Multifunctional hydrogels for biomedical applications:
Gespeichert in:
| Weitere Verfasser: | , , |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
[2022]
|
| Ausgabe: | 1. Auflage |
| Schlagworte: | |
| Online-Zugang: | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34716-2/ Inhaltsverzeichnis |
| Beschreibung: | xiii, 364 Seiten Illustrationen, Diagramme 24.4 cm x 17 cm |
| ISBN: | 9783527347162 352734716X |
Internformat
MARC
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| 015 | |a 21,N50 |2 dnb | ||
| 016 | 7 | |a 1247295958 |2 DE-101 | |
| 020 | |a 9783527347162 |c : circa EUR 149.00 (DE) (freier Preis) |9 978-3-527-34716-2 | ||
| 020 | |a 352734716X |9 3-527-34716-X | ||
| 024 | 3 | |a 9783527347162 | |
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| 035 | |a (OCoLC)1334006388 | ||
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| 084 | |8 1\p |a 540 |2 23sdnb | ||
| 084 | |a MED 960 |2 stub | ||
| 245 | 1 | 0 | |a Multifunctional hydrogels for biomedical applications |c edited by Ricardo A. Pires, Iva Pashkuleva, Rui L. Reis |
| 250 | |a 1. Auflage | ||
| 263 | |a 202205 | ||
| 264 | 1 | |a Weinheim |b Wiley-VCH |c [2022] | |
| 264 | 4 | |c © 2022 | |
| 300 | |a xiii, 364 Seiten |b Illustrationen, Diagramme |c 24.4 cm x 17 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Hydrogel |0 (DE-588)4160909-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Biomedizinische Technik |0 (DE-588)4006882-1 |2 gnd |9 rswk-swf |
| 653 | |a Cell Therapies & Tissue Engineering | ||
| 653 | |a Chemie | ||
| 653 | |a Chemistry | ||
| 653 | |a Materials Science | ||
| 653 | |a Materialwissenschaften | ||
| 653 | |a Medical Science | ||
| 653 | |a Medizin | ||
| 653 | |a Soft Matter | ||
| 653 | |a Supramolecular Chemistry | ||
| 653 | |a Supramolekulare Chemie | ||
| 653 | |a Zelltherapien u. Tissue Engineering | ||
| 653 | |a CH85: Supramolekulare Chemie | ||
| 653 | |a MD52: Zelltherapien u. Tissue Engineering | ||
| 653 | |a MSG0: Soft Matter | ||
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Hydrogel |0 (DE-588)4160909-8 |D s |
| 689 | 0 | 1 | |a Biomedizinische Technik |0 (DE-588)4006882-1 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Pires, Ricardo A. |4 edt | |
| 700 | 1 | |a Pashkuleva, Iva |4 edt | |
| 700 | 1 | |a Reis, Rui L. |d 1967- |0 (DE-588)1194098916 |4 edt | |
| 710 | 2 | |a Wiley-VCH |0 (DE-588)16179388-5 |4 pbl | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, PDF |z 978-3-527-82581-3 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, EPUB |z 978-3-527-82583-7 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, oBook |z 978-3-527-82582-0 |
| 856 | 4 | 2 | |m X:MVB |u http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34716-2/ |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-033629226 | ||
| 883 | 1 | |8 1\p |a vlb |d 20211210 |q DE-101 |u https://d-nb.info/provenance/plan#vlb | |
Datensatz im Suchindex
| _version_ | 1804184043602837504 |
|---|---|
| adam_text | CONTENTS
PREFACE
XIII
1
EXTRACELLULAR
MATRIX
HYDROGELS
FROM
DECELLULARIZED
TISSUES
FOR
BIOLOGICAL
AND
BIOMEDICAL APPLICATIONS
1
BRENDAN
C.
JONES,
NICOLA
ELVASSORE,
PAOLO
DE
COPPI,
AND
GIOVANNI
G.
GIOBBE
1.1
INTRODUCTION
TO
HYDROGELS
1
1.1.1
DEFINITION
AND
USE
OF
HYDROGELS
IN
BIOMEDICAL
APPLICATIONS
1
1.1.2
CLASSIFICATION
AND
PROPERTIES
OF
HYDROGELS
2
1.1.2.1
SYNTHETIC
HYDROGELS
3
1.1.2.2
NATURAL
HYDROGELS
5
1.2
KEY
FEATURES
AND
FUNCTIONS
OF
THE
EXTRACELLULAR
MATRIX
IN
HOMEOSTASIS
AND
DEVELOPMENT
6
1.3
EXTRACELLULAR
MATRIX-BASED
HYDROGELS
DERIVED
FROM
DECELLULARIZATION
OF
ORGANS
8
1.3.1
PRODUCTION
OF
ECM
HYDROGELS
8
1.3.2
CHARACTERIZATION
OF
ECM
HYDROGELS
10
1.3.3
PANCREATIC
ECM-DERIVED
HYDROGELS
11
1.3.4
ECM
HYDROGELS
DERIVED
FROM
LIVER
12
1.3.5
LUNG
ECM
HYDROGELS
13
1.3.6
HYDROGELS
DERIVED
FROM
DECELLULARIZED
COLON
14
1.3.7
ECM-DERIVED
HYDROGELS
FROM
SMALL
INTESTINE
15
1.3.8
