Immune memory and vaccines: great debates : a subject collection from Cold Spring Harbor perspectives in biology
Gespeichert in:
| 1. Verfasser: | |
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| Weitere Verfasser: | |
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cold Spring Harbor, New York
Cold Spring Harbor Laboratory Press
[2018]
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| Schriftenreihe: | Cold Spring Harbor perspectives in biology
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext Inhaltsverzeichnis Klappentext |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | ix, 418 Seiten Illustrationen 27 cm |
| ISBN: | 9781621821540 1621821544 |
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| 245 | 1 | 0 | |a Immune memory and vaccines |b great debates : a subject collection from Cold Spring Harbor perspectives in biology |c edited by Shane Crotty, La Jolla Institute for Allergy and Immunology, Rafi Ahmed, Emory Vaccine Center |
| 264 | 1 | |a Cold Spring Harbor, New York |b Cold Spring Harbor Laboratory Press |c [2018] | |
| 264 | 4 | |c © 2018 | |
| 300 | |a ix, 418 Seiten |b Illustrationen |c 27 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Cold Spring Harbor perspectives in biology | |
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Immunologic memory | |
| 650 | 4 | |a Vaccines | |
| 650 | 4 | |a B cells | |
| 650 | 4 | |a T cells | |
| 650 | 4 | |a Immunologic Memory | |
| 650 | 4 | |a Vaccines | |
| 650 | 4 | |a B-Lymphocytes | |
| 650 | 4 | |a T-Lymphocytes | |
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| 700 | 1 | |a Crotty, Shane |4 edt |4 wpr |4 aut | |
| 700 | 1 | |a Ahmed, Rafi |0 (DE-588)173280900 |4 edt |4 wpr | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |z 978-1-621822-58-5 |
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Datensatz im Suchindex
| _version_ | 1804182017589379072 |
|---|---|
| adam_text | Contents Preface, ¡x DO MEMORY CD4 T CELLS KEEP THEIR CELL-TYPE PROGRAMMING: PLASTICITY VERSUS FATE COMMITMENT? Epigenome: A Dynamic Vehicle for Transmitting and Recording Cytokine Signaling, 1 John L Johnson and Golnaz Vahedi Т-Cell Heterogeneity, Plasticity, and Selection in Humans, 9 Federica Sallasta, Antonino Cassotta, Daniel Hoces, Mathilde Foglierini, and Antonio Lanzavecchia Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells, 1 7 Shane Crotty WHAT ARE THE PRIMARY LIMITATIONS IN B-CELL AFFINITY MATURATION, AND HOW MUCH AFFINITY MATURATION CAN WE DRIVE WITH VACCINATION? A Role for Antibody Feedback, 29 Kai֊Mkhael Toellner, Daniel M.-Y. Sze, and Yang Zhang Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection?, 37 Christopher T. Stamper and Patrick C. Wtlson Lessons from the Antibody Response to HIV-1,45 Gabriel D. Victora and Hugo Mouquet Breaking through Immunity s Class Ceiling, 53 Garnett Kelsoe and Barton F. Haynes WHICH DENGUE VACCINE APPROACH IS THE MOST PROMISING, AND SHOULD WE BE CONCERNED ABOUT ENHANCED DISEASE AFTER VACCINATION? The Risks of Incomplete immunity to Dengue Virus Revealed by Vaccination, 61 Stephen S. Whitehead and Kanta Subbarao The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials, 69 Aravinda Aí. de Silva and Eva Harris
Contents Questions Raised by the Development and Implementation of Dengue Vaccines: Example of the Sanofi Rasteur Tetravalent Dengue Vaccine, 81 Bruno Guy There Is Only One True Winner, 91 Scott B. Halstead The Challenges of a Dengue Vaccine, 103 Gavin Screaton and Juthathip Mongkolsapaya IS IT POSSIBLE TO DEVELOP CANCER VACCINES TO NEOANTIGENS, WHAT ARE THE MAJOR CHALLENGES, AND HOW CAN THESE BE OVERCOME? Neoantigens: Nothing New in Spite of the Name, 113 Olivera ]. Finn and Hans-Georg Rammensee Targeting the Right Antigens in the Right Patients, 121 Stephen P. Schoenberger Neoantigens as Vaccine Targets for Cancer, 127 Haydn T. Kissiek IS IT POSSIBLE TO DEVELOP A UNIVERSAL INFLUENZAVÍRUS VACCINE? Potential Target Antigens and Critical Aspects for a Universal Influenza Vaccine, 137 Florian Krammer, Adolfo García-Sastre, and Peter Palese Outflanking Antibody Immunodominance on the Road to Universal Influenza Vaccination, 145 Davide Angeletti and Jonathan W. Yewdell Immunogenetic Considerations Underlying В-Cell Biology in the Development of a Ran-Subtype Influenza AVaccine Targeting the Hemagglutinin Stem, 155 Sarah E Andrews, Barney S. Graham, John R. Mascóla, and Adrian B. McDermott Potential for a Universal Influenza Vaccine, 163 James E. Crowe, Jr. DO THE MICROBIOTA INFLUENCE VACCINES AND PROTECTIVE IMMUNITYTO PATHOGENS? Engaging Our Endogenous Adjuvants, 171 Nicholas Collins and Yasmine Belkaid If So, Is There Potential for Efficacious Microbiota-Based Vaccines?, 179 Dan R. Littman VI
