Integrative human biochemistry: a textbook for medical biochemistry
Gespeichert in:
| Hauptverfasser: | , |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York
Springer
[2021]
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| Ausgabe: | Second edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xxvii, 669 Seiten Illustrationen |
| ISBN: | 9783030487393 |
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| 245 | 1 | 0 | |a Integrative human biochemistry |b a textbook for medical biochemistry |c Andrea T. Da Poian, Miguel A.R.B. Castanho |
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| 650 | 4 | |a Biochemical Phenomena | |
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Datensatz im Suchindex
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| adam_text | Contents Part I 1 The Molecules of Life Introduction: Life Is Made of Molecules!.......................................... 1.1 Selected Illustrative Example #1 : The Molecular Origin of Life................................................................................. 1.1.1 The Replicator Hypothesis................................................ 1.1.2 The Metabolism Hypothesis............................................ 1.2 Selected Illustrative Example #2: Viruses—Molecular Machines Interfering with Life..................................................... 1.3 Selected Illustrative Example #3 : Molecules as Tools—Drug Discovery and Development.............................. Selected Bibliography............................................................................. Challenging Case 1.1: The Origin of Life and Panspermia.................. Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insights........................................................................... Final Discussion................................................................................. Challenging Case 1.2: Science in Fiction—Mighty Weakness vs. Micropower............................................................. Source................................................................................................. Case
Description................................................................................. Questions............................................................................................. Biochemical Insights........................................................................... Final Discussion................................................................................. Challenging Case 1.3: Mars—NASA’s Laboratory for the Origin of Life ... On Earth!....................................................................... Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insight........................................................................... Final Discussion................................................................................. 3 4 5 5 10 15 21 22 22 22 23 24 26 27 27 27 28 29 31 32 32 32 34 35 35 xix
XX 2 3 Contents The Chemistry and Physics of Life...................................................... 2.1 The Basics of Chemistry in Ceils and Tissues................................ 2.1.1 Principal Biological Buffers.............................................. 2.2 More than Only Chemistry: There Is Physics Too.......................... Selected Bibliography............................................................................ Challenging Case 2.1: Going Deep into Respiratory Acidosis.............. Source................................................................................................ Case Description................................................................................ Questions............................................................................................ Biochemical Insights.......................................................................... Final Discussion................................................................................ Challenging Case 2.2: Reindeer Know the Color of UV Light............ Source................................................................................................ Case Description................................................................................ Questions............................................................................................ Biochemical Insight.......................................................................... Final Discussion: Examples of Missing and Misplaced Colors in Literature and
Music...................................................................... Challenging Case 2.3: Malacocephalus—The Strange Case of the Radioactive Fish from the Deep Sea.................................. Source................................................................................................ Case Description................................................................................ Questions............................................................................................ Biochemical Insight.......................................................................... Final Discussion................................................................................ 37 43 50 52 61 62 62 62 64 65 68 70 70 70 71 72 The Families of Biological Molecules................................................ 3.1 Lipids and the Organization of Their Supramolecular Assemblies.................................................................................... 3.1.1 The Structure of Biological Membranes.......................... 3.1.2 The Structure of Lipoproteins.......................................... 3.2 Saccharides and Their Polymers and Derivatives........................ 3.2.1 From Monomers to Polymers: Polysaccharides.............. 3.2.2 Molecular Conjugates of Mono- and Oligosaccharides.. . 3.2.3 Molecular Conjugates of Oligosaccharides...................... 3.2.4 Polymers of Saccharide Conjugates: Nucleic Acids........ 3.3 Amino Acids and Their Polymers: Peptides and Proteins............ 3.3.1 From Monomers to Polymers: Peptides and Proteins .... 3.3.2
Structure and Function in Proteins.................................... 3.3.3 Cooperative Interplay Between Tertiary-Level and Quaternary-Level Structure........................................ 3.3.4 Enzymes............................................................................ Selected Bibliography............................................................................ Challenging Case 3.1: Biochemistry in Dali’s (he)art.......................... Source................................................................................................ Case Description................................................................................. 89 73 75 75 75 82 82 85 90 98 105 110 116 117 123 126 131 136 144 149 155 164 165 165 165
Contents Questions............................................................................................. Biochemical Insights........................................................................... Final Discussion................................................................................. Further Reading................................................................................. Challenging Case 3.2: From Best with Proteins to Worst with DNA... Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insights........................................................................... Final Discussion................................................................................. Challenging Case 3.3: London Fatberg Analysis—Impact of Urban Obesity on the Metropolitan Vasculature...................... Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insights........................................................................... Final Discussion................................................................................. XXI 168
168 169 169 170 170 170 174 174 175 176 176 176 181 182 184 Part II The Interplay and Regulation of Metabolism 4 Introduction to Metabolism................................................................. 4.1 Consecutive Reactions Without Enzymes..................................... 4.2 Consecutive Reactions with Enzymes........................................... 4.2.1 The Bases of Enzymatic Catalysis and Its Impact in Metabolism................................................................... Selected Bibliography............................................................................... Challenging Case 4.1: The Dark Side of Caffeine................................ Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insight........................................................................... Final Discussion: Facts and Fantasies About Energy Drinks............ Challenging Case 4.2: Missing the Obvious ... Twice! The Devil Is in the Details, so Is Recognition by Peers................................ Sources............................................................................................... Description......................................................................................... Questions.............................................................................................
