Kidney biomarkers: clinical aspects and laboratory determination
Gespeichert in:
Format: | Elektronisch E-Book |
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Sprache: | English |
Veröffentlicht: |
Amsterdam
Academic Press
2020
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Schlagworte: | |
Online-Zugang: | TUM01 |
Beschreibung: | Includes index Further reading -- Chapter 2: Utility of the ''omics ́́in kidney disease: Methods of analysis, sampling considerations, and technical approa ... -- Introduction -- Statistical methods in analysis and interpretation of biomarkers in kidney disease -- Metrics for prediction performance (diagnostic potential) -- Quantification of prediction performance -- True positive rate and false positive rate -- Receiver-operating characteristic curve -- Summary indices -- Area under the ROC curve (AUC) -- Optimal prediction threshold -- Partial area under the curve Limitations of statistical metrics used for prediction performance -- Metrics to evaluating incremental diagnostic value -- Incremental value: How to evaluate? -- Improvement in discrimination -- Improvement in reclassification -- Net reclassification improvement -- Categorical net reclassification improvement -- Weighted net reclassification improvement -- Category-free net reclassification improvement -- Integrated discrimination improvement -- Decision and clinical use of analytic measures -- Recommendations for sample collection, storage, and preparation -- Tissue samples -- Biofluids Nontargeted versus targeted analysis -- Proteomics and metabolomics in nephrology -- Potential impact of proteomics and metabolomics in renal diseases -- Proteomics and the kidney -- The proteomics sample -- Urine -- Kidney tissue and cell culture -- Techniques used in proteome analysis -- Proteomics methods based on mass spectrometry -- First step: Protein separation -- Gel-based proteome analysis -- Gel-free proteome analysis -- Liquid chromatography (LC) -- Capillary electrophoresis -- Second step: Protein identification Two-dimensional gel electrophoresis coupled with mass spectrometry (2DE-MS) -- Liquid chromatography coupled to mass spectrometry (LC-MS/MS) -- Capillary electrophoresis coupled with mass spectrometry (CE-MS) -- Matrix-assisted laser desorption/ionization-time of flight coupled with mass spectrometry (MALDI-TOF/MS) -- Solid-phase chromatography coupled with mass spectrometry (SELDI-MS) -- Differential protein profiling -- Mass spectrometry -- (a) Peptide mass fingerprinting -- (b) Electrospray ionization -- (c) Peptide sequencing using tandem mass spectrometers |
Beschreibung: | 1 Online-Ressource |
ISBN: | 9780128163740 0128163747 |
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500 | |a Further reading -- Chapter 2: Utility of the ''omics ́́in kidney disease: Methods of analysis, sampling considerations, and technical approa ... -- Introduction -- Statistical methods in analysis and interpretation of biomarkers in kidney disease -- Metrics for prediction performance (diagnostic potential) -- Quantification of prediction performance -- True positive rate and false positive rate -- Receiver-operating characteristic curve -- Summary indices -- Area under the ROC curve (AUC) -- Optimal prediction threshold -- Partial area under the curve | ||
500 | |a Limitations of statistical metrics used for prediction performance -- Metrics to evaluating incremental diagnostic value -- Incremental value: How to evaluate? -- Improvement in discrimination -- Improvement in reclassification -- Net reclassification improvement -- Categorical net reclassification improvement -- Weighted net reclassification improvement -- Category-free net reclassification improvement -- Integrated discrimination improvement -- Decision and clinical use of analytic measures -- Recommendations for sample collection, storage, and preparation -- Tissue samples -- Biofluids | ||
500 | |a Nontargeted versus targeted analysis -- Proteomics and metabolomics in nephrology -- Potential impact of proteomics and metabolomics in renal diseases -- Proteomics and the kidney -- The proteomics sample -- Urine -- Kidney tissue and cell culture -- Techniques used in proteome analysis -- Proteomics methods based on mass spectrometry -- First step: Protein separation -- Gel-based proteome analysis -- Gel-free proteome analysis -- Liquid chromatography (LC) -- Capillary electrophoresis -- Second step: Protein identification | ||
500 | |a Two-dimensional gel electrophoresis coupled with mass spectrometry (2DE-MS) -- Liquid chromatography coupled to mass spectrometry (LC-MS/MS) -- Capillary electrophoresis coupled with mass spectrometry (CE-MS) -- Matrix-assisted laser desorption/ionization-time of flight coupled with mass spectrometry (MALDI-TOF/MS) -- Solid-phase chromatography coupled with mass spectrometry (SELDI-MS) -- Differential protein profiling -- Mass spectrometry -- (a) Peptide mass fingerprinting -- (b) Electrospray ionization -- (c) Peptide sequencing using tandem mass spectrometers | ||
