Beta-arrestins: methods and protocols
This volume looks at various approaches to study the pleiotropic roles of b-arrestins (b-arrs) in the control of signal transduction, and the resulting cellular and in vivo consequences that arise. The chapters in this book cover diverse topics around b-arrs such as their established roles in GPCR r...
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| Weitere Verfasser: | , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer New York
2019
|
| Ausgabe: | 1st ed. 2019 |
| Schriftenreihe: | Methods in Molecular Biology
1957 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 URL des Erstveröffentlichers |
| Zusammenfassung: | This volume looks at various approaches to study the pleiotropic roles of b-arrestins (b-arrs) in the control of signal transduction, and the resulting cellular and in vivo consequences that arise. The chapters in this book cover diverse topics around b-arrs such as their established roles in GPCR regulation and trafficking; regulatory scaffolding functions of b-arrs in MAPK signaling, cAMP hydrolysis and cytoskeletal dynamics; proteomic analysis of the b-arr interactome; mathematical modelling of b-arr signaling networks; functional selectivity involving biased ligands; nucleocytoplasmic trafficking and primary cilia-associated functions of b-arrs; conformational plasticity of b-arrs; and the roles of b-arrs in allergic inflammation, Type 2 Diabetes, Parkinson's disease, and cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Beta-Arrestins: Methods and Protocols is a valuable resource for researchers interested in learning more about the function and regulation of b-arrestins |
| Beschreibung: | A Brief History of the b-Arrestins -- b-Arrestins: Multitask Scaffolds Orchestrating the Where and When In Cell Signaling -- Methods to Monitor the Trafficking of β-Arrestin/G Protein-Coupled Receptor Complexes using Enhanced Bystander BRET -- Methods to Investigate b-Arrestin-Mediated Regulation of GPCR Function in Human Airway Smooth Muscle -- Measuring Recruitment of b-Arrestin to G Protein-Coupled Heterodimers using Bioluminescence Resonance Energy Transfer -- Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination using BRET -- Using In Vitro Pull-Down and In Cell Overexpression Assays to Study Protein Interactions with Arrestin -- Methods to Investigate Arrestins in Complex with Phosphodiesterases -- Methods to Characterize Protein Interactions with β-arrestin in cellulo -- Methods to Investigate the β-Arrestin-Mediated control of ARF6 Activation to Regulate Trafficking and Actin Cytoskeleton Remodeling -- - Methods to Investigate the Roles of b-Arrestin-Dependent RalGDS Activation in GPCR-Stimulated Membrane Blebbing -- Methods to Determine Interaction Interfaces between b-Arrestins and Their Protein Partners -- Workflow Description to Dynamically Model β-Arrestin Signaling Networks -- Proteomic Analysis of the β-Arrestin Interactome -- Quantitating Ligand Bias using the Competitive Model of Ligand Activity -- Methods to Investigate the Nucleocytoplasmic Shuttling Properties of b-Arrestins -- Monitoring β-Arrestin2 Targeting to the Centrosome, Basal Body and Primary Cilium by Fluorescence Microscopy -- A Mass Spectrometry-Based Structural Assay for Activation-Dependent Conformational Changes in β-Arrestins -- Probing Arrestin Function using Intramolecular FlAsH-BRET Biosensors -- Methods to Study the Roles of b-Arrestins in Meningococcal Signaling -- Methods to Investigate the Roles for β-Arrestin2 in Allergic Inflammatory Airway Disease -- - Methods to Study Roles of β-Arrestins in the Regulation of Pancreatic β-Cell Function -- Methods to Investigate β-Arrestin Function in Metabolic Regulation -- Methods to Investigate the Role of b-Arrestin Signaling in Parkinson's Ddisease -- Methods to Investigate β-Arrestin-1/β-Catenin Signaling in Ovarian Cancer Cells |
| Beschreibung: | 1 Online-Ressource (XIV, 409 Seiten) Illustrationen |
| ISBN: | 9781493991587 |
| DOI: | 10.1007/978-1-4939-9158-7 |
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| isbn | 9781493991587 |