Biochemical Insights........................................................................... Final Discussion................................................................................. Challenging Case 4.3: Building Models in Metabolism, Descriptive, Predictive ... Useful!..................................................................... Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insight........................................................................... Final Discussion................................................................................. 189 191 197 200 213 214 214 214 220 221 228 230 230 230 235 236 243 245 245 245 246 247 249
xxįį 5 6 Contents Regulation of Metabolisms............................ .................................... 5.1 Levels of Regulation: Impact and Time Scale.............................. 5.2 Inhibition and Activation of Enzymes by Ligands........................ 5.2.1 Nomenclature of Ligands.................................................. 5.3 The Availability of Primary Precursors in a Metabolic Pathway. . 5.3.1 Transport of Metabolites and Effectors Across Membranes........................................................................ 5.4 Slower (But Efficient!) Mechanisms of Controlling Enzyme Action.............................................................................. 5.5 Key Molecules in Energy Metabolism.......................................... Selected Bibliography.............................................................................. Challenging Case 5.1 : Mushroom Poisons Starring on Stage and Science.................................................................................. Source................................................................................................ Case Description................................................................................ Questions............................................................................................ Biochemical Insights.......................................................................... Final Discussion................................................................................ Challenging Case 5.2: The Biochemistry of Zombies..........................
Source................................................................................................ Case Description................................................................................ Questions............................................................................................ Biochemical Insights.......................................................................... Final Discussion................................................................................ Energy Conservation in Metabolism: The Mechanisms of ATP Synthesis.................................................................................. 6.1 ATP Synthesis by Substrate-Level Phosphorylation.................... 6.1.1 A Historical Perspective of the Fermentation Process Discovery............................................................ 6.1.2 An Overview of the ATP Synthesis by Substrate-Level Phosphorylation During Fermentation.............................. 6.1.3 Glucose Fermentation Reactions...................................... 6.2 ATP Synthesis Through Oxidative Phosphorylation.................... 6.2.1 A Historical Perspective of the Understanding of Cellular Respiration...................................................... 6.2.2 An Overview of Oxidative Phosphorylation Process........ 6.2.3 The Electron Transport System........................................ 6.2.4 The ATP Synthesis Through Oxidative Phosphorylation. . 6.2.5 Regulation of Oxidative Phosphorylation........................ Selected
Bibliography............................................................................ Challenging Case 6.1 : The Tragic Matter in Energy Management........ Source................................................................................................ Case Description................................................................................ Questions............................................................................................ 253 258 260 266 267 268 273 278 282 283 283 283 287 290 294 296 296 296 299 299 300 301 302 303 306 309 310 312 318 320 329 332 337 338 338 338 340
Contents 7 xxiii Biochemical Insight........................................................................... Final Discussion................................................................................. Challenging Case 6.2: The Force Comes from Within........................... Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insights........................................................................... Final Discussion................................................................................. Challenging Case 6.3: A Curious Girl Has Fallen into a Mad World.. . Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insights........................................................................... Final Discussion................................................................................. 341 342 344 344 344 346 349 353 354 354 354 356 357 360 Catabolism of the Major Biomolecules............................................... 7.1 An Overview of Catabolism......................................................... 7.2 Citric Acid
Cycle: The Central Pathway for the Oxidation of the Three Classes of Nutrient Molecules................................... 7.2.1 Citric Acid Cycle Reactions............................................... 7.2.2 Citric Acid Cycle as a Dynamic Pathway........................ 7.2.3 A Historical Overview of CAC Discovery........................ 7.2.4 Regulation of Citric Acid Cycle......................................... 7.3 Catabolism of Carbohydrates......................................................... 7.3.1 Carbohydrate Oxidation Reactions................................... 7.3.2 Regulation of Pyruvate Conversion to Acetyl-CoA.......... 7.4 Catabolism of Lipids..................................................................... 7.4.1 TAG Mobilization and Fatty Acid Transport in the Bloodstream............................................................. 7.4.2 Activation of Fatty Acids................................................... 7.4.3 Fatty Acid Transport into Mitochondria.......................... 7.4.4 ß-Oxidation: The Pathway for Fatty Acid Degradation... 7.4.5 Regulation of Fatty Acid Oxidation................................... 7.4.6 Fatty Acid Conversion to Ketone Bodies.......................... 7.5 Catabolism of Amino Acids........................................................... 7.5.1 An Overview of the Amino Acid Catabolism.................. 7.5.2 Amino Acid Metabolism in the Liver............................... 7.5.3 Amino Acid Metabolism in Other Tissues......................... Selected