CELLULAR
RESPONSES
TO
ECM
HYDROGELS
17
1.4
COMMERCIALLY
AVAILABLE
PRODUCTS
18
REFERENCES
19
2
COLLAGEN-BASED
SYSTEMS
TO
MIMIC
THE
EXTRACELLULAR
ENVIRONMENT
23
UMBER
CHEEMA
AND
VIVEK
MUDERA
2.1
CELLS
IN
TISSUES
23
2.2
COLLAGEN
IN
TISSUES
24
2.2.1
STRUCTURE OF
COLLAGEN
25
2.2.2
COLLAGEN
SOURCES
25
2.3
CONTROLLING
COLLAGEN
ARCHITECTURE
26
VI
CONTENTS
2.3.1
2.3.2
2.3.3
2.4
2.4.1
2.4.2
2.4.3
2.4.4
2.4.5
2.4.6
2.5
DIRECTION:
COLLAGEN
ORIENTATION
26
DIAMETER:
COLLAGEN
FIBRIL
DIAMETER
27
DENSITY:
FIBRIL
PACKING
AND
CROSS-LINKING
28
ENGINEERING
COLLAGEN
SCAFFOLDS
29
COLLAGEN
CROSS-LINKING
29
DIFFUSION
OF
NUTRIENTS AND
OXYGEN
THROUGH
COLLAGEN
SCAFFOLDS
29
PROLIFERATION
OF
CELLS
IN
3D
30
MECHANICAL
STIMULATION
AND
BIOREACTORS
31
GROWTH
FACTORS
32
DRUG-LOADED
SCAFFOLDS
32
CONCLUSIONS
33
REFERENCES
33
3
DESIGNING
ELASTIN-LIKE
RECOMBINAMERS
FOR
THERAPEUTIC
AND
REGENERATIVE
PURPOSES
37
JOSE
CARLOS
RODRIGUEZ-CABELLO,
SARA
ESCALERA,
DIANA
JUANES-GUSANO,
MERCEDES
SANTOS,
AND
ALESSANDRA
GIROTTI
3.1
3.2
3.2.1
3.2.2
3.2.3
3.2.4
3.3
3.3.1
3.3.2
3.4
INTRODUCTION
37
ELR-BASED
HYDROGELS
IN
TISSUE
ENGINEERING
39
HYDROGELS
IN
MUSCULOSKELETAL
TISSUE
REGENERATION
42
HYDROGELS
IN
CARDIOVASCULAR
TISSUE
REGENERATION
44
HYDROGELS
IN
SKIN
TISSUE
REGENERATION
46
HYDROGELS
IN
NEURAL
TISSUE
REGENERATION
47
ELR-BASED
HYDROGELS
FOR
DRUG
DELIVERY
48
PHYSICALLY
CROSS-LINKED
HYDROGELS
48
CHEMICALLY
CROSS-LINKED
HYDROGELS
52
FUTURE
REMARKS
56
REFERENCES
56
4
ENZYME-ASSISTED
HYDROGEL
FORMATION
FOR
TISSUE
ENGINEERING
APPLICATIONS
63
SILVIA
PEREZ-RAFAEL,
EVA
RAMON,
AND
TZANKO
TZANOV
4.1
4.2
4.2.1
4.2.1.1
4.2.1.2
4.2.1.3
4.2.2
4.3
4.3.1
4.3.1.1
4.3.1.2
4.3.1.3
4.3.1.4
INTRODUCTION
63
ENZYMATICALLY
CROSS-LINKED
HYDROGELS
66
OXIDOREDUCTASES
67
PEROXIDASES
-
HRP
67
TYROSINASE
72
LACCASE
72
TRANSFERASES:
TRANSGLUTAMINASE
73
SUPRAMOLECULAR
ENZYME-DRIVEN
HYDROGELATION
75
HYDROLASES
75
PHOSPHATASES
75
METALLOPROTEINASES
80
THERMOLYSIN
80
P-LACTAMASES
80
CONTENTS
VII
4.3.2
4.4
DNA
POLYMERASES
80
CONCLUSIONS
81
REFERENCES
83
5
HIERARCHICAL
PEPTIDE
AND
PROTEIN-BASED
BIOMATERIALS:
FROM
MOLECULAR
STRUCTURE
TO
DIRECTED
SELF-ASSEMBLY
AND
APPLICATIONS
97
YINCHEN
YUAN,
YEJIAO
SHI,
AND
HELENA
S.
AZEVEDO
5.1
5.2
INTRODUCTION
97
MOLECULAR
DESIGN/SELECTION
OF
BUILDING
BLOCKS
FOR
HIERARCHICAL
SELF-ASSEMBLY
98
5.2.1
5.2.2
5.2.3
5.2.4
5.3
5.3.1
5.3.2
5.3.3
5.3.4
5.3.5
5.3.6
5.3.7
5.3.8
5.4
HYDROPHOBIC
AROMATIC
AMINO
ACIDS
98
HYDROPHOBIC
ALIPHATIC
AMINO
ACIDS
106
HYDROPHILIC
CHARGED
AMINO
ACIDS
107
OTHERS
108
HIERARCHICAL
ASSEMBLY
THROUGH
ENVIRONMENTAL
MANIPULATION
108
TEMPERATURE
108
MAGNETIC
FIELD
108
ELECTRIC
FIELD
110
PATTERNED
SUBSTRATES
110
SHEAR
FORCES
111
PH
111
ULTRASOUND
112
OTHER
METHODS
112
TECHNIQUES
FOR
THE
CHARACTERIZATION
OF
HIERARCHICALLY
ORGANIZED
BIOMATERIALS
113
5.4.1
5.4.2
5.4.3
5.5
POLARIZED
LIGHT
MICROSCOPY
113
HIGH-RESOLUTION
MICROSCOPY
(AFM,
TEM,
AND
SEM)
115
SMALL-ANGLE
X-RAY
SCATTERING
(SAXS)
115
APPLICATION
OF
HIERARCHICAL
SELF-ASSEMBLING
PEPTIDE
AND
PROTEIN-BASED
BIOMATERIALS
IN
TISSUE
REGENERATION
117
5.5.1
5.5.2
5.5.3
5.6
CORNEA
117
BLOODVESSELS
118
SKELETAL
MUSCLE
119
CONCLUSIONS
120
ACKNOWLEDGMENTS
120
REFERENCES
121
6
SHORT
PEPTIDE
HYDROGELS
FOR
BIOMEDICAL
APPLICATIONS
127
PRIYADARSHI
CHAKRABORTY,
LIHI
ADLER-ABRAMOVICH,
AND
EHUD
GAZIT
6.1
6.2
6.2.1
6.2.2
INTRODUCTION
127
SHORT
PEPTIDE
HYDROGELS
128
FMOC-PROTECTED
SHORT
PEPTIDES
128
SHORT
PEPTIDE
HYDROGELS
WITH
ALTERNATING
HYDROPHOBIC/HYDROPHILIC
AMINO
ACID
RESIDUES
128
VIII
|
CONTENTS
6.2.3
P-HAIRPIN
PEPTIDES
129
6.2.4
ACETYL-PROTECTED
SHORT
PEPTIDES
129
6.3
BIOMEDICAL
APPLICATIONS
OF
SHORT
PEPTIDE
HYDROGELS
129
6.3.1
2D/3D
CELL
SCAFFOLDING
129
6.3.2
TISSUE
ENGINEERING
131
6.3.3
WOUND
HEALING
134
6.3.4
DRUG
DELIVERY
137
6.4
CONCLUSIONS
AND
OUTLOOK
139
REFERENCES
140
7
SUPRAMOLECULAR
ASSEMBLIES
OF
GLYCOPEPTIDES
AS
MIMICS
OF
THE
EXTRACELLULAR
MATRIX
149
DIANA
SOARES
DA
COSTA,
ALEXANDRA
BRITO,
RUI
L.
