Rho GTPases: molecular biology in health and disease
"Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Publishing Co. Pte Ltd.
© 2018
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | "Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology. This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity controlled by Rho-dependent pathways, namely, cell-cell interactions and mechanotransduction. It also describes how post-translational modifications control Rho activity and how this is exploited by pathogenic bacteria. Part 3 explores several examples of the variety of pathophysiological processes controlled by Rho signaling, and gives a successful example of translational research, from the inhibition of Rho activation to the development of new molecules against osteoporosis. This updated review on the biology of Rho GTPases is an essential read for molecular and cell biologists. It is also an invaluable guide to post-graduate and medical students who wish to deepen their knowledge in cell biology."-- |
| Beschreibung: | Description based on online resource; title from PDF title page (viewed December 6, 2017) |
| Beschreibung: | 1 Online-Ressource (213 Seiten) Illustrationen. (some col.) |
| ISBN: | 9789813228795 |
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| 520 | |a "Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology. This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity controlled by Rho-dependent pathways, namely, cell-cell interactions and mechanotransduction. It also describes how post-translational modifications control Rho activity and how this is exploited by pathogenic bacteria. Part 3 explores several examples of the variety of pathophysiological processes controlled by Rho signaling, and gives a successful example of translational research, from the inhibition of Rho activation to the development of new molecules against osteoporosis. This updated review on the biology of Rho GTPases is an essential read for molecular and cell biologists. It is also an invaluable guide to post-graduate and medical students who wish to deepen their knowledge in cell biology."-- | ||
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Datensatz im Suchindex
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| dewey-full | 572/.633 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572/.633 |
| dewey-search | 572/.633 |
| dewey-sort | 3572 3633 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| discipline_str_mv | Biologie |
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| id | DE-604.BV047124579 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T16:30:25Z |
| indexdate | 2024-07-10T09:03:19Z |
| institution | BVB |
| isbn | 9789813228795 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032530819 |
| oclc_num | 1237587995 |
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| physical | 1 Online-Ressource (213 Seiten) Illustrationen. (some col.) |
| psigel | ZDB-124-WOP |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | World Scientific Publishing Co. Pte Ltd. |
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| spelling | Rho GTPases (Fort) Rho GTPases molecular biology in health and disease edited by Philippe Fort, Anne Blangy Singapore World Scientific Publishing Co. Pte Ltd. © 2018 1 Online-Ressource (213 Seiten) Illustrationen. (some col.) txt rdacontent c rdamedia cr rdacarrier Description based on online resource; title from PDF title page (viewed December 6, 2017) "Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology. This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity controlled by Rho-dependent pathways, namely, cell-cell interactions and mechanotransduction. It also describes how post-translational modifications control Rho activity and how this is exploited by pathogenic bacteria. Part 3 explores several examples of the variety of pathophysiological processes controlled by Rho signaling, and gives a successful example of translational research, from the inhibition of Rho activation to the development of new molecules against osteoporosis. This updated review on the biology of Rho GTPases is an essential read for molecular and cell biologists. It is also an invaluable guide to post-graduate and medical students who wish to deepen their knowledge in cell biology."-- Rho GTPases Cellular signal transduction Electronic books Fort, Philippe Sonstige oth Blangy, Anne Sonstige oth http://www.worldscientific.com/worldscibooks/10.1142/10674#t=toc Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Rho GTPases molecular biology in health and disease Rho GTPases Cellular signal transduction Electronic books |
| title | Rho GTPases molecular biology in health and disease |
| title_alt | Rho GTPases (Fort) |
| title_auth | Rho GTPases molecular biology in health and disease |
| title_exact_search | Rho GTPases molecular biology in health and disease |
| title_exact_search_txtP | Rho GTPases molecular biology in health and disease |
| title_full | Rho GTPases molecular biology in health and disease edited by Philippe Fort, Anne Blangy |
| title_fullStr | Rho GTPases molecular biology in health and disease edited by Philippe Fort, Anne Blangy |
| title_full_unstemmed | Rho GTPases molecular biology in health and disease edited by Philippe Fort, Anne Blangy |
| title_short | Rho GTPases |
| title_sort | rho gtpases molecular biology in health and disease |
| title_sub | molecular biology in health and disease |
| topic | Rho GTPases Cellular signal transduction Electronic books |
| topic_facet | Rho GTPases Cellular signal transduction Electronic books |
| url | http://www.worldscientific.com/worldscibooks/10.1142/10674#t=toc |
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