The CliniBook: Clinical gene transfer state of the art
This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory is...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
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Les Ulis
EDP Sciences
[2012]
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| Online-Zugang: | FAW01 FAB01 FCO01 FHA01 FKE01 FLA01 UPA01 Volltext |
| Zusammenfassung: | This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation |
| Beschreibung: | Description based on online resource; title from PDF title page (publisher's Web site, viewed 30. Aug 2022) |
| Beschreibung: | 1 Online-Ressource (589 pages) |
| ISBN: | 9782842542375 |
| DOI: | 10.1051/978-2-84254-237-5 |
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| spelling | Cohen-Haguenauer, Odile Verfasser aut The CliniBook Clinical gene transfer state of the art Odile Cohen-Haguenauer Les Ulis EDP Sciences [2012] © 2012 1 Online-Ressource (589 pages) txt rdacontent c rdamedia cr rdacarrier Description based on online resource; title from PDF title page (publisher's Web site, viewed 30. Aug 2022) This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation In English MEDICAL / Laboratory Medicine bisacsh Genetic transformation Aiuti, Alessandro ctb Ali, Robin R. ctb Alici, Evren ctb Almqvist, Per ctb Annunziata, Patrizia ctb Anton, Martina ctb Artus, Alexandre ctb Athanasopoulos, Takis ctb Aubourg, Patrick ctb Auregan, Gwennaelle ctb Auricchio, Alberto ctb Ayuso, Eduard ctb Bandeira, Vanessa ctb Bartholomae, Cynthia C. ctb Baum, Christopher ctb Bayart, Émilie ctb Bednarski, Christien ctb Bellier, Bertrand ctb Biasco, Luca ctb Bigey, Pascal ctb Blouin, Véronique ctb Bode, Juergen ctb Bonvento, Gilles ctb Bosch, Fatima ctb https://doi.org/10.1051/978-2-84254-237-5 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Cohen-Haguenauer, Odile The CliniBook Clinical gene transfer state of the art MEDICAL / Laboratory Medicine bisacsh Genetic transformation |
| title | The CliniBook Clinical gene transfer state of the art |
| title_auth | The CliniBook Clinical gene transfer state of the art |
| title_exact_search | The CliniBook Clinical gene transfer state of the art |
| title_exact_search_txtP | The CliniBook Clinical gene transfer state of the art |
| title_full | The CliniBook Clinical gene transfer state of the art Odile Cohen-Haguenauer |
| title_fullStr | The CliniBook Clinical gene transfer state of the art Odile Cohen-Haguenauer |
| title_full_unstemmed | The CliniBook Clinical gene transfer state of the art Odile Cohen-Haguenauer |
| title_short | The CliniBook |
| title_sort | the clinibook clinical gene transfer state of the art |
| title_sub | Clinical gene transfer state of the art |
| topic | MEDICAL / Laboratory Medicine bisacsh Genetic transformation |
| topic_facet | MEDICAL / Laboratory Medicine Genetic transformation |
| url | https://doi.org/10.1051/978-2-84254-237-5 |
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