Stem cells: scientific facts and fiction
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London, UK
Elsevier, Academic Press
[2021]
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| Ausgabe: | Third edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | ix, 411 Seiten Illustrationen |
| ISBN: | 9780128203378 |
Internformat
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Datensatz im Suchindex
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| adam_text | Contents 1. 2. 3. 4. The biology of the cell 1 Organisms are composed of cells DNA, genes, and chromosomes How is the amount of mRNA regulated? Transcription factors From mRNA to a functional protein From DNA and proteins to a cell with a specific function Epigenetic regulation RNA interference DNA differences between genomes: mutation or variation? Diseases due to variations and genome mutations Dominant or recessive? DNA outside the nucleus: bacterial remains Cell lines and cell culture 2 3 8 8 9 12 12 15 15 16 17 18 19 Embryonic development 31 Fertilization and early embryo development Sex cells and germ cell tumors 39 47 What are stem cells? 51 What makes stem cells different from other cells? Totipotency, pluripotency, and embryonic stem cells Multipotency, unipotency, and adult stem cells Cell division and aging: the role of telomerase The relationship between cell division and differentiation: epigenetics Epigenetics in stem cells 52 53 56 59 59 60 Of mice and men: the history of embryonic stem cells 67 How it all began: pluripotent cells in early embryos Mouse embryonal carcinoma cell lines Pluripotent cells in an early embryo Mouse embryonic stem cell lines 67 70 73 75 v
vi 5. Contents Towards human embryonic stem cells On the road to stem cell therapy Biased interpretation? The future: stem cell transplantation as a clinical treatment Breakthrough of the decade in the 21st century: induced pluripotent stem cells 77 85 87 88 Origins and types of stem cells 95 Pluripotent stem cells: past, present, and future Bone marrow Organoids: miniorgans in a dish Umbilical cord blood 96 96 97 101 102 105 108 109 110 Cloning: history and current applications 131 Before Dolly Cloning pets: Copy Cat and Snuppy Just imagine what could be ... Cloning domestic livestock Cloning challenges Monkey cloning 131 141 143 148 150 152 Regenerative medicine: clinical applications of stem cells 159 Embryonal carcinoma or teratocarcinoma stem cells Embryonic stem cells Germline stem cells Induced pluripotent stem cells Multipotent (adult) stem cells 6. 7. 89 What is therapeutic cell transplantation? How many cells are needed for cell transplantation? Why will some diseases be treatable with stem cells in the future and others not? Loss of one cell type or more cell types Diabetes type I: an autoimmune disease Macular degeneration: the ideal disease? Deafness Spinal cord injury and multiple sclerosis: restoring demyelination Inherited and acquired diseases What are the best stem cells for transplantation? Can we combine gene therapy with stem cell transplantation? In what part of the body should stem cells be transplanted and where do they exert their effect? Which cell types will become available for cell transplantation? Adult stem cells Embryonic and induced
pluripotent stem cells 162 165 167 169 171 172 173 174 178 180 185 189 191 191 194
Contents 8. 9. 10. 11. 12. vii Transplantation of stem cells: where do we stand? Exosomes from stem and progenitor cells—a safer alternative? What are the risks associated with a stem cell transplantation? When will stem cells be rejected after transplantation? How does the body s immune system recognize a cell as foreign ? Reverse rejection: graft-versus-host How to prevent rejection of a cell transplant? Tissue engineering 196 201 201 204 205 208 210 214 Stem cells in veterinary medicine 221 Treatment of family pets Tendon in the horse Osteoarthritis in dogs Induced pluripotent stem cells 222 223 225 226 Cardiomyocytes from stem cells: what can we do with them? 231 The heart and cardiac repair Stem cells models of heart disease From pluripotent stem cells to cardiomyocytes 232 234 236 Adult stem cells: generation of self-organizing mini-organs in a dish 257 Adult stem cells in internal organs Adult stem cells in the intestine Adult stem cells in muscle tissue What have we learnt about adult stem cells? The future: organoids to repair tissues and organs? 259 259 261 263 263 Stem cell tourism 275 What is stem cell tourism ? What is the difference between commercial stem cell treatments, early-phase medical intervention, and standard stem cell clinical practice? Perspective of the International Society for Stem Cell Research (ISSCR) 275 278 285 Cancer stem cells: where do they come from and where are they going? 299 Cancer: observations and some questions to start with Introduction to stem cells and cancer A brief history of cancer stem cells 300 301 301
