Chimeric Antigen Receptor T Cells: Development and Production
This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell charac...
Saved in:
| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
New York, NY
Springer US
2020
|
| Edition: | 1st ed. 2020 |
| Series: | Methods in Molecular Biology
2086 |
| Subjects: | |
| Online Access: | UBR01 TUM01 Volltext |
| Summary: | This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes |
| Item Description: | CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers -- Selection of Antibody Fragments for CAR-T Cell Therapy from Phage Display Libraries -- Phase I/II Manufacture of Lentiviral Vectors under GMP in an Academic Setting -- Production of Lentivirus for the Establishment of CAR-T Cells -- Optimized Production of Lentiviral Vectors for CAR-T Cell -- Lentiviral Vectors Production in Suspension Culture Using Serum-Free Medium for the Transduction of CAR-T Cells -- In vitro Transcribed (IVT)-mRNA CAR Therapy Development -- Generation of Chimeric Antigen Receptor T Cells Using Gammaretroviral Vectors -- Generation of CAR+ T Lymphocytes using the Sleeping Beauty Transposon System -- Platforms for Clinical-grade Car-T Cell Expansion -- CAR-T Cell Expansion in a Xuri Cell Expansion System W25 -- Methods and Process Optimization for Large Scale CAR T Expansion Using the G-Rex Cell Culture Platform -- Replication Competent Lentivirus Analysis of Vector Transduced T Cell Products used in Cancer Immunotherapy Clinical Trials -- Immunophenotypic Analysis of CAR-T Cells -- Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies -- Determination of Cytotoxic Potential of CAR-T Cells in Co-cultivation Assays -- Analysis of CAR-mediated Tonic Signaling -- Generation of Tumor Cells Expressing Firefly Luciferase (fLuc) to Evaluate the Effectiveness of CAR in a Murine Model -- Analysis of Antitumor Effects of CAR-T Cells in Mice with Solid Tumors |
| Physical Description: | 1 Online-Ressource (XI, 274 Seiten) Illustrationen |
| ISBN: | 9781071601464 |
| DOI: | 10.1007/978-1-0716-0146-4 |
Staff View
MARC
| LEADER | 00000nmm a2200000zcb4500 | ||
|---|---|---|---|
| 001 | BV047606957 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 211123s2020 |||| o||u| ||||||eng d | ||
| 020 | |a 9781071601464 |9 978-1-07-160146-4 | ||
| 024 | 7 | |a 10.1007/978-1-0716-0146-4 |2 doi | |
| 035 | |a (ZDB-2-PRO)978-1-0716-0146-4 | ||
| 035 | |a (OCoLC)1286870803 | ||
| 035 | |a (DE-599)BVBBV047606957 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 |a DE-91 | ||
| 082 | 0 | |a 614.5999 | |
| 245 | 1 | 0 | |a Chimeric Antigen Receptor T Cells |b Development and Production |c edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro |
| 250 | |a 1st ed. 2020 | ||
| 264 | 1 | |a New York, NY |b Springer US |c 2020 | |
| 300 | |a 1 Online-Ressource (XI, 274 Seiten) |b Illustrationen | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Methods in Molecular Biology |v 2086 | |
| 500 | |a CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers -- Selection of Antibody Fragments for CAR-T Cell Therapy from Phage Display Libraries -- Phase I/II Manufacture of Lentiviral Vectors under GMP in an Academic Setting -- Production of Lentivirus for the Establishment of CAR-T Cells -- Optimized Production of Lentiviral Vectors for CAR-T Cell -- Lentiviral Vectors Production in Suspension Culture Using Serum-Free Medium for the Transduction of CAR-T Cells -- In vitro Transcribed (IVT)-mRNA CAR Therapy Development -- Generation of Chimeric Antigen Receptor T Cells Using Gammaretroviral Vectors -- Generation of CAR+ T Lymphocytes using the Sleeping Beauty Transposon System -- Platforms for Clinical-grade Car-T Cell Expansion -- CAR-T Cell Expansion in a Xuri Cell Expansion System W25 -- Methods and Process Optimization for Large Scale CAR T Expansion Using the G-Rex Cell Culture Platform -- Replication Competent Lentivirus Analysis of Vector Transduced T Cell Products used in Cancer Immunotherapy Clinical Trials -- Immunophenotypic Analysis of CAR-T Cells -- Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies -- Determination of Cytotoxic Potential of CAR-T Cells in Co-cultivation Assays -- Analysis of CAR-mediated Tonic Signaling -- Generation of Tumor Cells Expressing Firefly Luciferase (fLuc) to Evaluate the Effectiveness of CAR in a Murine Model -- Analysis of Antitumor Effects of CAR-T Cells in Mice with Solid Tumors | ||
| 520 | |a This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes | ||
| 650 | 4 | |a Cancer research | |
| 650 | 4 | |a Cell biology | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Pharmacology | |
| 700 | 1 | |a Swiech, Kamilla |e Sonstige |0 (DE-588)1141328607 |4 oth | |
| 700 | 1 | |a Malmegrim, Kelen Cristina Ribeiro |e Sonstige |4 oth | |