Contents Issues of Sovereignty, Federalism, and Points-Testing in the Prokaryotic and Eukaryotic Spaces of the Host-Microbial Superorganism, 187 Andrew J. Macpherson DO MEMORY В CELLS FORM SECONDARY GERMINAL CENTERS? Impact of Antibody Class and Quality of Memory Т-Cell Help at Recall, 197 Louise J. McHeyzer-Williams, Chad Dufaud, and Michael G. McHeyzer-Williams It Depends, 207 Kathryn A. Pape and Marc K. Jenkins Yes and No, 213 Mark J. Shlomchik WILL SYSTEMS BIOLOGY DELIVER ITS PROMISE AND CONTRIBUTE TO THE DEVELOPMENT OF NEW OR IMPROVED VACCINES? Seeing the Forest Rather than a Few Trees, 221 Mark M. Davis and Cristina M. Tato From Datato Understanding through Systems Biology, 231 Thomas Hagan and Bali Pulendran Systems Biology Views of Vaccine Innate and Adaptive Immunity, 241 Rino Rappuoli, Emilio Siena, and Oretta Finco What Really Constitutes the Study of Systems Biology and How Might Such an Approach Facilitate Vaccine Design, 251 Ronald N. Germain WHAT IS THE PREDICTIVE VALUE OF ANIMAL MODELS FOR VACCINE EFFICACY IN HUMANS? The Importance of Bridging Studies and Species-Independent Correlates of Protection, 259 Hana Golding, Surender Khurana, and Marina Zaitseva Reevaluating the Potential of Mouse Models for the Human Immune System, 271 Stephen C. Jameson and David Masopust Rigorous Simian Immunodefiency Virus Vaccine Trials Can Be Instructive, 279 Mauricio A. Martins and David I. Watkins Consideration of Strategies to Improve the Value of Animal Models, 289 Ramin Sedaghat Herati and E. John Wherry VII
Contents IS A HUMAN CD8 T-CELL VACCINE POSSIBLE, AND IF SO, WHAT WOULD IT TAKE? CD8 Т-Cell Vaccines: To В or Not to B?, 297 Lalit К. Berna, Stephen C. Jameson, and David Masopust Could a CD8+ Т-Cell Vaccine Prevent Persistent HIV Infection?, 303 Andrew J. McMichael CD8 T-Cell-Mediated Protective Immunity and Vaccination against Enteric Bacteria, 313 Marcelo В. Sztein WHAT IS WRONG WITH PERTUSSIS VACCINE IMMUNITY? The Problem of Waning Effectiveness of Pertussis Vaccines, 323 Nicolas Burdin, Lori Kestenbaum Handy, and Stanley A. Plotkin Why Immunological Memory to Pertussis Is Failing, 341 Dmitri A. Diavatopoulos and Kathryn Margaret Edwards Inducing and Recalling Vaccine-Specific Immunity, 349 Christiane S. Eberhardt and Claire-Anne Siegrist WHAT ARE THE MOST POWERFUL IMMUNOGEN DESIGN VACCINE STRATEGIES? A Structural Biologist s Perspective, 359 Peter D. Kwong Reverse Vaccinology 2.0 Shows Great Promise, 369 Dennis R. Burton IS THERE NATURAL KILLER CELL MEMORY AND CAN IT BE HARNESSED BY VACCINATION? Natural Killer Cells in Vaccination, 377 Harold R. Neely, Irina B. Mazo, Carmen Gerlach, and Ulrich H. von Andrian Vaccination Strategies Based on NK Cell and ILC Memory, 389 Megan A. Cooper, Todd A. Fehniger, and Marco Colonna NK Cell Memory and Immunization Strategies against Infectious Diseases and Cancer, 397 Joseph C. Sun and Lewis L. Lanier Can Natural Killer and CD8 T Cells Switch Jobs?, 405 Christine A. Biron and Marcus Altfeld Index, 413 VIII
Immune Memory and Vaccines Great Debates iler an initial encounter with a pathogen, the adaptive immune /Vsvstem creates immune՝ cells that remember the antigens on the pathogen and allow the hoch to rapitile mount a response during future encounters. Vaccines likewise generate immune memory, preventing the body from succumbing to potentially dangerous infections. Understand ing the mechanistic basis of immune memory is therefore essential for designing et lectivo vaccines. Written and edited bv exports in the field, this collection from Cold Spring Horhor Berspeclivos in Biology foc uses on the critical questions c urrently debated in the field of immune memore and vac cination. Topics include the plasticity of memory CD4 T cells, the formation of germinal centers by memory В cells, the contributions ot natural killer cells to immune mem ory, and the՝ influence ot commensal microbiola on immune responses. Several contributors respond to each question, providing a variety ot fresh, concise perspectives on each topic. Additional questions address the development and effectiveness of vac cines ter various pathogens (e.g., dengue virus and BordotcILi /icrtussis), as well as ellorts to develop vaccines against cancer. This volume is therefore valuable for all immunologists, cell biologists, and medical scientists wish ing to understand immunological memory, vaccines, and the implications for human health and disease.
