Essential developmental biology:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley
2022
|
| Ausgabe: | 4th edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | x, 532 Seiten Illustrationen, Diagramme |
| ISBN: | 9781119512851 |
Internformat
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Datensatz im Suchindex
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| adam_text | Contents Preface,ix About the companion website, xi Section i: Groundwork, i i The excitement of developmental biology, з Where the subject came from, 3 Impact of developmental biology, 4 Future impact, 5 շ How development works, 7 Ultrashort summary, 7 Gametogenesis, 10 Early development, 13 Growth and death, 19 3 Approaches to development: developmental genetics, 25 Developmental mutants, 25 Sex chromosomes, 27 Maternal and zygotic, 27 Genetic pathways, 28 Genetic mosaics, 30 Screening for mutants, 31 Cloning of genes, 32 Gain- and loss-of-function experiments, 32 Transgenesis, 32 Other gain-of-function techniques, 34 Targeted mutagenesis, 34 Other loss-of-function systems, 35 Gene duplication, 36 Limitations of developmental genetics, 37 4 Approaches to development: experimental embryology and its molecular basis, 39 Normal development, 39 Developmental commitment, 42 Criteria for proof, 48 Transcription factors, 48 Transcription factor families, 50 Other controls of gene activity, 51 Signaling systems, 51 Genetic regulatory networks, 57 5 Approaches to development: cell and molecular biology techniques, 61 Microscopy, 61 Optical techniques, 61 Confocal, multi-photon, and light sheet microscopes, 63 Image capture, 63 Anatomical and histological methods, 64 Microinjection, 66 Study of gene expression by molecular biology methods, 67 Study of gene expression by in situ methods, 72 Reporter genes, 75 Cell-labeling methods, 76
vi ♦ Contents 6 Cells into tissues, 81 Cells in embryos, 81 Cytoskeleton, 82 Small GTP-binding proteins, 84 Extracellular matrix, 84 Cell movement, 85 EpitheUal organization, 86 Morphogenetic processes, 88 Section 2: Major model organisms, 97 7 Major model organisms, 99 The big six, 99 Access and micromanipulation, 101 Genetics and genomes, 101 Relevance and tempo, 102 Other organisms, 102 8 Xenopus, 107 Oogenesis, maturation, and fertilization, 108 Normal development, 109 Fate maps, 114 Experimental methods, 115 Processes of regional specification, 119 9 The zebrafish, 135 Normal development, 135 Fate map, 140 Genetics, 141 Reverse genetic methods, 144 Embryological techniques, 145 Regional specification, 145 Other roles of the zebrafish, 150 10 The chick, 153 Normal development, 154 Fate map, 158 Regional specification of the early embryo, 159 Description of organogenesis in the chick, 164 n The mouse, 173 Mammalian fertilization, 173 Normal development of the mouse, 177 Fate map, 184 Regional specification in the mouse embryo, 185 Transgenic mice, 190 Embryonic stem cells, 192 Knockouts and knock-ins, 192 Nuclear transplantation and imprinting, 196 X-inactivation, 196 Teratocarcinoma, 198 12 Human early development, 203 Human reproduction, 203 Preimplantation development, 205 Human embryonic stem cells, 207 Human postimplantation development, 208 Postimplantation diagnosis: chorionic villus sampling and amniocentesis, 211 Ethics of human development, 211 13 Drosophila, 217 Insects, 217 Normal development, 219 Fate map, 222 Pole plasm, 224 Drosophila developmental
genetics, 224 The developmental program, 227 The dorsoventral pattern, 228 The anteroposterior system, 232 14 Caenorhabditis elegans, 247 Adult anatomy, 248 Embryonic development, 249 Regional specification in the embryo, 251 Analysis of postembryonic development, 259 The germ line, 262 Programmed cell death, 264 Section 3: Organogenesis, 269 15 Techniques for studying organogenesis and postnatal development, 271 Genetics, 271 Clonal analysis, 275 Tissue and organ culture, 278 Cell analysis and separation, 279 і б Development of the nervous system, 283 Overall structure and cell types, 283 Regional specification, 286 Neurogenesis and gliogenesis, 292 The neural crest, 299 Development of neuronal connectivity, 303 17 Development of mesodermal organs, 315 Somitogenesis, 315 Myogenesis, 322 The kidney, 323
