Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals:
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Köln
[2020]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Item Description: | Zusammenfassung in deutscher und englischer Sprache |
| Physical Description: | viii, 98 Blätter Illustrationen, Diagramme |
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MARC
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| 100 | 1 | |a Radermacher, Jan |e Verfasser |0 (DE-588)1255746912 |4 aut | |
| 245 | 1 | 0 | |a Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals |c vorgelegt von Jan Erik Radermacher aus Waldbröl |
| 264 | 1 | |a Köln |c [2020] | |
| 300 | |a viii, 98 Blätter |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Zusammenfassung in deutscher und englischer Sprache | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033638493&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-033638493 | ||
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| _version_ | 1804184060464988160 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
LIST
OF
FIGURES
HI
ABSTRACT
IV
ZUSAMMENFASSUNG
VI
LIST
OF
ABBREVIATIONS
VIII
INTRODUCTION
1
THE
MELANOCORTIN
SYSTEM
IN
THE
ARCUATE
NUCLEUS
OF
THE
HYPOTHALAMUS
2
DIVERSITY
OF
INPUTS
RELEVANT
TO
ARH
NEURONS
5
NEURONAL
DIVERSITY
AND
RECEPTOR
HETEROGENEITY
TOWARDS
ENDOCRINE
FACTORS
7
ENERGY
REQUIREMENTS
OF
A
MAMMALIAN
ORGANISM
8
THERMOREGULATION
AND
NEURONAL
MECHANISMS
FOR
TEMPERATURE
HOMEOSTASIS
10
THERMOGENESIS
12
NEURONAL
BASIS
FOR
THERMOREGULATION
13
THERMOSENSORY
INPUTS
TO
THE
CNS
15
TRANSIENT
RECEPTOR
POTENTIAL
(TRP)
ION
CHANNELS
AS
TEMPERATURE
SENSORS
16
PATHWAYS
FOR
NEURAL
CONTROL
OF
THERMOREGULATORY
EFFECTORS
19
IS
THE
ENERGY
HOMEOSTASIS
SYSTEM
INVOLVED
IN
THERMOREGULATION
?
19
AIM
OF
THE
STUDY
21
MATERIALS
AND
METHODS
23
ANIMALS
23
MOUSE
LINES
23
GENOTYPING
23
BRAIN
SLICE
PREPARATION
AND
ELECTROPHYSIOLOGY
24
ELECTROPHYSIOLOGY
25
SYNAPTIC
ISOLATION
AND
REDUCTION
OF
ACTIVITY
DEPENDENT
PEPTIDE
SIGNALING
27
PEPTIDE
SIGNALLING
27
VOLTAGE-CLAMP
OF
TEMPERATURE-AND
PEPTIDE-INDUCED