| 700 | 1 | |a Picanc̦o-Castro, Virgínia |e Sonstige |0 (DE-588)1141328208 |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9781071601457 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9781071601471 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9781071601488 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-1-0716-0146-4 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-2-PRO | ||
| 940 | 1 | |q ZDB-2-PRO_2020_Fremddaten | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-032991941 | ||
| 966 | e | |u https://doi.org/10.1007/978-1-0716-0146-4 |l UBR01 |p ZDB-2-PRO |x Verlag |3 Volltext | |
| 966 | e | |u https://doi.org/10.1007/978-1-0716-0146-4 |l TUM01 |p ZDB-2-PRO |x Verlag |3 Volltext | |
Record in the Search Index
| _version_ | 1804182971604795392 |
|---|---|
| adam_txt | |
| any_adam_object | |
| any_adam_object_boolean | |
| author_GND | (DE-588)1141328607 (DE-588)1141328208 |
| building | Verbundindex |
| bvnumber | BV047606957 |
| collection | ZDB-2-PRO |
| ctrlnum | (ZDB-2-PRO)978-1-0716-0146-4 (OCoLC)1286870803 (DE-599)BVBBV047606957 |
| dewey-full | 614.5999 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 614 - Forensic medicine; incidence of disease |
| dewey-raw | 614.5999 |
| dewey-search | 614.5999 |
| dewey-sort | 3614.5999 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| doi_str_mv | 10.1007/978-1-0716-0146-4 |
| edition | 1st ed. 2020 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>04223nmm a2200505zcb4500</leader><controlfield tag="001">BV047606957</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">211123s2020 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781071601464</subfield><subfield code="9">978-1-07-160146-4</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-1-0716-0146-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-2-PRO)978-1-0716-0146-4</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1286870803</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV047606957</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-91</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">614.5999</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Chimeric Antigen Receptor T Cells</subfield><subfield code="b">Development and Production</subfield><subfield code="c">edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1st ed. 2020</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York, NY</subfield><subfield code="b">Springer US</subfield><subfield code="c">2020</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (XI, 274 Seiten)</subfield><subfield code="b">Illustrationen</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Methods in Molecular Biology</subfield><subfield code="v">2086</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers -- Selection of Antibody Fragments for CAR-T Cell Therapy from Phage Display Libraries -- Phase I/II Manufacture of Lentiviral Vectors under GMP in an Academic Setting -- Production of Lentivirus for the Establishment of CAR-T Cells -- Optimized Production of Lentiviral Vectors for CAR-T Cell -- Lentiviral Vectors Production in Suspension Culture Using Serum-Free Medium for the Transduction of CAR-T Cells -- In vitro Transcribed (IVT)-mRNA CAR Therapy Development -- Generation of Chimeric Antigen Receptor T Cells Using Gammaretroviral Vectors -- Generation of CAR+ T Lymphocytes using the Sleeping Beauty Transposon System -- Platforms for Clinical-grade Car-T Cell Expansion -- CAR-T Cell Expansion in a Xuri Cell Expansion System W25 -- Methods and Process Optimization for Large Scale CAR T Expansion Using the G-Rex Cell Culture Platform -- Replication Competent Lentivirus Analysis of Vector Transduced T Cell Products used in Cancer Immunotherapy Clinical Trials -- Immunophenotypic Analysis of CAR-T Cells -- Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies -- Determination of Cytotoxic Potential of CAR-T Cells in Co-cultivation Assays -- Analysis of CAR-mediated Tonic Signaling -- Generation of Tumor Cells Expressing Firefly Luciferase (fLuc) to Evaluate the Effectiveness of CAR in a Murine Model -- Analysis of Antitumor Effects of CAR-T Cells in Mice with Solid Tumors</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer research</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell biology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmacology</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Swiech, Kamilla</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)1141328607</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Malmegrim, Kelen Cristina Ribeiro</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Picanc̦o-Castro, Virgínia</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)1141328208</subfield><subfield code="4">oth</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9781071601457</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9781071601471</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9781071601488</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-1-0716-0146-4</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-PRO</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-PRO_2020_Fremddaten</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-032991941</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-1-0716-0146-4</subfield><subfield code="l">UBR01</subfield><subfield code="p">ZDB-2-PRO</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-1-0716-0146-4</subfield><subfield code="l">TUM01</subfield><subfield code="p">ZDB-2-PRO</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV047606957 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T18:38:40Z |
