This book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action. The detailed chapters within will provide readers with a baseline und...

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Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	New York, NY Springer US 2020
Ausgabe:	1st ed. 2020
Schriftenreihe:	Methods in Pharmacology and Toxicology
Schlagworte:	Pharmaceutical technology Cancer research Immunology Aufsatzsammlung
Online-Zugang:	UBR01 TUM01 URL des Erstveröffentlichers
Zusammenfassung:	This book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action. The detailed chapters within will provide readers with a baseline understanding of the pros and cons as well as key considerations for applying assays that are more reflective of the human immune-tumor microenvironment in order to increase their translatability into the clinic. Written for the Methods in Pharmacology and Toxicology series, the contents of this volume include the kind of specifics and real-world implementation advice to ensure success in the lab. Authoritative and practical, Immuno-Oncology: Cellular and Translational Approaches aims to aid researchers working on biotechnology and pharmaceutical efforts to search for the next generation of safer and more effective cancer immunotherapeutics. The chapter "Considerations in Developing Reporter Gene Bioassays for Biologics" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com
Beschreibung:	An In Vitro System Combining Tumor Cells and Lymphocytes to Predict the In Vivo Response of Immunomodulatory Antibodies -- High-Throughput Direct Cell Counting Method for Immuno-Oncology Functional Assays Using Image Cytometry -- In Vitro Immunotherapy Potency Assays Using Real-Time Cell Analysis -- Assessing the Potency of T Cell-Redirecting Therapeutics Using In Vitro Cancer Cell Killing Assays -- Induction and Potential Reversal of a T Cell Exhaustion-Like State: In Vitro Potency Assay for Functional Screening of Immune Checkpoint Drug Candidates -- Validation of an Image-Based 3D Natural Killer Cell-Mediated Cytotoxicity Assay -- 3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment -- Considerations in Developing Reporter Gene Bioassays for Biologics -- Miniaturized Single Cell Imaging for Developing Immuno-Oncology Combinational Therapies -- Precision Medicine: The Function of Receptor Occupancy in Drug Development -- In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics -- The Quest for the Next-Generation of Tumor Targets: Discovery and Prioritization in the Genomics Era
ISBN:	9781071601716
DOI:	10.1007/978-1-0716-0171-6