Keynes & Aidley's Nerve and muscle:
Gespeichert in:
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| Format: | Buch |
| Sprache: | English |
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Cambridge, United Kingdom
Cambridge University Press
[2021]
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| Ausgabe: | Fifth edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xxvii, 297 Seiten Illustrationen, Diagramme |
| ISBN: | 9781108816878 9781108495059 |
Internformat
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Datensatz im Suchindex
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| adam_text | Contents Preface Acknowledgements List of Abbreviations page xiii xiv xv I I Structural Organisation of the Nervous System t 1.1 1.2 1.3 1.4 1.5 Nervous Systems The Anatomy of a Neuron Unmyelinated Nerve Fibres Myelinated Nerve Fibres Nerve Fibre Responses to Injury l 2 2 2 I Resting and Action Potentials ю 2.1 2.2 2.3 2.4 Electrophysiological Recording Methods Intracellular Recording of the MembranePotential Extracellular Recording of the Nervous Impulse Excitation to із 14 17 З I Background Ionic Homeostasis of Excitable Cells 22 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Structure of the Cell Membrane Ion Distributions in Nerve and Muscle The Genesis of Resting Potentials The Donnan Equilibrium System in Muscle Direct Tests of the Donnan Hypothesis The Active Transport of Ions Quantitative Reconstruction of Resting Cellular Ionic Homeostasis 22 4 I Membrane Permeability Changes During Excitation 4.1 4.2 4.3 4.4 4.5 Impedance Changes During the Spike The Sodium Hypothesis Predictions of the Sodium Hypothesis Voltage Clamp Experiments Equivalent Electrical Circuit Description of the Nerve Membrane 4.6 Separation of Ionic Current Components in Response to Voltage Change 4.7 Mathematical Reconstruction of Ionic Current Properties 5 1 Voltage-Gated Ion Channels 5.1 cDNA Sequencing Studies 5.2 The Structure of Voltage-Gated Ion Channels 4 8 25 26 28 31 32 38 41 41 41 43 46 47 49 52 55 55 55
5.3 5.4 5.5 5.6 5.7 Biophysical Measurements of Channel Protein Conformational Changes Charge Movements in Excitable Cell Membranes The Sodium Channel Gating Mechanism The Ionic Selectivity of Voltage-Gated Channels Effect of Ion Occupancy on Channel Permeation: The Independence Principle 6 1 Cable Theory and Saltatory Conduction 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 The Spread of Voltage Changes in a Cable System Passive Spread of Voltage Changes Along an Unmyelinated Nerve Spread of Excitation in an Unmyelinated Nerve Action Potential Conduction Velocity and Direction Saltatory Conduction in Myelinated Nerves Factors Affecting Conduction Velocity Factors Affecting the Threshold for Excitation After-potentials 7 1 Neuromuscular Transmission 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 The Motor Unit Presynaptic Transmitter Release Graded and Regenerative Components of the Postsynaptic Response The Qpantal Nature of Presynaptic Events Ionic Current Flows Underlying the End-Plate Potential Patch Clamp Studies The Nicotinic Acetylcholine Receptor Specific Pharmacological Properties of the Neuromuscular Junction 8 1 Synaptic Transmission in the Nervous System 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 8.9 8.10 Synaptic Excitation in Motor Neurons Excitatory Postsynaptic Potentials Inhibition in Motor Neurons Interaction of IPSPs with EPSPs Presynaptic Inhibition Slow Synaptic Potentials G-Protein-Linked Receptors Electrical Synapses Long-Term Potentiation and Depression Glial Buffering of the Interstitial Space Following Neuronal Activity 60 62 66 68 69 73 73 75 76 78 79 84 85 87 88 88 89 91 94 97 99 101
