The neurobiology, physiology, and psychology of pain: the neuroscience of pain, anesthetics, and analgesics
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Academic Press, Elsevier
[2022]
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| Beschreibung: | xxii, 435 Seiten Illustrationen, Diagramme 28 cm |
| ISBN: | 9780128205891 |
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| 245 | 1 | 0 | |a The neurobiology, physiology, and psychology of pain |b the neuroscience of pain, anesthetics, and analgesics |c edited by Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, Colin R. Martin |
| 264 | 1 | |a London |b Academic Press, Elsevier |c [2022] | |
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Datensatz im Suchindex
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| adam_text | Contents Contributors Preface 2. A new mutation in NTRK1 gene is associated with congenital insensitivity to pain without anhidrosis xv xxi Part 1 Molecular and cellular aspects Mogge Hajiesmaeil, Fatemeh Yazarlou, Maryam Sobhani, and Soudeh Ghafouri-Fard 1. KCNQ/Kv7 channels as therapeutic target to treat neuropathic pain Introduction The applications to other areas Mini-dictionary of terms Key facts Summary points References Zizhen Wu and Qing Yang Introduction KCNQ/Kv7 channel family members KCNQ proteins and function KCNQ channel compositions KCNQ channels in primary sensory neurons and their contribution to neuropathic pain Primary sensory neurons and neuropathic pain KCNQ channels in primary sensory neurons Plasticity of KCNQ channels and their contribution to neuropathic pain KCNQ channels as therapeutic target to treat neuropathic pain KCNQ channels as therapeutic target to treat established pain KCNQ channels as therapeutic target to prevent the development of neuropathic pain Challenges Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of KCNQ/Kv7 channels and neuropathic pain Summary points References 3 3 3 4 13 19 19 20 20 20 3. Prdml2, a key transcriptional regulator of the nociceptive lineage 5 Simon Vermeiren, Simon Desiderio, and Eric ]. Bellefroid 3 Introduction 23 Painlessness genes 24 Mutations in PRDM12 cause CIP and midface toddler excoriation syndrome 25 Prdml 2 is selectively expressed in developing somatosensory ganglia in the nociceptive lineage 26 Prdml 2 is essential for the emergence of the entire nociceptive
lineage 26 How does Prdm! 2 function in the specification and maturation of nociceptive neurons? 26 Does Prdml 2 play a role in mature nociceptors? 27 ^ 3 7 3 3 • Ю 10 Applications to other areas Other agents of interest Mini-dictionary of terms 10 10 10 Key facts showing the importance of Prdm12 in nociceptors Summary points References 28 28 29 29 29 29 V
vi Contents 4. Genetics of chronic widespread musculoskeletal pain Maria Jesus Alvarez-Cubero, Sergio Cuenca-Lôpez, Veronica Arenas-Rodriguez, Fernando Estévez-Lôpez, and Luis Javier Martinez-Gonzalez Introduction HeritabiJity of chronic widespread musculoskeletal pain Candidate gene studies in chronic widespread musculoskeletal pain Case-control studies Association genotype-phenotype SNPs that has been studied in only one analysis in fibromyalgia GWAS Interactions (gene-gene and gene-environment) Future perspectives (mainly, research agenda) Applications to other areas Mini-dictionary of terms Key facts Summary points References 3$ 9 41 41 41 41 Mongi Benjeddou and Ana M. Peirô 45 46 47 48 49 50 52 53 53 53 53 54 54 54 6. Propofol anesthesia and molecular changes in the brain Desanka Milanovic, Zeljko Pavkovic, and Vesna Pesic Introduction Formulation matter 58 59 59 59 60 61 61 61 62 62 63 64 64 7. Protein kinase G is a molecular switch for pain Ying-Ju Sung and Richard T. Ambron 5. Fentanyl: Polymorphisms, and adverse events Opioid fentanyl use in pain management Fentanyl pharmacology Fentanyl safety profile Fentanyl misuse and abuse Potential pharmacogenetics markers in fentanyl pain management Candidate genes Barriers to implementation Conclusions Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of fentanyl Summary points References Neural and molecular targets of propofol Propofol-induced brain molecular changes during postanesthesia period Molecular changes that reflect alterations in neuronal activity at the peak of brain
growth spurt Age-dependent peculiarities in the expression of neurotrophins and their downstream signaling pathways Neuronal activity and synaptic plasticity Molecular autograph of longer exposures to propofol at the peak of the brain growth spurt Propofol and age-related brain pathology Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of propofol anesthesia and molecular changes in the brain Summary points References 57 58 Introduction 67 Pain is perceived via inputs from nociceptive circuits that are adaptive 67 Nociception 67 The acute perception of pain 68 The prolonged perception of pain 68 Long-term potentiation 68 LTH and persistent pain 69 Distinction between persistent and chronic pain 70 LTH is induced by protein kinase G, a positive injury signal in nociceptive neurons 70 PKG-1 a is a nociceptive positive injury signal for LTH in rats 70 Persistent activity of PKG-1 a in sensory neurons after nerve injury in rats 71 Development of a novel potent PKG inhibitor 72 N46 effectively alleviates chronic osteoarthritic and inflammation-induced pain 74 Side effects and the fate of N46 in vivo 74 Conclusions 75 Applications to other areas 75 Other agents of interest 75 Mini-dictionary of terms 75
Contents Key facts Summary points References 75 75 76 8. Adrenergic agonists and antagonists enhance opioid receptor activity Robert Root-Bernstein Introduction Anatomical and cellular codistribution of opioid and adrenergic functions Mechanisms of adrenergic receptor-opioid receptor cross-talk Opioids bind to adrenergic receptors Adrenergic compounds bind to opioid receptors Opioid receptor-adrenergic receptor heterodimerization A model of adrenoceptor-opioid receptor cross-talk Synergistic effects of adrenergic-opioid receptor cross-talk in the treatment of pain Prevention of desensitization and mutual resensitization of opioid and adrenergic receptor function by each other s ligands Applications to other areas: Local anesthetic enhancement and opioid sparing uses Other agents of interest: Ascorbic acid, tramadol and tapentadol, and ketamine Mini-dictionary of terms Key facts Summary points References 79 79 80 80 80 8^ 8i 84 94 94 96 98 98 100 100 100 100 10. Clinacanthus nutans L., analgesia, and the L-arginine/nitric oxide-mediated/cyclic-guanosine monophosphate-independent pathway Zainul Amiruddin Zakaria 84 Introduction 104 Herbal remedies for the treatment of pain 104 85 Clinacanthus nutans L. Report on findings related to the antinociceptive activity of C. nutans 104 85 Antinociceptive profile of MCNL and the possible mechanisms of antinociception 86 86 86 86 9. Inflammatory and neuropathic pain impact on the opioid function in the mesocorticolimbic system Yolanda Campos-Jurado, Javier Cuitavi, Natalia Landsberg, Jesus D. Lorente, and Lucia Hipolito Introduction A
