Adaptive Oncogenesis: A New Understanding of How Cancer Evolves inside Us
Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer's occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecos...
Gespeichert in:
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, MA
Harvard University Press
[2018]
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| Schlagworte: | |
| Online-Zugang: | FAW01 FAB01 FCO01 FHA01 FKE01 FLA01 UPA01 URL des Erstveröffentlichers |
| Zusammenfassung: | Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer's occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the body's tissues. His theory ties cancer's progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genes-but not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cells' ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a species' habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregori's perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissues' natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective |
| Beschreibung: | Description based on online resource; title from PDF title page (publisher's Web site, viewed 24. Aug 2021) |
| Beschreibung: | 1 online resource (250 pages) 16 line illustrations |
| ISBN: | 9780674985964 |
| DOI: | 10.4159/9780674985964 |
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| 520 | |a Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer's occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the body's tissues. His theory ties cancer's progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genes-but not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cells' ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a species' habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregori's perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissues' natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective | ||
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| spelling | DeGregori, James DeGregori Verfasser aut Adaptive Oncogenesis A New Understanding of How Cancer Evolves inside Us James DeGregori DeGregori Cambridge, MA Harvard University Press [2018] © 2018 1 online resource (250 pages) 16 line illustrations txt rdacontent c rdamedia cr rdacarrier Description based on online resource; title from PDF title page (publisher's Web site, viewed 24. Aug 2021) Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer's occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the body's tissues. His theory ties cancer's progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genes-but not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cells' ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a species' habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregori's perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissues' natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective In English SCIENCE / Life Sciences / Evolution bisacsh Cancer Etiology Cancer Genetic aspects Carcinogenesis Cells Evolution https://doi.org/10.4159/9780674985964 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | DeGregori, James DeGregori Adaptive Oncogenesis A New Understanding of How Cancer Evolves inside Us SCIENCE / Life Sciences / Evolution bisacsh Cancer Etiology Cancer Genetic aspects Carcinogenesis Cells Evolution |
| title | Adaptive Oncogenesis A New Understanding of How Cancer Evolves inside Us |
| title_auth | Adaptive Oncogenesis A New Understanding of How Cancer Evolves inside Us |
| title_exact_search | Adaptive Oncogenesis A New Understanding of How Cancer Evolves inside Us |
| title_exact_search_txtP | Adaptive Oncogenesis A New Understanding of How Cancer Evolves inside Us |
| title_full | Adaptive Oncogenesis A New Understanding of How Cancer Evolves inside Us James DeGregori DeGregori |
| title_fullStr | Adaptive Oncogenesis A New Understanding of How Cancer Evolves inside Us James DeGregori DeGregori |
| title_full_unstemmed | Adaptive Oncogenesis A New Understanding of How Cancer Evolves inside Us James DeGregori DeGregori |
| title_short | Adaptive Oncogenesis |
| title_sort | adaptive oncogenesis a new understanding of how cancer evolves inside us |
| title_sub | A New Understanding of How Cancer Evolves inside Us |
| topic | SCIENCE / Life Sciences / Evolution bisacsh Cancer Etiology Cancer Genetic aspects Carcinogenesis Cells Evolution |
| topic_facet | SCIENCE / Life Sciences / Evolution Cancer Etiology Cancer Genetic aspects Carcinogenesis Cells Evolution |
| url | https://doi.org/10.4159/9780674985964 |
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