103 106 106 107 109 110 111 111 114 116 117 118
9 I The Mechanism of Contraction in Skeletal Muscle 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 9.9 9.10 9.11 10 Anatomy The Structure of the Myofibril The Sliding-Filament Theory The Lengths of the Filaments The Relation Between Sarcomere Length and Isometric Tension The Molecular Basis of Contraction Myosin Actin Interactions Between Actin, Myosin and ATP The Molecular Basis of Activation Maintenance of Structural Integrity in Contracting Sarcomeres I The Activation of Skeletal Muscle 121 121 122 124 125 125 127 127 129 130 131 132 135 10.1 Background Conductances in Skeletal Muscle 10.2 10.3 10.4 10.5 10.6 10.7 10.8 10.9 Membranes Ionic Currents Mediating Skeletal Muscle Membrane Activation The Surface and Transverse Tubular Membrane Systems in Skeletal Muscle Surface and Transverse Tubular Components of the Muscle Action Potential Partial Separation of Surface and Transverse Tubular Electrophysiological Activity Electrophysiological Relationships Between Surface and Transverse Tubular Propagation of Excitation Physiological Modulation of Surface and Transverse Tubular Membrane Function Reconstruction of Transverse Tubular Functional Changes During Exercise Functional and Clinical Implications of Altered Transverse Tubular Membrane Properties 11 I Excitation-Contraction Coupling in Skeletal Muscle 135 137 141 143 145 147 150 152 153 154 11.1 Dependence of Excitation-Contraction Coupling on Membrane Potential 154 11.2 Involvement of Intracellular Ca2+ in Excitation-Contraction Coupling 11.3 The Measurement of Intracellular Ca2+ 11.4 Voltage-Dependent Release of Intracellularly Stored
Ca2+ in Excitation-Contraction Coupling 155 156 158 11.5 Triad Complexes Between the Transverse Tubular and Sarcoplasmic Reticular Membranes I60
11.6 11.7 11.8 11.9 11.10 11.11 11.12 11.13 11.14 Triggering Molecules for the Release of Sarcoplasmic Reticular Ca2+ Tubular Voltage Detection Mechanisms Triggering Excitation-Contraction Coupling Sarcoplasmic Reticular Ca2+ Release Through the Ryanodine Receptor Structural Evidence for DHPR-RyR Coupling Physiological Evidence for DHPR-RyR Configurational Coupling Cooperative DHPR-RyR Interactions Malignant Hyperthermia as an Inherited RyRl Defect Restoration of Sarcoplasmic Reticular Ca2+ Following Repolarisation Ryanodine Receptor-Na+ Channel Feedback Interactions Related to Excitation-Contraction Coupling 162 164 167 169 170 173 174 175 176 12 I Contractile Function in Skeletal Muscle iso 12.1 12.2 12.3 12.4 12.5 12.6 12.7 12.8 12.9 12.10 12.11 Isometric and Isotonic Contractions Isometric Twitch and Tetanus Isotonic Contractions Energetics of Contraction Work and Power Output by Muscle Heat Production During Muscle Activity Muscle Efficiency The Energy Source for Muscle Contraction Energy Balances During Muscular Exercise Muscle Fatigue Generation of Osmotically Active Metabolites During Muscular Exercise Osmotic Stabilisation by Cellular IГ Buffering Mechanisms Intrinsic Osmotic Consequences of Altered Ion Balances During Exercise Cellular Ionic Regulatory Mechanisms Ensuring Ion and Osmotic Balances During Exercise Trophic Changes in Skeletal Muscle Age-Related Sarcopaenia 180 12.12 12.13 12.14 12.15 12.16 181 183 185 186 187 187 188 190 192 192 193 195 197 197 198 13 I Cardiac Muscle 200 13.1 13.2 13.3 13.4 200 201 202 13.5 Structure and Organisation of Cardiac