short introduction to the opioid receptors The endogenous opioid system: A key component of analgesia, reward, and aversion Chronic pain alters brain function and connectivity recruiting motivational and emotional regions PET imaging confirms pain-induced alterations of ORs in the MCLS during pain Preclinical studies show altered MOR density or function derived from the presence of pain Animal models of pain showed altered DA-related behaviors derived from the pharmacological activation of MORs Inflammatory pain promotes increased opioid self-administration 98 Dynorfin/KOR system (Dyn/KOR) of the MCLS: A new key player in pain field Applications to other areas Mini-dictionary of terms Key facts of pain-induced changes in OR function Summary points References vii 9^ 92 92 92 Antinociceptive profile of PEP and the possible mechanisms of antinociception Phytoconstituents of MCNL and PEP Conclusion based on the reported antinociceptive activity of MCNL and PEP Involvement of peripheral and central antinociceptive mechanisms Involvement of various mechanisms of antinociception 109 Role of general opioidergic system Involvement of specific opioidergic system subtypes Role of nonopioidergic systems Involvement of transient receptor potential vanilloid type 1 (TRPV1) receptors, glutamatergic system, protein kinase C (PKC)-mediated pathway, and bradykininergic system 104 104 106 107 107 108 109 110 110 110
viii Contents Involvement of a2-adrenergic, /З-adrenergic, adenosinergic, dopaminergic, or muscarinic cholinergic receptor systems Involvement of various types of K+ channels Role of NO-mediated pathways Applications to other areas Other agents of interest Mini-dictionary of terms Key facts Key facts of analgesia Summary points References 110 111 111 111 112 112 113 113 113 113 11. The orally bioavailable imidazodiazepine, KRM-II-81, is a novel potentiator of a2/3-containing GABAa receptors with analgesic efficacy Ro к Cerne, Jodi L. Smith, Janet L. Fisher, Lalit K. Golani, Daniel E. Knutson, James M. Cook, and Jeffrey M. Witkin Introduction GABA receptors GABAa receptor potentiating benzodiazepines and pain Alpha 2/3-containing GABAa receptors KRM-II-81 KRM-II-81 and pain Side effect burden Applications to other therapeutic areas Other agents of interest Mini-dictionary of terms Key facts Summary points Acknowledgments Conflict of interest References Further reading 117 118 120 12 123 123 124 124 124 124 1 124 127 12. Extrasynaptic a5GABAA receptors and their role in nociception and pathological pain 130 130 132 132 133 133 133 133 135 135 135 135 136 136 13. ATP-sensitive potassium channels in pain and analgesia Tais de Campos Lima, Débora de Oliveira Santos, and Celina Monteiro da Cruz Lotufo ATP-sensitive potassium channels (Katp) Possible role for Katp channels in primary nociceptive neurons during hyperglycemia Katp involvement in the mechanisms of analgesic substances Application to other areas Other agents of interest Mini-dictionary of terms Key facts Summary
points References 139 141 143 146 146 146 146 147 147 14. Astrocyte-neuron lactate shuttle and pain Keisuke Miyamoto and Masahiro Ohsawa Ûrzula Franco-Enzâstiga, Yarim E. De la Luz-Cuellar, Luis Eduardo Hernândez-Reyes, Guadalupe Raya-Tafolla, Jorge E. Torres-Lôpez, Janet Murbartiân, Vinicio Granados-Soto, and Rodolfo Delgado-Lezama Introduction GABAa receptors Expression of a5GABAA receptors at spinal cord and DRG GABAergic tonic current in the spinal cord GABAergic tonic current in spinal cord in mammals Extrasynaptic asGABAA receptors in the rate-dependent depression (RDD)of the Hoffmann reflex (HR) Function of extrasynaptic a5GABAA receptors in primary afferent fibers Extrasynaptic spinal asGABAA receptors in pain Extrasynaptic a5GABAA receptors regulation Applications to other areas Other agents of interest Mini-dictionary of terms Key facts on a5GABAA receptors in pain Summary points Acknowledgments References 129 130 Introduction Applications to other areas Other agents of interest Mini-dictionary of terms Key facts Key facts of astrocyte-neuron lactate shuttle Summary points References 151 154 154 156 157 157 157 157
Contents ix 17. Neurons of the parabrachial nucleus, nociceptive input, and pain pathways 15. Nociception and sweet solutions: Applications to inflammatory pain Khawla Q. Nuseir, Manal Kassab, and Ahmad Altarifi Introduction Inflammatory pain pathways Pain behaviors and assessment Use of sweet solutions for inflammatory pain Mechanisms of sweet solutions for inflammatory pain Sweet tasting solutions used for analgesia Clinical applications Importance of treatment of neonatal pain Applications to other areas Other agents of interest Other agents of interest Mini-dictionary of terms Key facts Key facts of prematurity Summary points References Introduction Anatomy of the PBN Afferent pain transmitting pathways to the LPB Nociceptive neurons in the LPB and their aversive pathway to amygdala and bed nucleus of the stria terminalis (BNST) CGRP-positive neurons in the PBel Nociceptive neurons in the LPB and their autonomic connection with the hypothalamus Pain-modulating pathways from the LPB Conclusion Applications to other areas Mini-dictionary of terms Summary points References 162 163 163 164 164 164 165 165 165 166 166 166 166 166 167 16. Interlinking interleukin-33 (IL-33), neuroinflammation and neuropathic pain 18. 184 185 186 186 187 187 187 188 188 189 189 189 Anterior cingulate cortex, pain perception, and pathological neuronal plasticity during chronic pain Fernando Kasanetz, Mario A. Acuna, and Thomas Nevian Camila Rodrigues Ferraz, Fernanda Soares Rasquel-Oliveira, Sergio Marques Borghi, Anelise Franciosi, Thacyana Teixeira Carvalho, Telma Saraiva-Santos, Nayara
