Chimeric Antigen Receptor T Cells: Development and Production
This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell charac...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer US
2020
|
| Ausgabe: | 1st ed. 2020 |
| Schriftenreihe: | Methods in Molecular Biology
2086 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 URL des Erstveröffentlichers |
| Zusammenfassung: | This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes |
| Beschreibung: | CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers -- Selection of Antibody Fragments for CAR-T Cell Therapy from Phage Display Libraries -- Phase I/II Manufacture of Lentiviral Vectors under GMP in an Academic Setting -- Production of Lentivirus for the Establishment of CAR-T Cells -- Optimized Production of Lentiviral Vectors for CAR-T Cell -- Lentiviral Vectors Production in Suspension Culture Using Serum-Free Medium for the Transduction of CAR-T Cells -- In vitro Transcribed (IVT)-mRNA CAR Therapy Development -- Generation of Chimeric Antigen Receptor T Cells Using Gammaretroviral Vectors -- Generation of CAR+ T Lymphocytes using the Sleeping Beauty Transposon System -- Platforms for Clinical-grade Car-T Cell Expansion -- CAR-T Cell Expansion in a Xuri Cell Expansion System W25 -- Methods and Process Optimization for Large Scale CAR T Expansion Using the G-Rex Cell Culture Platform -- Replication Competent Lentivirus Analysis of Vector Transduced T Cell Products used in Cancer Immunotherapy Clinical Trials -- Immunophenotypic Analysis of CAR-T Cells -- Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies -- Determination of Cytotoxic Potential of CAR-T Cells in Co-cultivation Assays -- Analysis of CAR-mediated Tonic Signaling -- Generation of Tumor Cells Expressing Firefly Luciferase (fLuc) to Evaluate the Effectiveness of CAR in a Murine Model -- Analysis of Antitumor Effects of CAR-T Cells in Mice with Solid Tumors |
| Beschreibung: | 1 Online-Ressource (XI, 274 Seiten) Illustrationen |
| ISBN: | 9781071601464 |
| DOI: | 10.1007/978-1-0716-0146-4 |
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| 520 | |a This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes | ||
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| spelling | Chimeric Antigen Receptor T Cells Development and Production edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro 1st ed. 2020 New York, NY Springer US 2020 1 Online-Ressource (XI, 274 Seiten) Illustrationen txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 2086 CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers -- Selection of Antibody Fragments for CAR-T Cell Therapy from Phage Display Libraries -- Phase I/II Manufacture of Lentiviral Vectors under GMP in an Academic Setting -- Production of Lentivirus for the Establishment of CAR-T Cells -- Optimized Production of Lentiviral Vectors for CAR-T Cell -- Lentiviral Vectors Production in Suspension Culture Using Serum-Free Medium for the Transduction of CAR-T Cells -- In vitro Transcribed (IVT)-mRNA CAR Therapy Development -- Generation of Chimeric Antigen Receptor T Cells Using Gammaretroviral Vectors -- Generation of CAR+ T Lymphocytes using the Sleeping Beauty Transposon System -- Platforms for Clinical-grade Car-T Cell Expansion -- CAR-T Cell Expansion in a Xuri Cell Expansion System W25 -- Methods and Process Optimization for Large Scale CAR T Expansion Using the G-Rex Cell Culture Platform -- Replication Competent Lentivirus Analysis of Vector Transduced T Cell Products used in Cancer Immunotherapy Clinical Trials -- Immunophenotypic Analysis of CAR-T Cells -- Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies -- Determination of Cytotoxic Potential of CAR-T Cells in Co-cultivation Assays -- Analysis of CAR-mediated Tonic Signaling -- Generation of Tumor Cells Expressing Firefly Luciferase (fLuc) to Evaluate the Effectiveness of CAR in a Murine Model -- Analysis of Antitumor Effects of CAR-T Cells in Mice with Solid Tumors This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes Cancer research Cell biology Immunology Pharmacology Swiech, Kamilla Sonstige (DE-588)1141328607 oth Malmegrim, Kelen Cristina Ribeiro Sonstige oth Picanc̦o-Castro, Virgínia Sonstige (DE-588)1141328208 oth Erscheint auch als Druck-Ausgabe 9781071601457 Erscheint auch als Druck-Ausgabe 9781071601471 Erscheint auch als Druck-Ausgabe 9781071601488 https://doi.org/10.1007/978-1-0716-0146-4 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Chimeric Antigen Receptor T Cells Development and Production Cancer research Cell biology Immunology Pharmacology |
| title | Chimeric Antigen Receptor T Cells Development and Production |
| title_auth | Chimeric Antigen Receptor T Cells Development and Production |
| title_exact_search | Chimeric Antigen Receptor T Cells Development and Production |
| title_exact_search_txtP | Chimeric Antigen Receptor T Cells Development and Production |
| title_full | Chimeric Antigen Receptor T Cells Development and Production edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro |
| title_fullStr | Chimeric Antigen Receptor T Cells Development and Production edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro |
| title_full_unstemmed | Chimeric Antigen Receptor T Cells Development and Production edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro |
| title_short | Chimeric Antigen Receptor T Cells |
| title_sort | chimeric antigen receptor t cells development and production |
| title_sub | Development and Production |
| topic | Cancer research Cell biology Immunology Pharmacology |
| topic_facet | Cancer research Cell biology Immunology Pharmacology |
| url | https://doi.org/10.1007/978-1-0716-0146-4 |
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