Bibliography............................................................................. Challenging Case 7.1: Into the Wilderness of Metabolic Deregulation................................................................................... Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insights..................................................................... Final Discussion................................................................................. 363 363 367 368 369 370 373 373 374 376 377 378 379 380 381 386 387 388 389 390 396 398 399 399 399 400 401 402
Contents XXIV Challenging Case 7.2: A Mystic Man with an Aura of Flowers............ Source................................................................................................ Case Description................................................................................ Questions............................................................................................ Biochemical Insights.......................................................................... Final Discussion................................................................................ 8 9 Metabolic Responses to Hyperglycemia: Regulation and Integration of Metabolism in the Absorptive State.................. 8.1 Glucose Sensing by Cells.............................................................. 8.2 Biosynthesis of Glycogen............................................................ 8.2.1 Formation of UDP-Glucose.............................................. 8.2.2 Reactions for the Initiation of Glycogen Synthesis from UDP-Glucose.......................................................... 8.2.3 Reactions for the Elongation of Glycogen Chain............ 8.2.4 Regulation of Glycogen Synthesis.................................... 8.3 Biosynthesis of Lipids.................................................................. 8.3.1 Synthesis of Fatty Acids.................................................... 8.3.2 Synthesis of Triacylglycerols............................................ 8.4 Hormonal Responses to Hyperglycemia: Role of Insulin............ 8.4.1 Discovery of
Insulin.......................................................... 8.4.2 Mechanisms of Insulin Action.......................................... 8.4.3 Effects of Insulin on Energy Metabolism........................ 8.5 Metabolic Interplay in Response to Hyperglycemia.................... Selected Bibliography............................................................................ Challenging Case 8.1: Beyond the Enigmatic Smile—The Occult Hyperlipidemia of Mona Lisa...................................................... Source................................................................................................ Case Description................................................................................ Questions............................................................................................ Biochemical Insights.......................................................................... Final Discussion................................................................................ Challenging Case 8.2: Dolores Bothered to Kill Her Dying Husband.. Source................................................................................................ Case Description................................................................................ Questions............................................................................................ Biochemical Insights.......................................................................... Final Discussion................................................................................ Regulation and
Integration of Metabolism During Hypoglycemia...................................................................................... 9.1 Overview of Metabolism During Fasting: Exemplifying with Studies on Therapeutic Starvation........................................ 9.2 Glycogen Degradation in the Liver.............................................. 9.2.1 Reactions of Glycogen Degradation................................ 9.2.2 Regulation of Glycogen Degradation in the Liver............ 404 404 404 406 407 411 413 415 420 422 423 424 425 431 432 448 449 450 451 455 457 458 459 459 459 461 462 465 467 467 467 468 469 473 477 480 484 486 489
Contents xxv 9.3 491 491 495 496 498 501 Gluconeogenesis........................................................................... 9.3.1 Gluconeogenesis Reactions............................................... 9.3.2 Precursors for the Synthesis of Glucose.......................... 9.3.3 Regulation of Gluconeogenesis......................................... 9.3.4 Dynamic Utilization of Gluconeogenesis Precursors .... 9.4 Hormonal Responses to Hypoglycemia......................................... 9.4.1 Glucagon: Mechanism of Action and Effects on Energy Metabolism....................................................... 9.4.2 Glucocorticoids: Mechanism of Action and Effects on Energy Metabolism....................................................... Selected Bibliography............................................................................... Challenging Case 9.1: Kenny Faced the Fa(s)t....................................... Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insight........................................................................... Final Discussion................................................................................. Challenging Case 9.2: The Lychee Paradox: Deliciously Sugary, Dangerously Hypoglycémiant.......................................................
Sources............................................................................................... Description......................................................................................... Questions............................................................................................. Biochemical Insights........................................................................... Final Discussion................................................................................. Challenging Case 9.3: The Bizarre Death of Elaine Robinson.............. Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insight........................................................................... Final Discussion................................................................................. 10 Regulation and Integration of Metabolism During Physical Activity................................................................................... 10.1 Muscle Contraction..................................................................... 10.1.1 Structural Organization of the Contractile Apparatus .. . 10.1.2 Mechanism of Muscle Contraction................................ 10.1.3 Regulation of Muscle Contraction.................................. 10.2 Different Metabolic Profiles of the Skeletal Muscle Fibers........