AniteHi Artero, Rubia Casagrande, and Waldiceu A. Verri, Jr. IL-33 Neuropathic pain and glial cells IL-33 and glial cells Oligodendrocytes Microglia Astrocytes Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of IL-33 in neuropathic pain Summary points Funding References Yosuke Arima, Yoshinori Otani, and Masashi Fujitani ^^ 172 173 174 174 175 176 176 177 177 177 178 178 179 Introduction 193 ACC is a critical hub Jinking neuronal circuits for nociception and emotion 194 ACC activation is associated with the affective component of pain 194 ACC neuronal activity mediates pain-induced negative affect 195 Nociception-related neurons in the ACC 196 Distinct cortical representation of acute and chronic pain 197 Pathological neuronal plasticity in the ACC associated to chronic pain 198 Applications to other areas 198 Interfering with pathological cortical plasticity as a therapeutic approach for chronic pain 198 Other agents of interest 199 Anterior insular cortex and pain affect 199
x Contents Mini-dictionary of terms 200 Key facts 200 Key facts of neuronal plasticity in health and disease 200 Summary points 200 References 201 19. Sleep deprivation, headache, and Fos immunohistochemistry Fos-immunohistochemistry 203 203 204 204 204 205 205 205 206 207 207 207 21. Pain transmission and peripheral group Ilf metabotropic glutamate receptors (mGluRs) Introduction Glutamate metabolism in peripheral nervous system Glutamate release and pain Glutamate receptor signaling: iGluR and mGluR Localization of peripheral group III mGluR Negative modulation of pain transmission Group III mGluRs in non-neuronal glial cells Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of activity-dependent inhibition Summary points References 228 228 228 229 229 230 233 234 235 235 235 235 236 207 Animal model of sleep deprivation 208 Animal model of headache (activation of the trigeminovascular system) 210 Experimental studies of sleep deprivation and headache pain 211 Applications to other areas 213 Mini-dictionary of terms 213 Key facts 213 Key facts of sleep deprivation and headache 213 Summary points 213 References 213 20. Antinociceptive glucagon-like peptides Duygun Altinta^ Aykan Introduction to the glucagon-like peptides Applications to other areas Glucagon-like peptide-1 and its analogs Glucagon-like peptide-2 Other agents of interest Mini-dictionary of terms 223 223 223 Eui Ho Park and Hee Chui Han Seonghoon Kim and Jeong-wook Park Introduction Pain, headache, and sleep deprivation The pathophysiologic relationship between sleep
deprivation and headache Modulation of headache and sleep-wake cycles Headache Sleep Pharmacologic relationships between headache and sleep Adenosine Orexin Melatonin Pituitary adenylate cyclase activating peptide (PACAP) Experimental research to examine headache and sleep deprivation Key facts of glucagon-like peptides Summary points References 218 218 219 221 222 223 22. TRPM8 receptor and menthol in pain management Hannu Kokki and Merja Kokki Introduction Transient receptor potential channels Menthol Multimodal pain therapy Posttraumatic and postoperative pain Musculoskeletal pain Neuropathic pain Headache and migraine Pregnant and lactating women Children and adolescent Elderly Obesity Other agents of interest Applications to other areas Mini-dictionary of terms Key facts of TRPM8 receptor and menthol Summary points References Further reading 239 240 240 241 244 244 245 246 246 247 247 247 247 248 248 249 249 249 251
Contents Part II Other agents of interest: Adjuvants Mini-dictionary of terms Summary points References Physiology, imaging and physical recordings 23. Anesthetic and proconvulsant effects of ketamine on EEG xi 282 283 284 284 26. Computed tomography-guided procedures for epidural injections Shaila Gowda and Charles Akos Szabo Rohit Aiyer and Semih Gungor Introduction Ketamine effects as anesthetic Ketamine effects as proconvulsant EEG analysis of ketamine effects Scalp vs intracranial EEG effects of ketamine in nonhuman primate model of an idiopathic generalized epilepsy Effects of other agents on EEG Key facts of anesthetic and proconvulsant effects of ketamine on EEG Summary points References 255 256 257 257 258 259 261 261 261 24. Electroencephalography and anesthetic doses of ketamine Logan Voss and Jamie Sleigh Introduction 265 Spectral EEG changes 265 Connectivity metrics 267 Neurophysiological underpinnings of the EEG effects of ketamine 268 Interactions between ketamine and other hypnotic drugs 269 Applications to other areas 270 Other agents of interest 270 Mini dictionary of terms 271 Key facts 271 Summary points 271 References 272 25. Linking heart function and analgesia Giorgia Saltelli, Antonella Paladini, Martina Rekatsina, and Giustino Varrassi Introduction 275 Analgesic drugs 276 Opioids 276 NSAIDs 277 Paracetamol 282 Application to other areas: Effects of NSAIDs on the kidney 282 Introduction 287 General principles and technique common to all types of CT-guided epidural injections 287 Patient positioning 287 Three phases of CT-guidedinterventions 287
Epidural injections 289 Interlaminar epidural injections 290 Cervical transforaminal epidural steroid injections 290 Thoracic transforaminal epidural steroid injections 291 Lumbar transforaminal steroid injections 292 Radiation safety 294 Complications 294 Conclusion 295 Applications to other areas 295 Other agents of interest 295 Mini-dictionary of terms 296 Key facts 296 Summary points 296 References 296 27. Chronic pain: Linking deep brain stimulation and sensory functional MRI Witold H. Polanski and Johann Klein Introduction 299 History of deep brain stimulation for chronic pain 299 Central pain processing 300 Modern visualization of DBS targets 301 Application to other areas 302 Other methods of interest 302 Mini-dictionary of terms 303 Key facts 303 Key facts of deep brain stimulation 303 Key facts of sensory functional MRI 303 Key facts of diffusion tensor imaging (DTI) 304 Summary points 304 References 304
xii Contents 28. Neurocognition and placebo analgesia: Linking in functional magnetic resonance imaging Sara Palermo Introduction Understanding the placebo effect: From the biological approach to the advent of neuroimaging techniques Pain modulatory mechanisms relevant for the neuroimaging study of PA Pain and nociceptive stimuli in neuroimaging study of PA Pain evaluation and temporal phases in neuroimaging study of PA Sample characteristic relevant for the neuroimaging study of PA Neurocognitive predictors in neuroimaging study of PA: Attention, expectation, and reappraisal The neuroimaging meta-analytic approach to the study of PA and related neurocognitive factors Neuroimaging findings in the study of PA in Alzheimer s disease Future directions Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of functional magnetic resonance imaging Summary points References 3Q7 308 309 3Qg 326 327 327 330 331 331 332 332 332 333 310 30. Muscle origins of myofascial pain syndrome 311 Ш 313 313 313 314 314 314 313 313 29. Linking the cortex, functional spectroscopy, and pain: Features and applications Wolnei Caumo, Janete S. Bandeira, and Jairo Alberto Dussan-Sarria Basic concepts Cortical functions related to pain processing Role of the motor cortex in pain processing Role of the PFC in pain processing Nature of brain regions recruited during pain: Insights from human imaging studies The biological rationale behind near-infrared spectroscopy fNIRS neuroimaging: Technical aspects, advantages, limitations, and applications The sequence of steps to
