Cell biology: a short course
"This text tells the story of cells as the units of life in a colorful and student-friendly manner, taking an "essentials only" approach. By using the successful model of previously published "Short Courses," this text succeeds in conveying the key points without overburdeni...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ ; Chichester, West Sussex, Uk
Wiley Blackwell
2022
|
| Ausgabe: | Fourth edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | "This text tells the story of cells as the units of life in a colorful and student-friendly manner, taking an "essentials only" approach. By using the successful model of previously published "Short Courses," this text succeeds in conveying the key points without overburdening the reader with secondary information. The authors skillfully present concepts by illustrating them with clear diagrams and examples from current research. Special boxed sections focus on the importance of cell biology in medicine and industry today. This text is completely updated from the successful "Cell Biology, A Short Course, 3e," includes new chapters"-- |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xv, 320 Seiten Illustrationen, Diagramme |
| ISBN: | 9781119757764 |
Internformat
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Datensatz im Suchindex
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| adam_text | CONTENTS Preface, xi SECTION 2 Acknowledgments, xiii THE CELL, 33 THE MOLECULAR BIOLOGY OF About the companion website, xv SECTION 1 THE STRUCTURE OF THE CELL, 1 О3 The DNA Molecule Is a Double Helix, 37 Hydrogen Bonds Form Between Base Pairs, 37 О 1 A LOOK AT CELLS AND TISSUES, 3 Only Two Types of Cell, 3 Cell Division, 4 Viruses, 4 DNA STRUCTURE AND THE GENETIC CODE, 35 The Structure of DNA, 35 DNA Strands Are Antiparallel, 37 The Two DNA Strands Are Complementary, 39 DNA as the Genetic Material, 39 Packaging of DNA Molecules into Chromosomes, 39 Origin of Eukaryotic Cells, 6 Cell Specialization in Animals, 8 Eukaryotic Chromosomes and Chromatin Structure, 39 Prokaryotic Chromosomes, 40 Stem Cells and Tissue Replacement, 10 The Cell Wall, 11 Plasmids, 41 Microscopes Reveal Cell Structure, 11 Vimses, 42 The Genetic Code, 42 The Modem Light Microscope, 11 Amino Acids and Proteins, 42 Reading the Genetic Code, 42 The Transmission Electron Microscope, 12 The Scanning Electron Microscope, 14 Amino Acid Names Are Abbreviated, 44 Fluorescence Microscopy, 14 Increasing the Resolution of Fluorescence Microscopes, 15 The Code Is Degenerate but Unambiguous, 44 Start and Stop Codons and the Reading Frame, 45 The Code Is Nearly Universal, 45 Fluorescent Proteins, 15 О2 MEMBRANES AND ORGANELLES, 21 Basic Properties of Cell Membranes, 21 Organelles Bounded by Double-Membrane Envelopes, 22 The Nucleus, 22 Mitochondria, 24 Organelles Bounded by Single Membranes, 24 Missense Mutations, 46 О4 DNA AS A DATA STORAGE MEDIUM, 51 DNA Replication, 51 The DNA Replication Fork, 51 Proteins Open up
the DNA Double Helix During Replication, 51 Peroxisomes, 25 DnaA Protein, 52 Endoplasmic Reticulum, 25 DnaB and DnaC Proteins, 52 Single-Stranded DNA-Binding Proteins, 52 Golgi Apparatus, 25 Lysosomes, 25 The Connected Cell, 26 Organelle Junctions, 26 Cell Junctions, 26 Biochemistry of DNA Replication, 52 DNA Synthesis Requires an RNA Primer, 55 RNA Primers Are Removed, 55 The Self-Correcting DNA Polymerase, 55 vii