10.3 Overview of ATP Synthesis in the Muscle Cells........................ 10.4 Muscle Cell Metabolism During Physical Activity.................... 10.4.1 Role of the Cellular Energy Charge in the Muscle Cell Metabolism............................................................... 10.4.2 Metabolic Pathways for ATP Synthesis in the Skeletal Muscle............................................................................. 10.5 Hormonal Regulation During Physical Activity: Role of Adrenaline....................................................................... 502 507 511 512 512 512 513 514 516 517 517 517 518 519 521 522 522 522 523 524 525 527 528 528 534 536 538 540 542 542 546 553
xxvi 11 Contents 10.5.1 Molecular Mechanisms of Adrenaline Action................ 10.5.2 Effects of Adrenaline on Energy Metabolism................ Selected Bibliography............................................................................. Challenging Case 10.1: Iron Muscles—Men of Steel.......................... Source................................................................................................. Case Description................................................................................. Questions............................................................................................. Biochemical Insights.......................................................................... Final Discussion................................................................................ Challenging Case 10.2: Armstrong’s Race to the Sun.......................... Sources.............................................................................................. Case Description................................................................................ Questions............................................................................................ Biochemical Insights.......................................................................... Final Discussion................................................................................ Challenging Case 10.3: K. V. Switzer’s Run for Rights........................ Source................................................................................................ Case
Description................................................................................ Questions............................................................................................ Biochemical Insights.......................................................................... Final Discussion................................................................................ 554 556 559 560 560 560 564 565 569 571 571 571 573 574 580 582 582 582 584 586 588 Control of Body Weight and the Modem Metabolic Diseases........ 11.1 Humoral Control of Food Ingestion............................................ 11.1.1 A Historical Perspective of the Role of Hypothalamus in Food Intake................................................................ 11.1.2 Feptin: A Hormone Indicative of Adiposity.................. 11.1.3 Intestinal Peptides: Triggers of Postprandial Satiety.... 11.1.4 Ghrelin: The Main Orexigenic Hormone........................ 11.1.5 The Arcuate Nucleus and the Melanocortin System .... 11.2 Control of Energy Expenditure.................................................. 11.2.1 Adaptive Thermogenesis................................................ 11.2.2 Role of Thyroid Hormones............................................ 11.3 Obesity and the Metabolic Syndrome........................................ 11.3.1 Chronic Inflammation and Insulin Resistance in Obesity........................................................................ 11.3.2 Origin of Inflammation in Obesity.................................. Selected
Bibliography............................................................................ Challenging Case 11.1: The Capsules of (H)eating Beauty.................. Source................................................................................................ Case Description................................................................................ Questions............................................................................................ Biochemical Insights.......................................................................... Final Discussion................................................................................ 591 593 594 596 600 604 606 608 608 612 617 618 620 623 624 624 624 627 628 631
Contents xxvii Challenging Case 11.2: Running to Eternity in Between Suet and Sweat..................................................................................... Sources............................................................................................... Case Description................................................................................. Questions............................................................................................. Biochemical Insights........................................................................... Final Discussion................................................................................. Challenging Case 11.3: Malthus Meets Metabolism............................ Sources............................................................................................... Case Description................................................................................. Questions............................................................................................. Biochemical Insights........................................................................... Final Discussion................................................................................. 634 634 634 636 637 640 641 641 641 642 643 644 Credits........................................................................................................... 645 Index 647