| indexdate | 2024-07-10T09:16:02Z |
| institution | BVB |
| isbn | 9781071601464 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032991941 |
| oclc_num | 1286870803 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-91 DE-BY-TUM |
| owner_facet | DE-355 DE-BY-UBR DE-91 DE-BY-TUM |
| physical | 1 Online-Ressource (XI, 274 Seiten) Illustrationen |
| psigel | ZDB-2-PRO ZDB-2-PRO_2020_Fremddaten |
| publishDate | 2020 |
| publishDateSearch | 2020 |
| publishDateSort | 2020 |
| publisher | Springer US |
| record_format | marc |
| series2 | Methods in Molecular Biology |
| spelling | Chimeric Antigen Receptor T Cells Development and Production edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro 1st ed. 2020 New York, NY Springer US 2020 1 Online-Ressource (XI, 274 Seiten) Illustrationen txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 2086 CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers -- Selection of Antibody Fragments for CAR-T Cell Therapy from Phage Display Libraries -- Phase I/II Manufacture of Lentiviral Vectors under GMP in an Academic Setting -- Production of Lentivirus for the Establishment of CAR-T Cells -- Optimized Production of Lentiviral Vectors for CAR-T Cell -- Lentiviral Vectors Production in Suspension Culture Using Serum-Free Medium for the Transduction of CAR-T Cells -- In vitro Transcribed (IVT)-mRNA CAR Therapy Development -- Generation of Chimeric Antigen Receptor T Cells Using Gammaretroviral Vectors -- Generation of CAR+ T Lymphocytes using the Sleeping Beauty Transposon System -- Platforms for Clinical-grade Car-T Cell Expansion -- CAR-T Cell Expansion in a Xuri Cell Expansion System W25 -- Methods and Process Optimization for Large Scale CAR T Expansion Using the G-Rex Cell Culture Platform -- Replication Competent Lentivirus Analysis of Vector Transduced T Cell Products used in Cancer Immunotherapy Clinical Trials -- Immunophenotypic Analysis of CAR-T Cells -- Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies -- Determination of Cytotoxic Potential of CAR-T Cells in Co-cultivation Assays -- Analysis of CAR-mediated Tonic Signaling -- Generation of Tumor Cells Expressing Firefly Luciferase (fLuc) to Evaluate the Effectiveness of CAR in a Murine Model -- Analysis of Antitumor Effects of CAR-T Cells in Mice with Solid Tumors This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes Cancer research Cell biology Immunology Pharmacology Swiech, Kamilla Sonstige (DE-588)1141328607 oth Malmegrim, Kelen Cristina Ribeiro Sonstige oth Picanc̦o-Castro, Virgínia Sonstige (DE-588)1141328208 oth Erscheint auch als Druck-Ausgabe 9781071601457 Erscheint auch als Druck-Ausgabe 9781071601471 Erscheint auch als Druck-Ausgabe 9781071601488 https://doi.org/10.1007/978-1-0716-0146-4 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Chimeric Antigen Receptor T Cells Development and Production Cancer research Cell biology Immunology Pharmacology |
| title | Chimeric Antigen Receptor T Cells Development and Production |
| title_auth | Chimeric Antigen Receptor T Cells Development and Production |
| title_exact_search | Chimeric Antigen Receptor T Cells Development and Production |
| title_exact_search_txtP | Chimeric Antigen Receptor T Cells Development and Production |
| title_full | Chimeric Antigen Receptor T Cells Development and Production edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro |
| title_fullStr | Chimeric Antigen Receptor T Cells Development and Production edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro |
| title_full_unstemmed | Chimeric Antigen Receptor T Cells Development and Production edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro |
| title_short | Chimeric Antigen Receptor T Cells |
| title_sort | chimeric antigen receptor t cells development and production |
| title_sub | Development and Production |
| topic | Cancer research Cell biology Immunology Pharmacology |
| topic_facet | Cancer research Cell biology Immunology Pharmacology |
| url | https://doi.org/10.1007/978-1-0716-0146-4 |
| work_keys_str_mv | AT swiechkamilla chimericantigenreceptortcellsdevelopmentandproduction AT malmegrimkelencristinaribeiro chimericantigenreceptortcellsdevelopmentandproduction AT picancocastrovirginia chimericantigenreceptortcellsdevelopmentandproduction |