Contents Preface, ¡x DO MEMORY CD4 T CELLS KEEP THEIR CELL-TYPE PROGRAMMING: PLASTICITY VERSUS FATE COMMITMENT? Epigenome: A Dynamic Vehicle for Transmitting and Recording Cytokine Signaling, 1 John L Johnson and Golnaz Vahedi Т-Cell Heterogeneity, Plasticity, and Selection in Humans, 9 Federica Sallasta, Antonino Cassotta, Daniel Hoces, Mathilde Foglierini, and Antonio Lanzavecchia Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells, 1 7 Shane Crotty WHAT ARE THE PRIMARY LIMITATIONS IN B-CELL AFFINITY MATURATION, AND HOW MUCH AFFINITY MATURATION CAN WE DRIVE WITH VACCINATION? A Role for Antibody Feedback, 29 Kai֊Mkhael Toellner, Daniel M.-Y. Sze, and Yang Zhang Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection?, 37 Christopher T. Stamper and Patrick C. Wtlson Lessons from the Antibody Response to HIV-1,45 Gabriel D. Victora and Hugo Mouquet Breaking through Immunity s Class Ceiling, 53 Garnett Kelsoe and Barton F. Haynes WHICH DENGUE VACCINE APPROACH IS THE MOST PROMISING, AND SHOULD WE BE CONCERNED ABOUT ENHANCED DISEASE AFTER VACCINATION? The Risks of Incomplete immunity to Dengue Virus Revealed by Vaccination, 61 Stephen S. Whitehead and Kanta Subbarao The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials, 69 Aravinda Aí. de Silva and Eva Harris
Contents Questions Raised by the Development and Implementation of Dengue Vaccines: Example of the Sanofi Rasteur Tetravalent Dengue Vaccine, 81 Bruno Guy There Is Only One True Winner, 91 Scott B. Halstead The Challenges of a Dengue Vaccine, 103 Gavin Screaton and Juthathip Mongkolsapaya IS IT POSSIBLE TO DEVELOP CANCER VACCINES TO NEOANTIGENS, WHAT ARE THE MAJOR CHALLENGES, AND HOW CAN THESE BE OVERCOME? Neoantigens: Nothing New in Spite of the Name, 113 Olivera ]. Finn and Hans-Georg Rammensee Targeting the Right Antigens in the Right Patients, 121 Stephen P. Schoenberger Neoantigens as Vaccine Targets for Cancer, 127 Haydn T. Kissiek IS IT POSSIBLE TO DEVELOP A UNIVERSAL INFLUENZAVÍRUS VACCINE? Potential Target Antigens and Critical Aspects for a Universal Influenza Vaccine, 137 Florian Krammer, Adolfo García-Sastre, and Peter Palese Outflanking Antibody Immunodominance on the Road to Universal Influenza Vaccination, 145 Davide Angeletti and Jonathan W. Yewdell Immunogenetic Considerations Underlying В-Cell Biology in the Development of a Ran-Subtype Influenza AVaccine Targeting the Hemagglutinin Stem, 155 Sarah E Andrews, Barney S. Graham, John R. Mascóla, and Adrian B. McDermott Potential for a Universal Influenza Vaccine, 163 James E. Crowe, Jr. DO THE MICROBIOTA INFLUENCE VACCINES AND PROTECTIVE IMMUNITYTO PATHOGENS? Engaging Our Endogenous Adjuvants, 171 Nicholas Collins and Yasmine Belkaid If So, Is There Potential for Efficacious Microbiota-Based Vaccines?, 179 Dan R. Littman VI
Contents Issues of Sovereignty, Federalism, and Points-Testing in the Prokaryotic and Eukaryotic Spaces of the Host-Microbial Superorganism, 187 Andrew J. Macpherson DO MEMORY В CELLS FORM SECONDARY GERMINAL CENTERS? Impact of Antibody Class and Quality of Memory Т-Cell Help at Recall, 197 Louise J. McHeyzer-Williams, Chad Dufaud, and Michael G. McHeyzer-Williams It Depends, 207 Kathryn A. Pape and Marc K. Jenkins Yes and No, 213 Mark J. Shlomchik WILL SYSTEMS BIOLOGY DELIVER ITS PROMISE AND CONTRIBUTE TO THE DEVELOPMENT OF NEW OR IMPROVED VACCINES? Seeing the Forest Rather than a Few Trees, 221 Mark M. Davis and Cristina M. Tato From Datato Understanding through Systems Biology, 231 Thomas Hagan and Bali Pulendran Systems Biology Views of Vaccine Innate and Adaptive Immunity, 241 Rino Rappuoli, Emilio