Andreal Da Poian · Miguel A. R. В. Castanho Integrative Human Biochemistry A Textbook for Medical Biochemistry, Second Edition This book covers in detail the mechanisms for how energy is managed in the human body. The basic principles that elucidate the reactivity and physical interactions of matter are addressed and quantified with simple approaches. Three-dimensional representa tions of molecules are presented throughout the book so molecules can be viewed as unique entities in their shape and function. The book is focused on the molecular mechanisms of cellular processes in the context of human physiological situations such as fasting, feeding and physical exercise, in which metabolic regulation is highlighted. Furthermore the book uses key historical experiments that opened up new concepts in biochemistry to further illustrate how the human body functions at molecular level, helping students to appreciate how scientific knowledge emerges. New to this edition • 30 challenging practical case studies (2-3 at the end of each chapter) based on movies, no fels, biographies, documentaries, paintings, and other cultural and artistic creations far beyond canonic academic exercises. • A set of challenging questions and problems in the end of each case study to further engage students with the applications of medical biochemistry - Insights into the answers to the challenging questions to help steer teaching/learning interactions key to productive lectures, PBL (problem-based learning) or traditional tutorials, or e-learning approaches. Advance praise for the second edition The
Challenging Cases are compelling both from a scientific viewpoint and for the per spective they provide on the history of medicine. David M. Jameson, University of Hawaii Using case studies to reinforce the biochemistry lessons is extremely effective - as well as entertaining! Joseph P. Albanesi, UT Southwestern Medical Center Advance Praise for the first edition This textbook provides a modern and integrative perspective of human biochemistry and will be a faithful companion to health science students following curricula in which this discipline is addressed. This textbook will be a most useful tool for the teaching community. Joan Guinovart, Past-president of the International Union of Biochemistry and Molecular Biology, IUBMB
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Contents Part I 1 The Molecules of Life Introduction: Life Is Made of Molecules!. 1.1 Selected Illustrative Example #1 : The Molecular Origin of Life. 1.1.1 The Replicator Hypothesis. 1.1.2 The Metabolism Hypothesis. 1.2 Selected Illustrative Example #2: Viruses—Molecular Machines Interfering with Life. 1.3 Selected Illustrative Example #3 : Molecules as Tools—Drug Discovery and Development. Selected Bibliography. Challenging Case 1.1: The Origin of Life and Panspermia. Source. Case Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 1.2: Science in Fiction—Mighty Weakness vs. Micropower. Source. Case
Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 1.3: Mars—NASA’s Laboratory for the Origin of Life . On Earth!. Source. Case Description. Questions. Biochemical Insight. Final Discussion. 3 4 5 5 10 15 21 22 22 22 23 24 26 27 27 27 28 29 31 32 32 32 34 35 35 xix
XX 2 3 Contents The Chemistry and Physics of Life. 2.1 The Basics of Chemistry in Ceils and Tissues. 2.1.1 Principal Biological Buffers. 2.2 More than Only Chemistry: There Is Physics Too. Selected Bibliography. Challenging Case 2.1: Going Deep into Respiratory Acidosis. Source. Case Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 2.2: Reindeer Know the Color of UV Light. Source. Case Description. Questions. Biochemical Insight. Final Discussion: Examples of Missing and Misplaced Colors in Literature and
Music. Challenging Case 2.3: Malacocephalus—The Strange Case of the Radioactive Fish from the Deep Sea. Source. Case Description. Questions. Biochemical Insight. Final Discussion. 37 43 50 52 61 62 62 62 64 65 68 70 70 70 71 72 The Families of Biological Molecules. 3.1 Lipids and the Organization of Their Supramolecular Assemblies. 3.1.1 The Structure of Biological Membranes. 3.1.2 The Structure of Lipoproteins. 3.2 Saccharides and Their Polymers and Derivatives. 3.2.1 From Monomers to Polymers: Polysaccharides. 3.2.2 Molecular Conjugates of Mono- and Oligosaccharides. . 3.2.3 Molecular Conjugates of Oligosaccharides. 3.2.4 Polymers of Saccharide Conjugates: Nucleic Acids. 3.3 Amino Acids and Their Polymers: Peptides and Proteins. 3.3.1 From Monomers to Polymers: Peptides and Proteins . 3.3.2
Structure and Function in Proteins. 3.3.3 Cooperative Interplay Between Tertiary-Level and Quaternary-Level Structure. 3.3.4 Enzymes. Selected Bibliography. Challenging Case 3.1: Biochemistry in Dali’s (he)art. Source. Case Description. 89 73 75 75 75 82 82 85 90 98 105 110 116 117 123 126 131 136 144 149 155 164 165 165 165
Contents Questions. Biochemical Insights. Final Discussion. Further Reading. Challenging Case 3.2: From Best with Proteins to Worst with DNA. Source. Case Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 3.3: London Fatberg Analysis—Impact of Urban Obesity on the Metropolitan Vasculature. Source. Case Description. Questions. Biochemical Insights. Final Discussion. XXI 168
168 169 169 170 170 170 174 174 175 176 176 176 181 182 184 Part II The Interplay and Regulation of Metabolism 4 Introduction to Metabolism. 4.1 Consecutive Reactions Without Enzymes. 4.2 Consecutive Reactions with Enzymes. 4.2.1 The Bases of Enzymatic Catalysis and Its Impact in Metabolism. Selected Bibliography. Challenging Case 4.1: The Dark Side of Caffeine. Source. Case Description. Questions. Biochemical Insight. Final Discussion: Facts and Fantasies About Energy Drinks. Challenging Case 4.2: Missing the Obvious . Twice! The Devil Is in the Details, so Is Recognition by Peers. Sources. Description. Questions.