Muscle Cells Electrical Initiation of the Heartbeat The Cardiac Action Potential Extracellular Measurement of Cardiac Electrophysiological Activity’ Physiological Interpretation of the Electrocardiogram 203 205
13.6 13.7 13.8 13.21 Ionic Currents in Cardiac Muscle Pacemaker Activity in Specialised Cardiac Regions Phase 0 Depolarisation and Early Phase 1 Repolarisation: Na+ and Transient Outward K+ Currents The Phase 2 Plateau: Inward Ca2+ Current Phase 3 Repolarisation: Voltage-Dependent Outward K* Currents Phase 4 Electrical Diastole: Inward Rectifying K+ Currents The Prolonged Refractory Period in Cardiac Muscle Varying Ionic Current Contributions in Different Cardiomyocyte Types Cardiac Excitation-Contraction Coupling Forms of Ca2+-Induced Ca2+ Release in Cardiac Myocyte Subtypes Cardiomyocyte Recovery from Excitation Cardiac and Skeletal Myocyte Activation Characteristics Compared Nervous Control of the Heart: FeedforwardModulation Feedback Actions on Excitation-Contraction Coupling Related to Ca2+ Homeostasis Feedback Actions on Excitation-Contraction Coupling Related to Cellular Energetics Recapitulation 14 I Ion Channel Function and Cardiac Arrhythmogenesis 14.1 14.2 Experimental Studies of Cardiac Arrhythmogenesis 226 Arrhythmic Substrate Arising from Spatial Heterogeneities in Action Potential Generation and Propagation at the Tissue Level 228 Arrhythmic Substrate Arising from Spatial Heterogeneities in Action Potential Recovery at the Tissue Level 230 Arrhythmic Substrate Arising from Temporal Electrophysiological Heterogeneities at the Tissue Level 231 Arrhythmic Triggers at the Cellular Level 233 Action Potential Activation and Conduction Abnormalities: Impaired Na+ Channel Function and Atrial Arrhythmia 235 Action Potential Activation and Conduction Abnormalities:
Impaired Na+ Channel Function and Ventricular Arrhythmia 2Յ6 Action Potential Repolarisation Abnormalities: Long QT Syndromes and Ventricular Arrhythmia 2 Յ8 Gain of Na+ Channel Function: LQTS3 239 Gain of Ca2+ Channel Function: LQTS8 (Timothy Syndrome) 242 13.9 13.10 13.11 13.12 13.13 13.14 13.15 13.16 13.17 13.18 13.19 13.20 14.3 14.4 14.5 14.6 14.7 14.8 14.9 14.10 206 207 2Ü8 20У 210 21Ü 211 211 212 214 215 216 218 221 222 224 225
14.11 Loss of К+ Channel Function: Hypokalaemic Murine Models for Acquired LQTS 14.12 Congenital LQTS Related to Loss of K+ Channel Function 14.13 Pro-Arrhythmic Perturbations in Intracellular Ca2+ Homeostasis 14.14 Altered Intracellular Ca2+ Homeostasis: Catecholaminergic Polymorphic Ventricular Tachycardia 14.15 Mechanistic Schemes for Ca2+-Mediated Arrhythmias 14.16 Pro-Arrhythmic Consequences of Compromised Cellular Energetics 14.17 Pro-Arrhythmic Structural Remodelling Resulting from Upstream Pathophysiological Changes 14.18 Translation of Mechanistic Insights into Therapeutic Strategy 15 I Smooth Muscle 15.1 15.2 15.3 15.4 15.5 15.6 15.7 15.8 15.9 15.10 15.11 15.12 15.13 15.14 Structure of Smooth Muscle Cells Functional Features of Smooth Muscle Interstitial Cell of Cajal Networks Pacing Properties of Interstitial Cells of Cajal Propagation of Interstitial Cell of Cajal Pacing Events Electrical Coupling Between Interstitial Cells of Cajal and Smooth Muscle Cells Membrane Excitation in Smooth Muscle Cells Excitation-Contraction Coupling in Smooth Muscle Cells Pharmacomechanical Coupling in Smooth Muscle Cells Store-Operated and Mechanosensitive Ion Channels in Smooth Muscle Cells Ca2+-Mediated Contractile Activation Effects of Myosin Light Chain Phosphorylation Levels Mechanical Properties of Smooth Muscle Propagation of Excitation and Contraction in Smooth Muscle Further Reading References Index Colour plates can be found between pages 140 and 141. 242 243 244 245 247 248 249 249 252 252 253 254 255 258 258 259 260 262 265 265 267 268 269 271 274 292