perform neuroscience studies using fNIRS Dynamic trace pattern evoked by electrical stimulation Applications of fNIRS in pain research fNIRS and cortical connectivity in pain research Remarks and future directions Applications to other areas Mini-dictionary of terms Key factors related to fNIRS Summary points References 320 Eva Maria Martinez-Jimenez, Daniel Lopez-Lopez, Carlos Romero-Morales, Victoria Mazoteras-Pardo, Marta Elena Losa-lglesias, David Rodriguez-Sanz, Marta San-Antolin-Gil, Ricardo Becerro-de-Bengoa-Vailejo, and César Calvo-Lobo Introduction Nociception in muscle tissue Referred pain and peripheral sensitization process Sympathetic facilitation of muscle pain Central sensitization Clinical applications Conclusion Application to other areas Other agents of interest Mini-dictionary of terms Key facts of myofascial pain Summary points References 337 338 339 339 339 342 342 342 342 342 343 343 343 Partlll 320 Psychology and behavior 321 31. Behavioral markers of pain: 322 Understanding the cognitive, motor, and societal interactions in the pain experience 322 322 323 S.A. Holmes, A. Quinlan, and M.E. Pierce Psychology and cognition Fear avoidance Pain catastrophizing Cognitive performance 349 349 349 350
Contents xiii Comorbidities and chronic pain Motor behavior Motor response to pain Changing our motor behaviors Social interactions and pain behavior convention Social interaction Community structure—Access to resources Biological sex and gender What is coming in the next 5-10 years? Conclusion Application to other areas Other agents of interest Mini-dictionary of terms Key facts Summary points References 350 351 351 351 352 352 353 353 354 354 355 355 355 355 356 356 32. Adverse life events, sensitization of spinal nociception, and chronic pain risk 34. Nociception-related behavioral phenotypes in adult zebrafish Jamie L. Rhudy and Natalie Hellman Adverse life events: A definition Adverse life events and health Adverse life events and chronic pain The impact of adversity (stress) on nociception in animals Pain systems and their assessment in humans Adversity and pain processing in humans Adversity, latent sensitization, and pain risk implications and future directions Summary Applications to other areas Other agents of interest Mini-dictionary of terms Key facts about adversity Summary points Conflict of interest References 359 359 359 360 360 361 368 369 370 371 371 371 371 371 372 372 33. Cognitive-affective modulation of pain: The placebo and nocebo phenomena and their impact on pain treatment Sergiu Albu, Hans Linsenbardt, and Mary W. Meagher Introduction Psychological mechanisms of placebo analgesia and nocebo hyperalgesia Neurobiological and neurochemical mechanisms of placebo analgesia and nocebo hyperalgesia 377 The relevance of placebo and nocebo effects for pain
treatment in clinical practice 380 Applications to other areas 382 Placebo and nocebo phenomena related to nonopioid drugs and implications for pain treatment 382 Other agents of interest 382 Role of cognitive behavioral therapy in placebo/nocebo and pain treatment 382 Mini-dictionary of terms 383 Key facts of placebo analgesia 383 Key facts of nocebo hyperalgesia 384 Summary points 384 References 385 375 376 Fabiano V. Costa, Luiz V. Rosa, Allan V Kalueff, and Denis B. Rosemberg Introduction Nociception and pain in animal models Zebrafish as animal model for translational pain research Zebrafish-based pain models Applications to other areas Other agents of interest Mini-dictionary of terms Key facts Key facts of zebrafish Summary points References 387 387 388 389 390 390 391 391 391 391 391 35. Pain, implantable pain devices, and psychosocial aspects of pain Vishal Varshney, Thomas Rutledge, Maya D Eon, and Krishnan Chakravarthy Anatomy of pain pathways Psychosocial aspects of neuropathic pain Rationale for psychosocial evaluations Effect of spinal cord stimulation on pain processing Effects of modes of stimulation on psychosocial aspects of pain Conclusions Application to other areas Other agents of interest Mini-dictionary of terms 395 396 397 398 399 400 401 401 401
xiv Contents Key facts of pain, implantable devices, and psychosocial aspects of pain Summary points References 401 402 402 36. Influence of psychological factors on myofascial pain 412 412 412 412 412 Part IV Resources Marta San-Antolfn-Gil, Daniel Lopez-Löpez, Ricardo Becerro-de-Bengoa-Vallejo, Marta Elena Losa-lglesias, Carlos Romero-Morales, David Rodriguez-Sanz, Victoria Mazoteras-Pardo, Eva Maria Martinez-Jiménez, and César Calvo-Lobo Introduction Myofascial trigger point types Relationship between psychological factors and myofascial pain Personality traits and myofascial pain Anxiety and myofascial pain Depression and myofascial pain Catastrophism and myofascial pain Pain fear-avoidance and kinesiophobia and myofascial pain Central sensitization and myofascial pain Clinical applications Application to other areas Other agents of interest Mini-dictionary of terms Key facts of myofascial pain Summary points References 37. Recommended resources, sites, and research groups for the neuroscience of anesthetics and analgesics 405 .nr 406 406 408 409 409 410 411 411 412 Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy Introduction Resources Applications to other areas Mini-dictionary of terms Key points Summary points Acknowledgments References Index 419 420 420 424 425 425 425 426 427