viii CONTENTS Mismatch Repair Backs Up the Proofreading Mechanism, 55 DNA Repair after Replication, 56 О 7 PROTEIN STRUCTURE, 103 Naming Proteins, 103 Polymers of Amino Acids, 104 The Amino Acid Building Blocks, 104 Spontaneous and Chemically Induced Base Changes, 56 Repair Processes, 57 Gene Structure and Organization in Eukaryotes, 59 The Unique Properties of Each Amino Acid, 107 Other Amino Acids Are Found in Nature, 109 Introns and Exons - Additional Complexity in Eukaryotic Genes, 59 The Three-Dimensional Structures of Proteins, 109 Hydrogen Bonds, 109 The Major Classes of Eukaryotic DNA, 60 Electrostatic Interactions, 109 Van der Waals Forces, 109 Gene Nomenclature, 61 Hydrophobic Interactions, 109 Disulfide Bonds, 109 ® 5 TRANSCRIPTION AND THE CONTROL OF GENE Levels of Complexity, 110 EXPRESSION, 67 The Primary Structure, 110 Structure of RNA, 67 RNA Polymerase, 67 The Secondary Structure, 111 Gene Notation, 68 Tertiary Structure: Domains and Motifs, 114 Quaternary Structure: Assemblies of Protein Subunits, 118 Bacterial RNA Synthesis, 69 Control of Bacterial Gene Expression, 71 Prosthetic Groups, 118 Lac, an Inducible Operon, 71 Trp, a Repressible Operon, 74 Eukaryotic RNA Synthesis, 75 Messenger RNA Processing in Eukaryotes, 76 • The Primary Structure Contains all the Information Necessary to Specify Higher-Level Structures, 119 Protein-Protein Interactions Underlie all of Cell Biology, 119 Control of Eukaryotic Gene Expression, 77 Glucocorticoids Cross the Plasma Membrane to Activate Transcription, 79 Noncoding RNAs and the Control of Eukaryotic Gene Expression,
80 Micro RNAs, 80 Long Noncoding RNAs, 81 Circular RNAs, 81 © 6 MANUFACTURING PROTEIN, 85 ® б RECOMBINANT DNA TECHNOLOGY AND GENETIC ENGINEERING, 123 DNA Cloning, 123 Creating the Clone, 124 Introduction of Foreign DNA Molecules into Bacteria, 124 Genomic DNA Clones, 126 Uses of DNA Clones, 128 Southern Blotting, 129 In-Situ Hybridization, 130 Attachment of an Amino Acid to Its tRNA, 85 Transfer RNA, the Anticodon, and Wobble, 85 The Ribosome, 89 Bacterial Protein Synthesis, 89 Ribosome-Binding Site, 89 Chain Initiation, 90 Initiation Factor 2 Is a GTPase, 90 The 70S Initiation Complex, 91 Elongation of the Protein Chain in Bacteria, 92 Northern Blotting, 130 Production of Mammalian Proteins in Bacteria and Eukaryotic Cells, 130 Polymerase Chain Reaction, 132 DNA Sequencing, 133 “Omics”, 135 Transcriptomics, 135 Microarrays, 135 RNA-Seq, 136 The Polyribosome, 94 ChlP-Seq and Epigenomics, 136 Termination of Protein Synthesis, 94 The Ribosome Is Recycled, 95 Other “Omics”, 137 Identifying the Gene Responsible for a Disease, 137 Eukaryotic Protein Synthesis Is a Little More Complex, 95 Reverse Genetics, 137 Antibiotics and Protein Synthesis, 97 Protein Destruction, 98 Transgenic and Knockout Mice, 137 RNA Interference (RNAi), 139
ІХ CONTENTS CRISPR/Cas9,139 Ethics of DNA Testing for Inherited Disease, 140 SECTION 3 CELL COMMUNICATION, 145 Inositol Trisphosphate Controls Secretion in the Exocrine Pancreas, 179 Cyclic Adenosine Monophosphate Helps Us Smell, 181 Receptor Tyrosine Kinases and the Map Kinase Cascade, 183 Growth Factors Can Trigger a Calcium Signal, 185 Akt and the Glucose Carrier: How Insulin Works, 185 О 9 CARRIERS, CHANNELS, AND VOLTAGES, 147 Carriers, 147 The Glucose Carrier, 149 The Sodium/Calcium Exchanger, 150 The Sodium/Potassium ATPase, 150 The Calcium ATPase, 151 The Potassium Gradient and the Resting Voltage, 152 Potassium Channels Make the Plasma Membrane Permeable to Potassium Ions, 152 Concentration Gradients and Electrical Voltage Can Balance, 154 The Action Potential, 156 The Blood Supply Is Under Nervous System Control, 193 The Voltage-Gated Sodium Channel, 158 The Sodium Action Potential, 158 The Blood Supply Is Under Hormonal Control, 194 10 SIGNALLING THROUGH IONS, 165 