|
| adam_txt |
Contents Preface Acknowledgements List of Abbreviations page xiii xiv xv I I Structural Organisation of the Nervous System t 1.1 1.2 1.3 1.4 1.5 Nervous Systems The Anatomy of a Neuron Unmyelinated Nerve Fibres Myelinated Nerve Fibres Nerve Fibre Responses to Injury l 2 2 2 I Resting and Action Potentials ю 2.1 2.2 2.3 2.4 Electrophysiological Recording Methods Intracellular Recording of the MembranePotential Extracellular Recording of the Nervous Impulse Excitation to із 14 17 З I Background Ionic Homeostasis of Excitable Cells 22 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Structure of the Cell Membrane Ion Distributions in Nerve and Muscle The Genesis of Resting Potentials The Donnan Equilibrium System in Muscle Direct Tests of the Donnan Hypothesis The Active Transport of Ions Quantitative Reconstruction of Resting Cellular Ionic Homeostasis 22 4 I Membrane Permeability Changes During Excitation 4.1 4.2 4.3 4.4 4.5 Impedance Changes During the Spike The Sodium Hypothesis Predictions of the Sodium Hypothesis Voltage Clamp Experiments Equivalent Electrical Circuit Description of the Nerve Membrane 4.6 Separation of Ionic Current Components in Response to Voltage Change 4.7 Mathematical Reconstruction of Ionic Current Properties 5 1 Voltage-Gated Ion Channels 5.1 cDNA Sequencing Studies 5.2 The Structure of Voltage-Gated Ion Channels 4 8 25 26 28 31 32 38 41 41 41 43 46 47 49 52 55 55 55
5.3 5.4 5.5 5.6 5.7 Biophysical Measurements of Channel Protein Conformational Changes Charge Movements in Excitable Cell Membranes The Sodium Channel Gating Mechanism The Ionic Selectivity of Voltage-Gated Channels Effect of Ion Occupancy on Channel Permeation: The Independence Principle 6 1 Cable Theory and Saltatory Conduction 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 The Spread of Voltage Changes in a Cable System Passive Spread of Voltage Changes Along an Unmyelinated Nerve Spread of Excitation in an Unmyelinated Nerve Action Potential Conduction Velocity and Direction Saltatory Conduction in Myelinated Nerves Factors Affecting Conduction Velocity Factors Affecting the Threshold for Excitation After-potentials 7 1 Neuromuscular Transmission 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 The Motor Unit Presynaptic Transmitter Release Graded and Regenerative Components of the Postsynaptic Response The Qpantal Nature of Presynaptic Events Ionic Current Flows Underlying the End-Plate Potential Patch Clamp Studies The Nicotinic Acetylcholine Receptor Specific Pharmacological Properties of the Neuromuscular Junction 8 1 Synaptic Transmission in the Nervous System 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 8.9 8.10 Synaptic Excitation in Motor Neurons Excitatory Postsynaptic Potentials Inhibition in Motor Neurons Interaction of IPSPs with EPSPs Presynaptic Inhibition Slow Synaptic Potentials G-Protein-Linked Receptors Electrical Synapses Long-Term Potentiation and Depression Glial Buffering of the Interstitial Space Following Neuronal Activity 60 62 66 68 69 73 73 75 76 78 79 84 85 87 88 88 89 91 94 97 99 101