Biochemical Insights. Final Discussion. Challenging Case 4.3: Building Models in Metabolism, Descriptive, Predictive . Useful!. Source. Case Description. Questions. Biochemical Insight. Final Discussion. 189 191 197 200 213 214 214 214 220 221 228 230 230 230 235 236 243 245 245 245 246 247 249
xxįį 5 6 Contents Regulation of Metabolisms. . 5.1 Levels of Regulation: Impact and Time Scale. 5.2 Inhibition and Activation of Enzymes by Ligands. 5.2.1 Nomenclature of Ligands. 5.3 The Availability of Primary Precursors in a Metabolic Pathway. . 5.3.1 Transport of Metabolites and Effectors Across Membranes. 5.4 Slower (But Efficient!) Mechanisms of Controlling Enzyme Action. 5.5 Key Molecules in Energy Metabolism. Selected Bibliography. Challenging Case 5.1 : Mushroom Poisons Starring on Stage and Science. Source. Case Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 5.2: The Biochemistry of Zombies.
Source. Case Description. Questions. Biochemical Insights. Final Discussion. Energy Conservation in Metabolism: The Mechanisms of ATP Synthesis. 6.1 ATP Synthesis by Substrate-Level Phosphorylation. 6.1.1 A Historical Perspective of the Fermentation Process Discovery. 6.1.2 An Overview of the ATP Synthesis by Substrate-Level Phosphorylation During Fermentation. 6.1.3 Glucose Fermentation Reactions. 6.2 ATP Synthesis Through Oxidative Phosphorylation. 6.2.1 A Historical Perspective of the Understanding of Cellular Respiration. 6.2.2 An Overview of Oxidative Phosphorylation Process. 6.2.3 The Electron Transport System. 6.2.4 The ATP Synthesis Through Oxidative Phosphorylation. . 6.2.5 Regulation of Oxidative Phosphorylation. Selected
Bibliography. Challenging Case 6.1 : The Tragic Matter in Energy Management. Source. Case Description. Questions. 253 258 260 266 267 268 273 278 282 283 283 283 287 290 294 296 296 296 299 299 300 301 302 303 306 309 310 312 318 320 329 332 337 338 338 338 340
Contents 7 xxiii Biochemical Insight. Final Discussion. Challenging Case 6.2: The Force Comes from Within. Source. Case Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 6.3: A Curious Girl Has Fallen into a Mad World. . Source. Case Description. Questions. Biochemical Insights. Final Discussion. 341 342 344 344 344 346 349 353 354 354 354 356 357 360 Catabolism of the Major Biomolecules. 7.1 An Overview of Catabolism. 7.2 Citric Acid
Cycle: The Central Pathway for the Oxidation of the Three Classes of Nutrient Molecules. 7.2.1 Citric Acid Cycle Reactions. 7.2.2 Citric Acid Cycle as a Dynamic Pathway. 7.2.3 A Historical Overview of CAC Discovery. 7.2.4 Regulation of Citric Acid Cycle. 7.3 Catabolism of Carbohydrates. 7.3.1 Carbohydrate Oxidation Reactions. 7.3.2 Regulation of Pyruvate Conversion to Acetyl-CoA. 7.4 Catabolism of Lipids. 7.4.1 TAG Mobilization and Fatty Acid Transport in the Bloodstream. 7.4.2 Activation of Fatty Acids. 7.4.3 Fatty Acid Transport into Mitochondria. 7.4.4 ß-Oxidation: The Pathway for Fatty Acid Degradation. 7.4.5 Regulation of Fatty Acid Oxidation. 7.4.6 Fatty Acid Conversion to Ketone Bodies. 7.5 Catabolism of Amino Acids. 7.5.1 An Overview of the Amino Acid Catabolism. 7.5.2 Amino Acid Metabolism in the Liver. 7.5.3 Amino Acid Metabolism in Other Tissues. Selected
Bibliography. Challenging Case 7.1: Into the Wilderness of Metabolic Deregulation. Source. Case Description. Questions. Biochemical Insights. Final Discussion. 363 363 367 368 369 370 373 373 374 376 377 378 379 380 381 386 387 388 389 390 396 398 399 399 399 400 401 402
Contents XXIV Challenging Case 7.2: A Mystic Man with an Aura of Flowers. Source. Case Description. Questions. Biochemical Insights. Final Discussion. 8 9 Metabolic Responses to Hyperglycemia: Regulation and Integration of Metabolism in the Absorptive State. 8.1 Glucose Sensing by Cells. 8.2 Biosynthesis of Glycogen. 8.2.1 Formation of UDP-Glucose. 8.2.2 Reactions for the Initiation of Glycogen Synthesis from UDP-Glucose. 8.2.3 Reactions for the Elongation of Glycogen Chain. 8.2.4 Regulation of Glycogen Synthesis. 8.3 Biosynthesis of Lipids. 8.3.1 Synthesis of Fatty Acids. 8.3.2 Synthesis of Triacylglycerols. 8.4 Hormonal Responses to Hyperglycemia: Role of Insulin. 8.4.1 Discovery of
Insulin. 8.4.2 Mechanisms of Insulin Action. 8.4.3 Effects of Insulin on Energy Metabolism. 8.5 Metabolic Interplay in Response to Hyperglycemia. Selected Bibliography. Challenging Case 8.1: Beyond the Enigmatic Smile—The Occult Hyperlipidemia of Mona Lisa. Source. Case Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 8.2: Dolores Bothered to Kill Her Dying Husband. Source. Case Description. Questions. Biochemical Insights. Final Discussion. Regulation and