REIS,
AND
IVA
PASHKULEVA
7.1
INTRODUCTION
149
7.2
GLYCOPROTEINS
AND
PROTEOGLYCANS
IN
THE
ECM
150
7.3
DESIGN
OF
SELF-ASSEMBLING
PEPTIDE-SACCHARIDE
CONJUGATES
151
7.4
SUPRAMOLECULAR
SYSTEMS
GENERATED
BY
INTERFACIAL
CO-ASSEMBLY
154
7.5
CONCLUSIONS
155
ACKNOWLEDGMENTS
156
REFERENCES
156
8
SUPRAMOLECULAR
ASSEMBLIES
FOR
CANCER
DIAGNOSIS
AND
TREATMENT
161
SHUONG
LIU
AND
BING
XU
8.1
INTRODUCTION
161
8.2
CANCER
DIAGNOSIS
162
8.2.1
OPTICAL
IMAGING
162
8.2.2
MAGNETIC
RESONANCE
IMAGING
(MRI)
165
8.2.3
PHOTOACOUSTIC
IMAGING
169
8.3
CANCER
TREATMENT
173
8.3.1
DRUG
DELIVERY
173
8.3.2
ENZYME-INSTRUCTED
SELF-ASSEMBLY
(EISA
FOR
CANCER
THERAPY)
175
8.4
FUTURE
PERSPECTIVES
189
REFERENCES
190
9
POLYZWITTERIONIC
HYDROGELS
AS
WOUND
DRESSING
MATERIALS
195
KONSTANS
RUSEVA
AND
ELENA
VASSILEVA
9.1
POLYZWITTERIONS
195
9.1.1
GENERAL
STRUCTURE
AND
PROPERTIES
195
9.1.2
NONFOULING
PROPERTIES
195
9.2
WOUND
MANAGEMENT
AND
WOUND
DRESSINGS
197
9.3
PZIS
AS
DRESSINGS
MATERIALS
FOR
ACUTE
WOUNDS
198
9.3.1
POLYCARBOXYBETAINES
(PCBS)
198
9.3.2
POLYSULFOBETAINES
202
9.4
PZI
AS
DRESSINGS
FOR
CHRONIC
WOUNDS
MANAGEMENT
206
CONTENTS
IX
9.4.1
DRESSINGS
FOR
CHRONIC
WOUNDS
MANAGEMENT
BASED
ON
POLYCARBOXYBETAINES
206
9.4.2
9.5
POLYSULFOBETAINES
AS
DRESSINGS
FOR
CHRONIC
WOUNDS
MANAGEMENT
208
CONCLUSIONS
212
REFERENCES
213
10
HYALURONAN-BASED
HYDROGELS
AS
MODULATORS
OF
CELLULAR
BEHAVIOR
217
SARA
AMORIM,
RUI
L.
REIS,
AND
RICARDO
A.
PIRES
10.1
10.2
10.2.1
10.2.2
10.3
10.3.1
10.3.1.1
10.3.1.2
10.3.2
10.4
INTRODUCTION
217
BIOLOGICAL
RELEVANCE
OF
HYALURONAN
218
HYALURONAN
IN
BIOLOGICAL
TISSUES
AND
FLUIDS
218
HYALURONAN
AS
A
SIGNALING
MOLECULE
218
HYALURONAN-BASED
SYSTEMS
FOR
BIOMEDICAL
APPLICATIONS
220
HYDROGELS
FOR
TISSUE
ENGINEERING
220
DIFFERENTIATION
OF
STEM
CELLS
220
SPACE
FILLING
HYDROGELS
223
3D
CANCER
MODELS
224
CONCLUSION
AND
FUTURE
REMARKS
226
ACKNOWLEDGMENTS
226
REFERENCES
226
11
HYDROGEL
FIBERS
PRODUCED
VIA
MICROFLUIDICS
233
KONGCHANG
WEI,
CLAUDIO
TONCELLI,
RENE
M.
ROSSI,
AND
LUCIANO
F.
