Genotoxicity assessment: methods and protocols
This current edition explores new tests for genotoxicity testing, along with other well-known techniques. This will further help in our understanding of the genotoxic effects of chemicals. The book has different sections dealing with various assays for gene mutation, chromosomal abnormalities, prima...
Gespeichert in:
| Weitere Verfasser: | , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer New York
2019
|
| Ausgabe: | 2nd ed. 2019 |
| Schriftenreihe: | Methods in Molecular Biology
2031 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 URL des Erstveröffentlichers |
| Zusammenfassung: | This current edition explores new tests for genotoxicity testing, along with other well-known techniques. This will further help in our understanding of the genotoxic effects of chemicals. The book has different sections dealing with various assays for gene mutation, chromosomal abnormalities, primary DNA damage, etc. It also delves into plant models, animals and their alternates, as well as in silico approaches for genetic toxicology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Genotoxicity Assessment: Methods and Protocols, Second Edition serves as a highly useful and ready resource for research students and scientists working in regulatory toxicology as well as biomedical, biochemical, and pharmaceutical sciences |
| Beschreibung: | In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay -- Erythrocyte-Based Pig-a Gene Mutation Assay -- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes -- In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests -- Dicentric Chromosome Assay (DCA) and Cytokinesis-Block Micronucleus (CBMN) Assay in the Field of Biological Dosimetry -- Chromosomal Aberration Test in Human Lymphocytes -- In Vivo Micronucleus Assay in Mouse Bone Marrow -- Micronucleus Cytome Assays in Human Lymphocytes and Buccal Cells -- Micronucleus Analysis by Flow Cytometry -- Hen's Egg Test for Micronucleus Induction (HET-MN) -- Comparative Genomic Hybridization (CGH) in Genotoxicology -- The Comet Assay: Assessment of In Vitro and In Vivo DNA Damage -- The Comet Assay in Human Biomonitoring -- The Comet Assay in Marine Animals -- Multicolour Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers -- Detection of DNA Double Strand Breaks Using Pulse Field Gel Electrophoresis -- Detection of UV-Induced Thymine Dimers -- Micronucleus Assay with Tetrad Cells of Tradescantia -- The Wing-Spot and the Comet Tests as Useful Assays for Detecting Genotoxicity in Drosophila -- In Silico Approaches in Predictive Genetic Toxicology |
| Beschreibung: | 1 Online-Ressource (XI, 378 Seiten) Illustrationen |
| ISBN: | 9781493996469 |
| DOI: | 10.1007/978-1-4939-9646-9 |
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| 520 | |a This current edition explores new tests for genotoxicity testing, along with other well-known techniques. This will further help in our understanding of the genotoxic effects of chemicals. The book has different sections dealing with various assays for gene mutation, chromosomal abnormalities, primary DNA damage, etc. It also delves into plant models, animals and their alternates, as well as in silico approaches for genetic toxicology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Genotoxicity Assessment: Methods and Protocols, Second Edition serves as a highly useful and ready resource for research students and scientists working in regulatory toxicology as well as biomedical, biochemical, and pharmaceutical sciences | ||
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| edition | 2nd ed. 2019 |
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| isbn | 9781493996469 |
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| spelling | Genotoxicity assessment methods and protocols edited by Alok Dhawan, Mahima Bajpayee 2nd ed. 2019 New York, NY Springer New York 2019 1 Online-Ressource (XI, 378 Seiten) Illustrationen txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 2031 In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay -- Erythrocyte-Based Pig-a Gene Mutation Assay -- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes -- In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests -- Dicentric Chromosome Assay (DCA) and Cytokinesis-Block Micronucleus (CBMN) Assay in the Field of Biological Dosimetry -- Chromosomal Aberration Test in Human Lymphocytes -- In Vivo Micronucleus Assay in Mouse Bone Marrow -- Micronucleus Cytome Assays in Human Lymphocytes and Buccal Cells -- Micronucleus Analysis by Flow Cytometry -- Hen's Egg Test for Micronucleus Induction (HET-MN) -- Comparative Genomic Hybridization (CGH) in Genotoxicology -- The Comet Assay: Assessment of In Vitro and In Vivo DNA Damage -- The Comet Assay in Human Biomonitoring -- The Comet Assay in Marine Animals -- Multicolour Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers -- Detection of DNA Double Strand Breaks Using Pulse Field Gel Electrophoresis -- Detection of UV-Induced Thymine Dimers -- Micronucleus Assay with Tetrad Cells of Tradescantia -- The Wing-Spot and the Comet Tests as Useful Assays for Detecting Genotoxicity in Drosophila -- In Silico Approaches in Predictive Genetic Toxicology This current edition explores new tests for genotoxicity testing, along with other well-known techniques. This will further help in our understanding of the genotoxic effects of chemicals. The book has different sections dealing with various assays for gene mutation, chromosomal abnormalities, primary DNA damage, etc. It also delves into plant models, animals and their alternates, as well as in silico approaches for genetic toxicology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Genotoxicity Assessment: Methods and Protocols, Second Edition serves as a highly useful and ready resource for research students and scientists working in regulatory toxicology as well as biomedical, biochemical, and pharmaceutical sciences Pharmacology Human genetics Ecotoxicology Dhawan, Alok (DE-588)1143841379 edt Bajpayee, Mahima ca. 20./21. Jh. (DE-588)1247776662 edt Erscheint auch als Druck-Ausgabe 978-1-4939-9648-3 https://doi.org/10.1007/978-1-4939-9646-9 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Genotoxicity assessment methods and protocols Pharmacology Human genetics Ecotoxicology |
| title | Genotoxicity assessment methods and protocols |
| title_auth | Genotoxicity assessment methods and protocols |
| title_exact_search | Genotoxicity assessment methods and protocols |
| title_exact_search_txtP | Genotoxicity assessment methods and protocols |
| title_full | Genotoxicity assessment methods and protocols edited by Alok Dhawan, Mahima Bajpayee |
| title_fullStr | Genotoxicity assessment methods and protocols edited by Alok Dhawan, Mahima Bajpayee |
| title_full_unstemmed | Genotoxicity assessment methods and protocols edited by Alok Dhawan, Mahima Bajpayee |
| title_short | Genotoxicity assessment |
| title_sort | genotoxicity assessment methods and protocols |
| title_sub | methods and protocols |
| topic | Pharmacology Human genetics Ecotoxicology |
| topic_facet | Pharmacology Human genetics Ecotoxicology |
| url | https://doi.org/10.1007/978-1-4939-9646-9 |
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