The gene regulatory network of the tumor suppressor p53:
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| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Jena
[2020]
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | 40 Seiten, 70 ungezählte Seiten Illustrationen, Diagramme 30 cm |
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MARC
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| 245 | 1 | 0 | |a The gene regulatory network of the tumor suppressor p53 |c von Dr. rer. nat. Dr. rer. med. Martin Fischer |
| 264 | 1 | |a Jena |c [2020] | |
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Datensatz im Suchindex
| _version_ | 1804182728540684288 |
|---|---|
| adam_text | INDEX
OF
CONTENTS
PREFACE
.....................................................................................................................
1
1
INTRODUCTION
.................................................................................................
2
1.1
THE
HISTORY
OF
P53
.............................................................................................
2
1.2
REGULATION
OF
P53
ACTIVITY
................................................................................
3
1.3
TRANSCRIPTIONAL
REGULATION
BY
P53
....................................................................
5
1.4
CELL
CYCLE
TRANSCRIPTION
CONTROL:
DREAM/MUVB
AND
RB-E2F
COMPLEXES
.......
7
1.5
VIRAL
ONCOPROTEINS:
THE
CASE
OF
HPV
E7
......................................................
11
2
RESULTS
AND
DISCUSSION
..........................................................................
13
2.1
THE
STEP-WISE
META-ANALYSIS
APPROACH
..........................................................
13
2.2
THE
*
CORE
*
OF
THE
P53
GENE
REGULATORY
NETWORK
...............................................
15
2.3
THE
TWO
MAJOR
CLASSES
OF
CELL
CYCLE
GENES:
G1/S
AND
G2/M
..........................
17
2.4
THE
P53-P21-DREAM/RB
PATHWAY
REGULATES
CELL
CYCLE
GENES
......................
19
2.5
HUMAN
PAPILLOMA
VIRUS
E7
ONCOPROTEIN
ABROGATES
THE
P53-P21-DREAM
PATHWAY
...........................................................................................................
22
2.6
CONSERVATION
AND
DIVERGENCE
OF
THE
P53
GENE
REGULATORY
NETWORK
BETWEEN
MOUSE
AND
HUMAN
...........................................................................................
23
3
SUMMARY
AND
PERSPECTIVE
......................................................................
29
4
ZUSAMMENFASSUNG
UND
AUSBLICK
...........................................................
30
5
REFERENCES
................................................................................................
32
EHRENWDRTLICHE
ERKLARUNG
....................................................................................
40
DANKSAGUNG
...........................................................................................................
41
6
RESEARCH
PUBLICATIONS
6.1
FISCHER,
M.,
QUAAS,
M.,
NICKEL,
A.,
AND
ENGELAND,
K.
(2015).
INDIRECT
P53-
DEPENDENT
TRANSCRIPTIONAL
REPRESSION
OF
SURVIVIN,
CDC25C,
AND
PLK1
GENES
|
| adam_txt |
INDEX
OF
CONTENTS
PREFACE
.
1
1
INTRODUCTION
.
2
1.1
THE
HISTORY
OF
P53
.
2
1.2
REGULATION
OF
P53
ACTIVITY
.
3
1.3
TRANSCRIPTIONAL
REGULATION
BY
P53
.
5
1.4
CELL
CYCLE
TRANSCRIPTION
CONTROL:
DREAM/MUVB
AND
RB-E2F
COMPLEXES
.
7
1.5
VIRAL
ONCOPROTEINS:
THE
CASE
OF
HPV
E7
.
11
2
RESULTS
AND
DISCUSSION
.
13
2.1
THE
STEP-WISE
META-ANALYSIS
APPROACH
.
13
2.2
THE
*
CORE
*
OF
THE
P53
GENE
REGULATORY
NETWORK
.
15
2.3
THE
TWO
MAJOR
CLASSES
OF
CELL
CYCLE
GENES:
G1/S
AND
G2/M
.
17
2.4
THE
P53-P21-DREAM/RB
PATHWAY
REGULATES
CELL
CYCLE
GENES
.
19
2.5
HUMAN
PAPILLOMA
VIRUS
E7
ONCOPROTEIN
ABROGATES
THE
P53-P21-DREAM
PATHWAY
.
22
2.6
CONSERVATION
AND
DIVERGENCE
OF
THE
P53
GENE
REGULATORY
NETWORK
BETWEEN
MOUSE
AND
HUMAN
.
23
3
SUMMARY
AND
PERSPECTIVE
.
29
4
ZUSAMMENFASSUNG
UND
AUSBLICK
.
30
5
REFERENCES
.
32
EHRENWDRTLICHE
ERKLARUNG
.
40
DANKSAGUNG
.
41
6
RESEARCH
PUBLICATIONS
6.1
FISCHER,
M.,
QUAAS,
M.,
NICKEL,
A.,
AND
ENGELAND,
K.
(2015).
INDIRECT
P53-
DEPENDENT
TRANSCRIPTIONAL
REPRESSION
OF
SURVIVIN,
CDC25C,
AND
PLK1
GENES |
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| discipline_str_mv | Medizin |
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| spelling | Fischer, Martin 1987- Verfasser (DE-588)1047271346 aut The gene regulatory network of the tumor suppressor p53 von Dr. rer. nat. Dr. rer. med. Martin Fischer Jena [2020] 40 Seiten, 70 ungezählte Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Habilitationsschrift Friedrich-Schiller-Universität Jena 2020 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1227072651/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032840314&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p aepgnd 0,31715 20210311 DE-101 https://d-nb.info/provenance/plan#aepgnd 2\p aepgnd 0,06339 20210311 DE-101 https://d-nb.info/provenance/plan#aepgnd 3\p aepgnd 0,06339 20210311 DE-101 https://d-nb.info/provenance/plan#aepgnd |
| spellingShingle | Fischer, Martin 1987- The gene regulatory network of the tumor suppressor p53 |
| subject_GND | (DE-588)4113937-9 |
| title | The gene regulatory network of the tumor suppressor p53 |
| title_auth | The gene regulatory network of the tumor suppressor p53 |
| title_exact_search | The gene regulatory network of the tumor suppressor p53 |
| title_exact_search_txtP | The gene regulatory network of the tumor suppressor p53 |
| title_full | The gene regulatory network of the tumor suppressor p53 von Dr. rer. nat. Dr. rer. med. Martin Fischer |
| title_fullStr | The gene regulatory network of the tumor suppressor p53 von Dr. rer. nat. Dr. rer. med. Martin Fischer |
| title_full_unstemmed | The gene regulatory network of the tumor suppressor p53 von Dr. rer. nat. Dr. rer. med. Martin Fischer |
| title_short | The gene regulatory network of the tumor suppressor p53 |
| title_sort | the gene regulatory network of the tumor suppressor p53 |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1227072651/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032840314&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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