Siena, and Oretta Finco What Really Constitutes the Study of Systems Biology and How Might Such an Approach Facilitate Vaccine Design, 251 Ronald N. Germain WHAT IS THE PREDICTIVE VALUE OF ANIMAL MODELS FOR VACCINE EFFICACY IN HUMANS? The Importance of Bridging Studies and Species-Independent Correlates of Protection, 259 Hana Golding, Surender Khurana, and Marina Zaitseva Reevaluating the Potential of Mouse Models for the Human Immune System, 271 Stephen C. Jameson and David Masopust Rigorous Simian Immunodefiency Virus Vaccine Trials Can Be Instructive, 279 Mauricio A. Martins and David I. Watkins Consideration of Strategies to Improve the Value of Animal Models, 289 Ramin Sedaghat Herati and E. John Wherry VII
Contents IS A HUMAN CD8 T-CELL VACCINE POSSIBLE, AND IF SO, WHAT WOULD IT TAKE? CD8 Т-Cell Vaccines: To В or Not to B?, 297 Lalit К. Berna, Stephen C. Jameson, and David Masopust Could a CD8+ Т-Cell Vaccine Prevent Persistent HIV Infection?, 303 Andrew J. McMichael CD8 T-Cell-Mediated Protective Immunity and Vaccination against Enteric Bacteria, 313 Marcelo В. Sztein WHAT IS WRONG WITH PERTUSSIS VACCINE IMMUNITY? The Problem of Waning Effectiveness of Pertussis Vaccines, 323 Nicolas Burdin, Lori Kestenbaum Handy, and Stanley A. Plotkin Why Immunological Memory to Pertussis Is Failing, 341 Dmitri A. Diavatopoulos and Kathryn Margaret Edwards Inducing and Recalling Vaccine-Specific Immunity, 349 Christiane S. Eberhardt and Claire-Anne Siegrist WHAT ARE THE MOST POWERFUL IMMUNOGEN DESIGN VACCINE STRATEGIES? A Structural Biologist s Perspective, 359 Peter D. Kwong Reverse Vaccinology 2.0 Shows Great Promise, 369 Dennis R. Burton IS THERE NATURAL KILLER CELL MEMORY AND CAN IT BE HARNESSED BY VACCINATION? Natural Killer Cells in Vaccination, 377 Harold R. Neely, Irina B. Mazo, Carmen Gerlach, and Ulrich H. von Andrian Vaccination Strategies Based on NK Cell and ILC Memory, 389 Megan A. Cooper, Todd A. Fehniger, and Marco Colonna NK Cell Memory and Immunization Strategies against Infectious Diseases and Cancer, 397 Joseph C. Sun and Lewis L. Lanier Can Natural Killer and CD8 T Cells Switch Jobs?, 405 Christine A. Biron and Marcus Altfeld Index, 413 VIII
Immune Memory and Vaccines Great Debates iler an initial encounter with a pathogen, the adaptive immune /Vsvstem creates immune՝ cells that remember the antigens on the pathogen and allow the hoch to rapitile mount a response during future encounters. Vaccines likewise generate immune memory, preventing the body from succumbing to potentially dangerous infections. Understand ing the mechanistic basis of immune memory is therefore essential for designing et lectivo vaccines. Written and edited bv exports in the field, this collection from Cold Spring Horhor Berspeclivos in Biology foc uses on the critical questions c urrently debated in the field of immune memore and vac cination. Topics include the plasticity of memory CD4 T cells, the formation of germinal centers by memory В cells, the contributions ot natural killer cells to immune mem ory, and the՝ influence ot commensal microbiola on immune responses. Several contributors respond to each question, providing a variety ot fresh, concise perspectives on each topic. Additional questions address the development and effectiveness of vac cines ter various pathogens (e.g., dengue virus and BordotcILi /icrtussis), as well as ellorts to develop vaccines against cancer. This volume is therefore valuable for all immunologists, cell biologists, and medical scientists wish ing to understand immunological memory, vaccines, and the implications for human health and disease.