Calcium as a Signaling Ion, 165 Calcium Can Enter Cells from the Extracellular Medium, 165 Calcium Can Be Released from Organelles, 166 Processes Activated by Cytosolic Calcium Are Extremely Diverse, 167 Return of Calcium to Resting Levels, 169 Propagating the Signal, 170 Transmitters Are Released at Synapses, 170 Ligand-Gated Ion Charnels Respond to Transmitters, 170 Rapid Communication: From Neurons to Their Ihrgets, 171 Inhibitory Transmission, 172 Signaling at the Neuromuscular Junction, 175 Չ Intracellular Receptors, 190 Guanylate Cyclase Is a Receptor for Nitric Oxide, 190 Many Steroid Hormone
Receptors Are Transcription Factors, 190 Crosstalk - Signaling Pathways or Signaling Webs?, 190 Signaling in the Control of Muscle Blood Supply, 192 The Blood Supply Is Under Local Control, 193 The Pain Receptor Neuron, 156 The Strength of a Signal Is Coded by Action Potential Frequency, 159 Myelination and Rapid Action Potential Transmission, 161 Չ Cytokine Receptors, 187 Signaling Through Proteolysis, 188 Wnt Proteins Signal Through Receptors that Prevent Proteolysis of Beta Catenin, 188 Low Oxygen Levels Are Sensed by Preventing Proteolysis of Hypoxia-Inducing Factor, 189 11 New Blood Vessels in Growing Muscle, 194 SECTION 4 THE MECHANICS OF THE CELL, 199 ©12 INTRACELLULAR TRAFFICKING, 201 Principles of Protein Transport, 201 Proteins Enter Organelles in Different Ways, 201 Vesicles Shuttle Proteins Around the Cell Through Fission and Fusion, 202 The Destination of a Protein Is Determined by Sorting Signals, 204 GTPases Are Master Regulators of Traffic, 205 Trafficking to the Endoplasmic Reticulum and Plasma Membrane, 205 Synthesis on the Rough Endoplasmic Reticulum, 205 Glycosylation: The Endoplasmic Reticulum and Golgi System, 206 Coatomer-Coated Vesicles, 207 Trans Golgi Network and Protein Secretion, 208 Trafficking to the Lysosome, 209 Endocytosis Is a Gateway into the Cell, 209 SIGNALLING THROUGH ENZYMES, 179 G Protein-Coupled Receptors and Second Messengers, 179 G Protein-Coupled Receptors Are an Abundant Class of Cell Surface Receptors, 179 Clathrin-Coated Vesicles, 209 Delivery of Enzymes to Lysosomes, 209 Lysosomes Degrade Proteins from both Outside and Inside
of the Cell: Autophagy, 210 Trafficking to and from the Nucleus, 210
x CONTENTS The Nuclear Pore Complex, 211 Gated Transport Through the Nuclear Pore, 212 GTPases in Nuclear Transport, 212 Trafficking to Other Organelles, 212 Transport to Mitochondria, 212 Transport to Peroxisomes, 215 О 13 CELLULAR SCAFFOLDING, 219 Microtubules, 219 Functions of Microtubules, 222 Intracellular Transport and Cellular Architecture, 222 Cell Movement by Cilia and Flagella, 223 Microfilaments, 225 Functions of Microfilaments, 226 Muscle Contraction, 226 Meiosis and Fertilization, 242 Meiosis, 242 Crossing Over and Linkage, 245 Cell Death, 246 Cell Stress Activates the Intrinsic Apoptotic Pathway, 246 Communication with the External Environment Can Activate the Extrinsic Apoptotic Pathway, 247 Default Death: Apoptosis as a Result of Absence of Growth Factors, 248 SECTION 5 О 15 CASE STUDY, 253 CASE STUDY: CYSTIC FIBROSIS, 255 Cystic Fibrosis Is a Severe Genetic Disease, 255 Microfilament-Based Cell Migration, 227 Intermediate Filaments, 228 The Fundamental Lesion in Cystic Fibrosis Lies in Chloride Transport, 256 Functions of Intermediate Filaments, 229 Cloning the CFTR Gene, 256 Anchoring Cell Junctions, 229 The Nuclear Lamina, 230 The CFTR Gene Codes for a Chloride Ion Channel, 257 Replacing or Repairing the Gene, 259 Tailoring Treatment to the Patient’s Lesion, 260 О 14 CONTROLLING CELL NUMBER, 233 M-phase, 235 Mitosis, 235 New Treatments for CF, 261 Diagnostic Tests for CF, 261 Prenatal implantation diagnosis for CF, 262 Conclusion, 262 Cytokinesis, 236 Control of the Cell Cycle, 238 Answers to Review Questions, 265 The Cell Cycle Is Driven by Kinase