BOESEL
11.1
11.1.1
11.1.2
INTRODUCTION
TO
MICROFLUIDICS
AND
MICROFLUIDIC
WET
SPINNING
233
FUNDAMENTALS
OF
MICROFLUIDICS
233
APPLICATION
OF
MICROFLUIDICS
TO
FIBER
PRODUCTION:
MICROFLUIDIC
WET
SPINNING
234
11.2
11.3
FABRICATION
OF
CHIPS
FOR
MICROFLUIDIC
WET
SPINNING
237
BIOMEDICAL
APPLICATIONS
OF
HYDROGEL
FIBERS
PRODUCED
VIA
MICROFLUIDICS
242
11.3.1
11.3.1.1
11.3.1.2
11.3.2
11.3.2.1
11.3.2.2
11.3.3
11.3.4
11.4
11.4.1
11.4.2
11.5
TISSUE
ENGINEERING
243
SINGLE-FIBER
SCAFFOLDS
243
ASSEMBLED
FIBER
SCAFFOLDS
249
SENSORS
AND
ACTUATORS
251
SENSORS
251
ACTUATORS
255
CONTROLLED
DRUG
DELIVERY
256
OTHER
BIOMEDICAL
APPLICATIONS
257
HYDROGEL
OPTICAL
FIBERS
257
MATERIALS
258
APPLICATIONS
262
CONCLUSIONS
263
ACKNOWLEDGMENTS
264
REFERENCES
264
CONTENTS
12
EMBEDDING
HYDROGELS
INTO
MICROFLUIDIC
CHIPS:
VASCULAR
TRANSPORT
ANALYSES
AND
DRUG
DELIVERY
OPTIMIZATION
275
ANA
M.
MARTINS,
ALEXANDER
B.
COOK,
MARTINA
DI
FRANCESCO,
MARIA
GRAZIA
BARBATO,
SAYANTI
BRAHMACHARI,
MARTINA
PANNUZZO,
AND
PAOLO
DECUZZI
12.1
INTRODUCTION:
MICROFLUIDIC
CHIPS
FOR
MODELING
HUMAN
DISEASES
AND
DEVELOPING
NEW
THERAPIES
275
12.2
12.3
12.3.1
12.3.2
12.4
HYDROGELS
TO
MIMIC
THE
EXTRACELLULAR
MATRIX
(ECM)
276
FABRICATION
OF
MICROFLUIDIC
CHIPS
277
SINGLE-CHANNEL
MICROFLUIDIC
CHIPS
277
DOUBLE-CHANNEL
MICROFLUIDIC
CHIP
281
APPLICATIONS
OF
MICROFLUIDIC
CHIPS
IN
BIOPHYSICAL
TRANSPORT
ANALYSIS
282
12.4.1
12.4.2
12.5
12.6
12.7
SINGLE-CHANNEL
MICROFLUIDIC
CHIPS
282
DOUBLE-CHANNEL
MICROFLUIDIC
CHIPS
282
NANOPARTICLE
TRANSPORT
ANALYSES
284
COMPUTER
SIMULATIONS
OF
NANOPARTICLE
AND
CELL
TRANSPORT
285
CONCLUSIONS
AND
FUTURE
DIRECTIONS
287
REFERENCES
288
13
MULTIFUNCTIONAL
GRANULAR
HYDROGELS
FOR
TISSUE-SPECIFIC
REPAIR
295
RUI
J.
ALMEIDA,
ANA
FERNANDES,
VITOR
M.
GASPAR,
AND
JOAO
F.
MANO
13.1
13.2
13.2.1
13.2.2
13.2.3
13.2.4
13.2.5
13.3
13.3.1
13.3.2
13.3.3
13.3.4
13.4
INTRODUCTION
295
GRANULAR
HYDROGELS
-
FUNCTIONAL
FEATURES
AND
DESIGN
297
INJECTABILITY
299
INTER-PARTICLE
ANNEALING
TOWARD
MAPS
ASSEMBLY
300
VOID
SPACES
AND
MICROPOROSITY
304
MODULARITY
AND
MULTIFUNCTIONALITY
IN
GRANULAR
SYSTEMS
305
BIOACTIVE
MOLECULES
DELIVERY
306
GRANULAR
HYDROGELS
FOR
TISSUE-SPECIFIC
REPAIR
308
VASCULARIZATION
STRATEGIES
308
SKIN
TISSUES
REPAIR
311
BONE
TISSUE
REPAIR
313
EMERGING
TRENDS
AND
APPLICATIONS
317
CONCLUSIONS
AND FUTURE
PERSPECTIVES
317
ACKNOWLEDGMENTS
318
REFERENCES
318
14
INJECTABLE
HYDROGELS
AS
A
STEM
CELL
DELIVERY
PLATFORM
FOR
WOUND
HEALING
323
QIAN
XU,
SIGEN
A.,
AND
WENXIN
WANG
14.1
14.1.1
14.1.2
14.1.2.1
WOUND
HEALING
323
CLINICAL
NEEDS
FOR
WOUND
HEALING
323
WOUND
HEALING
PATHOLOGY
323
HEMOSTASIS
325
CONTENTS
XI
14.1.2.2
14.1.2.3
14.1.2.4
14.2
14.2.1
14.2.2
14.2.3
INFLAMMATION
326
PROLIFERATION
326
REMODELING
328
STEM
CELLS
FOR
SKIN
WOUND
HEALING
328
STEM
CELL
OVERVIEW
328
ADIPOSE-DERIVED
STEM
CELLS
FOR
WOUND
HEALING
329
CURRENT
LIMITATIONS
AND FUTURE
DIRECTIONS
OF
SCS
FOR
WOUND
HEALING
330
14.3
14.3.1
14.3.1.1
14.3.1.2
14.3.1.3
14.3.2
INJECTABLE
HYDROGEL
DRESSING
AS
A
DELIVERY
PLATFORM
331
TYPES
OF
INJECTABLE
HYDROGELS
332
NATURALLY
DERIVED
INJECTABLE
HYDROGELS
334
SYNTHETIC
INJECTABLE
HYDROGELS
335
HYBRID
INJECTABLE
HYDROGELS
339
INJECTABLE
HYDROGELS
AS
SCAFFOLDING
FOR
STEM
CELLS
DELIVERY
340
REFERENCES
343
INDEX
357
|
| adam_txt |
CONTENTS
PREFACE
XIII
1
EXTRACELLULAR
MATRIX
HYDROGELS
FROM
DECELLULARIZED
TISSUES
FOR
BIOLOGICAL
AND
BIOMEDICAL APPLICATIONS
1
BRENDAN
C.
JONES,
NICOLA
ELVASSORE,
PAOLO
DE
COPPI,
AND
GIOVANNI
G.
