiency. 160 7.2.1 Obesity. 160 7.3 Proopiomelanocortin (POMC) Deficiency. 161 7.3.1 Triad of Obesity, Adrenal Insufficiency, and Reddish Hair. 161 7.4 Lipodystrophy Syndromes. 163 7.4.1 Atrophy of Adipose Tissue. 163 7.4.2 Hepatomegaly. 163 References. 165 8 Eponymous Terms and Selected Historical Figures in Endocrinology.171 8.1 Eponyms Related to the Pituitary Gland. 171 8.1.1 Wolfram Syndrome (DIDMOAD). 171 8.1.2 Histiocytosis X. 172 8.2 Eponyms Related to the Thyroid Gland. 172 8.2.1 Pendred’s Syndrome. 172 8.3 Eponyms Related to the Adrenal Glands. 174 8.3.1 Carney Dyad or Carney-Stratakis Syndrome. 174 8.3.2 Allgrove Syndrome. 175 8.4 Eponyms Related to the Pancreas. 175 8.4.1 Kussmaul’s Breathing (Diabetic Ketoacidosis). 175 8.4.2 Somogyi Effect. 175 8.5 Eponyms Related to the Parathyroid Glands and Bone Metabolism.176 8.5.1 Albers-Schönberg Disease. 176 8.5.2 McCune-Albright Syndrome. 177 8.6 Miscellaneous Eponyms. 177 8.7 A Brief Account of Selected Historical Figures in Endocrinology. 177 8.7.1 Harvey Cushing (1869-1939). 177 8.7.2 Hakaru Hashimoto (1881-1934). 178 8.7.3 Thomas Addison (1793-1860). 179 8.7.4 Fuller Albright (1900-1969). 179 8.7.5 Jerome W. Conn (1907-1994). 180 xvi Contents 8.7.6 Frederick Banting (1891-1941). 180 8.7.7 Robert Graves (1797-1853). 181 8.7.8 Edward Kendall (1888-1972). 181 References. 182 Appendix. 187 Index. 193 Andrea Manni · Akuffo Guarde Endocrine Pathophysiology A Concise Guide to the Physical Exam 'this practical guide presents a concise approach to exploring endo crine pathophysiology through the physical exam, emphasizing com mon clinical signs in endocrinology that can be elicited through inspection, palpation, percussion or auscultation. The established and proposed mechanisms underlying these physical signs are highlight ed, allowing students, residents and trainees to better appreciate endo crine pathophysiology at the bedside. The text is organized sensibly to facilitate quick and efficient review by medical trainees. Major diseases in endocrinology are grouped by organ systems - pituitary, thyroid, adrenal, and so on. Specific physical examination findings in each primary endocrine disease are reviewed and grouped under the categories of clinical features and pathophysi ology, followed by related clinical and pathophysiology pearls. A brief description of the clinical finding is followed by a summary of the pathophysiologic mechanisms underlying the stated clinical finding. Relevant normal physiology and pathophysiology are reviewed where applicable, to facilitate learning. There are numerous texts on the pathophysiologic basis of diagnostic and laboratory findings in endocrinology. There is, however, no dedi cated text to address questions that might be asked by trainees. Endo crine Pathophysiology satisfies this need in the literature.
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indexdate	2024-07-10T09:40:14Z
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isbn	9783030498719
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physical	XVII, 200 Seiten Illustrationen
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spelling	Manni, Andrea Verfasser (DE-588)140635912 aut Endocrine pathophysiology a concise guide to the physical exam Andrea Manni, Akuffo Quarde Cham Springer [2020] XVII, 200 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Endocrinology Endocrinology Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Endokrinopathie (DE-588)4113435-7 gnd rswk-swf Endokrine Drüse (DE-588)4113433-3 gnd rswk-swf Endokrinopathie (DE-588)4113435-7 s DE-604 Endokrine Drüse (DE-588)4113433-3 s Pathophysiologie (DE-588)4044898-8 s Quarde, Akuffo Verfasser aut Erscheint auch als Online-Ausgabe 978-3-030-49872-6 Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033893587&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033893587&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext
spellingShingle	Manni, Andrea Quarde, Akuffo Endocrine pathophysiology a concise guide to the physical exam Endocrinology Endocrinology Pathophysiologie (DE-588)4044898-8 gnd Endokrinopathie (DE-588)4113435-7 gnd Endokrine Drüse (DE-588)4113433-3 gnd
subject_GND	(DE-588)4044898-8 (DE-588)4113435-7 (DE-588)4113433-3
title	Endocrine pathophysiology a concise guide to the physical exam
title_auth	Endocrine pathophysiology a concise guide to the physical exam
title_exact_search	Endocrine pathophysiology a concise guide to the physical exam
title_exact_search_txtP	Endocrine pathophysiology a concise guide to the physical exam
title_full	Endocrine pathophysiology a concise guide to the physical exam Andrea Manni, Akuffo Quarde
title_fullStr	Endocrine pathophysiology a concise guide to the physical exam Andrea Manni, Akuffo Quarde
title_full_unstemmed	Endocrine pathophysiology a concise guide to the physical exam Andrea Manni, Akuffo Quarde
title_short	Endocrine pathophysiology
title_sort	endocrine pathophysiology a concise guide to the physical exam
title_sub	a concise guide to the physical exam
topic	Endocrinology Endocrinology Pathophysiologie (DE-588)4044898-8 gnd Endokrinopathie (DE-588)4113435-7 gnd Endokrine Drüse (DE-588)4113433-3 gnd
topic_facet	Endocrinology Endocrinology Pathophysiologie Endokrinopathie Endokrine Drüse
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033893587&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033893587&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT manniandrea endocrinepathophysiologyaconciseguidetothephysicalexam AT quardeakuffo endocrinepathophysiologyaconciseguidetothephysicalexam

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