Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response:
The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited. CN inhibitors (CNIs) inhibit CN phosphatase acti...
Gespeichert in:
| 1. Verfasser: | |
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| Weitere Verfasser: | , , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2021
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| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited. CN inhibitors (CNIs) inhibit CN phosphatase activity to suppress many kinds of immune functions and have been used in the medical domain to prevent hyper immune reactions. However, CNIs are reported to also induce immunosuppression-derived adverse effects such as increased frequency and/or severity of infections and increased tumor incidences. CNIs might affect several T-cell derived immune functions to induce compromised host. Among the affected immune functions, T-cell dependent antibody response (TDAR) is an important factor to resist infections and thought to be the useful endpoint on evaluating immunotoxicity of chemicals; therefore, this AOP describes the linkage between the inhibition of CN activity and impairment of TDAR. |
| Beschreibung: | 1 Online-Ressource (61 Seiten) |
| DOI: | 10.1787/3c988dde-en |
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| illustrated | Not Illustrated |
| index_date | 2024-07-03T19:34:54Z |
| indexdate | 2024-12-18T19:02:01Z |
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| language | English |
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| spelling | Komatsu, Hiroyuki Verfasser aut Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response Hiroyuki Komatsu ... [et al] Paris OECD Publishing 2021 1 Online-Ressource (61 Seiten) txt rdacontent c rdamedia cr rdacarrier OECD Series on Adverse Outcome Pathways The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited. CN inhibitors (CNIs) inhibit CN phosphatase activity to suppress many kinds of immune functions and have been used in the medical domain to prevent hyper immune reactions. However, CNIs are reported to also induce immunosuppression-derived adverse effects such as increased frequency and/or severity of infections and increased tumor incidences. CNIs might affect several T-cell derived immune functions to induce compromised host. Among the affected immune functions, T-cell dependent antibody response (TDAR) is an important factor to resist infections and thought to be the useful endpoint on evaluating immunotoxicity of chemicals; therefore, this AOP describes the linkage between the inhibition of CN activity and impairment of TDAR. Social Issues/Migration/Health Environment Sugimoto, Junichiro ctb Goto, Ken ctb Kushima, Kiyoshi ctb https://doi.org/10.1787/3c988dde-en Verlag kostenfrei Volltext |
| spellingShingle | Komatsu, Hiroyuki Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response Social Issues/Migration/Health Environment |
| title | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response |
| title_auth | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response |
| title_exact_search | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response |
| title_exact_search_txtP | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response |
| title_full | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response Hiroyuki Komatsu ... [et al] |
| title_fullStr | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response Hiroyuki Komatsu ... [et al] |
| title_full_unstemmed | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response Hiroyuki Komatsu ... [et al] |
| title_short | Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response |
| title_sort | adverse outcome pathway on inhibition of calcineurin activity leading to impaired t cell dependent antibody response |
| topic | Social Issues/Migration/Health Environment |
| topic_facet | Social Issues/Migration/Health Environment |
| url | https://doi.org/10.1787/3c988dde-en |
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