Essential tremor: current concepts and controversies
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, MA ; San Diego, CA
Academic Press, an imprint of Elsevier
2022
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| Ausgabe: | First edition |
| Schriftenreihe: | International review of neurobiology
volume 163 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | x, 355 Seiten Illustrationen |
| ISBN: | 9780323899741 |
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| 245 | 1 | 0 | |a Essential tremor |b current concepts and controversies |c edited by Sheng-Han Kuo (Departement of Neurology, College of Physicians and Surgeons; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, United States), Elan D. Louis (Departement of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States) |
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Datensatz im Suchindex
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| adam_text | Contents Contributors ix Section I What s in a Name? Nomenclature of essential tremor: Syndrome or family of diseases? 1 Elan D. Louis and Sheng-Han Kuo 1. Is essential tremor a family of diseases or a syndrome? A family of diseases 7 Giulietta Μ. Riboldi and Steven J. Frucht 1. Introduction 8 2. Demographic and clinical features of the ET-family—A common origin with 9 different branches 16 3. ET-family neuropathology 4. ET-family neurophysiology 17 5. Evidence from genetics: Interfamilial variability and overlap 19 6. Evidence from imaging studies 20 7. Conclusions 21 References 21 2. Is essential tremor a family of diseases or a syndrome? A syndrome 31 Sanjay Pandey 1. Introduction 32 2. Definition of a syndrome 33 3. Essential tremor: Syndrome or family of diseases”? 34 4. Discussion 50 5. Conclusion 51 References 51 Section II Essential tremor: Is this an electrical or a degenerative disorder? Or is it both? 61 Elan D. Louis and Sheng-Han Kuo 3. Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder 65 Phyllis L Faust 1. Introduction 66 v|
vi Contents 2. Clinical features of ET as a degenerative disorder 68 3. Neuroimaging findings suggest cerebellar degeneration in ET 72 4. Pathological findings in ET demonstrate cerebellar degeneration 77 5. Cerebellar pathology and clinical heterogeneity in ET 92 6. ET as a degenerative disorder: Insight into disease mechanisms 92 7. Conclusions 94 References 94 4. Is essential tremor a degenerative or an electrical disorder? Electrical disorder 103 Hyun Joo Cho 1. Introduction 104 2. ET is an electric disorder 105 3. Essential tremor is not a primary neurodegenerative disorder 114 4. Conclusion and future direction 119 References 120 Section III How important is the inferior olive in essential tremor? An evolving story 129 Sheng-Han Kuo and Elan D. Louis 5. Is the inferior olive central to essential tremor? Yes 133 Eric J. Lang and Adrian Handforth 1. Clues to circuit dysfunction in essential tremor 2. Ю-induced PC synchrony as related to tremor 134 ’ 137 3. The olivocerebellar-DCN circuit and tremor: Potential players 147 4. Conclusions 155 References 157 6. Is inferior olive central to the pathophysiology of essential tremor? No 167 Mario Manto 1. Epidemiology 168 2. Clinical presentation 168 3. Genetics 170 4. Diagnosis 170 5. Pathogenesis 171 6. Re-considering our physiological conceptualization of cerebellar tremor 179 7. Conclusion 181 References 181
Contents vii Section IV Essential tremor as a harbinger: What is the cognitive fallout of having essential tremor? 189 Elan D. Louis and Sheng-Han Kuo 7. Does essential tremor increase risk of cognitive impairment and dementia? Yes 195 Stephanie Cosentino and Ludy C Shih 1. Introduction 196 2. Cognitive impairment in ET 198 3. Clinic based studies 200 4. Population based studies 202 5. Question of misdiagnosis 206 6. Mechanisms of cognitive impairment in ET 210 7. Mechanisms: Cerebellar dysfunction 210 8. Mechanisms: Extra-cerebellar dysfunction 213 9. Mechanisms: Co-morbid degenerative disease 215 10. Summary and conclusions 218 11. Clinical relevance and future directions 219 References 224 8. Does essential tremor increase the risk of dementia? No 233 Alex Rajput 1. Introduction 234 2. Question 234 3. Background and definitions 234 4. Studies 237 5. Discussion 248 6. Conclusion 250 References 250 Section V Is essential tremor a disorder primarily due to GABA dysfunction? 255 Sheng-Han Kuo and Elan D. Louis 9. Is essential tremor a disorder of primary GABA dysfunction? Yes 259 Alexandre Gironell 1. Background 260 2. GABA 264 3. GABA studies in essential tremor 266 4. GABA hypothesis:Supporting evidence 276 5. Final remarks 278 References 278