GIOBBE
1.1
INTRODUCTION
TO
HYDROGELS
1
1.1.1
DEFINITION
AND
USE
OF
HYDROGELS
IN
BIOMEDICAL
APPLICATIONS
1
1.1.2
CLASSIFICATION
AND
PROPERTIES
OF
HYDROGELS
2
1.1.2.1
SYNTHETIC
HYDROGELS
3
1.1.2.2
NATURAL
HYDROGELS
5
1.2
KEY
FEATURES
AND
FUNCTIONS
OF
THE
EXTRACELLULAR
MATRIX
IN
HOMEOSTASIS
AND
DEVELOPMENT
6
1.3
EXTRACELLULAR
MATRIX-BASED
HYDROGELS
DERIVED
FROM
DECELLULARIZATION
OF
ORGANS
8
1.3.1
PRODUCTION
OF
ECM
HYDROGELS
8
1.3.2
CHARACTERIZATION
OF
ECM
HYDROGELS
10
1.3.3
PANCREATIC
ECM-DERIVED
HYDROGELS
11
1.3.4
ECM
HYDROGELS
DERIVED
FROM
LIVER
12
1.3.5
LUNG
ECM
HYDROGELS
13
1.3.6
HYDROGELS
DERIVED
FROM
DECELLULARIZED
COLON
14
1.3.7
ECM-DERIVED
HYDROGELS
FROM
SMALL
INTESTINE
15
1.3.8
CELLULAR
RESPONSES
TO
ECM
HYDROGELS
17
1.4
COMMERCIALLY
AVAILABLE
PRODUCTS
18
REFERENCES
19
2
COLLAGEN-BASED
SYSTEMS
TO
MIMIC
THE
EXTRACELLULAR
ENVIRONMENT
23
UMBER
CHEEMA
AND
VIVEK
MUDERA
2.1
CELLS
IN
TISSUES
23
2.2
COLLAGEN
IN
TISSUES
24
2.2.1
STRUCTURE OF
COLLAGEN
25
2.2.2
COLLAGEN
SOURCES
25
2.3
CONTROLLING
COLLAGEN
ARCHITECTURE
26
VI
CONTENTS
2.3.1
2.3.2
2.3.3
2.4
2.4.1
2.4.2
2.4.3
2.4.4
2.4.5
2.4.6
2.5
DIRECTION:
COLLAGEN
ORIENTATION
26
DIAMETER:
COLLAGEN
FIBRIL
DIAMETER
27
DENSITY:
FIBRIL
PACKING
AND
CROSS-LINKING
28
ENGINEERING
COLLAGEN
SCAFFOLDS
29
COLLAGEN
CROSS-LINKING
29
DIFFUSION
OF
NUTRIENTS AND
OXYGEN
THROUGH
COLLAGEN
SCAFFOLDS
29
PROLIFERATION
OF
CELLS
IN
3D
30
MECHANICAL
STIMULATION
AND
BIOREACTORS
31
GROWTH
FACTORS
32
DRUG-LOADED
SCAFFOLDS
32
CONCLUSIONS
33
REFERENCES
33
3
DESIGNING
ELASTIN-LIKE
RECOMBINAMERS
FOR
THERAPEUTIC
AND
REGENERATIVE
PURPOSES
37
JOSE
CARLOS
RODRIGUEZ-CABELLO,
SARA
ESCALERA,
DIANA
JUANES-GUSANO,
MERCEDES
SANTOS,
AND
ALESSANDRA
GIROTTI
3.1
3.2
3.2.1
3.2.2
3.2.3
3.2.4
3.3
3.3.1
3.3.2
3.4
INTRODUCTION
37
ELR-BASED
HYDROGELS
IN
TISSUE
ENGINEERING
39
HYDROGELS
IN
MUSCULOSKELETAL
TISSUE
REGENERATION
42
HYDROGELS
IN
CARDIOVASCULAR
TISSUE
REGENERATION
44
HYDROGELS
IN
SKIN
TISSUE
REGENERATION
46
HYDROGELS
IN
NEURAL
TISSUE
REGENERATION
47
ELR-BASED
HYDROGELS
FOR
DRUG
DELIVERY
48
PHYSICALLY
CROSS-LINKED
HYDROGELS
48
CHEMICALLY
CROSS-LINKED
HYDROGELS
52
FUTURE
REMARKS
56
REFERENCES
56
4
ENZYME-ASSISTED
HYDROGEL
FORMATION
FOR
TISSUE
ENGINEERING
APPLICATIONS
63
SILVIA
PEREZ-RAFAEL,
EVA
RAMON,
AND
TZANKO
TZANOV
4.1
4.2
4.2.1
4.2.1.1
4.2.1.2
4.2.1.3
4.2.2
4.3
4.3.1
4.3.1.1
4.3.1.2
4.3.1.3
4.3.1.4
INTRODUCTION
63
ENZYMATICALLY
CROSS-LINKED
HYDROGELS
66
OXIDOREDUCTASES
67
PEROXIDASES
-
HRP
67
TYROSINASE
72
LACCASE
72
TRANSFERASES:
TRANSGLUTAMINASE
73
SUPRAMOLECULAR
ENZYME-DRIVEN
HYDROGELATION
75
HYDROLASES
75
PHOSPHATASES
75
METALLOPROTEINASES
80
THERMOLYSIN
80
P-LACTAMASES
80
CONTENTS
VII
4.3.2
4.4
DNA
POLYMERASES
80
CONCLUSIONS
81
REFERENCES
83
5
HIERARCHICAL
PEPTIDE
AND
PROTEIN-BASED
BIOMATERIALS:
FROM
MOLECULAR
STRUCTURE
TO
DIRECTED
SELF-ASSEMBLY
AND
APPLICATIONS
97
YINCHEN
YUAN,
YEJIAO
SHI,
AND
HELENA
S.