viii Contents The behavior of cancer cells: not all tumors and not all cells within a tumor, look the same A Darwinian view: evolution of a tumor Colon adenoma: a case in point for the role of an adult stem cell as the stem cell of origin Development of a colon adenoma When does a tumor become malignant and metastasize to different organs? Interaction between cancer cells and their environment leads to phenotypic heterogeneity How to become a cancer stem cell: epithelial mesenchymal transition Epithelial-mesenchymal transition and mesenchymal—epithelial transition: a renewed view on the role of cancer stem cells How could developmental signal transduction pathways become active in cancer cells? Cancer stem cells as circulating tumor cells The final step: initiation of metastatic growth A cancer stem cell: can it differentiate to another cell type? Cancer stem cells: development of new drugs to treat cancer? Conclusions and research challenges 13, Human stem cells for organs-on-chips: clinical trials without patients? Introduction What are organs-on-chips? New drugs and why would we need human organ and disease-on-chip models? Human organ-on-chip models: for which diseases? Human disease models as organ-on-chip: challenges Where are we now with organ-on-chip technology? Human stem cells as a critical component of organ-on-chip model systems Pluripotent or adult stem cells in the organ-on-chip? How to make stem cells differentiate to the right types of cells in the body Formation of functional tissues and organs using Organ-on-Chip technology What can organs-on-chip
be used for? Model systems for drug toxicity screening Human disease models for drug target discovery and drug development: role for organs-on-chip Some conclusions 304 305 306 307 309 310 317 318 319 320 321 321 323 326 329 330 330 333 337 337 338 342 342 344 344 346 346 348 351
Contents 14. 15. 16. Index ix Stem cells for discovery of effective and safe new drugs 353 Drug discovery: a short historical perspective Modern drug discovery Challenges and opportunities in drug discovery How is the safety of new drugs secured? 353 357 358 363 Patents, opportunities, and challenges: legal and intellectual property issues associated with stem cells 369 Companies and alliances Patent issues: current intetlectual property landscape Wisconsin Alumni Research Foundation Europe versus the United States More legal and ethical issues Privacy and ownership 371 372 373 374 380 381 Stem cell perspectives: a vision of the future 383 Combining technologies: new human disease models for drug discovery Personalized medicine and safer drugs A final note 388 390 399 401
Third Edition Stem Cells Scientific Facts and Fiction Christine L. Mummery · Anja van de Stolpe · Bernard Roeien · Hans devers Stem Cells: Scientific Facts and Fiction, Third Edition, provides a state-of-the-art over view on the field of stem cells and their current applications. The book incorporates the history and firsthand commentaries in the field from clinical and research leaders, covering interesting topics of note, including the first clinicai trials to treat Parkinson disease, macular degeneration, and corneal replacement, the cloning of monkeys, the organoid field, and CRISPR-edited genomics. In addition, coverage of adult, embryonic stem cells and İPS celis is included. This new edition distinguishes itself from the multiplicity of websites about stem cells with a broad view of the field. Key Features • • • Explains, in a straightforward, nonspecialist language, the basic biology of stem cells and their applications in modern medicine and future therapy Provides new and expanded coverage of cloning, organoids, synthetic” embryos, and much more Includes detailed illustrations to assist users with learning on how research is done About the Authors Christine L. Mummery. Professor of Developmental Biology at Leiden University Medi cal Centre in Leiden, Professor of Vascular Microfluidics Technology at the University of Twente, the Netherlands. Anja van de Stolpe, Chief Scientific Officer, Philips Molecular Pathway Dx, Eindhoven, the Netherlands Bernard Roeien, Associate professor at the Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht
University in Utrecht, the Netherlands. Hans Clevers, Principal Investigator at the Hubrecht Institute for Developmental Biology and Stem Cell Research (KNAW) and the Princess Máxima Center for Pediatric Oncology and Professor of Molecular Genetics at the UMC Utrecht and Utrecht University and Oncode Investigator, the Netherlands.
