Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors:
Airway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of '...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
2012
|
| Ausgabe: | 1st ed. 2012 |
| Schriftenreihe: | Advances in Anatomy, Embryology and Cell Biology
211 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Airway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of 'sensory airway receptors' is largely based on their action potential characteristics, electrophysiologically registered from the vagal nerve. However, the architecture of airways and lungs makes it nearly impossible to functionally locate the exact nerve terminals that are responsible for the transduction of a particular intrapulmonary stimulus. In this monograph we focus on three sensory receptor end organs in lungs that are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). Unravelling the main functional morphological and neurochemical characteristics of these sensory receptors using advanced immunohistochemistry and confocal microscopy has already allowed us to draw important conclusions about their potential function(s). The current development of ex vivo lung models for the selective identification of SMARs, NEBs and VPRs using vital staining will certainly facilitate direct physiological studies of these morphologically well-characterised airway receptors, since these models allow direct live studies of their functional properties |
| Beschreibung: | 1 Online-Ressource (XII, 118 Seiten 23 illus., 21 illus. in color.) |
| ISBN: | 9783642227721 |
| DOI: | 10.1007/978-3-642-22772-1 |
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| 520 | |a Airway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of 'sensory airway receptors' is largely based on their action potential characteristics, electrophysiologically registered from the vagal nerve. However, the architecture of airways and lungs makes it nearly impossible to functionally locate the exact nerve terminals that are responsible for the transduction of a particular intrapulmonary stimulus. In this monograph we focus on three sensory receptor end organs in lungs that are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). Unravelling the main functional morphological and neurochemical characteristics of these sensory receptors using advanced immunohistochemistry and confocal microscopy has already allowed us to draw important conclusions about their potential function(s). The current development of ex vivo lung models for the selective identification of SMARs, NEBs and VPRs using vital staining will certainly facilitate direct physiological studies of these morphologically well-characterised airway receptors, since these models allow direct live studies of their functional properties | ||
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| dewey-full | 612 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
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| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| doi_str_mv | 10.1007/978-3-642-22772-1 |
| edition | 1st ed. 2012 |
| format | Electronic eBook |
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| id | DE-604.BV047942961 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T19:35:40Z |
| indexdate | 2024-07-10T09:25:51Z |
| institution | BVB |
| isbn | 9783642227721 |
| language | English |
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| physical | 1 Online-Ressource (XII, 118 Seiten 23 illus., 21 illus. in color.) |
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| publisher | Springer Berlin Heidelberg |
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| series2 | Advances in Anatomy, Embryology and Cell Biology |
| spelling | Brouns, Inge Verfasser aut Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors by Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen 1st ed. 2012 Berlin, Heidelberg Springer Berlin Heidelberg 2012 1 Online-Ressource (XII, 118 Seiten 23 illus., 21 illus. in color.) txt rdacontent c rdamedia cr rdacarrier Advances in Anatomy, Embryology and Cell Biology 211 Airway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of 'sensory airway receptors' is largely based on their action potential characteristics, electrophysiologically registered from the vagal nerve. However, the architecture of airways and lungs makes it nearly impossible to functionally locate the exact nerve terminals that are responsible for the transduction of a particular intrapulmonary stimulus. In this monograph we focus on three sensory receptor end organs in lungs that are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). Unravelling the main functional morphological and neurochemical characteristics of these sensory receptors using advanced immunohistochemistry and confocal microscopy has already allowed us to draw important conclusions about their potential function(s). The current development of ex vivo lung models for the selective identification of SMARs, NEBs and VPRs using vital staining will certainly facilitate direct physiological studies of these morphologically well-characterised airway receptors, since these models allow direct live studies of their functional properties Human Physiology Neurochemistry Human physiology Pintelon, Isabel aut Timmermans, Jean-Pierre aut Adriaensen, Dirk aut Erscheint auch als Druck-Ausgabe 9783642227714 Erscheint auch als Druck-Ausgabe 9783642227738 https://doi.org/10.1007/978-3-642-22772-1 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Brouns, Inge Pintelon, Isabel Timmermans, Jean-Pierre Adriaensen, Dirk Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors Human Physiology Neurochemistry Human physiology |
| title | Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors |
| title_auth | Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors |
| title_exact_search | Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors |
| title_exact_search_txtP | Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors |
| title_full | Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors by Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen |
| title_fullStr | Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors by Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen |
| title_full_unstemmed | Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors by Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen |
| title_short | Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors |
| title_sort | novel insights in the neurochemistry and function of pulmonary sensory receptors |
| topic | Human Physiology Neurochemistry Human physiology |
| topic_facet | Human Physiology Neurochemistry Human physiology |
| url | https://doi.org/10.1007/978-3-642-22772-1 |
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