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Contents Contributors Preface 2. A new mutation in NTRK1 gene is associated with congenital insensitivity to pain without anhidrosis xv xxi Part 1 Molecular and cellular aspects Mogge Hajiesmaeil, Fatemeh Yazarlou, Maryam Sobhani, and Soudeh Ghafouri-Fard 1. KCNQ/Kv7 channels as therapeutic target to treat neuropathic pain Introduction The applications to other areas Mini-dictionary of terms Key facts Summary points References Zizhen Wu and Qing Yang Introduction KCNQ/Kv7 channel family members KCNQ proteins and function KCNQ channel compositions KCNQ channels in primary sensory neurons and their contribution to neuropathic pain Primary sensory neurons and neuropathic pain KCNQ channels in primary sensory neurons Plasticity of KCNQ channels and their contribution to neuropathic pain KCNQ channels as therapeutic target to treat neuropathic pain KCNQ channels as therapeutic target to treat established pain KCNQ channels as therapeutic target to prevent the development of neuropathic pain Challenges Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of KCNQ/Kv7 channels and neuropathic pain Summary points References 3 3 3 4 13 19 19 20 20 20 3. Prdml2, a key transcriptional regulator of the nociceptive lineage 5 Simon Vermeiren, Simon Desiderio, and Eric ]. Bellefroid 3 Introduction 23 Painlessness genes 24 Mutations in PRDM12 cause CIP and midface toddler excoriation syndrome 25 Prdml 2 is selectively expressed in developing somatosensory ganglia in the nociceptive lineage 26 Prdml 2 is essential for the emergence of the entire nociceptive
lineage 26 How does Prdm! 2 function in the specification and maturation of nociceptive neurons? 26 Does Prdml 2 play a role in mature nociceptors? 27 ^ 3 7 3 3 • Ю 10 Applications to other areas Other agents of interest Mini-dictionary of terms 10 10 10 Key facts showing the importance of Prdm12 in nociceptors Summary points References 28 28 29 29 29 29 V
vi Contents 4. Genetics of chronic widespread musculoskeletal pain Maria Jesus Alvarez-Cubero, Sergio Cuenca-Lôpez, Veronica Arenas-Rodriguez, Fernando Estévez-Lôpez, and Luis Javier Martinez-Gonzalez Introduction HeritabiJity of chronic widespread musculoskeletal pain Candidate gene studies in chronic widespread musculoskeletal pain Case-control studies Association genotype-phenotype SNPs that has been studied in only one analysis in fibromyalgia GWAS Interactions (gene-gene and gene-environment) Future perspectives (mainly, research agenda) Applications to other areas Mini-dictionary of terms Key facts Summary points References 3$ 9 41 41 41 41 Mongi Benjeddou and Ana M. Peirô 45 46 47 48 49 50 52 53 53 53 53 54 54 54 6. Propofol anesthesia and molecular changes in the brain Desanka Milanovic, Zeljko Pavkovic, and Vesna Pesic Introduction Formulation matter 58 59 59 59 60 61 61 61 62 62 63 64 64 7. Protein kinase G is a molecular switch for pain Ying-Ju Sung and Richard T. Ambron 5. Fentanyl: Polymorphisms, and adverse events Opioid fentanyl use in pain management Fentanyl pharmacology Fentanyl safety profile Fentanyl misuse and abuse Potential pharmacogenetics markers in fentanyl pain management Candidate genes Barriers to implementation Conclusions Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of fentanyl Summary points References Neural and molecular targets of propofol Propofol-induced brain molecular changes during postanesthesia period Molecular changes that reflect alterations in neuronal activity at the peak of brain
growth spurt Age-dependent peculiarities in the expression of neurotrophins and their downstream signaling pathways Neuronal activity and synaptic plasticity Molecular autograph of longer exposures to propofol at the peak of the brain growth spurt Propofol and age-related brain pathology Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of propofol anesthesia and molecular changes in the brain Summary points References 57 58 Introduction 67 Pain is perceived via inputs from nociceptive circuits that are adaptive 67 Nociception 67 The acute perception of pain 68 The prolonged perception of pain 68 Long-term potentiation 68 LTH and persistent pain 69 Distinction between persistent and chronic pain 70 LTH is induced by protein kinase G, a positive injury signal in nociceptive neurons 70 PKG-1 a is a nociceptive positive injury signal for LTH in rats 70 Persistent activity of PKG-1 a in sensory neurons after nerve injury in rats 71 Development of a novel potent PKG inhibitor 72 N46 effectively alleviates chronic osteoarthritic and inflammation-induced pain 74 Side effects and the fate of N46 in vivo 74 Conclusions 75 Applications to other areas 75 Other agents of interest 75 Mini-dictionary of terms 75
Contents Key facts Summary points References 75 75 76 8. Adrenergic agonists and antagonists enhance opioid receptor activity Robert Root-Bernstein Introduction Anatomical and cellular codistribution of opioid and adrenergic functions Mechanisms of adrenergic receptor-opioid receptor cross-talk Opioids bind to adrenergic receptors Adrenergic compounds bind to opioid receptors Opioid receptor-adrenergic receptor heterodimerization A model of adrenoceptor-opioid receptor cross-talk Synergistic effects of adrenergic-opioid receptor cross-talk in the treatment of pain Prevention of desensitization and mutual resensitization of opioid and adrenergic receptor function by each other's ligands Applications to other areas: Local anesthetic enhancement and opioid sparing uses Other agents of interest: Ascorbic acid, tramadol and tapentadol, and ketamine Mini-dictionary of terms Key facts Summary points References 79 79 80 80 80 8^ 8i 84 94 94 96 98 98 100 100 100 100 10. Clinacanthus nutans L., analgesia, and the L-arginine/nitric oxide-mediated/cyclic-guanosine monophosphate-independent pathway Zainul Amiruddin Zakaria 84 Introduction 104 Herbal remedies for the treatment of pain 104 85 Clinacanthus nutans L. Report on findings related to the antinociceptive activity of C. nutans 104 85 Antinociceptive profile of MCNL and the possible mechanisms of antinociception 86 86 86 86 9. Inflammatory and neuropathic pain impact on the opioid function in the mesocorticolimbic system Yolanda Campos-Jurado, Javier Cuitavi, Natalia Landsberg, Jesus D. Lorente, and Lucia Hipolito Introduction A
short introduction to the opioid receptors The endogenous opioid system: A key component of analgesia, reward, and aversion Chronic pain alters brain function and connectivity recruiting motivational and emotional regions PET imaging confirms pain-induced alterations of ORs in the MCLS during pain Preclinical studies show altered MOR density or function derived from the presence of pain Animal models of pain showed altered DA-related behaviors derived from the pharmacological activation of MORs Inflammatory pain promotes increased opioid self-administration 98 Dynorfin/KOR system (Dyn/KOR) of the MCLS: A new key player in pain field Applications to other areas Mini-dictionary of terms Key facts of pain-induced changes in OR function Summary points References vii 9^ 92 92 92 Antinociceptive profile of PEP and the possible mechanisms of antinociception Phytoconstituents of MCNL and PEP Conclusion based on the reported antinociceptive activity of MCNL and PEP Involvement of peripheral and central antinociceptive mechanisms Involvement of various mechanisms of antinociception 109 Role of general opioidergic system Involvement of specific opioidergic system subtypes Role of nonopioidergic systems Involvement of transient receptor potential vanilloid type 1 (TRPV1) receptors, glutamatergic system, protein kinase C (PKC)-mediated pathway, and bradykininergic system 104 104 106 107 107 108 109 110 110 110