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| adam_txt |
Contents 1. 2. 3. 4. The biology of the cell 1 Organisms are composed of cells DNA, genes, and chromosomes How is the amount of mRNA regulated? Transcription factors From mRNA to a functional protein From DNA and proteins to a cell with a specific function Epigenetic regulation RNA interference DNA differences between genomes: mutation or variation? Diseases due to variations and genome mutations Dominant or recessive? DNA outside the nucleus: bacterial remains Cell lines and cell culture 2 3 8 8 9 12 12 15 15 16 17 18 19 Embryonic development 31 Fertilization and early embryo development Sex cells and germ cell tumors 39 47 What are stem cells? 51 What makes stem cells different from other cells? Totipotency, pluripotency, and embryonic stem cells Multipotency, unipotency, and adult stem cells Cell division and aging: the role of telomerase The relationship between cell division and differentiation: epigenetics Epigenetics in stem cells 52 53 56 59 59 60 Of mice and men: the history of embryonic stem cells 67 How it all began: pluripotent cells in early embryos Mouse embryonal carcinoma cell lines Pluripotent cells in an early embryo Mouse embryonic stem cell lines 67 70 73 75 v
vi 5. Contents Towards human embryonic stem cells On the road to stem cell therapy Biased interpretation? The future: stem cell transplantation as a clinical treatment Breakthrough of the decade in the 21st century: induced pluripotent stem cells 77 85 87 88 Origins and types of stem cells 95 Pluripotent stem cells: past, present, and future Bone marrow Organoids: miniorgans in a dish Umbilical cord blood 96 96 97 101 102 105 108 109 110 Cloning: history and current applications 131 Before Dolly Cloning pets: Copy Cat and Snuppy Just imagine what could be . Cloning domestic livestock Cloning challenges Monkey cloning 131 141 143 148 150 152 Regenerative medicine: clinical applications of stem cells 159 Embryonal carcinoma or teratocarcinoma stem cells Embryonic stem cells Germline stem cells Induced pluripotent stem cells Multipotent (adult) stem cells 6. 7. 89 What is therapeutic cell transplantation? How many cells are needed for cell transplantation? Why will some diseases be treatable with stem cells in the future and others not? Loss of one cell type or more cell types Diabetes type I: an autoimmune disease Macular degeneration: the ideal disease? Deafness Spinal cord injury and multiple sclerosis: restoring demyelination Inherited and acquired diseases What are the best stem cells for transplantation? Can we combine gene therapy with stem cell transplantation? In what part of the body should stem cells be transplanted and where do they exert their effect? Which cell types will become available for cell transplantation? Adult stem cells Embryonic and induced
pluripotent stem cells 162 165 167 169 171 172 173 174 178 180 185 189 191 191 194
Contents 8. 9. 10. 11. 12. vii Transplantation of stem cells: where do we stand? Exosomes from stem and progenitor cells—a safer alternative? What are the risks associated with a stem cell transplantation? When will stem cells be rejected after transplantation? How does the body's immune system recognize a cell as "foreign"? Reverse rejection: graft-versus-host How to prevent rejection of a cell transplant? Tissue engineering 196 201 201 204 205 208 210 214 Stem cells in veterinary medicine 221 Treatment of family pets Tendon in the horse Osteoarthritis in dogs Induced pluripotent stem cells 222 223 225 226 Cardiomyocytes from stem cells: what can we do with them? 231 The heart and cardiac repair Stem cells models of heart disease From pluripotent stem cells to cardiomyocytes 232 234 236 Adult stem cells: generation of self-organizing mini-organs in a dish 257 Adult stem cells in internal organs Adult stem cells in the intestine Adult stem cells in muscle tissue What have we learnt about adult stem cells? The future: organoids to repair tissues and organs? 259 259 261 263 263 Stem cell tourism 275 What is "stem cell tourism"? What is the difference between commercial stem cell "treatments," early-phase medical intervention, and standard stem cell clinical practice? Perspective of the International Society for Stem Cell Research (ISSCR) 275 278 285 Cancer stem cells: where do they come from and where are they going? 299 Cancer: observations and some questions to start with Introduction to stem cells and cancer A brief history of cancer stem cells 300 301 301