Contents ♦ vii Germ cell and gonadal development, 326 Sex determination, 330 Limb development, 330 Blood and blood vessels, 340 The heart, 343 18 Development of endodermal organs, 355 Normal development, 355 Organization of the gut tube, 356 Fate map of the endoderm, 359 Experimental analysis of endoderm development, 359 The pancreas, 366 19 Drosophila imaginai discs, 373 Metamorphosis, 373 Genetic study of larval development, 374 Disc development, 378 Compartments and selector genes, 378 Regional patterning of the wing disc, 381 Regeneration and transdetermination, 384 Morphogen gradients and polarity, 387 Molecular biology of cancer, 442 Cancer stem cells, 443 Cancer progression, 444 Cancer therapy, 445 22 Pluripotent stem cells and their applications, 449 Human embryonic stem cells, 449 Induced pluripotent stem cells, 451 Somatic cell nuclear transfer, 453 Direct reprogramming, 454 Applications of human pluripotent stem cells, 455 Cell transplantation therapy, 457 Cell transplantation therapies using pluripotent stem cells, 459 Transplantation therapy for diabetes, 460 Retinal pigment epithelium, 462 Spinal repair, 463 Cardiomyocytes, 463 Parkinson’s disease, 463 Introduction of new therapies, 465 23 Evolution and development, 469 Section 4: Growth, evolution, regeneration, 391 20 Tissue organization and stem cells, 393 Types of tissue, 393 Tissue renewal, 397 Stem cells, 401 Intestinal epithelium, 403 Epidermis, 408 Hair follicles, 410 Hematopoietic system, 415 Mesenchymal stem cells and “transdifferentiation”, 419 Spermatogonia, 419 21 Growth, aging, and cancer, 425
Growth: control of size and proportion, 425 Biochemical pathways of growth control, 426 Growth control in insects, 429 Growth control in mammals, 431 Liver regeneration, 433 Growth in stature, 434 Aging, 436 Cell autonomous processes, 437 The insulin pathway and aging, 438 Caloric restriction, 438 Cancer, 440 Classification of tumors and precursor lesions, 440 Macroevolution, 470 Molecular taxonomy, 471 Phylogeny of animals, 472 The fossil record, 473 The primordial animal, 474 Basal animals, 479 What really happened in evolution?, 481 Segmented body plans and Hox genes, 482 Insect wings and legs, 483 Atavisms, 483 Vertebrate limbs, 485 24 Regeneration of missing parts, 491 Types of regeneration, 491 Distribution of regenerative capacity, 491 Planarian regeneration, 492 Insect limb regeneration, 497 Vertebrate limb regeneration, 499 The process of limb regeneration, 499 The source of cells for regeneration, 501 Regeneration of regional pattern, 502 Regeneration: ancestral or adaptive property?, 508 General properties of regeneration, 509 Glossary, 513 Index, 527
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| adam_txt |
Contents Preface,ix About the companion website, xi Section i: Groundwork, i i The excitement of developmental biology, з Where the subject came from, 3 Impact of developmental biology, 4 Future impact, 5 շ How development works, 7 Ultrashort summary, 7 Gametogenesis, 10 Early development, 13 Growth and death, 19 3 Approaches to development: developmental genetics, 25 Developmental mutants, 25 Sex chromosomes, 27 Maternal and zygotic, 27 Genetic pathways, 28 Genetic mosaics, 30 Screening for mutants, 31 Cloning of genes, 32 Gain- and loss-of-function experiments, 32 Transgenesis, 32 Other gain-of-function techniques, 34 Targeted mutagenesis, 34 Other loss-of-function systems, 35 Gene duplication, 36 Limitations of developmental genetics, 37 4 Approaches to development: experimental embryology and its molecular basis, 39 Normal development, 39 Developmental commitment, 42 Criteria for proof, 48 Transcription factors, 48 Transcription factor families, 50 Other controls of gene activity, 51 Signaling systems, 51 Genetic regulatory networks, 57 5 Approaches to development: cell and molecular biology techniques, 61 Microscopy, 61 Optical techniques, 61 Confocal, multi-photon, and light sheet microscopes, 63 Image capture, 63 Anatomical and histological methods, 64 Microinjection, 66 Study of gene expression by molecular biology methods, 67 Study of gene expression by in situ methods, 72 Reporter genes, 75 Cell-labeling methods, 76