viii Contents 10. Is essential tremor a disorder of GABA dysfunction? No 285 Steven Bellows and Joohi Jimenez-Shahed 1. Introduction 286 2. Accumulating evidence against GABA-mediated tremor expression 287 3. Tremor as a result of oscillating networks 289 4. Cerebellar dysfunction and tremor manifestations 29Ί 5. Purkinje cell hypersynchrony as a correlate of tremor 292 6. Conclusions and future directions 301 References 302 Section VI The future of pharmacotherapies for essential tremor: Enhancing GABA neurotransmission or reducing neuronal hyperexcitability? 311 Sheng-Han Kuo and Elan D. Louis 11. Enhancing GABA inhibition is the next generation of medications for essential tremor 317 William Ondo 1. Introduction 318 2. Essential tremor macro and microanatomy 318 3. y֊aminobutyric acid (GABA) and GABA receptors 320 4. Anatomic and pathological abnormalities in ET are associated with GABA 322 5. The role of inferior olivary nucleus/cerebellar connections 322 6. Functional imaging studies 7. GABAergic genetics and genetic manipulation in ET 323 324 ’ 8. Most medications that improve tremor target GABA-A receptors 325 9. GABA-B receptors 329 10. Future directions 329 References 330 12. Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor 335 Aparna Wagle Shukla 1. Introduction 2.Pathophysiology of essential tremor 336 337 3. Reducing hyperexcitability of Purkinje cell and other hyperexcitable neurons References 342 349
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| adam_txt |
Contents Contributors ix Section I What's in a Name? Nomenclature of essential tremor: Syndrome or family of diseases? 1 Elan D. Louis and Sheng-Han Kuo 1. Is essential tremor a family of diseases or a syndrome? A family of diseases 7 Giulietta Μ. Riboldi and Steven J. Frucht 1. Introduction 8 2. Demographic and clinical features of the ET-family—A common origin with 9 different branches 16 3. ET-family neuropathology 4. ET-family neurophysiology 17 5. Evidence from genetics: Interfamilial variability and overlap 19 6. Evidence from imaging studies 20 7. Conclusions 21 References 21 2. Is essential tremor a family of diseases or a syndrome? A syndrome 31 Sanjay Pandey 1. Introduction 32 2. Definition of a syndrome 33 3. Essential tremor: "Syndrome" or "family of diseases”? 34 4. Discussion 50 5. Conclusion 51 References 51 Section II Essential tremor: Is this an electrical or a degenerative disorder? Or is it both? 61 Elan D. Louis and Sheng-Han Kuo 3. Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder 65 Phyllis L Faust 1. Introduction 66 v|
vi Contents 2. Clinical features of ET as a degenerative disorder 68 3. Neuroimaging findings suggest cerebellar degeneration in ET 72 4. Pathological findings in ET demonstrate cerebellar degeneration 77 5. Cerebellar pathology and clinical heterogeneity in ET 92 6. ET as a degenerative disorder: Insight into disease mechanisms 92 7. Conclusions 94 References 94 4. Is essential tremor a degenerative or an electrical disorder? Electrical disorder 103 Hyun Joo Cho 1. Introduction 104 2. ET is an electric disorder 105 3. Essential tremor is not a primary neurodegenerative disorder 114 4. Conclusion and future direction 119 References 120 Section III How important is the inferior olive in essential tremor? An evolving story 129 Sheng-Han Kuo and Elan D. Louis 5. Is the inferior olive central to essential tremor? Yes 133 Eric J. Lang and Adrian Handforth 1. Clues to circuit dysfunction in essential tremor 2. Ю-induced PC synchrony as related to tremor 134 ’ 137 3. The olivocerebellar-DCN circuit and tremor: Potential players 147 4. Conclusions 155 References 157 6. Is inferior olive central to the pathophysiology of essential tremor? No 167 Mario Manto 1. Epidemiology 168 2. Clinical presentation 168 3. Genetics 170 4. Diagnosis 170 5. Pathogenesis 171 6. Re-considering our physiological conceptualization of cerebellar tremor 179 7. Conclusion 181 References 181