viii Contents The behavior of cancer cells: not all tumors and not all cells within a tumor, look the same A Darwinian view: evolution of a tumor Colon adenoma: a case in point for the role of an adult stem cell as the stem cell of origin Development of a colon adenoma When does a tumor become malignant and metastasize to different organs? Interaction between cancer cells and their environment leads to "phenotypic" heterogeneity How to become a cancer stem cell: epithelial mesenchymal transition Epithelial-mesenchymal transition and mesenchymal—epithelial transition: a renewed view on the role of cancer stem cells How could developmental signal transduction pathways become active in cancer cells? Cancer stem cells as circulating tumor cells The final step: initiation of metastatic growth A cancer stem cell: can it differentiate to another cell type? Cancer stem cells: development of new drugs to treat cancer? Conclusions and research challenges 13, Human stem cells for organs-on-chips: "clinical trials" without patients? Introduction What are organs-on-chips? New drugs and why would we need human organ and disease-on-chip models? Human organ-on-chip models: for which diseases? Human disease models as organ-on-chip: challenges Where are we now with organ-on-chip technology? Human stem cells as a critical component of organ-on-chip model systems Pluripotent or adult stem cells in the organ-on-chip? How to make stem cells "differentiate" to the right types of cells in the body Formation of functional tissues and organs using Organ-on-Chip technology What can "organs-on-chip"
be used for? Model systems for drug toxicity screening Human disease models for drug target discovery and drug development: role for organs-on-chip Some conclusions 304 305 306 307 309 310 317 318 319 320 321 321 323 326 329 330 330 333 337 337 338 342 342 344 344 346 346 348 351
Contents 14. 15. 16. Index ix Stem cells for discovery of effective and safe new drugs 353 Drug discovery: a short historical perspective Modern drug discovery Challenges and opportunities in drug discovery How is the safety of new drugs secured? 353 357 358 363 Patents, opportunities, and challenges: legal and intellectual property issues associated with stem cells 369 Companies and alliances Patent issues: current intetlectual property landscape Wisconsin Alumni Research Foundation Europe versus the United States More legal and ethical issues Privacy and ownership 371 372 373 374 380 381 Stem cell perspectives: a vision of the future 383 Combining technologies: new human disease models for drug discovery Personalized medicine and safer drugs A final note 388 390 399 401
Third Edition Stem Cells Scientific Facts and Fiction Christine L. Mummery · Anja van de Stolpe · Bernard Roeien · Hans devers Stem Cells: Scientific Facts and Fiction, Third Edition, provides a state-of-the-art over view on the field of stem cells and their current applications. The book incorporates the history and firsthand commentaries in the field from clinical and research leaders, covering interesting topics of note, including the first clinicai trials to treat Parkinson disease, macular degeneration, and corneal replacement, the cloning of monkeys, the organoid field, and CRISPR-edited genomics. In addition, coverage of adult, embryonic stem cells and İPS celis is included. This new edition distinguishes itself from the multiplicity of websites about stem cells with a broad view of the field. Key Features • • • Explains, in a straightforward, nonspecialist language, the basic biology of stem cells and their applications in modern medicine and future therapy Provides new and expanded coverage of cloning, organoids, "synthetic” embryos, and much more Includes detailed illustrations to assist users with learning on how research is done About the Authors Christine L. Mummery. Professor of Developmental Biology at Leiden University Medi cal Centre in Leiden, Professor of Vascular Microfluidics Technology at the University of Twente, the Netherlands. Anja van de Stolpe, Chief Scientific Officer, Philips Molecular Pathway Dx, Eindhoven, the Netherlands Bernard Roeien, Associate professor at the Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht
University in Utrecht, the Netherlands. Hans Clevers, Principal Investigator at the Hubrecht Institute for Developmental Biology and Stem Cell Research (KNAW) and the Princess Máxima Center for Pediatric Oncology and Professor of Molecular Genetics at the UMC Utrecht and Utrecht University and Oncode Investigator, the Netherlands. |
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| owner | DE-384 DE-29 DE-M382 |
| owner_facet | DE-384 DE-29 DE-M382 |
| physical | ix, 411 Seiten Illustrationen |
| publishDate | 2021 |
| publishDateSearch | 2021 |
| publishDateSort | 2021 |
| publisher | Elsevier, Academic Press |
| record_format | marc |
| spelling | Mummery, Christine L. 1953- (DE-588)1057904902 aut Stem cells scientific facts and fiction Christine L. Mummery, Anja van de Stolpe, Bernard Roelen, Hans Clevers Third edition London, UK Elsevier, Academic Press [2021] © 2021 ix, 411 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Stem cells Stem cells / Research Embryonic stem cells Cell differentiation Stem Cells Stem Cell Research Cell differentiation fast Embryonic stem cells fast Stem cells fast Stem cells / Research fast Fiktion (DE-588)4192723-0 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Forschung (DE-588)4017894-8 gnd rswk-swf Stammzelle (DE-588)4665329-6 gnd rswk-swf Genetik (DE-588)4071711-2 s Stammzelle (DE-588)4665329-6 s Forschung (DE-588)4017894-8 s Fiktion (DE-588)4192723-0 s DE-604 Stolpe, Anja van de 1956- (DE-588)108923130X aut Roelen, Bernard aut Clevers, Hans aut Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032551504&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032551504&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Mummery, Christine L. 1953- Stolpe, Anja van de 1956- Roelen, Bernard Clevers, Hans Stem cells scientific facts and fiction Stem cells Stem cells / Research Embryonic stem cells Cell differentiation Stem Cells Stem Cell Research Cell differentiation fast Embryonic stem cells fast Stem cells fast Stem cells / Research fast Fiktion (DE-588)4192723-0 gnd Genetik (DE-588)4071711-2 gnd Forschung (DE-588)4017894-8 gnd Stammzelle (DE-588)4665329-6 gnd |
| subject_GND | (DE-588)4192723-0 (DE-588)4071711-2 (DE-588)4017894-8 (DE-588)4665329-6 |
| title | Stem cells scientific facts and fiction |
| title_auth | Stem cells scientific facts and fiction |
| title_exact_search | Stem cells scientific facts and fiction |
| title_exact_search_txtP | Stem cells scientific facts and fiction |
| title_full | Stem cells scientific facts and fiction Christine L. Mummery, Anja van de Stolpe, Bernard Roelen, Hans Clevers |
| title_fullStr | Stem cells scientific facts and fiction Christine L. Mummery, Anja van de Stolpe, Bernard Roelen, Hans Clevers |
| title_full_unstemmed | Stem cells scientific facts and fiction Christine L. Mummery, Anja van de Stolpe, Bernard Roelen, Hans Clevers |
| title_short | Stem cells |
| title_sort | stem cells scientific facts and fiction |
| title_sub | scientific facts and fiction |
| topic | Stem cells Stem cells / Research Embryonic stem cells Cell differentiation Stem Cells Stem Cell Research Cell differentiation fast Embryonic stem cells fast Stem cells fast Stem cells / Research fast Fiktion (DE-588)4192723-0 gnd Genetik (DE-588)4071711-2 gnd Forschung (DE-588)4017894-8 gnd Stammzelle (DE-588)4665329-6 gnd |
| topic_facet | Stem cells Stem cells / Research Embryonic stem cells Cell differentiation Stem Cells Stem Cell Research Fiktion Genetik Forschung Stammzelle |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032551504&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032551504&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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