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Contents Preface, ¡x DO MEMORY CD4 T CELLS KEEP THEIR CELL-TYPE PROGRAMMING: PLASTICITY VERSUS FATE COMMITMENT? Epigenome: A Dynamic Vehicle for Transmitting and Recording Cytokine Signaling, 1 John L Johnson and Golnaz Vahedi Т-Cell Heterogeneity, Plasticity, and Selection in Humans, 9 Federica Sallasta, Antonino Cassotta, Daniel Hoces, Mathilde Foglierini, and Antonio Lanzavecchia Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells, 1 7 Shane Crotty WHAT ARE THE PRIMARY LIMITATIONS IN B-CELL AFFINITY MATURATION, AND HOW MUCH AFFINITY MATURATION CAN WE DRIVE WITH VACCINATION? A Role for Antibody Feedback, 29 Kai֊Mkhael Toellner, Daniel M.-Y. Sze, and Yang Zhang Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection?, 37 Christopher T. Stamper and Patrick C. Wtlson Lessons from the Antibody Response to HIV-1,45 Gabriel D. Victora and Hugo Mouquet Breaking through Immunity's Class Ceiling, 53 Garnett Kelsoe and Barton F. Haynes WHICH DENGUE VACCINE APPROACH IS THE MOST PROMISING, AND SHOULD WE BE CONCERNED ABOUT ENHANCED DISEASE AFTER VACCINATION? The Risks of Incomplete immunity to Dengue Virus Revealed by Vaccination, 61 Stephen S. Whitehead and Kanta Subbarao The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials, 69 Aravinda Aí. de Silva and Eva Harris
Contents Questions Raised by the Development and Implementation of Dengue Vaccines: Example of the Sanofi Rasteur Tetravalent Dengue Vaccine, 81 Bruno Guy There Is Only One True Winner, 91 Scott B. Halstead The Challenges of a Dengue Vaccine, 103 Gavin Screaton and Juthathip Mongkolsapaya IS IT POSSIBLE TO DEVELOP CANCER VACCINES TO NEOANTIGENS, WHAT ARE THE MAJOR CHALLENGES, AND HOW CAN THESE BE OVERCOME? Neoantigens: Nothing New in Spite of the Name, 113 Olivera ]. Finn and Hans-Georg Rammensee Targeting the Right Antigens in the Right Patients, 121 Stephen P. Schoenberger Neoantigens as Vaccine Targets for Cancer, 127 Haydn T. Kissiek IS IT POSSIBLE TO DEVELOP A "UNIVERSAL" INFLUENZAVÍRUS VACCINE? Potential Target Antigens and Critical Aspects for a Universal Influenza Vaccine, 137 Florian Krammer, Adolfo García-Sastre, and Peter Palese Outflanking Antibody Immunodominance on the Road to Universal Influenza Vaccination, 145 Davide Angeletti and Jonathan W. Yewdell Immunogenetic Considerations Underlying В-Cell Biology in the Development of a Ran-Subtype Influenza AVaccine Targeting the Hemagglutinin Stem, 155 Sarah E Andrews, Barney S. Graham, John R. Mascóla, and Adrian B. McDermott Potential for a Universal Influenza Vaccine, 163 James E. Crowe, Jr. DO THE MICROBIOTA INFLUENCE VACCINES AND PROTECTIVE IMMUNITYTO PATHOGENS? Engaging Our Endogenous Adjuvants, 171 Nicholas Collins and Yasmine Belkaid If So, Is There Potential for Efficacious Microbiota-Based Vaccines?, 179 Dan R. Littman VI
Contents Issues of Sovereignty, Federalism, and Points-Testing in the Prokaryotic and Eukaryotic Spaces of the Host-Microbial Superorganism, 187 Andrew J. Macpherson DO MEMORY В CELLS FORM SECONDARY GERMINAL CENTERS? Impact of Antibody Class and Quality of Memory Т-Cell Help at Recall, 197 Louise J. McHeyzer-Williams, Chad Dufaud, and Michael G. McHeyzer-Williams It Depends, 207 Kathryn A. Pape and Marc K. Jenkins Yes and No, 213 Mark J. Shlomchik WILL SYSTEMS BIOLOGY DELIVER ITS PROMISE AND CONTRIBUTE TO THE DEVELOPMENT OF NEW OR IMPROVED VACCINES? Seeing the Forest Rather than a Few Trees, 221 Mark M. Davis and Cristina M. Tato From Datato Understanding through Systems Biology, 231 Thomas Hagan and Bali Pulendran Systems Biology Views of Vaccine Innate and Adaptive Immunity, 241 Rino Rappuoli, Emilio Siena, and Oretta Finco What Really Constitutes the Study of "Systems Biology" and How Might Such an Approach Facilitate Vaccine Design, 251 Ronald N. Germain WHAT IS THE PREDICTIVE VALUE OF ANIMAL MODELS FOR VACCINE EFFICACY IN HUMANS? The Importance of Bridging Studies and Species-Independent Correlates of Protection, 259 Hana Golding, Surender Khurana, and Marina Zaitseva Reevaluating the Potential of Mouse Models for the Human Immune System, 271 Stephen C. Jameson and David Masopust Rigorous Simian Immunodefiency Virus Vaccine Trials Can Be Instructive, 279 Mauricio A. Martins and David I. Watkins Consideration of Strategies to Improve the Value of Animal Models, 289 Ramin Sedaghat Herati and E. John Wherry VII