viii Contents Involvement of a2-adrenergic, /З-adrenergic, adenosinergic, dopaminergic, or muscarinic cholinergic receptor systems Involvement of various types of K+ channels Role of NO-mediated pathways Applications to other areas Other agents of interest Mini-dictionary of terms Key facts Key facts of analgesia Summary points References 110 111 111 111 112 112 113 113 113 113 11. The orally bioavailable imidazodiazepine, KRM-II-81, is a novel potentiator of a2/3-containing GABAa receptors with analgesic efficacy Ro к Cerne, Jodi L. Smith, Janet L. Fisher, Lalit K. Golani, Daniel E. Knutson, James M. Cook, and Jeffrey M. Witkin Introduction GABA receptors GABAa receptor potentiating benzodiazepines and pain Alpha 2/3-containing GABAa receptors KRM-II-81 KRM-II-81 and pain Side effect burden Applications to other therapeutic areas Other agents of interest Mini-dictionary of terms Key facts Summary points Acknowledgments Conflict of interest References Further reading 117 118 120 12 123 123 124 124 124 124 1 124 127 12. Extrasynaptic a5GABAA receptors and their role in nociception and pathological pain 130 130 132 132 133 133 133 133 135 135 135 135 136 136 13. ATP-sensitive potassium channels in pain and analgesia Tais de Campos Lima, Débora de Oliveira Santos, and Celina Monteiro da Cruz Lotufo ATP-sensitive potassium channels (Katp) Possible role for Katp channels in primary nociceptive neurons during hyperglycemia Katp involvement in the mechanisms of analgesic substances Application to other areas Other agents of interest Mini-dictionary of terms Key facts Summary
points References 139 141 143 146 146 146 146 147 147 14. Astrocyte-neuron lactate shuttle and pain Keisuke Miyamoto and Masahiro Ohsawa Ûrzula Franco-Enzâstiga, Yarim E. De la Luz-Cuellar, Luis Eduardo Hernândez-Reyes, Guadalupe Raya-Tafolla, Jorge E. Torres-Lôpez, Janet Murbartiân, ' Vinicio Granados-Soto, and Rodolfo Delgado-Lezama Introduction GABAa receptors Expression of a5GABAA receptors at spinal cord and DRG GABAergic tonic current in the spinal cord GABAergic tonic current in spinal cord in mammals Extrasynaptic asGABAA receptors in the rate-dependent depression (RDD)of the Hoffmann reflex (HR) Function of extrasynaptic a5GABAA receptors in primary afferent fibers Extrasynaptic spinal asGABAA receptors in pain Extrasynaptic a5GABAA receptors regulation Applications to other areas Other agents of interest Mini-dictionary of terms Key facts on a5GABAA receptors in pain Summary points Acknowledgments References 129 130 Introduction Applications to other areas Other agents of interest Mini-dictionary of terms Key facts Key facts of astrocyte-neuron lactate shuttle Summary points References 151 154 154 156 157 157 157 157
Contents ix 17. Neurons of the parabrachial nucleus, nociceptive input, and pain pathways 15. Nociception and sweet solutions: Applications to inflammatory pain Khawla Q. Nuseir, Manal Kassab, and Ahmad Altarifi Introduction Inflammatory pain pathways Pain behaviors and assessment Use of sweet solutions for inflammatory pain Mechanisms of sweet solutions for inflammatory pain Sweet tasting solutions used for analgesia Clinical applications Importance of treatment of neonatal pain Applications to other areas Other agents of interest Other agents of interest Mini-dictionary of terms Key facts Key facts of prematurity Summary points References Introduction Anatomy of the PBN Afferent pain transmitting pathways to the LPB Nociceptive neurons in the LPB and their aversive pathway to amygdala and bed nucleus of the stria terminalis (BNST) CGRP-positive neurons in the PBel Nociceptive neurons in the LPB and their autonomic connection with the hypothalamus Pain-modulating pathways from the LPB Conclusion Applications to other areas Mini-dictionary of terms Summary points References 162 163 163 164 164 164 165 165 165 166 166 166 166 166 167 16. Interlinking interleukin-33 (IL-33), neuroinflammation and neuropathic pain 18. 184 185 186 186 187 187 187 188 188 189 189 189 Anterior cingulate cortex, pain perception, and pathological neuronal plasticity during chronic pain Fernando Kasanetz, Mario A. Acuna, and Thomas Nevian Camila Rodrigues Ferraz, Fernanda Soares Rasquel-Oliveira, Sergio Marques Borghi, Anelise Franciosi, Thacyana Teixeira Carvalho, Telma Saraiva-Santos, Nayara
AniteHi Artero, Rubia Casagrande, and Waldiceu A. Verri, Jr. IL-33 Neuropathic pain and glial cells IL-33 and glial cells Oligodendrocytes Microglia Astrocytes Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of IL-33 in neuropathic pain Summary points Funding References Yosuke Arima, Yoshinori Otani, and Masashi Fujitani ^^ 172 173 174 174 175 176 176 177 177 177 178 178 179 Introduction 193 ACC is a critical hub Jinking neuronal circuits for nociception and emotion 194 ACC activation is associated with the affective component of pain 194 ACC neuronal activity mediates pain-induced negative affect 195 Nociception-related neurons in the ACC 196 Distinct cortical representation of acute and chronic pain 197 Pathological neuronal plasticity in the ACC associated to chronic pain 198 Applications to other areas 198 Interfering with pathological cortical plasticity as a therapeutic approach for chronic pain 198 Other agents of interest 199 Anterior insular cortex and pain affect 199