AZEVEDO
5.1
5.2
INTRODUCTION
97
MOLECULAR
DESIGN/SELECTION
OF
BUILDING
BLOCKS
FOR
HIERARCHICAL
SELF-ASSEMBLY
98
5.2.1
5.2.2
5.2.3
5.2.4
5.3
5.3.1
5.3.2
5.3.3
5.3.4
5.3.5
5.3.6
5.3.7
5.3.8
5.4
HYDROPHOBIC
AROMATIC
AMINO
ACIDS
98
HYDROPHOBIC
ALIPHATIC
AMINO
ACIDS
106
HYDROPHILIC
CHARGED
AMINO
ACIDS
107
OTHERS
108
HIERARCHICAL
ASSEMBLY
THROUGH
ENVIRONMENTAL
MANIPULATION
108
TEMPERATURE
108
MAGNETIC
FIELD
108
ELECTRIC
FIELD
110
PATTERNED
SUBSTRATES
110
SHEAR
FORCES
111
PH
111
ULTRASOUND
112
OTHER
METHODS
112
TECHNIQUES
FOR
THE
CHARACTERIZATION
OF
HIERARCHICALLY
ORGANIZED
BIOMATERIALS
113
5.4.1
5.4.2
5.4.3
5.5
POLARIZED
LIGHT
MICROSCOPY
113
HIGH-RESOLUTION
MICROSCOPY
(AFM,
TEM,
AND
SEM)
115
SMALL-ANGLE
X-RAY
SCATTERING
(SAXS)
115
APPLICATION
OF
HIERARCHICAL
SELF-ASSEMBLING
PEPTIDE
AND
PROTEIN-BASED
BIOMATERIALS
IN
TISSUE
REGENERATION
117
5.5.1
5.5.2
5.5.3
5.6
CORNEA
117
BLOODVESSELS
118
SKELETAL
MUSCLE
119
CONCLUSIONS
120
ACKNOWLEDGMENTS
120
REFERENCES
121
6
SHORT
PEPTIDE
HYDROGELS
FOR
BIOMEDICAL
APPLICATIONS
127
PRIYADARSHI
CHAKRABORTY,
LIHI
ADLER-ABRAMOVICH,
AND
EHUD
GAZIT
6.1
6.2
6.2.1
6.2.2
INTRODUCTION
127
SHORT
PEPTIDE
HYDROGELS
128
FMOC-PROTECTED
SHORT
PEPTIDES
128
SHORT
PEPTIDE
HYDROGELS
WITH
ALTERNATING
HYDROPHOBIC/HYDROPHILIC
AMINO
ACID
RESIDUES
128
VIII
|
CONTENTS
6.2.3
P-HAIRPIN
PEPTIDES
129
6.2.4
ACETYL-PROTECTED
SHORT
PEPTIDES
129
6.3
BIOMEDICAL
APPLICATIONS
OF
SHORT
PEPTIDE
HYDROGELS
129
6.3.1
2D/3D
CELL
SCAFFOLDING
129
6.3.2
TISSUE
ENGINEERING
131
6.3.3
WOUND
HEALING
134
6.3.4
DRUG
DELIVERY
137
6.4
CONCLUSIONS
AND
OUTLOOK
139
REFERENCES
140
7
SUPRAMOLECULAR
ASSEMBLIES
OF
GLYCOPEPTIDES
AS
MIMICS
OF
THE
EXTRACELLULAR
MATRIX
149
DIANA
SOARES
DA
COSTA,
ALEXANDRA
BRITO,
RUI
L.
REIS,
AND
IVA
PASHKULEVA
7.1
INTRODUCTION
149
7.2
GLYCOPROTEINS
AND
PROTEOGLYCANS
IN
THE
ECM
150
7.3
DESIGN
OF
SELF-ASSEMBLING
PEPTIDE-SACCHARIDE
CONJUGATES
151
7.4
SUPRAMOLECULAR
SYSTEMS
GENERATED
BY
INTERFACIAL
CO-ASSEMBLY
154
7.5
CONCLUSIONS
155
ACKNOWLEDGMENTS
156
REFERENCES
156
8
SUPRAMOLECULAR
ASSEMBLIES
FOR
CANCER
DIAGNOSIS
AND
TREATMENT
161
SHUONG
LIU
AND
BING
XU
8.1
INTRODUCTION
161
8.2
CANCER
DIAGNOSIS
162
8.2.1
OPTICAL
IMAGING
162
8.2.2
MAGNETIC
RESONANCE
IMAGING
(MRI)
165
8.2.3
PHOTOACOUSTIC
IMAGING
169
8.3
CANCER
TREATMENT
173
8.3.1
DRUG
DELIVERY
173
8.3.2
ENZYME-INSTRUCTED
SELF-ASSEMBLY
(EISA
FOR
CANCER
THERAPY)
175
8.4
FUTURE
PERSPECTIVES
189
REFERENCES
190
9
POLYZWITTERIONIC
HYDROGELS
AS
WOUND
DRESSING
MATERIALS
195
KONSTANS
RUSEVA
AND
ELENA
VASSILEVA
9.1
POLYZWITTERIONS
195
9.1.1
GENERAL
STRUCTURE
AND
PROPERTIES
195
9.1.2
NONFOULING
PROPERTIES
195
9.2
WOUND
MANAGEMENT
AND
WOUND
DRESSINGS
197
9.3
PZIS
AS
DRESSINGS
MATERIALS
FOR
ACUTE
WOUNDS
198
9.3.1
POLYCARBOXYBETAINES
(PCBS)
198
9.3.2
POLYSULFOBETAINES
202
9.4
PZI
AS
DRESSINGS
FOR
CHRONIC
WOUNDS
MANAGEMENT
206
CONTENTS
IX
9.4.1
DRESSINGS
FOR
CHRONIC
WOUNDS
MANAGEMENT
BASED
ON
POLYCARBOXYBETAINES
206
9.4.2
9.5
POLYSULFOBETAINES
AS
DRESSINGS
FOR
CHRONIC
WOUNDS
MANAGEMENT
208
CONCLUSIONS
212
REFERENCES
213
10
HYALURONAN-BASED
HYDROGELS
AS
MODULATORS
OF
CELLULAR
BEHAVIOR
217
SARA
AMORIM,
RUI
L.