Activities, 238 Glossary, 273 Checkpoints Tell the Cell Cycle When to Stop and When to Go, 239 Index, 307 The Mitotic Checkpoint Determines When the Cell Cycle Ends, 241 Cell Cycle Control and Cancer, 241
|
| adam_txt |
CONTENTS Preface, xi SECTION 2 Acknowledgments, xiii THE CELL, 33 THE MOLECULAR BIOLOGY OF About the companion website, xv SECTION 1 THE STRUCTURE OF THE CELL, 1 О3 The DNA Molecule Is a Double Helix, 37 Hydrogen Bonds Form Between Base Pairs, 37 О 1 A LOOK AT CELLS AND TISSUES, 3 Only Two Types of Cell, 3 Cell Division, 4 Viruses, 4 DNA STRUCTURE AND THE GENETIC CODE, 35 The Structure of DNA, 35 DNA Strands Are Antiparallel, 37 The Two DNA Strands Are Complementary, 39 DNA as the Genetic Material, 39 Packaging of DNA Molecules into Chromosomes, 39 Origin of Eukaryotic Cells, 6 Cell Specialization in Animals, 8 Eukaryotic Chromosomes and Chromatin Structure, 39 Prokaryotic Chromosomes, 40 Stem Cells and Tissue Replacement, 10 The Cell Wall, 11 Plasmids, 41 Microscopes Reveal Cell Structure, 11 Vimses, 42 The Genetic Code, 42 The Modem Light Microscope, 11 Amino Acids and Proteins, 42 Reading the Genetic Code, 42 The Transmission Electron Microscope, 12 The Scanning Electron Microscope, 14 Amino Acid Names Are Abbreviated, 44 Fluorescence Microscopy, 14 Increasing the Resolution of Fluorescence Microscopes, 15 The Code Is Degenerate but Unambiguous, 44 Start and Stop Codons and the Reading Frame, 45 The Code Is Nearly Universal, 45 Fluorescent Proteins, 15 О2 MEMBRANES AND ORGANELLES, 21 Basic Properties of Cell Membranes, 21 Organelles Bounded by Double-Membrane Envelopes, 22 The Nucleus, 22 Mitochondria, 24 Organelles Bounded by Single Membranes, 24 Missense Mutations, 46 О4 DNA AS A DATA STORAGE MEDIUM, 51 DNA Replication, 51 The DNA Replication Fork, 51 Proteins Open up
the DNA Double Helix During Replication, 51 Peroxisomes, 25 DnaA Protein, 52 Endoplasmic Reticulum, 25 DnaB and DnaC Proteins, 52 Single-Stranded DNA-Binding Proteins, 52 Golgi Apparatus, 25 Lysosomes, 25 The Connected Cell, 26 Organelle Junctions, 26 Cell Junctions, 26 Biochemistry of DNA Replication, 52 DNA Synthesis Requires an RNA Primer, 55 RNA Primers Are Removed, 55 The Self-Correcting DNA Polymerase, 55 vii
viii CONTENTS Mismatch Repair Backs Up the Proofreading Mechanism, 55 DNA Repair after Replication, 56 О 7 PROTEIN STRUCTURE, 103 Naming Proteins, 103 Polymers of Amino Acids, 104 The Amino Acid Building Blocks, 104 Spontaneous and Chemically Induced Base Changes, 56 Repair Processes, 57 Gene Structure and Organization in Eukaryotes, 59 The Unique Properties of Each Amino Acid, 107 Other Amino Acids Are Found in Nature, 109 Introns and Exons - Additional Complexity in Eukaryotic Genes, 59 The Three-Dimensional Structures of Proteins, 109 Hydrogen Bonds, 109 The Major Classes of Eukaryotic DNA, 60 Electrostatic Interactions, 109 Van der Waals Forces, 109 Gene Nomenclature, 61 Hydrophobic Interactions, 109 Disulfide Bonds, 109 ® 5 TRANSCRIPTION AND THE CONTROL OF GENE Levels of Complexity, 110 EXPRESSION, 67 The Primary Structure, 110 Structure of RNA, 67 RNA Polymerase, 67 The Secondary Structure, 111 Gene Notation, 68 Tertiary Structure: Domains and Motifs, 114 Quaternary Structure: Assemblies of Protein Subunits, 118 Bacterial RNA Synthesis, 69 Control of Bacterial Gene Expression, 71 Prosthetic Groups, 118 Lac, an Inducible Operon, 71 Trp, a Repressible Operon, 74 Eukaryotic RNA Synthesis, 75 Messenger RNA Processing in Eukaryotes, 76 • The Primary Structure Contains all the Information Necessary to Specify Higher-Level Structures, 119 Protein-Protein Interactions Underlie all of Cell Biology, 119 Control of Eukaryotic Gene Expression, 77 Glucocorticoids Cross the Plasma Membrane to Activate Transcription, 79 Noncoding RNAs and the Control of Eukaryotic Gene Expression,