Contents IS A HUMAN CD8 T-CELL VACCINE POSSIBLE, AND IF SO, WHAT WOULD IT TAKE? CD8 Т-Cell Vaccines: To В or Not to B?, 297 Lalit К. Berna, Stephen C. Jameson, and David Masopust Could a CD8+ Т-Cell Vaccine Prevent Persistent HIV Infection?, 303 Andrew J. McMichael CD8 T-Cell-Mediated Protective Immunity and Vaccination against Enteric Bacteria, 313 Marcelo В. Sztein WHAT IS WRONG WITH PERTUSSIS VACCINE IMMUNITY? The Problem of Waning Effectiveness of Pertussis Vaccines, 323 Nicolas Burdin, Lori Kestenbaum Handy, and Stanley A. Plotkin Why Immunological Memory to Pertussis Is Failing, 341 Dmitri A. Diavatopoulos and Kathryn Margaret Edwards Inducing and Recalling Vaccine-Specific Immunity, 349 Christiane S. Eberhardt and Claire-Anne Siegrist WHAT ARE THE MOST POWERFUL IMMUNOGEN DESIGN VACCINE STRATEGIES? A Structural Biologist's Perspective, 359 Peter D. Kwong Reverse Vaccinology 2.0 Shows Great Promise, 369 Dennis R. Burton IS THERE NATURAL KILLER CELL MEMORY AND CAN IT BE HARNESSED BY VACCINATION? Natural Killer Cells in Vaccination, 377 Harold R. Neely, Irina B. Mazo, Carmen Gerlach, and Ulrich H. von Andrian Vaccination Strategies Based on NK Cell and ILC Memory, 389 Megan A. Cooper, Todd A. Fehniger, and Marco Colonna NK Cell Memory and Immunization Strategies against Infectious Diseases and Cancer, 397 Joseph C. Sun and Lewis L. Lanier Can Natural Killer and CD8 T Cells Switch Jobs?, 405 Christine A. Biron and Marcus Altfeld Index, 413 VIII
Immune Memory and Vaccines Great Debates iler an initial encounter with a pathogen, the adaptive immune /Vsvstem creates immune՝ cells that remember the antigens on the pathogen and allow the hoch' to rapitile mount a response during future encounters. Vaccines likewise generate immune memory, preventing the body from succumbing to potentially dangerous infections. Understand ing the mechanistic basis of immune memory is therefore essential for designing et lectivo vaccines. Written and edited bv exports in the field, this collection from Cold Spring Horhor Berspeclivos in Biology' foc uses on the critical questions c urrently debated in the field of immune memore' and vac cination. Topics include the plasticity of memory CD4 T cells, the formation of germinal centers by memory В cells, the contributions ot natural killer cells to immune mem ory, and the՝ influence ot commensal microbiola on immune responses. Several contributors respond to each question, providing a variety ot fresh, concise perspectives on each topic. Additional questions address the development and effectiveness of vac cines ter various pathogens (e.g., dengue virus and BordotcILi /icrtussis), as well as ellorts to develop vaccines against cancer. This volume is therefore valuable for all immunologists, cell biologists, and medical scientists wish ing to understand immunological memory, vaccines, and the implications for human health and disease.
Contents Preface, ¡x DO MEMORY CD4 T CELLS KEEP THEIR CELL-TYPE PROGRAMMING: PLASTICITY VERSUS FATE COMMITMENT? Epigenome: A Dynamic Vehicle for Transmitting and Recording Cytokine Signaling, 1 John L Johnson and Golnaz Vahedi Т-Cell Heterogeneity, Plasticity, and Selection in Humans, 9 Federica Sallasta, Antonino Cassotta, Daniel Hoces, Mathilde Foglierini, and Antonio Lanzavecchia Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells, 1 7 Shane Crotty WHAT ARE THE PRIMARY LIMITATIONS IN B-CELL AFFINITY MATURATION, AND HOW MUCH AFFINITY MATURATION CAN WE DRIVE WITH VACCINATION? A Role for Antibody Feedback, 29 Kai֊Mkhael Toellner, Daniel M.-Y. Sze, and Yang Zhang Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection?, 37 Christopher T. Stamper and Patrick C. Wtlson Lessons from the Antibody Response to HIV-1,45 Gabriel D. Victora and Hugo Mouquet Breaking through Immunity's Class Ceiling, 53 Garnett Kelsoe and Barton F. Haynes WHICH DENGUE VACCINE APPROACH IS THE MOST PROMISING, AND SHOULD WE BE CONCERNED ABOUT ENHANCED DISEASE AFTER VACCINATION? The Risks of Incomplete immunity to Dengue Virus Revealed by Vaccination, 61 Stephen S. Whitehead and Kanta Subbarao The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials, 69 Aravinda Aí. de Silva and Eva Harris