Contents vii Section IV Essential tremor as a harbinger: What is the cognitive fallout of having essential tremor? 189 Elan D. Louis and Sheng-Han Kuo 7. Does essential tremor increase risk of cognitive impairment and dementia? Yes 195 Stephanie Cosentino and Ludy C Shih 1. Introduction 196 2. Cognitive impairment in ET 198 3. Clinic based studies 200 4. Population based studies 202 5. Question of misdiagnosis 206 6. Mechanisms of cognitive impairment in ET 210 7. Mechanisms: Cerebellar dysfunction 210 8. Mechanisms: Extra-cerebellar dysfunction 213 9. Mechanisms: Co-morbid degenerative disease 215 10. Summary and conclusions 218 11. Clinical relevance and future directions 219 References 224 8. Does essential tremor increase the risk of dementia? No 233 Alex Rajput 1. Introduction 234 2. Question 234 3. Background and definitions 234 4. Studies 237 5. Discussion 248 6. Conclusion 250 References 250 Section V Is essential tremor a disorder primarily due to GABA dysfunction? 255 Sheng-Han Kuo and Elan D. Louis 9. Is essential tremor a disorder of primary GABA dysfunction? Yes 259 Alexandre Gironell 1. Background 260 2. GABA 264 3. GABA studies in essential tremor 266 4. GABA hypothesis:Supporting evidence 276 5. Final remarks 278 References 278
viii Contents 10. Is essential tremor a disorder of GABA dysfunction? No 285 Steven Bellows and Joohi Jimenez-Shahed 1. Introduction 286 2. Accumulating evidence against GABA-mediated tremor expression 287 3. Tremor as a result of oscillating networks 289 4. Cerebellar dysfunction and tremor manifestations 29Ί 5. Purkinje cell hypersynchrony as a correlate of tremor 292 6. Conclusions and future directions 301 References 302 Section VI The future of pharmacotherapies for essential tremor: Enhancing GABA neurotransmission or reducing neuronal hyperexcitability? 311 Sheng-Han Kuo and Elan D. Louis 11. Enhancing GABA inhibition is the next generation of medications for essential tremor 317 William Ondo 1. Introduction 318 2. Essential tremor macro and microanatomy 318 3. y֊aminobutyric acid (GABA) and GABA receptors 320 4. Anatomic and pathological abnormalities in ET are associated with GABA 322 5. The role of inferior olivary nucleus/cerebellar connections 322 6. Functional imaging studies 7. GABAergic genetics and genetic manipulation in ET 323 324 ’ 8. Most medications that improve tremor target GABA-A receptors 325 9. GABA-B receptors 329 10. Future directions 329 References 330 12. Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor 335 Aparna Wagle Shukla 1. Introduction 2.Pathophysiology of essential tremor 336 337 3. Reducing hyperexcitability of Purkinje cell and other hyperexcitable neurons References 342 349 |
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| spelling | Essential tremor current concepts and controversies edited by Sheng-Han Kuo (Departement of Neurology, College of Physicians and Surgeons; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, United States), Elan D. Louis (Departement of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States) First edition Cambridge, MA ; San Diego, CA Academic Press, an imprint of Elsevier 2022 x, 355 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier International review of neurobiology volume 163 Essenzieller Tremor (DE-588)4249470-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Essenzieller Tremor (DE-588)4249470-9 s DE-604 Kuo, Sheng-Han edt Louis, Elan D. edt Erscheint auch als Online-Ausgabe 978-0-323-89975-8 International review of neurobiology volume 163 (DE-604)BV002534817 163 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033697463&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Essential tremor current concepts and controversies |
| title_auth | Essential tremor current concepts and controversies |
| title_exact_search | Essential tremor current concepts and controversies |
| title_exact_search_txtP | Essential tremor current concepts and controversies |
| title_full | Essential tremor current concepts and controversies edited by Sheng-Han Kuo (Departement of Neurology, College of Physicians and Surgeons; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, United States), Elan D. Louis (Departement of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States) |
| title_fullStr | Essential tremor current concepts and controversies edited by Sheng-Han Kuo (Departement of Neurology, College of Physicians and Surgeons; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, United States), Elan D. Louis (Departement of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States) |
| title_full_unstemmed | Essential tremor current concepts and controversies edited by Sheng-Han Kuo (Departement of Neurology, College of Physicians and Surgeons; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, United States), Elan D. Louis (Departement of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States) |
| title_short | Essential tremor |
| title_sort | essential tremor current concepts and controversies |
| title_sub | current concepts and controversies |
| topic | Essenzieller Tremor (DE-588)4249470-9 gnd |
| topic_facet | Essenzieller Tremor Aufsatzsammlung |
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