Insatiable appetite: food as cultural signifier in the Middle East and beyond
Gespeichert in:
Weitere Verfasser: | , , |
---|---|
Format: | Buch |
Sprache: | English |
Veröffentlicht: |
Leiden ; Boston
Brill
[2020]
|
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
Beschreibung: | XI, 362 Seiten Illustrationen 24 cm |
ISBN: | 9789004407626 9789004413023 |
Internformat
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245 | 1 | 0 | |a Insatiable appetite |b food as cultural signifier in the Middle East and beyond |c edited by Kirill Dmitriev, Julia Hauser, Bilal Orfali |
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Datensatz im Suchindex
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adam_text | INHALTSVERZEICHNIS
ABKUERZUNGSVERZEICHNIS 2
1 EINLEITUNG 3
1.1 G LIOBLASTOM
E...............................................................................................
3
1.1.1 AETIOLOGIE &
EPIDEMIOLOGIE...............................................................
3
1.1.2 DIAGNOSTIK .
.
...................................................................................
5
1.1.3 THERAPIE
...................................................................................
... . 8
1.1.4
LANGZEITUEBERLEBEN...........................................................................
12
1.2 DNA-METHYLIERUNG IM MENSCHLICHEN G E N O M
............................................. 13
1.3 DNA-METHYLIERUNG IN DER
TUMORGENESE...................................................... 15
1.4 Z
IELSETZUNG......................................................................................
17
2 MATERIAL UND METHODEN 19
2.1
STUDIENKOLLEKTIVE.........................................................................................
19
2.1.1 LTS/STS
KOLLEKTIV...........................................................................
19
2.1.2
NORMALHIMPROBEN..........................................................................
19
2.1.3
VALIDIERUNGSKOLLEKTIVE.....................................................................
20
2.1.4
ETHIKVOTUM......................................................................................
21
2.2 M
ATERIAL..................................................................................................
22
2.3 M
ETHODEN.....................................................................................................
26
2.3.1 BEURTEILUNG VON
GEWEBEPROBEN...................................................... 26
2.3.2
DNA-EXTRAKTION.............................................................................
26
2.3.3
DNA-FRAGMENTIERUNG....................................................................
26
2.3.4 METHYL-CPG IMMUNPRAEZIPITATION (M C IP
)....................................... 27
2.3.5
MICROARRAYANALYSE..........................................................................
29
2.3.6 MASSARRAY
.
...................................................................................
30
2.4 STATISTISCHE UND BIOINFORMATISCHE A N ALY SEN
................................................ 34
2.4.1 PRAEPROZESSIERUNG UND NORMALISIERUNG DER
MICROARRAYDATEN............. 34
2.4.2 HYPOTHESENTESTS
..............................................................................
34
2.4.3
UEBERLEBENSANALYSE...........................................................................
35
2.4.4 REPRODUZIERBARE
DATENANALYSE......................................................... 35
3 ERGEBNISSE 39
3.1 ANREICHERUNG METHYLIERTER
DNA-FRAGMENTE................................................ 39
3.2 AUSSCHLUSS EINES G -C IM P
...........................................................................
41
3.3 GENOMWEITE
DNA-METHYLIERUNGSANALYSE...................................................
42
3.4 DIFFERENZIELL METHYLIERTE REGIONEN IN LTS UND S T S
....................................
44
3.5 UNTERSUCHUNG DER DMR MITTELS
MASSARRAY............................................. 45
3.6 METHYLIERUNG DER LOC283731/ISLR2
PROMOTOREN....................................... 47
3.7 MUTATIONEN IM LOC283731/ISLR2 LOKUS . .
.
............................................
48
3.8 PROGNOSEFAEHIGKEIT IM TCGA
VALIDIERUNGSKOLLEKTIV.................................... 49
3.9 PROGNOSEFAEHIGKEIT IM HEIDELBERG VALIDIERUNGSKOLLEKTIV
..............................
52
3.10 LOC283731 UND MGMT SIND NICHT KOM ETHYLIERT
.......................................
53
4 DISKUSSION 55
4.1 ANSATZ DER
BIOMARKERENTWICKLUNG...............................................................
55
4.2 MCIP UND MICROARRAYANALYSE
.......................................................................
56
4.3 VALIDERUNG MITTELS
MASSARRAY..................................................................
59
4.4 PUBLIZIERTE
BIOMARKERSTUDIEN........................................................................
59
4.5 REPRODUZIERBARE
DATENANALYSE.....................................................................
61
4.6 LOC283731
PROMOTORMETHYLIERUNG............................................................