80 Micro RNAs, 80 Long Noncoding RNAs, 81 Circular RNAs, 81 © 6 MANUFACTURING PROTEIN, 85 ® б RECOMBINANT DNA TECHNOLOGY AND GENETIC ENGINEERING, 123 DNA Cloning, 123 Creating the Clone, 124 Introduction of Foreign DNA Molecules into Bacteria, 124 Genomic DNA Clones, 126 Uses of DNA Clones, 128 Southern Blotting, 129 In-Situ Hybridization, 130 Attachment of an Amino Acid to Its tRNA, 85 Transfer RNA, the Anticodon, and Wobble, 85 The Ribosome, 89 Bacterial Protein Synthesis, 89 Ribosome-Binding Site, 89 Chain Initiation, 90 Initiation Factor 2 Is a GTPase, 90 The 70S Initiation Complex, 91 Elongation of the Protein Chain in Bacteria, 92 Northern Blotting, 130 Production of Mammalian Proteins in Bacteria and Eukaryotic Cells, 130 Polymerase Chain Reaction, 132 DNA Sequencing, 133 “Omics”, 135 Transcriptomics, 135 Microarrays, 135 RNA-Seq, 136 The Polyribosome, 94 ChlP-Seq and Epigenomics, 136 Termination of Protein Synthesis, 94 The Ribosome Is Recycled, 95 Other “Omics”, 137 Identifying the Gene Responsible for a Disease, 137 Eukaryotic Protein Synthesis Is a Little More Complex, 95 Reverse Genetics, 137 Antibiotics and Protein Synthesis, 97 Protein Destruction, 98 Transgenic and Knockout Mice, 137 RNA Interference (RNAi), 139
ІХ CONTENTS CRISPR/Cas9,139 Ethics of DNA Testing for Inherited Disease, 140 SECTION 3 CELL COMMUNICATION, 145 Inositol Trisphosphate Controls Secretion in the Exocrine Pancreas, 179 Cyclic Adenosine Monophosphate Helps Us Smell, 181 Receptor Tyrosine Kinases and the Map Kinase Cascade, 183 Growth Factors Can Trigger a Calcium Signal, 185 Akt and the Glucose Carrier: How Insulin Works, 185 О 9 CARRIERS, CHANNELS, AND VOLTAGES, 147 Carriers, 147 The Glucose Carrier, 149 The Sodium/Calcium Exchanger, 150 The Sodium/Potassium ATPase, 150 The Calcium ATPase, 151 The Potassium Gradient and the Resting Voltage, 152 Potassium Channels Make the Plasma Membrane Permeable to Potassium Ions, 152 Concentration Gradients and Electrical Voltage Can Balance, 154 The Action Potential, 156 The Blood Supply Is Under Nervous System Control, 193 The Voltage-Gated Sodium Channel, 158 The Sodium Action Potential, 158 The Blood Supply Is Under Hormonal Control, 194 10 SIGNALLING THROUGH IONS, 165 Calcium as a Signaling Ion, 165 Calcium Can Enter Cells from the Extracellular Medium, 165 Calcium Can Be Released from Organelles, 166 Processes Activated by Cytosolic Calcium Are Extremely Diverse, 167 Return of Calcium to Resting Levels, 169 Propagating the Signal, 170 Transmitters Are Released at Synapses, 170 Ligand-Gated Ion Charnels Respond to Transmitters, 170 Rapid Communication: From Neurons to Their Ihrgets, 171 Inhibitory Transmission, 172 Signaling at the Neuromuscular Junction, 175 Չ Intracellular Receptors, 190 Guanylate Cyclase Is a Receptor for Nitric Oxide, 190 Many Steroid Hormone