x Contents Mini-dictionary of terms 200 Key facts 200 Key facts of neuronal plasticity in health and disease 200 Summary points 200 References 201 19. Sleep deprivation, headache, and Fos immunohistochemistry Fos-immunohistochemistry 203 203 204 204 204 205 205 205 206 207 207 207 21. Pain transmission and peripheral group Ilf metabotropic glutamate receptors (mGluRs) Introduction Glutamate metabolism in peripheral nervous system Glutamate release and pain Glutamate receptor signaling: iGluR and mGluR Localization of peripheral group III mGluR Negative modulation of pain transmission Group III mGluRs in non-neuronal glial cells Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of activity-dependent inhibition Summary points References 228 228 228 229 229 230 233 234 235 235 235 235 236 207 Animal model of sleep deprivation 208 Animal model of headache (activation of the trigeminovascular system) 210 Experimental studies of sleep deprivation and headache pain 211 Applications to other areas 213 Mini-dictionary of terms 213 Key facts 213 Key facts of sleep deprivation and headache 213 Summary points 213 References 213 20. Antinociceptive glucagon-like peptides Duygun Altinta^ Aykan Introduction to the glucagon-like peptides Applications to other areas Glucagon-like peptide-1 and its analogs Glucagon-like peptide-2 Other agents of interest Mini-dictionary of terms 223 223 223 Eui Ho Park and Hee Chui Han Seonghoon Kim and Jeong-wook Park Introduction Pain, headache, and sleep deprivation The pathophysiologic relationship between sleep
deprivation and headache Modulation of headache and sleep-wake cycles Headache Sleep Pharmacologic relationships between headache and sleep Adenosine Orexin Melatonin Pituitary adenylate cyclase activating peptide (PACAP) Experimental research to examine headache and sleep deprivation Key facts of glucagon-like peptides Summary points References 218 218 219 221 222 223 22. TRPM8 receptor and menthol in pain management Hannu Kokki and Merja Kokki Introduction Transient receptor potential channels Menthol Multimodal pain therapy Posttraumatic and postoperative pain Musculoskeletal pain Neuropathic pain Headache and migraine Pregnant and lactating women Children and adolescent Elderly Obesity Other agents of interest Applications to other areas Mini-dictionary of terms Key facts of TRPM8 receptor and menthol Summary points References Further reading 239 240 240 241 244 244 245 246 246 247 247 247 247 248 248 249 249 249 251
Contents Part II Other agents of interest: Adjuvants Mini-dictionary of terms Summary points References Physiology, imaging and physical recordings 23. Anesthetic and proconvulsant effects of ketamine on EEG xi 282 283 284 284 26. Computed tomography-guided procedures for epidural injections Shaila Gowda and Charles Akos Szabo Rohit Aiyer and Semih Gungor Introduction Ketamine effects as anesthetic Ketamine effects as proconvulsant EEG analysis of ketamine effects Scalp vs intracranial EEG effects of ketamine in nonhuman primate model of an idiopathic generalized epilepsy Effects of other agents on EEG Key facts of anesthetic and proconvulsant effects of ketamine on EEG Summary points References 255 256 257 257 258 259 261 261 261 24. Electroencephalography and anesthetic doses of ketamine Logan Voss and Jamie Sleigh Introduction 265 Spectral EEG changes 265 Connectivity metrics 267 Neurophysiological underpinnings of the EEG effects of ketamine 268 Interactions between ketamine and other hypnotic drugs 269 Applications to other areas 270 Other agents of interest 270 Mini dictionary of terms 271 Key facts 271 Summary points 271 References 272 25. Linking heart function and analgesia Giorgia Saltelli, Antonella Paladini, Martina Rekatsina, and Giustino Varrassi Introduction 275 Analgesic drugs 276 Opioids 276 NSAIDs 277 Paracetamol 282 Application to other areas: Effects of NSAIDs on the kidney 282 Introduction 287 General principles and technique common to all types of CT-guided epidural injections 287 Patient positioning 287 Three phases of CT-guidedinterventions 287
Epidural injections 289 Interlaminar epidural injections 290 Cervical transforaminal epidural steroid injections 290 Thoracic transforaminal epidural steroid injections 291 Lumbar transforaminal steroid injections 292 Radiation safety 294 Complications 294 Conclusion 295 Applications to other areas 295 Other agents of interest 295 Mini-dictionary of terms 296 Key facts 296 Summary points 296 References 296 27. Chronic pain: Linking deep brain stimulation and sensory functional MRI Witold H. Polanski and Johann Klein Introduction 299 History of deep brain stimulation for chronic pain 299 Central pain processing 300 Modern visualization of DBS targets 301 Application to other areas 302 Other methods of interest 302 Mini-dictionary of terms 303 Key facts 303 Key facts of deep brain stimulation 303 Key facts of sensory functional MRI 303 Key facts of diffusion tensor imaging (DTI) 304 Summary points 304 References 304
xii Contents 28. Neurocognition and placebo analgesia: Linking in functional magnetic resonance imaging Sara Palermo Introduction Understanding the placebo effect: From the biological approach to the advent of neuroimaging techniques Pain modulatory mechanisms relevant for the neuroimaging study of PA Pain and nociceptive stimuli in neuroimaging study of PA Pain evaluation and temporal phases in neuroimaging study of PA Sample characteristic relevant for the neuroimaging study of PA Neurocognitive predictors in neuroimaging study of PA: Attention, expectation, and reappraisal The neuroimaging meta-analytic approach to the study of PA and related neurocognitive factors Neuroimaging findings in the study of PA in Alzheimer's disease Future directions Applications to other areas Other agents of interest Mini-dictionary of terms Key facts of functional magnetic resonance imaging Summary points References 3Q7 308 309 3Qg 326 327 327 330 331 331 332 332 332 333 310 30. Muscle origins of myofascial pain syndrome 311 Ш 313 313 313 314 314 314 313 313 29. Linking the cortex, functional spectroscopy, and pain: Features and applications Wolnei Caumo, Janete S. Bandeira, and Jairo Alberto Dussan-Sarria Basic concepts Cortical functions related to pain processing Role of the motor cortex in pain processing Role of the PFC in pain processing Nature of brain regions recruited during pain: Insights from human imaging studies The biological rationale behind near-infrared spectroscopy fNIRS neuroimaging: Technical aspects, advantages, limitations, and applications The sequence of steps to
perform neuroscience studies using fNIRS Dynamic trace pattern evoked by electrical stimulation Applications of fNIRS in pain research fNIRS and cortical connectivity in pain research Remarks and future directions Applications to other areas Mini-dictionary of terms Key factors related to fNIRS Summary points References 320 Eva Maria Martinez-Jimenez, Daniel Lopez-Lopez, Carlos Romero-Morales, Victoria Mazoteras-Pardo, Marta Elena Losa-lglesias, David Rodriguez-Sanz, Marta San-Antolin-Gil, Ricardo Becerro-de-Bengoa-Vailejo, and César Calvo-Lobo Introduction Nociception in muscle tissue Referred pain and peripheral sensitization process Sympathetic facilitation of muscle pain Central sensitization Clinical applications Conclusion Application to other areas Other agents of interest Mini-dictionary of terms Key facts of myofascial pain Summary points References 337 338 339 339 339 342 342 342 342 342 343 343 343 Partlll 320 Psychology and behavior 321 31. Behavioral markers of pain: 322 Understanding the cognitive, motor, and societal interactions in the pain experience 322 322 323 S.A. Holmes, A. Quinlan, and M.E. Pierce Psychology and cognition Fear avoidance Pain catastrophizing Cognitive performance 349 349 349 350