103 106 106 107 109 110 111 111 114 116 117 118
9 I The Mechanism of Contraction in Skeletal Muscle 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 9.9 9.10 9.11 10 Anatomy The Structure of the Myofibril The Sliding-Filament Theory The Lengths of the Filaments The Relation Between Sarcomere Length and Isometric Tension The Molecular Basis of Contraction Myosin Actin Interactions Between Actin, Myosin and ATP The Molecular Basis of Activation Maintenance of Structural Integrity in Contracting Sarcomeres I The Activation of Skeletal Muscle 121 121 122 124 125 125 127 127 129 130 131 132 135 10.1 Background Conductances in Skeletal Muscle 10.2 10.3 10.4 10.5 10.6 10.7 10.8 10.9 Membranes Ionic Currents Mediating Skeletal Muscle Membrane Activation The Surface and Transverse Tubular Membrane Systems in Skeletal Muscle Surface and Transverse Tubular Components of the Muscle Action Potential Partial Separation of Surface and Transverse Tubular Electrophysiological Activity Electrophysiological Relationships Between Surface and Transverse Tubular Propagation of Excitation Physiological Modulation of Surface and Transverse Tubular Membrane Function Reconstruction of Transverse Tubular Functional Changes During Exercise Functional and Clinical Implications of Altered Transverse Tubular Membrane Properties 11 I Excitation-Contraction Coupling in Skeletal Muscle 135 137 141 143 145 147 150 152 153 154 11.1 Dependence of Excitation-Contraction Coupling on Membrane Potential 154 11.2 Involvement of Intracellular Ca2+ in Excitation-Contraction Coupling 11.3 The Measurement of Intracellular Ca2+ 11.4 Voltage-Dependent Release of Intracellularly Stored
Ca2+ in Excitation-Contraction Coupling 155 156 158 11.5 Triad Complexes Between the Transverse Tubular and Sarcoplasmic Reticular Membranes I60
11.6 11.7 11.8 11.9 11.10 11.11 11.12 11.13 11.14 Triggering Molecules for the Release of Sarcoplasmic Reticular Ca2+ Tubular Voltage Detection Mechanisms Triggering Excitation-Contraction Coupling Sarcoplasmic Reticular Ca2+ Release Through the Ryanodine Receptor Structural Evidence for DHPR-RyR Coupling Physiological Evidence for DHPR-RyR Configurational Coupling Cooperative DHPR-RyR Interactions Malignant Hyperthermia as an Inherited RyRl Defect Restoration of Sarcoplasmic Reticular Ca2+ Following Repolarisation Ryanodine Receptor-Na+ Channel Feedback Interactions Related to Excitation-Contraction Coupling 162 164 167 169 170 173 174 175 176 12 I Contractile Function in Skeletal Muscle iso 12.1 12.2 12.3 12.4 12.5 12.6 12.7 12.8 12.9 12.10 12.11 Isometric and Isotonic Contractions Isometric Twitch and Tetanus Isotonic Contractions Energetics of Contraction Work and Power Output by Muscle Heat Production During Muscle Activity Muscle Efficiency The Energy Source for Muscle Contraction Energy Balances During Muscular Exercise Muscle Fatigue Generation of Osmotically Active Metabolites During Muscular Exercise Osmotic Stabilisation by Cellular IГ Buffering Mechanisms Intrinsic Osmotic Consequences of Altered Ion Balances During Exercise Cellular Ionic Regulatory Mechanisms Ensuring Ion and Osmotic Balances During Exercise Trophic Changes in Skeletal Muscle Age-Related Sarcopaenia 180 12.12 12.13 12.14 12.15 12.16 181 183 185 186 187 187 188 190 192 192 193 195 197 197 198 13 I Cardiac Muscle 200 13.1 13.2 13.3 13.4 200 201 202 13.5 Structure and Organisation of Cardiac