Receptors Are Transcription Factors, 190 Crosstalk - Signaling Pathways or Signaling Webs?, 190 Signaling in the Control of Muscle Blood Supply, 192 The Blood Supply Is Under Local Control, 193 The Pain Receptor Neuron, 156 The Strength of a Signal Is Coded by Action Potential Frequency, 159 Myelination and Rapid Action Potential Transmission, 161 Չ Cytokine Receptors, 187 Signaling Through Proteolysis, 188 Wnt Proteins Signal Through Receptors that Prevent Proteolysis of Beta Catenin, 188 Low Oxygen Levels Are Sensed by Preventing Proteolysis of Hypoxia-Inducing Factor, 189 11 New Blood Vessels in Growing Muscle, 194 SECTION 4 THE MECHANICS OF THE CELL, 199 ©12 INTRACELLULAR TRAFFICKING, 201 Principles of Protein Transport, 201 Proteins Enter Organelles in Different Ways, 201 Vesicles Shuttle Proteins Around the Cell Through Fission and Fusion, 202 The Destination of a Protein Is Determined by Sorting Signals, 204 GTPases Are Master Regulators of Traffic, 205 Trafficking to the Endoplasmic Reticulum and Plasma Membrane, 205 Synthesis on the Rough Endoplasmic Reticulum, 205 Glycosylation: The Endoplasmic Reticulum and Golgi System, 206 Coatomer-Coated Vesicles, 207 Trans Golgi Network and Protein Secretion, 208 Trafficking to the Lysosome, 209 Endocytosis Is a Gateway into the Cell, 209 SIGNALLING THROUGH ENZYMES, 179 G Protein-Coupled Receptors and Second Messengers, 179 G Protein-Coupled Receptors Are an Abundant Class of Cell Surface Receptors, 179 Clathrin-Coated Vesicles, 209 Delivery of Enzymes to Lysosomes, 209 Lysosomes Degrade Proteins from both Outside and Inside
of the Cell: Autophagy, 210 Trafficking to and from the Nucleus, 210
x CONTENTS The Nuclear Pore Complex, 211 Gated Transport Through the Nuclear Pore, 212 GTPases in Nuclear Transport, 212 Trafficking to Other Organelles, 212 Transport to Mitochondria, 212 Transport to Peroxisomes, 215 О 13 CELLULAR SCAFFOLDING, 219 Microtubules, 219 Functions of Microtubules, 222 Intracellular Transport and Cellular Architecture, 222 Cell Movement by Cilia and Flagella, 223 Microfilaments, 225 Functions of Microfilaments, 226 Muscle Contraction, 226 Meiosis and Fertilization, 242 Meiosis, 242 Crossing Over and Linkage, 245 Cell Death, 246 Cell Stress Activates the Intrinsic Apoptotic Pathway, 246 Communication with the External Environment Can Activate the Extrinsic Apoptotic Pathway, 247 Default Death: Apoptosis as a Result of Absence of Growth Factors, 248 SECTION 5 О 15 CASE STUDY, 253 CASE STUDY: CYSTIC FIBROSIS, 255 Cystic Fibrosis Is a Severe Genetic Disease, 255 Microfilament-Based Cell Migration, 227 Intermediate Filaments, 228 The Fundamental Lesion in Cystic Fibrosis Lies in Chloride Transport, 256 Functions of Intermediate Filaments, 229 Cloning the CFTR Gene, 256 Anchoring Cell Junctions, 229 The Nuclear Lamina, 230 The CFTR Gene Codes for a Chloride Ion Channel, 257 Replacing or Repairing the Gene, 259 Tailoring Treatment to the Patient’s Lesion, 260 О 14 CONTROLLING CELL NUMBER, 233 M-phase, 235 Mitosis, 235 New Treatments for CF, 261 Diagnostic Tests for CF, 261 Prenatal implantation diagnosis for CF, 262 Conclusion, 262 Cytokinesis, 236 Control of the Cell Cycle, 238 Answers to Review Questions, 265 The Cell Cycle Is Driven by Kinase
Activities, 238 Glossary, 273 Checkpoints Tell the Cell Cycle When to Stop and When to Go, 239 Index, 307 The Mitotic Checkpoint Determines When the Cell Cycle Ends, 241 Cell Cycle Control and Cancer, 241 |
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| author | Bolsover, Stephen R. 1954- Townsend-Nicholson, Andrea FitzHarris, Greg Shephard, Elizabeth Hyams, Jeremy S. Patel, Sandip |
| author_GND | (DE-588)1089099215 |
| author_facet | Bolsover, Stephen R. 1954- Townsend-Nicholson, Andrea FitzHarris, Greg Shephard, Elizabeth Hyams, Jeremy S. Patel, Sandip |
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| classification_tum | BIO 200 |
| ctrlnum | (OCoLC)1275369531 (DE-599)KXP1773426354 |
