The laboratory mouse:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton ; London ; New York
CRC Press, Taylor & Francis Group
2023
|
| Ausgabe: | Third edition |
| Schriftenreihe: | Laboratory animal pocket reference series
|
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | xvi, 228 Seiten Illustrationen |
| ISBN: | 9780367373207 9781032416854 |
Internformat
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| 245 | 1 | 0 | |a The laboratory mouse |c Mark A. Suckow, Sara A. Hashway, and Kathleen R. Pritchett-Corning |
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| 264 | 1 | |a Boca Raton ; London ; New York |b CRC Press, Taylor & Francis Group |c 2023 | |
| 300 | |a xvi, 228 Seiten |b Illustrationen | ||
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| 700 | 1 | |a Pritchett-Corning, Kathleen R. |e Verfasser |0 (DE-588)1281166898 |4 aut | |
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Datensatz im Suchindex
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contents preface. xüi about the authors. xv 1 important biological features. 1 introduction. 1 stocks and strains. 2 nomenclature. 3 anatomie and physiologie features. 5 normative values. 9 Basic Biologie Parameters. 9 Clinical Chemistry. 9 Urinalysis. 11 hematology. 12 immunodeficient mice. 13 wild mice. 15 behavior, well-being, and enrichment. 17 Behavior. 17 Well-being. 19 Enrichment. 20
references. 21 2 husbandry. 25 housing. 25 Caging. 25 Housing Systems. 28 и
vi contents Bedding. 30 barriers and containment.33 personal protective equipment (PPE). 36 special considerations for immunodeficient mice.37 environment.38 Temperature and Humidity. 38 Ventilation. 39 Illumination. 39 Noise and Vibration. 40 sanitation and pest control. 41 Sanitation. 41 Cage cleaning. 41 Room cleaning. 43 Research equipment cleaning. 43 Quality control.43 Pest Control. . 44 nutrition. 44 water.47
breeding. .47 Basic Genetics. 48 Breeding Schemes.49 Pheromone Influences. 52 Timed Pregnancy. 53 Genetic Monitoring. 54 identification and record keeping. 55 Identification. 55 Records. 57 transportation. 58 Between Institutions. 58 Within the Institution. 60 references. 60 3 management. 69 regulatory agencies and compliance.69 Institutional Animal Care and Use Committee (IACUC). 71 IACUC Composition. 71 Responsibilities of the IACUC. 72 occupational health and zoonotic diseases. 72 compassion
fatigue.75 references. 76
contents vü 4 clinical medicine. 79 basic veterinary supplies. 79 physical examination of the mouse.80 common spontaneous and noninfectious diseases. 82 Common Conditions Involving the Alimentary System .84 Non-neoplastic conditions.84 Alimentary tumors. 85 Common Conditions Involving the Cardiovascular System. 85 Non-neoplastic conditions. 85 Cardiovascular tumors. 87 Common Conditions Involving the Endocrine System. 87 Non-neoplastic conditions. 87 Endocrine tumors. 87 Hematopoietic and Immune System. 88 Non-neoplastic conditions. 88 Hematopoietic and immune system tumors. 89 Common Conditions Involving the Integumentary System.89 Non-neoplastic conditions.89 Tumors of skin and adnexae. 91 Common Conditions Involving the Musculoskeletal
System.93 Non-neoplastic conditions. 93 Musculoskeletal tumors.94 Common Conditions Involving the Nervous System. 94 Non-neoplastlc conditions. 94 Nervous system tumors. 96 Common Conditions Involving the Respiratory System.97 Non-neoplastic conditions. 97 Respiratory tumors. 97 Common Conditions Involving the Urogenital System. 97 Non-neoplastlc conditions. 97 Urogenital tumors. 98 Common Systemic or Multisystem Conditions. 98 Amyloidosis. 98 Hyalinosis.99 Conditions related to nutritional status.99 Stress-related changes. 100 common infectious diseases. 100
viii contents Diagnostic Methods.102 Viral Agents and Diseases. 103 Murine noroviruses (MNV). 104 Parvoviruses. 104 Mouse hepatitis virus (MHV). 105 Theiler’s mouse encephalomyelitis virus (TMEV). 106 Mouse rotavirus (MRV, EDIM).106 Murine astrovirus. 107 Mouse adenoviruses (MAV 1 and 2). 107 Lymphocytic choriomeningitis virus (LCMV). 108 Lactate dehydrogenase-elevating virus (LDV, . 108 Hantaviruses (Han). 108 Herpesviruses . 108 Ectromelia virus (mousepox). 108 Papovaviruses. 109 Paramyxoviruses. 110 Reovirus 3 (REO3).110 Bacterial Agents and Diseases.110 Bordetella species. :. 110 Filobacterium rodentium (formerly cilia-associated respiratory