Integration of Metabolism During Hypoglycemia. 9.1 Overview of Metabolism During Fasting: Exemplifying with Studies on Therapeutic Starvation. 9.2 Glycogen Degradation in the Liver. 9.2.1 Reactions of Glycogen Degradation. 9.2.2 Regulation of Glycogen Degradation in the Liver. 404 404 404 406 407 411 413 415 420 422 423 424 425 431 432 448 449 450 451 455 457 458 459 459 459 461 462 465 467 467 467 468 469 473 477 480 484 486 489
Contents xxv 9.3 491 491 495 496 498 501 Gluconeogenesis. 9.3.1 Gluconeogenesis Reactions. 9.3.2 Precursors for the Synthesis of Glucose. 9.3.3 Regulation of Gluconeogenesis. 9.3.4 Dynamic Utilization of Gluconeogenesis Precursors . 9.4 Hormonal Responses to Hypoglycemia. 9.4.1 Glucagon: Mechanism of Action and Effects on Energy Metabolism. 9.4.2 Glucocorticoids: Mechanism of Action and Effects on Energy Metabolism. Selected Bibliography. Challenging Case 9.1: Kenny Faced the Fa(s)t. Source. Case Description. Questions. Biochemical Insight. Final Discussion. Challenging Case 9.2: The Lychee Paradox: Deliciously Sugary, Dangerously Hypoglycémiant.
Sources. Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 9.3: The Bizarre Death of Elaine Robinson. Source. Case Description. Questions. Biochemical Insight. Final Discussion. 10 Regulation and Integration of Metabolism During Physical Activity. 10.1 Muscle Contraction. 10.1.1 Structural Organization of the Contractile Apparatus . . 10.1.2 Mechanism of Muscle Contraction. 10.1.3 Regulation of Muscle Contraction. 10.2 Different Metabolic Profiles of the Skeletal Muscle Fibers.
10.3 Overview of ATP Synthesis in the Muscle Cells. 10.4 Muscle Cell Metabolism During Physical Activity. 10.4.1 Role of the Cellular Energy Charge in the Muscle Cell Metabolism. 10.4.2 Metabolic Pathways for ATP Synthesis in the Skeletal Muscle. 10.5 Hormonal Regulation During Physical Activity: Role of Adrenaline. 502 507 511 512 512 512 513 514 516 517 517 517 518 519 521 522 522 522 523 524 525 527 528 528 534 536 538 540 542 542 546 553
xxvi 11 Contents 10.5.1 Molecular Mechanisms of Adrenaline Action. 10.5.2 Effects of Adrenaline on Energy Metabolism. Selected Bibliography. Challenging Case 10.1: Iron Muscles—Men of Steel. Source. Case Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 10.2: Armstrong’s Race to the Sun. Sources. Case Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 10.3: K. V. Switzer’s Run for Rights. Source. Case
Description. Questions. Biochemical Insights. Final Discussion. 554 556 559 560 560 560 564 565 569 571 571 571 573 574 580 582 582 582 584 586 588 Control of Body Weight and the Modem Metabolic Diseases. 11.1 Humoral Control of Food Ingestion. 11.1.1 A Historical Perspective of the Role of Hypothalamus in Food Intake. 11.1.2 Feptin: A Hormone Indicative of Adiposity. 11.1.3 Intestinal Peptides: Triggers of Postprandial Satiety. 11.1.4 Ghrelin: The Main Orexigenic Hormone. 11.1.5 The Arcuate Nucleus and the Melanocortin System . 11.2 Control of Energy Expenditure. 11.2.1 Adaptive Thermogenesis. 11.2.2 Role of Thyroid Hormones. 11.3 Obesity and the Metabolic Syndrome. 11.3.1 Chronic Inflammation and Insulin Resistance in Obesity. 11.3.2 Origin of Inflammation in Obesity. Selected
Bibliography. Challenging Case 11.1: The Capsules of (H)eating Beauty. Source. Case Description. Questions. Biochemical Insights. Final Discussion. 591 593 594 596 600 604 606 608 608 612 617 618 620 623 624 624 624 627 628 631
Contents xxvii Challenging Case 11.2: Running to Eternity in Between Suet and Sweat. Sources. Case Description. Questions. Biochemical Insights. Final Discussion. Challenging Case 11.3: Malthus Meets Metabolism. Sources. Case Description. Questions. Biochemical Insights. Final Discussion. 634 634 634 636 637 640 641 641 641 642 643 644 Credits. 645 Index 647