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| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
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| discipline | Biologie |
| discipline_str_mv | Biologie |
| edition | Fourth edition |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV047890673 |
| illustrated | Illustrated |
| index_date | 2024-07-03T19:26:00Z |
| indexdate | 2024-07-10T09:24:21Z |
| institution | BVB |
| isbn | 9781119757764 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-033272787 |
| oclc_num | 1275369531 |
| open_access_boolean | |
| owner | DE-703 DE-11 DE-355 DE-BY-UBR DE-M49 DE-BY-TUM |
| owner_facet | DE-703 DE-11 DE-355 DE-BY-UBR DE-M49 DE-BY-TUM |
| physical | xv, 320 Seiten Illustrationen, Diagramme |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| publisher | Wiley Blackwell |
| record_format | marc |
| spelling | Bolsover, Stephen R. 1954- Verfasser aut Cell biology a short course Stephen Bolsover, Andrea Townsend-Nicholson, Greg FitzHarris, Elizabeth Shephard, Jeremy Hyams, Sandip Patel Fourth edition Hoboken, NJ ; Chichester, West Sussex, Uk Wiley Blackwell 2022 xv, 320 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index "This text tells the story of cells as the units of life in a colorful and student-friendly manner, taking an "essentials only" approach. By using the successful model of previously published "Short Courses," this text succeeds in conveying the key points without overburdening the reader with secondary information. The authors skillfully present concepts by illustrating them with clear diagrams and examples from current research. Special boxed sections focus on the importance of cell biology in medicine and industry today. This text is completely updated from the successful "Cell Biology, A Short Course, 3e," includes new chapters"-- Cytologie (DE-588)4070177-3 gnd rswk-swf Cytology (DE-588)4123623-3 Lehrbuch gnd-content Cytologie (DE-588)4070177-3 s DE-604 Townsend-Nicholson, Andrea Verfasser aut FitzHarris, Greg Verfasser aut Shephard, Elizabeth Verfasser aut Hyams, Jeremy S. Verfasser (DE-588)1089099215 aut Patel, Sandip Verfasser aut Erscheint auch als Online-Ausgabe, PDF 978-1-119-75777-1 Erscheint auch als Online-Ausgabe, EPUB 978-1-119-75778-8 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033272787&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bolsover, Stephen R. 1954- Townsend-Nicholson, Andrea FitzHarris, Greg Shephard, Elizabeth Hyams, Jeremy S. Patel, Sandip Cell biology a short course Cytologie (DE-588)4070177-3 gnd |
| subject_GND | (DE-588)4070177-3 (DE-588)4123623-3 |
| title | Cell biology a short course |
| title_auth | Cell biology a short course |
| title_exact_search | Cell biology a short course |
| title_exact_search_txtP | Cell biology a short course |
| title_full | Cell biology a short course Stephen Bolsover, Andrea Townsend-Nicholson, Greg FitzHarris, Elizabeth Shephard, Jeremy Hyams, Sandip Patel |
| title_fullStr | Cell biology a short course Stephen Bolsover, Andrea Townsend-Nicholson, Greg FitzHarris, Elizabeth Shephard, Jeremy Hyams, Sandip Patel |
| title_full_unstemmed | Cell biology a short course Stephen Bolsover, Andrea Townsend-Nicholson, Greg FitzHarris, Elizabeth Shephard, Jeremy Hyams, Sandip Patel |
| title_short | Cell biology |
| title_sort | cell biology a short course |
| title_sub | a short course |
| topic | Cytologie (DE-588)4070177-3 gnd |
| topic_facet | Cytologie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033272787&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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