Muscle Cells Electrical Initiation of the Heartbeat The Cardiac Action Potential Extracellular Measurement of Cardiac Electrophysiological Activity’ Physiological Interpretation of the Electrocardiogram 203 205
13.6 13.7 13.8 13.21 Ionic Currents in Cardiac Muscle Pacemaker Activity in Specialised Cardiac Regions Phase 0 Depolarisation and Early Phase 1 Repolarisation: Na+ and Transient Outward K+ Currents The Phase 2 Plateau: Inward Ca2+ Current Phase 3 Repolarisation: Voltage-Dependent Outward K* Currents Phase 4 Electrical Diastole: Inward Rectifying K+ Currents The Prolonged Refractory Period in Cardiac Muscle Varying Ionic Current Contributions in Different Cardiomyocyte Types Cardiac Excitation-Contraction Coupling Forms of Ca2+-Induced Ca2+ Release in Cardiac Myocyte Subtypes Cardiomyocyte Recovery from Excitation Cardiac and Skeletal Myocyte Activation Characteristics Compared Nervous Control of the Heart: FeedforwardModulation Feedback Actions on Excitation-Contraction Coupling Related to Ca2+ Homeostasis Feedback Actions on Excitation-Contraction Coupling Related to Cellular Energetics Recapitulation 14 I Ion Channel Function and Cardiac Arrhythmogenesis 14.1 14.2 Experimental Studies of Cardiac Arrhythmogenesis 226 Arrhythmic Substrate Arising from Spatial Heterogeneities in Action Potential Generation and Propagation at the Tissue Level 228 Arrhythmic Substrate Arising from Spatial Heterogeneities in Action Potential Recovery at the Tissue Level 230 Arrhythmic Substrate Arising from Temporal Electrophysiological Heterogeneities at the Tissue Level 231 Arrhythmic Triggers at the Cellular Level 233 Action Potential Activation and Conduction Abnormalities: Impaired Na+ Channel Function and Atrial Arrhythmia 235 Action Potential Activation and Conduction Abnormalities:
Impaired Na+ Channel Function and Ventricular Arrhythmia 2Յ6 Action Potential Repolarisation Abnormalities: Long QT Syndromes and Ventricular Arrhythmia 2 Յ8 Gain of Na+ Channel Function: LQTS3 239 Gain of Ca2+ Channel Function: LQTS8 (Timothy Syndrome) 242 13.9 13.10 13.11 13.12 13.13 13.14 13.15 13.16 13.17 13.18 13.19 13.20 14.3 14.4 14.5 14.6 14.7 14.8 14.9 14.10 206 207 2Ü8 20У 210 21Ü 211 211 212 214 215 216 218 221 222 224 225
14.11 Loss of К+ Channel Function: Hypokalaemic Murine Models for Acquired LQTS 14.12 Congenital LQTS Related to Loss of K+ Channel Function 14.13 Pro-Arrhythmic Perturbations in Intracellular Ca2+ Homeostasis 14.14 Altered Intracellular Ca2+ Homeostasis: Catecholaminergic Polymorphic Ventricular Tachycardia 14.15 Mechanistic Schemes for Ca2+-Mediated Arrhythmias 14.16 Pro-Arrhythmic Consequences of Compromised Cellular Energetics 14.17 Pro-Arrhythmic Structural Remodelling Resulting from Upstream Pathophysiological Changes 14.18 Translation of Mechanistic Insights into Therapeutic Strategy 15 I Smooth Muscle 15.1 15.2 15.3 15.4 15.5 15.6 15.7 15.8 15.9 15.10 15.11 15.12 15.13 15.14 Structure of Smooth Muscle Cells Functional Features of Smooth Muscle Interstitial Cell of Cajal Networks Pacing Properties of Interstitial Cells of Cajal Propagation of Interstitial Cell of Cajal Pacing Events Electrical Coupling Between Interstitial Cells of Cajal and Smooth Muscle Cells Membrane Excitation in Smooth Muscle Cells Excitation-Contraction Coupling in Smooth Muscle Cells Pharmacomechanical Coupling in Smooth Muscle Cells Store-Operated and Mechanosensitive Ion Channels in Smooth Muscle Cells Ca2+-Mediated Contractile Activation Effects of Myosin Light Chain Phosphorylation Levels Mechanical Properties of Smooth Muscle Propagation of Excitation and Contraction in Smooth Muscle Further Reading References Index Colour plates can be found between pages 140 and 141. 242 243 244 245 247 248 249 249 252 252 253 254 255 258 258 259 260 262 265 265 267 268 269 271 274 292 |