62
4.7 INTEGRATIVE HIMTUMORDIAGNOSTIK
.................................................................
63
4.8
AUSBLICK........................................................................................................
64
5 ZUSAMMENFASSUNG 65
LITERATURVERZEICHNIS 67
EIGENE VEROEFFENTLICHUNGEN 79
LEBENSLAUF 83
DANKSAGUNG 85
EIDESSTATTLICHE VERSICHERUNG
87
|
adam_txt |
INHALTSVERZEICHNIS
ABKUERZUNGSVERZEICHNIS 2
1 EINLEITUNG 3
1.1 G LIOBLASTOM
E.
3
1.1.1 AETIOLOGIE &
EPIDEMIOLOGIE.
3
1.1.2 DIAGNOSTIK .
.
.
5
1.1.3 THERAPIE
.
. . 8
1.1.4
LANGZEITUEBERLEBEN.
12
1.2 DNA-METHYLIERUNG IM MENSCHLICHEN G E N O M
. 13
1.3 DNA-METHYLIERUNG IN DER
TUMORGENESE. 15
1.4 Z
IELSETZUNG.
17
2 MATERIAL UND METHODEN 19
2.1
STUDIENKOLLEKTIVE.
19
2.1.1 LTS/STS
KOLLEKTIV.
19
2.1.2
NORMALHIMPROBEN.
19
2.1.3
VALIDIERUNGSKOLLEKTIVE.
20
2.1.4
ETHIKVOTUM.
21
2.2 M
ATERIAL.
22
2.3 M
ETHODEN.
26
2.3.1 BEURTEILUNG VON
GEWEBEPROBEN. 26
2.3.2
DNA-EXTRAKTION.
26
2.3.3
DNA-FRAGMENTIERUNG.
26
2.3.4 METHYL-CPG IMMUNPRAEZIPITATION (M C IP
). 27
2.3.5
MICROARRAYANALYSE.
29
2.3.6 MASSARRAY
.
.
30
2.4 STATISTISCHE UND BIOINFORMATISCHE A N ALY SEN
. 34
2.4.1 PRAEPROZESSIERUNG UND NORMALISIERUNG DER
MICROARRAYDATEN. 34
2.4.2 HYPOTHESENTESTS
.
34
2.4.3
UEBERLEBENSANALYSE.
35
2.4.4 REPRODUZIERBARE
DATENANALYSE. 35
3 ERGEBNISSE 39
3.1 ANREICHERUNG METHYLIERTER
DNA-FRAGMENTE. 39
3.2 AUSSCHLUSS EINES G -C IM P
.
41
3.3 GENOMWEITE
DNA-METHYLIERUNGSANALYSE.
42
3.4 DIFFERENZIELL METHYLIERTE REGIONEN IN LTS UND S T S
.
44
3.5 UNTERSUCHUNG DER DMR MITTELS
MASSARRAY. 45
3.6 METHYLIERUNG DER LOC283731/ISLR2
PROMOTOREN. 47
3.7 MUTATIONEN IM LOC283731/ISLR2 LOKUS . .
.
.
48
3.8 PROGNOSEFAEHIGKEIT IM TCGA
VALIDIERUNGSKOLLEKTIV. 49
3.9 PROGNOSEFAEHIGKEIT IM HEIDELBERG VALIDIERUNGSKOLLEKTIV
.
52
3.10 LOC283731 UND MGMT SIND NICHT KOM ETHYLIERT
.
53
4 DISKUSSION 55
4.1 ANSATZ DER
BIOMARKERENTWICKLUNG.
55
4.2 MCIP UND MICROARRAYANALYSE
.
56
4.3 VALIDERUNG MITTELS
MASSARRAY.
59
4.4 PUBLIZIERTE
BIOMARKERSTUDIEN.
59
4.5 REPRODUZIERBARE
DATENANALYSE.
61
4.6 LOC283731
PROMOTORMETHYLIERUNG.
62
4.7 INTEGRATIVE HIMTUMORDIAGNOSTIK
.
63
4.8
AUSBLICK.