bacillus, CAR bacillus, CARB). Ill Citrobacter rodentium. Ill Clostridium piliforme. 112 Corynebacterium bovis. 112 Helicobacter. 112 Mycoplasma. 113 Rodentibacter pneumotropicus and R. heylit (formerly Pasteurella pneumotropica type Jawetz or Heyl). 113 Pseudomonas aeruginosa. 114 Staphylococcus. 114 Fungal Agents and Diseases. 115 Pneumocystis murina. 115 Intestinal protozoa.115 Parasitic Agents and Diseases. 117 Arthropods. 117 Helminths.119 treatment and supportive care of sick mice. 122 Drug Dosages. 122 General Treatment of Open Skin Lesions. 122
contents ix General Treatment of Weak Mice. 122 Provision of supplemental fluids. 123 Provision of food. 123 Provision of supplemental heat. 124 Treatment of Dystocia. 124 clinical endpoints. 125 treating disease on a colony basis. 129 Prevention of Spread. 129 Approaches to Elimination .131 Depopulation. 131 Test and cull. 131 Burnout. 132 Medical treatment. 132 Facility Decontamination. 133 references. 133 5 preventive medicine. 141 receiving. 141 Reviewing Health Reports. 141 Options for Newly Imported
Mice. 144 Transport directly to barrier.144 Quarantine. 144 Rederivation. 146 Cryopreservation. 148 testing of biological materials. 148 Risks for Humans and Animals. 148 health surveillance and monitoring. 150 Principles. 150 Selection of Test Subjects. 151 Diagnostic Testing. 153 disease prevention through sanitation. 153 references. 154 6 experimental methodology. 157 restraint. 157 Cage Transfer. 157 Restraint for Manipulation. 158 Restraint Devices. 159 sampling
methods. 159 Blood. 159
X contents Urine. 165 Feces. 167 Samples for DNA Analysis. 167 Vaginal Swabs. 168 compound administration. 169 Oral (PO). 169 Intramuscular (IM). 170 Intraperitoneal (IP). 171 Subcutaneous (SC). 172 Intradermal (ID).172 Intravenous (IV).172 Retro-orbital (RO). 173 Implantable Cannulas and Pumps. 174 anesthesia and analgesia. 175 Anesthesia. 175 Methods and drugs. 176 Periprocedural Care. 182 Analgesia. 185 euthanasia. . 188 Laws, Regulations, and
Guidelines. 189 Management Considerations.189 Scientific Considerations. 190 Experimental Endpoints. 190 Euthanasia Methods. 191 necropsy. 193 Equipment and Materials. 193 Necropsy Procedure. 195 External examination. . 196 Dissection and specimen collection. 196 Trimming tissues for histology. 199 Histopathology.200 Reporting and archiving data and specimens. 200 references. 200 7 resources and additional information. 209 organizations. 209 American Association for Laboratory Animal Science (AALAS), www.aalas.org. 209 Laboratory Animal Management Association (LAMA), www.lama-online.org. 210
contents xi American Society of Laboratory Animal Practitioners (ASLAP), www.aslap.org. 210 American College of Laboratory Animal Medicine (ACLAM), www.aclam.org. 210 Laboratory Animal Welfare Training Exchange (LAWTE), www.lawte.org. 211 Institute for Laboratory Animal Research (ILAR), www.nationalacademies.org/ilar/institute-for -laboratory-animal-research. 211 AAALAC International, www.aaalac.org. 211 Foundation for Biomedical Research (FBR), fbresearch.org. 212 National Association for Biomedical Research (NABR), www.nabr.org.212 publications. 212 Books. 212 Guideline Documents. 214 Periodicals. 214 electronic resources. 215 appendix. 217 suggested cassette numbering system and some trimming
suggestions. 217 index.221
With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. Revised to reflect advances since the second edition, The Laboratory Mouse continues to be the most accessible reference on the biology and care of the mouse in research settings. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers on the humane care and use of the mouse. The new edition adds information on novel technologies such as CRISPR-Cas and on housing systems and management practices; it covers new concepts such as pain assessment by facial expression and the importance of nest-building as an assessment tool of well-being. There are now expanded sections on anesthesia and analgesia, and on behavior and enrichment. An ideal quick reference for investigators, technicians, and animal caretakers charged with the care and/or use of mice in a research setting, this book will be particularly valuable to those new to working with mice who need to start research programs using these animals. |
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| isbn | 9780367373207 9781032416854 |
| language | English |
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