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| discipline | Biologie Medizin |
| discipline_str_mv | Biologie Medizin |
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| id | DE-604.BV047103936 |
| illustrated | Illustrated |
| index_date | 2024-07-03T16:23:54Z |
| indexdate | 2024-07-10T09:02:42Z |
| institution | BVB |
| isbn | 9781108816878 9781108495059 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032510251 |
| oclc_num | 1241675839 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-11 |
| physical | xxvii, 297 Seiten Illustrationen, Diagramme |
| publishDate | 2021 |
| publishDateSearch | 2021 |
| publishDateSort | 2021 |
| publisher | Cambridge University Press |
| record_format | marc |
| spelling | Huang, Christopher 1951- (DE-588)172146291 aut Keynes & Aidley's Nerve and muscle Christopher L.-H. Huang, University of Cambridge Nerve and muscle Fifth edition Cambridge, United Kingdom Cambridge University Press [2021] xxvii, 297 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Neurophysiologie (DE-588)4041897-2 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Nerv (DE-588)4171476-3 gnd rswk-swf Muskel (DE-588)4040895-4 gnd rswk-swf Muskel (DE-588)4040895-4 s Physiologie (DE-588)4045981-0 s DE-604 Neurophysiologie (DE-588)4041897-2 s Nerv (DE-588)4171476-3 s Keynes, Richard D. 1919-2010 Begründer eines Werks (DE-588)13426813X oth Aidley, David J. Begründer eines Werks oth Erscheint auch als Online-Ausgabe 978-1-108-85296-8 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032510251&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Huang, Christopher 1951- Keynes & Aidley's Nerve and muscle Neurophysiologie (DE-588)4041897-2 gnd Physiologie (DE-588)4045981-0 gnd Nerv (DE-588)4171476-3 gnd Muskel (DE-588)4040895-4 gnd |
| subject_GND | (DE-588)4041897-2 (DE-588)4045981-0 (DE-588)4171476-3 (DE-588)4040895-4 |
| title | Keynes & Aidley's Nerve and muscle |
| title_alt | Nerve and muscle |
| title_auth | Keynes & Aidley's Nerve and muscle |
| title_exact_search | Keynes & Aidley's Nerve and muscle |
| title_exact_search_txtP | Keynes & Aidley's Nerve and muscle |
| title_full | Keynes & Aidley's Nerve and muscle Christopher L.-H. Huang, University of Cambridge |
| title_fullStr | Keynes & Aidley's Nerve and muscle Christopher L.-H. Huang, University of Cambridge |
| title_full_unstemmed | Keynes & Aidley's Nerve and muscle Christopher L.-H. Huang, University of Cambridge |
| title_short | Keynes & Aidley's Nerve and muscle |
| title_sort | keynes aidley s nerve and muscle |
| topic | Neurophysiologie (DE-588)4041897-2 gnd Physiologie (DE-588)4045981-0 gnd Nerv (DE-588)4171476-3 gnd Muskel (DE-588)4040895-4 gnd |
| topic_facet | Neurophysiologie Physiologie Nerv Muskel |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032510251&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT huangchristopher keynesaidleysnerveandmuscle AT keynesrichardd keynesaidleysnerveandmuscle AT aidleydavidj keynesaidleysnerveandmuscle AT huangchristopher nerveandmuscle AT keynesrichardd nerveandmuscle AT aidleydavidj nerveandmuscle |