REIS,
AND
RICARDO
A.
PIRES
10.1
10.2
10.2.1
10.2.2
10.3
10.3.1
10.3.1.1
10.3.1.2
10.3.2
10.4
INTRODUCTION
217
BIOLOGICAL
RELEVANCE
OF
HYALURONAN
218
HYALURONAN
IN
BIOLOGICAL
TISSUES
AND
FLUIDS
218
HYALURONAN
AS
A
SIGNALING
MOLECULE
218
HYALURONAN-BASED
SYSTEMS
FOR
BIOMEDICAL
APPLICATIONS
220
HYDROGELS
FOR
TISSUE
ENGINEERING
220
DIFFERENTIATION
OF
STEM
CELLS
220
SPACE
FILLING
HYDROGELS
223
3D
CANCER
MODELS
224
CONCLUSION
AND
FUTURE
REMARKS
226
ACKNOWLEDGMENTS
226
REFERENCES
226
11
HYDROGEL
FIBERS
PRODUCED
VIA
MICROFLUIDICS
233
KONGCHANG
WEI,
CLAUDIO
TONCELLI,
RENE
M.
ROSSI,
AND
LUCIANO
F.
BOESEL
11.1
11.1.1
11.1.2
INTRODUCTION
TO
MICROFLUIDICS
AND
MICROFLUIDIC
WET
SPINNING
233
FUNDAMENTALS
OF
MICROFLUIDICS
233
APPLICATION
OF
MICROFLUIDICS
TO
FIBER
PRODUCTION:
MICROFLUIDIC
WET
SPINNING
234
11.2
11.3
FABRICATION
OF
CHIPS
FOR
MICROFLUIDIC
WET
SPINNING
237
BIOMEDICAL
APPLICATIONS
OF
HYDROGEL
FIBERS
PRODUCED
VIA
MICROFLUIDICS
242
11.3.1
11.3.1.1
11.3.1.2
11.3.2
11.3.2.1
11.3.2.2
11.3.3
11.3.4
11.4
11.4.1
11.4.2
11.5
TISSUE
ENGINEERING
243
SINGLE-FIBER
SCAFFOLDS
243
ASSEMBLED
FIBER
SCAFFOLDS
249
SENSORS
AND
ACTUATORS
251
SENSORS
251
ACTUATORS
255
CONTROLLED
DRUG
DELIVERY
256
OTHER
BIOMEDICAL
APPLICATIONS
257
HYDROGEL
OPTICAL
FIBERS
257
MATERIALS
258
APPLICATIONS
262
CONCLUSIONS
263
ACKNOWLEDGMENTS
264
REFERENCES
264
CONTENTS
12
EMBEDDING
HYDROGELS
INTO
MICROFLUIDIC
CHIPS:
VASCULAR
TRANSPORT
ANALYSES
AND
DRUG
DELIVERY
OPTIMIZATION
275
ANA
M.
MARTINS,
ALEXANDER
B.
COOK,
MARTINA
DI
FRANCESCO,
MARIA
GRAZIA
BARBATO,
SAYANTI
BRAHMACHARI,
MARTINA
PANNUZZO,
AND
PAOLO
DECUZZI
12.1
INTRODUCTION:
MICROFLUIDIC
CHIPS
FOR
MODELING
HUMAN
DISEASES
AND
DEVELOPING
NEW
THERAPIES
275
12.2
12.3
12.3.1
12.3.2
12.4
HYDROGELS
TO
MIMIC
THE
EXTRACELLULAR
MATRIX
(ECM)
276
FABRICATION
OF
MICROFLUIDIC
CHIPS
277
SINGLE-CHANNEL
MICROFLUIDIC
CHIPS
277
DOUBLE-CHANNEL
MICROFLUIDIC
CHIP
281
APPLICATIONS
OF
MICROFLUIDIC
CHIPS
IN
BIOPHYSICAL
TRANSPORT
ANALYSIS
282
12.4.1
12.4.2
12.5
12.6
12.7
SINGLE-CHANNEL
MICROFLUIDIC
CHIPS
282
DOUBLE-CHANNEL
MICROFLUIDIC
CHIPS
282
NANOPARTICLE
TRANSPORT
ANALYSES
284
COMPUTER
SIMULATIONS
OF
NANOPARTICLE
AND
CELL
TRANSPORT
285
CONCLUSIONS
AND
FUTURE
DIRECTIONS
287
REFERENCES
288
13
MULTIFUNCTIONAL
GRANULAR
HYDROGELS
FOR
TISSUE-SPECIFIC
REPAIR
295
RUI
J.
ALMEIDA,
ANA
FERNANDES,
VITOR
M.
GASPAR,
AND
JOAO
F.