Contents Questions Raised by the Development and Implementation of Dengue Vaccines: Example of the Sanofi Rasteur Tetravalent Dengue Vaccine, 81 Bruno Guy There Is Only One True Winner, 91 Scott B. Halstead The Challenges of a Dengue Vaccine, 103 Gavin Screaton and Juthathip Mongkolsapaya IS IT POSSIBLE TO DEVELOP CANCER VACCINES TO NEOANTIGENS, WHAT ARE THE MAJOR CHALLENGES, AND HOW CAN THESE BE OVERCOME? Neoantigens: Nothing New in Spite of the Name, 113 Olivera ]. Finn and Hans-Georg Rammensee Targeting the Right Antigens in the Right Patients, 121 Stephen P. Schoenberger Neoantigens as Vaccine Targets for Cancer, 127 Haydn T. Kissiek IS IT POSSIBLE TO DEVELOP A "UNIVERSAL" INFLUENZAVÍRUS VACCINE? Potential Target Antigens and Critical Aspects for a Universal Influenza Vaccine, 137 Florian Krammer, Adolfo García-Sastre, and Peter Palese Outflanking Antibody Immunodominance on the Road to Universal Influenza Vaccination, 145 Davide Angeletti and Jonathan W. Yewdell Immunogenetic Considerations Underlying В-Cell Biology in the Development of a Ran-Subtype Influenza AVaccine Targeting the Hemagglutinin Stem, 155 Sarah E Andrews, Barney S. Graham, John R. Mascóla, and Adrian B. McDermott Potential for a Universal Influenza Vaccine, 163 James E. Crowe, Jr. DO THE MICROBIOTA INFLUENCE VACCINES AND PROTECTIVE IMMUNITYTO PATHOGENS? Engaging Our Endogenous Adjuvants, 171 Nicholas Collins and Yasmine Belkaid If So, Is There Potential for Efficacious Microbiota-Based Vaccines?, 179 Dan R. Littman VI
Contents Issues of Sovereignty, Federalism, and Points-Testing in the Prokaryotic and Eukaryotic Spaces of the Host-Microbial Superorganism, 187 Andrew J. Macpherson DO MEMORY В CELLS FORM SECONDARY GERMINAL CENTERS? Impact of Antibody Class and Quality of Memory Т-Cell Help at Recall, 197 Louise J. McHeyzer-Williams, Chad Dufaud, and Michael G. McHeyzer-Williams It Depends, 207 Kathryn A. Pape and Marc K. Jenkins Yes and No, 213 Mark J. Shlomchik WILL SYSTEMS BIOLOGY DELIVER ITS PROMISE AND CONTRIBUTE TO THE DEVELOPMENT OF NEW OR IMPROVED VACCINES? Seeing the Forest Rather than a Few Trees, 221 Mark M. Davis and Cristina M. Tato From Datato Understanding through Systems Biology, 231 Thomas Hagan and Bali Pulendran Systems Biology Views of Vaccine Innate and Adaptive Immunity, 241 Rino Rappuoli, Emilio Siena, and Oretta Finco What Really Constitutes the Study of "Systems Biology" and How Might Such an Approach Facilitate Vaccine Design, 251 Ronald N. Germain WHAT IS THE PREDICTIVE VALUE OF ANIMAL MODELS FOR VACCINE EFFICACY IN HUMANS? The Importance of Bridging Studies and Species-Independent Correlates of Protection, 259 Hana Golding, Surender Khurana, and Marina Zaitseva Reevaluating the Potential of Mouse Models for the Human Immune System, 271 Stephen C. Jameson and David Masopust Rigorous Simian Immunodefiency Virus Vaccine Trials Can Be Instructive, 279 Mauricio A. Martins and David I. Watkins Consideration of Strategies to Improve the Value of Animal Models, 289 Ramin Sedaghat Herati and E. John Wherry VII
Contents IS A HUMAN CD8 T-CELL VACCINE POSSIBLE, AND IF SO, WHAT WOULD IT TAKE? CD8 Т-Cell Vaccines: To В or Not to B?, 297 Lalit К. Berna, Stephen C. Jameson, and David Masopust Could a CD8+ Т-Cell Vaccine Prevent Persistent HIV Infection?, 303 Andrew J. McMichael CD8 T-Cell-Mediated Protective Immunity and Vaccination against Enteric Bacteria, 313 Marcelo В. Sztein WHAT IS WRONG WITH PERTUSSIS VACCINE IMMUNITY? The Problem of Waning Effectiveness of Pertussis Vaccines, 323 Nicolas Burdin, Lori Kestenbaum Handy, and Stanley A. Plotkin Why Immunological Memory to Pertussis Is Failing, 341 Dmitri A. Diavatopoulos and Kathryn Margaret Edwards Inducing and Recalling Vaccine-Specific Immunity, 349 Christiane S. Eberhardt and Claire-Anne Siegrist WHAT ARE THE MOST POWERFUL IMMUNOGEN DESIGN VACCINE STRATEGIES? A Structural Biologist's Perspective, 359 Peter D. Kwong Reverse Vaccinology 2.0 Shows Great Promise, 369 Dennis R. Burton IS THERE NATURAL KILLER CELL MEMORY AND CAN IT BE HARNESSED BY VACCINATION? Natural Killer Cells in Vaccination, 377 Harold R. Neely, Irina B. Mazo, Carmen Gerlach, and Ulrich H. von Andrian Vaccination Strategies Based on NK Cell and ILC Memory, 389 Megan A. Cooper, Todd A. Fehniger, and Marco Colonna NK Cell Memory and Immunization Strategies against Infectious Diseases and Cancer, 397 Joseph C. Sun and Lewis L. Lanier Can Natural Killer and CD8 T Cells Switch Jobs?, 405 Christine A. Biron and Marcus Altfeld Index, 413 VIII