Andreal Da Poian · Miguel A. R. В. Castanho Integrative Human Biochemistry A Textbook for Medical Biochemistry, Second Edition This book covers in detail the mechanisms for how energy is managed in the human body. The basic principles that elucidate the reactivity and physical interactions of matter are addressed and quantified with simple approaches. Three-dimensional representa tions of molecules are presented throughout the book so molecules can be viewed as unique entities in their shape and function. The book is focused on the molecular mechanisms of cellular processes in the context of human physiological situations such as fasting, feeding and physical exercise, in which metabolic regulation is highlighted. Furthermore the book uses key historical experiments that opened up new concepts in biochemistry to further illustrate how the human body functions at molecular level, helping students to appreciate how scientific knowledge emerges. New to this edition • 30 challenging practical case studies (2-3 at the end of each chapter) based on movies, no\fels, biographies, documentaries, paintings, and other cultural and artistic creations far beyond canonic academic exercises. • A set of challenging questions and problems in the end of each case study to further engage students with the applications of medical biochemistry - Insights into the answers to the challenging questions to help steer teaching/learning interactions key to productive lectures, PBL (problem-based learning) or traditional tutorials, or e-learning approaches. Advance praise for the second edition The
Challenging Cases are compelling both from a scientific viewpoint and for the per spective they provide on the history of medicine. David M. Jameson, University of Hawaii Using case studies to reinforce the biochemistry lessons is extremely effective - as well as entertaining! Joseph P. Albanesi, UT Southwestern Medical Center Advance Praise for the first edition This textbook provides a modern and integrative perspective of human biochemistry and will be a faithful companion to health science students following curricula in which this discipline is addressed. This textbook will be a most useful tool for the teaching community. Joan Guinovart, Past-president of the International Union of Biochemistry and Molecular Biology, IUBMB |
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| spelling | Da Poian, Andrea T. Verfasser (DE-588)1135599378 aut Integrative human biochemistry a textbook for medical biochemistry Andrea T. Da Poian, Miguel A.R.B. Castanho Second edition New York Springer [2021] xxvii, 669 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Biochemistry Human physiology Biochemical Phenomena Biological Phenomena Metabolic Phenomena Physiologie (DE-588)4045981-0 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Biochemie (DE-588)4006777-4 s Physiologie (DE-588)4045981-0 s b DE-604 Castanho, Miguel Verfasser (DE-588)1011408384 aut Erscheint auch als Online-Ausgabe 978-3-030-48740-9 Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032526343&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032526343&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Da Poian, Andrea T. Castanho, Miguel Integrative human biochemistry a textbook for medical biochemistry Biochemistry Human physiology Biochemical Phenomena Biological Phenomena Metabolic Phenomena Physiologie (DE-588)4045981-0 gnd Biochemie (DE-588)4006777-4 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4006777-4 (DE-588)4123623-3 |
| title | Integrative human biochemistry a textbook for medical biochemistry |
| title_auth | Integrative human biochemistry a textbook for medical biochemistry |
| title_exact_search | Integrative human biochemistry a textbook for medical biochemistry |
| title_exact_search_txtP | Integrative human biochemistry a textbook for medical biochemistry |
| title_full | Integrative human biochemistry a textbook for medical biochemistry Andrea T. Da Poian, Miguel A.R.B. Castanho |
| title_fullStr | Integrative human biochemistry a textbook for medical biochemistry Andrea T. Da Poian, Miguel A.R.B. Castanho |
| title_full_unstemmed | Integrative human biochemistry a textbook for medical biochemistry Andrea T. Da Poian, Miguel A.R.B. Castanho |
| title_short | Integrative human biochemistry |
| title_sort | integrative human biochemistry a textbook for medical biochemistry |
| title_sub | a textbook for medical biochemistry |
| topic | Biochemistry Human physiology Biochemical Phenomena Biological Phenomena Metabolic Phenomena Physiologie (DE-588)4045981-0 gnd Biochemie (DE-588)4006777-4 gnd |
| topic_facet | Biochemistry Human physiology Biochemical Phenomena Biological Phenomena Metabolic Phenomena Physiologie Biochemie Lehrbuch |
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