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| spelling | Beta-arrestins methods and protocols edited by Mark G. H. Scott, Stéphane A. Laporte 1st ed. 2019 New York, NY Springer New York 2019 1 Online-Ressource (XIV, 409 Seiten) Illustrationen txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 1957 A Brief History of the b-Arrestins -- b-Arrestins: Multitask Scaffolds Orchestrating the Where and When In Cell Signaling -- Methods to Monitor the Trafficking of β-Arrestin/G Protein-Coupled Receptor Complexes using Enhanced Bystander BRET -- Methods to Investigate b-Arrestin-Mediated Regulation of GPCR Function in Human Airway Smooth Muscle -- Measuring Recruitment of b-Arrestin to G Protein-Coupled Heterodimers using Bioluminescence Resonance Energy Transfer -- Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination using BRET -- Using In Vitro Pull-Down and In Cell Overexpression Assays to Study Protein Interactions with Arrestin -- Methods to Investigate Arrestins in Complex with Phosphodiesterases -- Methods to Characterize Protein Interactions with β-arrestin in cellulo -- Methods to Investigate the β-Arrestin-Mediated control of ARF6 Activation to Regulate Trafficking and Actin Cytoskeleton Remodeling -- - Methods to Investigate the Roles of b-Arrestin-Dependent RalGDS Activation in GPCR-Stimulated Membrane Blebbing -- Methods to Determine Interaction Interfaces between b-Arrestins and Their Protein Partners -- Workflow Description to Dynamically Model β-Arrestin Signaling Networks -- Proteomic Analysis of the β-Arrestin Interactome -- Quantitating Ligand Bias using the Competitive Model of Ligand Activity -- Methods to Investigate the Nucleocytoplasmic Shuttling Properties of b-Arrestins -- Monitoring β-Arrestin2 Targeting to the Centrosome, Basal Body and Primary Cilium by Fluorescence Microscopy -- A Mass Spectrometry-Based Structural Assay for Activation-Dependent Conformational Changes in β-Arrestins -- Probing Arrestin Function using Intramolecular FlAsH-BRET Biosensors -- Methods to Study the Roles of b-Arrestins in Meningococcal Signaling -- Methods to Investigate the Roles for β-Arrestin2 in Allergic Inflammatory Airway Disease -- - Methods to Study Roles of β-Arrestins in the Regulation of Pancreatic β-Cell Function -- Methods to Investigate β-Arrestin Function in Metabolic Regulation -- Methods to Investigate the Role of b-Arrestin Signaling in Parkinson's Ddisease -- Methods to Investigate β-Arrestin-1/β-Catenin Signaling in Ovarian Cancer Cells This volume looks at various approaches to study the pleiotropic roles of b-arrestins (b-arrs) in the control of signal transduction, and the resulting cellular and in vivo consequences that arise. The chapters in this book cover diverse topics around b-arrs such as their established roles in GPCR regulation and trafficking; regulatory scaffolding functions of b-arrs in MAPK signaling, cAMP hydrolysis and cytoskeletal dynamics; proteomic analysis of the b-arr interactome; mathematical modelling of b-arr signaling networks; functional selectivity involving biased ligands; nucleocytoplasmic trafficking and primary cilia-associated functions of b-arrs; conformational plasticity of b-arrs; and the roles of b-arrs in allergic inflammation, Type 2 Diabetes, Parkinson's disease, and cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Beta-Arrestins: Methods and Protocols is a valuable resource for researchers interested in learning more about the function and regulation of b-arrestins Proteins Cell biology Scott, Mark ca. 20./21. Jh. (DE-588)1247840824 edt Laporte, Stéphane ca. 20./21. Jh. (DE-588)124784109X edt Erscheint auch als Druck-Ausgabe 978-1-4939-9159-4 https://doi.org/10.1007/978-1-4939-9158-7 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Beta-arrestins methods and protocols Proteins Cell biology |
| title | Beta-arrestins methods and protocols |
| title_auth | Beta-arrestins methods and protocols |
| title_exact_search | Beta-arrestins methods and protocols |
| title_exact_search_txtP | Beta-arrestins methods and protocols |
| title_full | Beta-arrestins methods and protocols edited by Mark G. H. Scott, Stéphane A. Laporte |
| title_fullStr | Beta-arrestins methods and protocols edited by Mark G. H. Scott, Stéphane A. Laporte |
| title_full_unstemmed | Beta-arrestins methods and protocols edited by Mark G. H. Scott, Stéphane A. Laporte |
| title_short | Beta-arrestins |
| title_sort | beta arrestins methods and protocols |
| title_sub | methods and protocols |
| topic | Proteins Cell biology |
| topic_facet | Proteins Cell biology |
| url | https://doi.org/10.1007/978-1-4939-9158-7 |
| work_keys_str_mv | AT scottmark betaarrestinsmethodsandprotocols AT laportestephane betaarrestinsmethodsandprotocols |