Immune Memory and Vaccines Great Debates iler an initial encounter with a pathogen, the adaptive immune /Vsvstem creates immune՝ cells that remember the antigens on the pathogen and allow the hoch' to rapitile mount a response during future encounters. Vaccines likewise generate immune memory, preventing the body from succumbing to potentially dangerous infections. Understand ing the mechanistic basis of immune memory is therefore essential for designing et lectivo vaccines. Written and edited bv exports in the field, this collection from Cold Spring Horhor Berspeclivos in Biology' foc uses on the critical questions c urrently debated in the field of immune memore' and vac cination. Topics include the plasticity of memory CD4 T cells, the formation of germinal centers by memory В cells, the contributions ot natural killer cells to immune mem ory, and the՝ influence ot commensal microbiola on immune responses. Several contributors respond to each question, providing a variety ot fresh, concise perspectives on each topic. Additional questions address the development and effectiveness of vac cines ter various pathogens (e.g., dengue virus and BordotcILi /icrtussis), as well as ellorts to develop vaccines against cancer. This volume is therefore valuable for all immunologists, cell biologists, and medical scientists wish ing to understand immunological memory, vaccines, and the implications for human health and disease. |
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| spelling | Immune memory and vaccines great debates : a subject collection from Cold Spring Harbor perspectives in biology edited by Shane Crotty, La Jolla Institute for Allergy and Immunology, Rafi Ahmed, Emory Vaccine Center Cold Spring Harbor, New York Cold Spring Harbor Laboratory Press [2018] © 2018 ix, 418 Seiten Illustrationen 27 cm txt rdacontent n rdamedia nc rdacarrier Cold Spring Harbor perspectives in biology Includes bibliographical references and index Immunologic memory Vaccines B cells T cells Immunologic Memory B-Lymphocytes T-Lymphocytes (DE-588)4143413-4 Aufsatzsammlung gnd-content Crotty, Shane edt wpr aut Ahmed, Rafi (DE-588)173280900 edt wpr Erscheint auch als Online-Ausgabe 978-1-621822-58-5 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032446556&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032446556&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032446556&sequence=000005&line_number=0003&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032446556&sequence=000007&line_number=0004&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Crotty, Shane Immune memory and vaccines great debates : a subject collection from Cold Spring Harbor perspectives in biology Immunologic memory Vaccines B cells T cells Immunologic Memory B-Lymphocytes T-Lymphocytes |
| subject_GND | (DE-588)4143413-4 |
| title | Immune memory and vaccines great debates : a subject collection from Cold Spring Harbor perspectives in biology |
| title_auth | Immune memory and vaccines great debates : a subject collection from Cold Spring Harbor perspectives in biology |
| title_exact_search | Immune memory and vaccines great debates : a subject collection from Cold Spring Harbor perspectives in biology |
| title_exact_search_txtP | Immune memory and vaccines great debates : a subject collection from Cold Spring Harbor perspectives in biology |
| title_full | Immune memory and vaccines great debates : a subject collection from Cold Spring Harbor perspectives in biology edited by Shane Crotty, La Jolla Institute for Allergy and Immunology, Rafi Ahmed, Emory Vaccine Center |
| title_fullStr | Immune memory and vaccines great debates : a subject collection from Cold Spring Harbor perspectives in biology edited by Shane Crotty, La Jolla Institute for Allergy and Immunology, Rafi Ahmed, Emory Vaccine Center |
| title_full_unstemmed | Immune memory and vaccines great debates : a subject collection from Cold Spring Harbor perspectives in biology edited by Shane Crotty, La Jolla Institute for Allergy and Immunology, Rafi Ahmed, Emory Vaccine Center |
| title_short | Immune memory and vaccines |
| title_sort | immune memory and vaccines great debates a subject collection from cold spring harbor perspectives in biology |
| title_sub | great debates : a subject collection from Cold Spring Harbor perspectives in biology |
| topic | Immunologic memory Vaccines B cells T cells Immunologic Memory B-Lymphocytes T-Lymphocytes |
| topic_facet | Immunologic memory Vaccines B cells T cells Immunologic Memory B-Lymphocytes T-Lymphocytes Aufsatzsammlung |
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