MANO
13.1
13.2
13.2.1
13.2.2
13.2.3
13.2.4
13.2.5
13.3
13.3.1
13.3.2
13.3.3
13.3.4
13.4
INTRODUCTION
295
GRANULAR
HYDROGELS
-
FUNCTIONAL
FEATURES
AND
DESIGN
297
INJECTABILITY
299
INTER-PARTICLE
ANNEALING
TOWARD
MAPS
ASSEMBLY
300
VOID
SPACES
AND
MICROPOROSITY
304
MODULARITY
AND
MULTIFUNCTIONALITY
IN
GRANULAR
SYSTEMS
305
BIOACTIVE
MOLECULES
DELIVERY
306
GRANULAR
HYDROGELS
FOR
TISSUE-SPECIFIC
REPAIR
308
VASCULARIZATION
STRATEGIES
308
SKIN
TISSUES
REPAIR
311
BONE
TISSUE
REPAIR
313
EMERGING
TRENDS
AND
APPLICATIONS
317
CONCLUSIONS
AND FUTURE
PERSPECTIVES
317
ACKNOWLEDGMENTS
318
REFERENCES
318
14
INJECTABLE
HYDROGELS
AS
A
STEM
CELL
DELIVERY
PLATFORM
FOR
WOUND
HEALING
323
QIAN
XU,
SIGEN
A.,
AND
WENXIN
WANG
14.1
14.1.1
14.1.2
14.1.2.1
WOUND
HEALING
323
CLINICAL
NEEDS
FOR
WOUND
HEALING
323
WOUND
HEALING
PATHOLOGY
323
HEMOSTASIS
325
CONTENTS
XI
14.1.2.2
14.1.2.3
14.1.2.4
14.2
14.2.1
14.2.2
14.2.3
INFLAMMATION
326
PROLIFERATION
326
REMODELING
328
STEM
CELLS
FOR
SKIN
WOUND
HEALING
328
STEM
CELL
OVERVIEW
328
ADIPOSE-DERIVED
STEM
CELLS
FOR
WOUND
HEALING
329
CURRENT
LIMITATIONS
AND FUTURE
DIRECTIONS
OF
SCS
FOR
WOUND
HEALING
330
14.3
14.3.1
14.3.1.1
14.3.1.2
14.3.1.3
14.3.2
INJECTABLE
HYDROGEL
DRESSING
AS
A
DELIVERY
PLATFORM
331
TYPES
OF
INJECTABLE
HYDROGELS
332
NATURALLY
DERIVED
INJECTABLE
HYDROGELS
334
SYNTHETIC
INJECTABLE
HYDROGELS
335
HYBRID
INJECTABLE
HYDROGELS
339
INJECTABLE
HYDROGELS
AS
SCAFFOLDING
FOR
STEM
CELLS
DELIVERY
340
REFERENCES
343
INDEX
357 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author2 | Pires, Ricardo A. Pashkuleva, Iva Reis, Rui L. 1967- |
| author2_role | edt edt edt |
| author2_variant | r a p ra rap i p ip r l r rl rlr |
| author_GND | (DE-588)1194098916 |
| author_facet | Pires, Ricardo A. Pashkuleva, Iva Reis, Rui L. 1967- |
| building | Verbundindex |
| bvnumber | BV048248876 |
| classification_tum | MED 960 |
| ctrlnum | (OCoLC)1334006388 (DE-599)DNB1247295958 |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| edition | 1. Auflage |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV048248876 |
| illustrated | Illustrated |
| index_date | 2024-07-03T19:56:32Z |
| indexdate | 2024-07-10T09:33:04Z |
| institution | BVB |
| institution_GND | (DE-588)16179388-5 |
| isbn | 9783527347162 352734716X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-033629226 |
| oclc_num | 1334006388 |
| open_access_boolean | |
| owner | DE-91G DE-BY-TUM |
| owner_facet | DE-91G DE-BY-TUM |
| physical | xiii, 364 Seiten Illustrationen, Diagramme 24.4 cm x 17 cm |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Multifunctional hydrogels for biomedical applications edited by Ricardo A. Pires, Iva Pashkuleva, Rui L. Reis 1. Auflage 202205 Weinheim Wiley-VCH [2022] © 2022 xiii, 364 Seiten Illustrationen, Diagramme 24.4 cm x 17 cm txt rdacontent n rdamedia nc rdacarrier Hydrogel (DE-588)4160909-8 gnd rswk-swf Biomedizinische Technik (DE-588)4006882-1 gnd rswk-swf Cell Therapies & Tissue Engineering Chemie Chemistry Materials Science Materialwissenschaften Medical Science Medizin Soft Matter Supramolecular Chemistry Supramolekulare Chemie Zelltherapien u. Tissue Engineering CH85: Supramolekulare Chemie MD52: Zelltherapien u. Tissue Engineering MSG0: Soft Matter (DE-588)4143413-4 Aufsatzsammlung gnd-content Hydrogel (DE-588)4160909-8 s Biomedizinische Technik (DE-588)4006882-1 s DE-604 Pires, Ricardo A. edt Pashkuleva, Iva edt Reis, Rui L. 1967- (DE-588)1194098916 edt Wiley-VCH (DE-588)16179388-5 pbl Erscheint auch als Online-Ausgabe, PDF 978-3-527-82581-3 Erscheint auch als Online-Ausgabe, EPUB 978-3-527-82583-7 Erscheint auch als Online-Ausgabe, oBook 978-3-527-82582-0 X:MVB http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34716-2/ DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033629226&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p vlb 20211210 DE-101 https://d-nb.info/provenance/plan#vlb |
| spellingShingle | Multifunctional hydrogels for biomedical applications Hydrogel (DE-588)4160909-8 gnd Biomedizinische Technik (DE-588)4006882-1 gnd |
| subject_GND | (DE-588)4160909-8 (DE-588)4006882-1 (DE-588)4143413-4 |
| title | Multifunctional hydrogels for biomedical applications |
| title_auth | Multifunctional hydrogels for biomedical applications |
| title_exact_search | Multifunctional hydrogels for biomedical applications |
| title_exact_search_txtP | Multifunctional hydrogels for biomedical applications |
| title_full | Multifunctional hydrogels for biomedical applications edited by Ricardo A. Pires, Iva Pashkuleva, Rui L. Reis |
| title_fullStr | Multifunctional hydrogels for biomedical applications edited by Ricardo A. Pires, Iva Pashkuleva, Rui L. Reis |
| title_full_unstemmed | Multifunctional hydrogels for biomedical applications edited by Ricardo A. Pires, Iva Pashkuleva, Rui L. Reis |
| title_short | Multifunctional hydrogels for biomedical applications |
| title_sort | multifunctional hydrogels for biomedical applications |
| topic | Hydrogel (DE-588)4160909-8 gnd Biomedizinische Technik (DE-588)4006882-1 gnd |
| topic_facet | Hydrogel Biomedizinische Technik Aufsatzsammlung |
| url | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34716-2/ http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033629226&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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