650 | 4 | |a Kidneys |x Diseases |x Molecular diagnosis | |
650 | 4 | |a Biochemical markers | |
700 | 1 | |a Ahuja, Seema S. |e Sonstige |4 oth | |
700 | 1 | |a Castillo, Brian |e Sonstige |4 oth | |
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discipline_str_mv | Medizin |
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index_date | 2024-07-03T16:07:39Z |
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institution | BVB |
isbn | 9780128163740 0128163747 |
language | English |
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spelling | Kidney biomarkers clinical aspects and laboratory determination edited by Seema S. Ahuja, Brian Castillo Amsterdam Academic Press 2020 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Includes index Further reading -- Chapter 2: Utility of the ''omics ́́in kidney disease: Methods of analysis, sampling considerations, and technical approa ... -- Introduction -- Statistical methods in analysis and interpretation of biomarkers in kidney disease -- Metrics for prediction performance (diagnostic potential) -- Quantification of prediction performance -- True positive rate and false positive rate -- Receiver-operating characteristic curve -- Summary indices -- Area under the ROC curve (AUC) -- Optimal prediction threshold -- Partial area under the curve Limitations of statistical metrics used for prediction performance -- Metrics to evaluating incremental diagnostic value -- Incremental value: How to evaluate? -- Improvement in discrimination -- Improvement in reclassification -- Net reclassification improvement -- Categorical net reclassification improvement -- Weighted net reclassification improvement -- Category-free net reclassification improvement -- Integrated discrimination improvement -- Decision and clinical use of analytic measures -- Recommendations for sample collection, storage, and preparation -- Tissue samples -- Biofluids Nontargeted versus targeted analysis -- Proteomics and metabolomics in nephrology -- Potential impact of proteomics and metabolomics in renal diseases -- Proteomics and the kidney -- The proteomics sample -- Urine -- Kidney tissue and cell culture -- Techniques used in proteome analysis -- Proteomics methods based on mass spectrometry -- First step: Protein separation -- Gel-based proteome analysis -- Gel-free proteome analysis -- Liquid chromatography (LC) -- Capillary electrophoresis -- Second step: Protein identification Two-dimensional gel electrophoresis coupled with mass spectrometry (2DE-MS) -- Liquid chromatography coupled to mass spectrometry (LC-MS/MS) -- Capillary electrophoresis coupled with mass spectrometry (CE-MS) -- Matrix-assisted laser desorption/ionization-time of flight coupled with mass spectrometry (MALDI-TOF/MS) -- Solid-phase chromatography coupled with mass spectrometry (SELDI-MS) -- Differential protein profiling -- Mass spectrometry -- (a) Peptide mass fingerprinting -- (b) Electrospray ionization -- (c) Peptide sequencing using tandem mass spectrometers Kidneys Diseases Molecular diagnosis Biochemical markers Ahuja, Seema S. Sonstige oth Castillo, Brian Sonstige oth Erscheint auch als Druck-Ausgabe 9780128159231 Erscheint auch als Druck-Ausgabe 0128159235 |
spellingShingle | Kidney biomarkers clinical aspects and laboratory determination Kidneys Diseases Molecular diagnosis Biochemical markers |
title | Kidney biomarkers clinical aspects and laboratory determination |
title_auth | Kidney biomarkers clinical aspects and laboratory determination |
title_exact_search | Kidney biomarkers clinical aspects and laboratory determination |
title_exact_search_txtP | Kidney biomarkers clinical aspects and laboratory determination |
title_full | Kidney biomarkers clinical aspects and laboratory determination edited by Seema S. Ahuja, Brian Castillo |
title_fullStr | Kidney biomarkers clinical aspects and laboratory determination edited by Seema S. Ahuja, Brian Castillo |
title_full_unstemmed | Kidney biomarkers clinical aspects and laboratory determination edited by Seema S. Ahuja, Brian Castillo |
title_short | Kidney biomarkers |
title_sort | kidney biomarkers clinical aspects and laboratory determination |
title_sub | clinical aspects and laboratory determination |
topic | Kidneys Diseases Molecular diagnosis Biochemical markers |
topic_facet | Kidneys Diseases Molecular diagnosis Biochemical markers |
work_keys_str_mv | AT ahujaseemas kidneybiomarkersclinicalaspectsandlaboratorydetermination AT castillobrian kidneybiomarkersclinicalaspectsandlaboratorydetermination |