CURRENTS
28
RECORDING
TEMPERATURE
AND
TEMPERATURE
PROTOCOLS
28
SINGLE
CELL
LABELING
AND
IMMUNOCYTOCHEMISTRY
30
CALCIUM
IMAGING
OF
POMC
GCAMP6S
NEURONS
31
IN
VIVO
TEMPERATURE
RECORDINGS
32
IMPLANTATION
OF
INTRACEREBRAL
(IC)
AND
INTRAPERITONEAL
(IP)
TEMPERATURE
PROBES
32
IN
VIVO
TEMPERATURE
RECORDINGS
33
DATA
ANALYSIS
34
RESULTS
35
TEMPERATURE
SENSITIVITY
OF
POMC
NEURONS
35
CALCIUM
IMAGING
OF
TEMPERATURE
SENSITIVE
POMC
GCAMP6S
NEURONS
39
INTRINSIC
ELECTROPHYSIOLOGICAL
PROPERTIES
41
TRPM8
ION
CHANNELS
ARE
INVOLVED
IN
COLD
SENSITIVITY
OF
POMC
NEURONS
43
TRPC5
ION
CHANNELS
ARE
THE
MAIN
TEMPERATURE
SENSOR
IN
COLD
SENSING
POMC
NEURONS
46
RELEVANCE
OF
TEMPERATURE
STIMULI
FOR
ARH
NEURONS
49
PHYSIOLOGICAL
TEMPERATURE
STIMULI
FOR
POMC
NEURONS
52
SPECIFIC
MODULATION
OF
POMC^
AND
P0MC
6LPLR+
NEURONS
BY
ENERGY
STATE
SENSING
SIGNALS
53
DISCUSSION
59
LOCAL
TEMPERATURE
AS
A
MODULATOR
FOR
POMC
NEURONS
60
WARM
SENSING
POMC
NEURONS
62
TEMPERATURE
INSENSITIVE
POMC
NEURONS
63
COLD
SENSITIVE
POMC
NEURONS
65
POMC
NEURON
SUBTYPES
POSSESS
SPECIFIC
ELECTROPHYSIOLOGICAL
PROPERTIES
67
PHYSIOLOGICAL
IMPLICATIONS
OF
TEMPERATURE
SENSING
POMC
NEURONS
68
SPECIFIC
REGULATION
OF
POM&
EPR+
AND
POM(FI
LPLR+
NEURONS
BY
ENERGY
STATE
SENSING
SIGNALS
71
CONCLUSION
74
OUTLOOK
75
SUPPLEMENTARY
FIGURES
78
REFERENCES
81
DANKSAGUNG
96
VERSICHERUNG
AN
EIDES
STATT
98
|
| adam_txt |
TABLE
OF
CONTENTS
LIST
OF
FIGURES
HI
ABSTRACT
IV
ZUSAMMENFASSUNG
VI
LIST
OF
ABBREVIATIONS
VIII
INTRODUCTION
1
THE
MELANOCORTIN
SYSTEM
IN
THE
ARCUATE
NUCLEUS
OF
THE
HYPOTHALAMUS
2
DIVERSITY
OF
INPUTS
RELEVANT
TO
ARH
NEURONS
5
NEURONAL
DIVERSITY
AND
RECEPTOR
HETEROGENEITY
TOWARDS
ENDOCRINE
FACTORS
7
ENERGY
REQUIREMENTS
OF
A
MAMMALIAN
ORGANISM
8
THERMOREGULATION
AND
NEURONAL
MECHANISMS
FOR
TEMPERATURE
HOMEOSTASIS
10
THERMOGENESIS
12
NEURONAL
BASIS
FOR
THERMOREGULATION
13
THERMOSENSORY
INPUTS
TO
THE
CNS
15
TRANSIENT
RECEPTOR
POTENTIAL
(TRP)
ION
CHANNELS
AS
TEMPERATURE
SENSORS
16
PATHWAYS
FOR
NEURAL
CONTROL
OF
THERMOREGULATORY
EFFECTORS
19
IS
THE
ENERGY
HOMEOSTASIS
SYSTEM
INVOLVED
IN
THERMOREGULATION
?