vi ♦ Contents 6 Cells into tissues, 81 Cells in embryos, 81 Cytoskeleton, 82 Small GTP-binding proteins, 84 Extracellular matrix, 84 Cell movement, 85 EpitheUal organization, 86 Morphogenetic processes, 88 Section 2: Major model organisms, 97 7 Major model organisms, 99 The big six, 99 Access and micromanipulation, 101 Genetics and genomes, 101 Relevance and tempo, 102 Other organisms, 102 8 Xenopus, 107 Oogenesis, maturation, and fertilization, 108 Normal development, 109 Fate maps, 114 Experimental methods, 115 Processes of regional specification, 119 9 The zebrafish, 135 Normal development, 135 Fate map, 140 Genetics, 141 Reverse genetic methods, 144 Embryological techniques, 145 Regional specification, 145 Other roles of the zebrafish, 150 10 The chick, 153 Normal development, 154 Fate map, 158 Regional specification of the early embryo, 159 Description of organogenesis in the chick, 164 n The mouse, 173 Mammalian fertilization, 173 Normal development of the mouse, 177 Fate map, 184 Regional specification in the mouse embryo, 185 Transgenic mice, 190 Embryonic stem cells, 192 Knockouts and knock-ins, 192 Nuclear transplantation and imprinting, 196 X-inactivation, 196 Teratocarcinoma, 198 12 Human early development, 203 Human reproduction, 203 Preimplantation development, 205 Human embryonic stem cells, 207 Human postimplantation development, 208 Postimplantation diagnosis: chorionic villus sampling and amniocentesis, 211 Ethics of human development, 211 13 Drosophila, 217 Insects, 217 Normal development, 219 Fate map, 222 Pole plasm, 224 Drosophila developmental
genetics, 224 The developmental program, 227 The dorsoventral pattern, 228 The anteroposterior system, 232 14 Caenorhabditis elegans, 247 Adult anatomy, 248 Embryonic development, 249 Regional specification in the embryo, 251 Analysis of postembryonic development, 259 The germ line, 262 Programmed cell death, 264 Section 3: Organogenesis, 269 15 Techniques for studying organogenesis and postnatal development, 271 Genetics, 271 Clonal analysis, 275 Tissue and organ culture, 278 Cell analysis and separation, 279 і б Development of the nervous system, 283 Overall structure and cell types, 283 Regional specification, 286 Neurogenesis and gliogenesis, 292 The neural crest, 299 Development of neuronal connectivity, 303 17 Development of mesodermal organs, 315 Somitogenesis, 315 Myogenesis, 322 The kidney, 323
Contents ♦ vii Germ cell and gonadal development, 326 Sex determination, 330 Limb development, 330 Blood and blood vessels, 340 The heart, 343 18 Development of endodermal organs, 355 Normal development, 355 Organization of the gut tube, 356 Fate map of the endoderm, 359 Experimental analysis of endoderm development, 359 The pancreas, 366 19 Drosophila imaginai discs, 373 Metamorphosis, 373 Genetic study of larval development, 374 Disc development, 378 Compartments and selector genes, 378 Regional patterning of the wing disc, 381 Regeneration and transdetermination, 384 Morphogen gradients and polarity, 387 Molecular biology of cancer, 442 Cancer stem cells, 443 Cancer progression, 444 Cancer therapy, 445 22 Pluripotent stem cells and their applications, 449 Human embryonic stem cells, 449 Induced pluripotent stem cells, 451 Somatic cell nuclear transfer, 453 Direct reprogramming, 454 Applications of human pluripotent stem cells, 455 Cell transplantation