64
5 ZUSAMMENFASSUNG 65
LITERATURVERZEICHNIS 67
EIGENE VEROEFFENTLICHUNGEN 79
LEBENSLAUF 83
DANKSAGUNG 85
EIDESSTATTLICHE VERSICHERUNG
87 |
any_adam_object | 1 |
any_adam_object_boolean | 1 |
author2 | Dmitriev, Kirill 1976- Hauser, Julia Orfali, Bilal 1980- |
author2_role | edt edt edt |
author2_variant | k d kd j h jh b o bo |
author_GND | (DE-588)138140030 (DE-588)1048310698 (DE-588)140143777 |
author_facet | Dmitriev, Kirill 1976- Hauser, Julia Orfali, Bilal 1980- |
building | Verbundindex |
bvnumber | BV048502637 |
classification_rvk | LC 17335 |
ctrlnum | (OCoLC)1151357154 (DE-599)BVBBV048502637 |
dewey-full | 939.4-956 |
dewey-hundreds | 900 - History & geography |
dewey-ones | 939 - Other parts of ancient world |
dewey-raw | 939.4-956 |
dewey-search | 939.4-956 |
dewey-sort | 3939.4 3956 |
dewey-tens | 930 - History of ancient world to ca. 499 |
discipline | Geschichte Sozial-/Kulturanthropologie / Empirische Kulturwissenschaft |
discipline_str_mv | Geschichte Sozial-/Kulturanthropologie / Empirische Kulturwissenschaft |
format | Book |
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genre_facet | Aufsatzsammlung |
geographic | Nordafrika (DE-588)4042482-0 gnd Naher Osten (DE-588)4068878-1 gnd |
geographic_facet | Nordafrika Naher Osten |
id | DE-604.BV048502637 |
illustrated | Illustrated |
index_date | 2024-07-03T20:45:04Z |
indexdate | 2024-07-10T09:39:53Z |
institution | BVB |
isbn | 9789004407626 9789004413023 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-033879881 |
oclc_num | 1151357154 |
open_access_boolean | |
owner | DE-19 DE-BY-UBM DE-188 |
owner_facet | DE-19 DE-BY-UBM DE-188 |
physical | XI, 362 Seiten Illustrationen 24 cm |
publishDate | 2020 |
publishDateSearch | 2020 |
publishDateSort | 2020 |
publisher | Brill |
record_format | marc |
spelling | Insatiable appetite food as cultural signifier in the Middle East and beyond edited by Kirill Dmitriev, Julia Hauser, Bilal Orfali Leiden ; Boston Brill [2020] XI, 362 Seiten Illustrationen 24 cm txt rdacontent n rdamedia nc rdacarrier Nahrung (DE-588)4171117-8 gnd rswk-swf Nordafrika (DE-588)4042482-0 gnd rswk-swf Naher Osten (DE-588)4068878-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Naher Osten (DE-588)4068878-1 g Nordafrika (DE-588)4042482-0 g Nahrung (DE-588)4171117-8 s DE-604 Dmitriev, Kirill 1976- (DE-588)138140030 edt Hauser, Julia (DE-588)1048310698 edt Orfali, Bilal 1980- (DE-588)140143777 edt V:DE-576;B:DE-16 application/pdf https://swbplus.bsz-bw.de/bsz1677421509inh.htm 20200229153154 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033879881&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Insatiable appetite food as cultural signifier in the Middle East and beyond Nahrung (DE-588)4171117-8 gnd |
subject_GND | (DE-588)4171117-8 (DE-588)4042482-0 (DE-588)4068878-1 (DE-588)4143413-4 |
title | Insatiable appetite food as cultural signifier in the Middle East and beyond |
title_auth | Insatiable appetite food as cultural signifier in the Middle East and beyond |
title_exact_search | Insatiable appetite food as cultural signifier in the Middle East and beyond |
title_exact_search_txtP | Insatiable appetite food as cultural signifier in the Middle East and beyond |
title_full | Insatiable appetite food as cultural signifier in the Middle East and beyond edited by Kirill Dmitriev, Julia Hauser, Bilal Orfali |
title_fullStr | Insatiable appetite food as cultural signifier in the Middle East and beyond edited by Kirill Dmitriev, Julia Hauser, Bilal Orfali |
title_full_unstemmed | Insatiable appetite food as cultural signifier in the Middle East and beyond edited by Kirill Dmitriev, Julia Hauser, Bilal Orfali |
title_short | Insatiable appetite |
title_sort | insatiable appetite food as cultural signifier in the middle east and beyond |
title_sub | food as cultural signifier in the Middle East and beyond |
topic | Nahrung (DE-588)4171117-8 gnd |
topic_facet | Nahrung Nordafrika Naher Osten Aufsatzsammlung |
url | https://swbplus.bsz-bw.de/bsz1677421509inh.htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033879881&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT dmitrievkirill insatiableappetitefoodasculturalsignifierinthemiddleeastandbeyond AT hauserjulia insatiableappetitefoodasculturalsignifierinthemiddleeastandbeyond AT orfalibilal insatiableappetitefoodasculturalsignifierinthemiddleeastandbeyond |
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