Contents xiii Comorbidities and chronic pain Motor behavior Motor response to pain Changing our motor behaviors Social interactions and pain behavior convention Social interaction Community structure—Access to resources Biological sex and gender What is coming in the next 5-10 years? Conclusion Application to other areas Other agents of interest Mini-dictionary of terms Key facts Summary points References 350 351 351 351 352 352 353 353 354 354 355 355 355 355 356 356 32. Adverse life events, sensitization of spinal nociception, and chronic pain risk 34. Nociception-related behavioral phenotypes in adult zebrafish Jamie L. Rhudy and Natalie Hellman Adverse life events: A definition Adverse life events and health Adverse life events and chronic pain The impact of adversity (stress) on nociception in animals Pain systems and their assessment in humans Adversity and pain processing in humans Adversity, latent sensitization, and pain risk implications and future directions Summary Applications to other areas Other agents of interest Mini-dictionary of terms Key facts about adversity Summary points Conflict of interest References 359 359 359 360 360 361 368 369 370 371 371 371 371 371 372 372 33. Cognitive-affective modulation of pain: The placebo and nocebo phenomena and their impact on pain treatment Sergiu Albu, Hans Linsenbardt, and Mary W. Meagher Introduction Psychological mechanisms of placebo analgesia and nocebo hyperalgesia Neurobiological and neurochemical mechanisms of placebo analgesia and nocebo hyperalgesia 377 The relevance of placebo and nocebo effects for pain
treatment in clinical practice 380 Applications to other areas 382 Placebo and nocebo phenomena related to nonopioid drugs and implications for pain treatment 382 Other agents of interest 382 Role of cognitive behavioral therapy in placebo/nocebo and pain treatment 382 Mini-dictionary of terms 383 Key facts of placebo analgesia 383 Key facts of nocebo hyperalgesia 384 Summary points 384 References 385 375 376 Fabiano V. Costa, Luiz V. Rosa, Allan V Kalueff, and Denis B. Rosemberg Introduction Nociception and pain in animal models Zebrafish as animal model for translational pain research Zebrafish-based pain models Applications to other areas Other agents of interest Mini-dictionary of terms Key facts Key facts of zebrafish Summary points References 387 387 388 389 390 390 391 391 391 391 391 35. Pain, implantable pain devices, and psychosocial aspects of pain Vishal Varshney, Thomas Rutledge, Maya D'Eon, and Krishnan Chakravarthy Anatomy of pain pathways Psychosocial aspects of neuropathic pain Rationale for psychosocial evaluations Effect of spinal cord stimulation on pain processing Effects of modes of stimulation on psychosocial aspects of pain Conclusions Application to other areas Other agents of interest Mini-dictionary of terms 395 396 397 398 399 400 401 401 401
xiv Contents Key facts of pain, implantable devices, and psychosocial aspects of pain Summary points ' References 401 402 402 36. Influence of psychological factors on myofascial pain 412 412 412 412 412 Part IV Resources Marta San-Antolfn-Gil, Daniel Lopez-Löpez, Ricardo Becerro-de-Bengoa-Vallejo, Marta Elena Losa-lglesias, Carlos Romero-Morales, David Rodriguez-Sanz, Victoria Mazoteras-Pardo, Eva Maria Martinez-Jiménez, and César Calvo-Lobo Introduction Myofascial trigger point types Relationship between psychological factors and myofascial pain Personality traits and myofascial pain Anxiety and myofascial pain Depression and myofascial pain Catastrophism and myofascial pain Pain fear-avoidance and kinesiophobia and myofascial pain Central sensitization and myofascial pain Clinical applications Application to other areas Other agents of interest Mini-dictionary of terms Key facts of myofascial pain Summary points References 37. Recommended resources, sites, and research groups for the neuroscience of anesthetics and analgesics 405 .nr 406 406 408 409 409 410 411 411 412 Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy Introduction Resources Applications to other areas Mini-dictionary of terms Key points Summary points Acknowledgments References Index 419 420 420 424 425 425 425 426 427 |
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| spelling | The neurobiology, physiology, and psychology of pain the neuroscience of pain, anesthetics, and analgesics edited by Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, Colin R. Martin London Academic Press, Elsevier [2022] xxii, 435 Seiten Illustrationen, Diagramme 28 cm txt rdacontent n rdamedia nc rdacarrier Schmerz (DE-588)4052823-6 gnd rswk-swf Pain Schmerz (DE-588)4052823-6 s DE-604 Rajendram, Rajkumar (DE-588)1154964566 edt Preedy, Victor R. (DE-588)1053842163 edt Patel, Vinood B. (DE-588)1154964388 edt Martin, Colin R. 1964- (DE-588)173460364 edt Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032973419&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | The neurobiology, physiology, and psychology of pain the neuroscience of pain, anesthetics, and analgesics |
| title_auth | The neurobiology, physiology, and psychology of pain the neuroscience of pain, anesthetics, and analgesics |
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| title_full | The neurobiology, physiology, and psychology of pain the neuroscience of pain, anesthetics, and analgesics edited by Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, Colin R. Martin |
| title_fullStr | The neurobiology, physiology, and psychology of pain the neuroscience of pain, anesthetics, and analgesics edited by Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, Colin R. Martin |
| title_full_unstemmed | The neurobiology, physiology, and psychology of pain the neuroscience of pain, anesthetics, and analgesics edited by Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, Colin R. Martin |
| title_short | The neurobiology, physiology, and psychology of pain |
| title_sort | the neurobiology physiology and psychology of pain the neuroscience of pain anesthetics and analgesics |
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