therapy, 457 Cell transplantation therapies using pluripotent stem cells, 459 Transplantation therapy for diabetes, 460 Retinal pigment epithelium, 462 Spinal repair, 463 Cardiomyocytes, 463 Parkinson’s disease, 463 Introduction of new therapies, 465 23 Evolution and development, 469 Section 4: Growth, evolution, regeneration, 391 20 Tissue organization and stem cells, 393 Types of tissue, 393 Tissue renewal, 397 Stem cells, 401 Intestinal epithelium, 403 Epidermis, 408 Hair follicles, 410 Hematopoietic system, 415 Mesenchymal stem cells and “transdifferentiation”, 419 Spermatogonia, 419 21 Growth, aging, and cancer, 425
Growth: control of size and proportion, 425 Biochemical pathways of growth control, 426 Growth control in insects, 429 Growth control in mammals, 431 Liver regeneration, 433 Growth in stature, 434 Aging, 436 Cell autonomous processes, 437 The insulin pathway and aging, 438 Caloric restriction, 438 Cancer, 440 Classification of tumors and precursor lesions, 440 Macroevolution, 470 Molecular taxonomy, 471 Phylogeny of animals, 472 The fossil record, 473 The primordial animal, 474 Basal animals, 479 What really happened in evolution?, 481 Segmented body plans and Hox genes, 482 Insect wings and legs, 483 Atavisms, 483 Vertebrate limbs, 485 24 Regeneration of missing parts, 491 Types of regeneration, 491 Distribution of regenerative capacity, 491 Planarian regeneration, 492 Insect limb regeneration, 497 Vertebrate limb regeneration, 499 The process of limb regeneration, 499 The source of cells for regeneration, 501 Regeneration of regional pattern, 502 Regeneration: ancestral or adaptive property?, 508 General properties of regeneration, 509 Glossary, 513 Index, 527 |
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| spelling | Slack, Jonathan M. W. 1949- Verfasser (DE-588)120766736 aut Essential developmental biology Professor Jonathan M.W. Slack (University of Bath, Bath, United Kingdom), Professor Leslie Dale (University College London, London, United Kingdom) 4th edition Hoboken, NJ Wiley 2022 x, 532 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Developmental biology Laboratory manuals Embryologie (DE-588)4014562-1 gnd rswk-swf Entwicklungsbiologie (DE-588)4152440-8 gnd rswk-swf Entwicklungsbiologie (DE-588)4152440-8 s DE-604 Embryologie (DE-588)4014562-1 s Dale, Leslie Verfasser (DE-588)124988070X aut Erscheint auch als Online-Ausgabe, PDF 978-1-119-51282-0 Erscheint auch als Online-Ausgabe, EPUB 978-1-119-51284-4 Vorangegangen ist 978-1-118-02286-3 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033019252&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Slack, Jonathan M. W. 1949- Dale, Leslie Essential developmental biology Developmental biology Laboratory manuals Embryologie (DE-588)4014562-1 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd |
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| title | Essential developmental biology |
| title_auth | Essential developmental biology |
| title_exact_search | Essential developmental biology |
| title_exact_search_txtP | Essential developmental biology |
| title_full | Essential developmental biology Professor Jonathan M.W. Slack (University of Bath, Bath, United Kingdom), Professor Leslie Dale (University College London, London, United Kingdom) |
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| title_full_unstemmed | Essential developmental biology Professor Jonathan M.W. Slack (University of Bath, Bath, United Kingdom), Professor Leslie Dale (University College London, London, United Kingdom) |
| title_short | Essential developmental biology |
| title_sort | essential developmental biology |
| topic | Developmental biology Laboratory manuals Embryologie (DE-588)4014562-1 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd |
| topic_facet | Developmental biology Laboratory manuals Embryologie Entwicklungsbiologie |
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