19
AIM
OF
THE
STUDY
21
MATERIALS
AND
METHODS
23
ANIMALS
23
MOUSE
LINES
23
GENOTYPING
23
BRAIN
SLICE
PREPARATION
AND
ELECTROPHYSIOLOGY
24
ELECTROPHYSIOLOGY
25
SYNAPTIC
ISOLATION
AND
REDUCTION
OF
ACTIVITY
DEPENDENT
PEPTIDE
SIGNALING
27
PEPTIDE
SIGNALLING
27
VOLTAGE-CLAMP
OF
TEMPERATURE-AND
PEPTIDE-INDUCED
CURRENTS
28
RECORDING
TEMPERATURE
AND
TEMPERATURE
PROTOCOLS
28
SINGLE
CELL
LABELING
AND
IMMUNOCYTOCHEMISTRY
30
CALCIUM
IMAGING
OF
POMC
GCAMP6S
NEURONS
31
IN
VIVO
TEMPERATURE
RECORDINGS
32
IMPLANTATION
OF
INTRACEREBRAL
(IC)
AND
INTRAPERITONEAL
(IP)
TEMPERATURE
PROBES
32
IN
VIVO
TEMPERATURE
RECORDINGS
33
DATA
ANALYSIS
34
RESULTS
35
TEMPERATURE
SENSITIVITY
OF
POMC
NEURONS
35
CALCIUM
IMAGING
OF
TEMPERATURE
SENSITIVE
POMC
GCAMP6S
NEURONS
39
INTRINSIC
ELECTROPHYSIOLOGICAL
PROPERTIES
41
TRPM8
ION
CHANNELS
ARE
INVOLVED
IN
COLD
SENSITIVITY
OF
POMC
NEURONS
43
TRPC5
ION
CHANNELS
ARE
THE
MAIN
TEMPERATURE
SENSOR
IN
COLD
SENSING
POMC
NEURONS
46
RELEVANCE
OF
TEMPERATURE
STIMULI
FOR
ARH
NEURONS
49
PHYSIOLOGICAL
TEMPERATURE
STIMULI
FOR
POMC
NEURONS
52
SPECIFIC
MODULATION
OF
POMC^
AND
P0MC
6LPLR+
NEURONS
BY
ENERGY
STATE
SENSING
SIGNALS
53
DISCUSSION
59
LOCAL
TEMPERATURE
AS
A
MODULATOR
FOR
POMC
NEURONS
60
WARM
SENSING
POMC
NEURONS
62
TEMPERATURE
INSENSITIVE
POMC
NEURONS
63
COLD
SENSITIVE
POMC
NEURONS
65
POMC
NEURON
SUBTYPES
POSSESS
SPECIFIC
ELECTROPHYSIOLOGICAL
PROPERTIES
67
PHYSIOLOGICAL
IMPLICATIONS
OF
TEMPERATURE
SENSING
POMC
NEURONS
68
SPECIFIC
REGULATION
OF
POM&
EPR+
AND
POM(FI
LPLR+
NEURONS
BY
ENERGY
STATE
SENSING
SIGNALS
71
CONCLUSION
74
OUTLOOK
75
SUPPLEMENTARY
FIGURES
78
REFERENCES
81
DANKSAGUNG
96
VERSICHERUNG
AN
EIDES
STATT
98 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Radermacher, Jan |
| author_GND | (DE-588)1255746912 |
| author_facet | Radermacher, Jan |
| author_role | aut |
| author_sort | Radermacher, Jan |
| author_variant | j r jr |
| building | Verbundindex |
| bvnumber | BV048258277 |
| ctrlnum | (DE-599)DNB1255726016 |
| discipline | Biologie |
| discipline_str_mv | Biologie |
| format | Book |
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| id | DE-604.BV048258277 |
| illustrated | Illustrated |
| index_date | 2024-07-03T19:59:15Z |
| indexdate | 2024-07-10T09:33:20Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-033638493 |
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| physical | viii, 98 Blätter Illustrationen, Diagramme |
| publishDate | 2020 |
| publishDateSearch | 2020 |
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| record_format | marc |
| spelling | Radermacher, Jan Verfasser (DE-588)1255746912 aut Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals vorgelegt von Jan Erik Radermacher aus Waldbröl Köln [2020] viii, 98 Blätter Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Zusammenfassung in deutscher und englischer Sprache (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1255726016/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033638493&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Radermacher, Jan Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals |
| subject_GND | (DE-588)4113937-9 |
| title | Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals |
| title_auth | Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals |
| title_exact_search | Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals |
| title_exact_search_txtP | Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals |
| title_full | Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals vorgelegt von Jan Erik Radermacher aus Waldbröl |
| title_fullStr | Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals vorgelegt von Jan Erik Radermacher aus Waldbröl |
| title_full_unstemmed | Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals vorgelegt von Jan Erik Radermacher aus Waldbröl |
| title_short | Differential modulation of POMC neuron subtypes by temperature and energy state dependent signals |
| title_sort | differential modulation of pomc neuron subtypes by temperature and energy state dependent signals |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1255726016/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033638493&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT radermacherjan differentialmodulationofpomcneuronsubtypesbytemperatureandenergystatedependentsignals |
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