Metastasis: mechanism to therapy : a subject collection from Cold Spring Harbor perspectives in medicine
"Metastasis is a critical stage in cancer progression in which cells from the original tumor spread to other locations in the body and seed secondary tumors. This volume examines the molecular mechanisms underlying metastasis, describing how malignant cells change morphology, migrate out of the...
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cold Spring Harbor, New York
Cold Spring Harbor Laboratory Press
[2020]
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| Schriftenreihe: | Cold Spring Harbor perspectives in medicine
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Zusammenfassung: | "Metastasis is a critical stage in cancer progression in which cells from the original tumor spread to other locations in the body and seed secondary tumors. This volume examines the molecular mechanisms underlying metastasis, describing how malignant cells change morphology, migrate out of the primary site, and establish new tumors at distant locations. It also discusses ongoing research into how this may be prevented"-- |
| Beschreibung: | viii, 325 Seiten Illustrationen 26 cm |
| ISBN: | 9781621823247 1621823245 |
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Datensatz im Suchindex
| _version_ | 1804182014413242368 |
|---|---|
| adam_text | Contents Preface, vii Cancer Cell Dormancy in Metastasis, 1 Matthew A. Summers, Michelle M. McDonald, and Peter I. Croucher Premetastasis, 11 Yoshiro Maru Brain Metastasis Organotropism, 31 Arseniy E. Yuzhalin and Dihua Yu Bone Tropism in Cancer Metastases, 47 Hai Wang, Weijie Zhang, Igor Bado, and Xiang H.-E Zhang Liver Tropism in Cancer: The Hepatic Metastatic Niche, 63 Ainhoa Mielgo and Michael C. Schmid Normal Aging and Its Role in Cancer Metastasis, 81 Mitchell Fane and Ashani T. Weeraratna The Immune Microenvironment and Cancer Metastasis, 99 Asmaa El-Kenawi, Kay Hănggi, and Brian Ruffell Myeloid Cells in Metastasis, 123 Agnieszka Swierczak and Jeffrey W. Pollard Impact of Immunometabolism on Cancer Metastasis: A Focus on T Cells and Macrophages, 145 Nina C. Flerin, Sotiria Pinioti, Alessio Menga, Alessandra Castegna, and Massimiliano Mozzone Extracellular Vesicles and Metastasis, 1 77 Shizhen Emily Wang Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis, 195 Toni Celíà-Terrassa and Mohit Kumar Jolly Clinical Perspectives in Brain Metastasis, 213 Krutika Deshpande, Ian Buchanan, Vahan Martirosian, and Josh Neman v
Contents New Approaches on Cancer Immunotherapy, 227 Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, and Mien-Chie Hung The Etiology and Impact of Muscle Wasting in Metastatic Cancer, 243 Anup K. Biswas and Swarnali Acharyya The Different Facets of Liquid Biopsy: A Kaleidoscopic View, 263 Zuhra Eslami-S, Luis Enrique Cortés-Hernández, Laure Cayrefourcq, and Catherine Alìx-Panabières Zebrafish In Vivo Models of Cancer and Metastasis, 279 Katy R. Asteli and Dirk Sieger Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy, 297 Andreia S. Margarida, Laura Barnes, Claire Vennin, and ]acco van Rheenen Index, 319 VI
Metastasis Mechanism to Therapy Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is respon sible for the majority of cancer deaths and, therefore, is a critical area of research. Work to better understand the metastatic cascade—how cells detach from a primary tumor, migrate through the body, and seed second ary tumors at distant locations—will lead to improved treatment options for patients with cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells. They also consider the selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracel lular vesicles at different steps of the metastatic cascade. Cellular plastic ity—including evidence for metastatic stem cells and the role of tumor cell dormancy in recurrent metastasis—is also covered. In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progres sion and
metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. This volume is therefore a vital reference for all cancer biologists and clinicianscientists concerned with defeating cancer.
|
| adam_txt |
Contents Preface, vii Cancer Cell Dormancy in Metastasis, 1 Matthew A. Summers, Michelle M. McDonald, and Peter I. Croucher Premetastasis, 11 Yoshiro Maru Brain Metastasis Organotropism, 31 Arseniy E. Yuzhalin and Dihua Yu Bone Tropism in Cancer Metastases, 47 Hai Wang, Weijie Zhang, Igor Bado, and Xiang H.-E Zhang Liver Tropism in Cancer: The Hepatic Metastatic Niche, 63 Ainhoa Mielgo and Michael C. Schmid Normal Aging and Its Role in Cancer Metastasis, 81 Mitchell Fane and Ashani T. Weeraratna The Immune Microenvironment and Cancer Metastasis, 99 Asmaa El-Kenawi, Kay Hănggi, and Brian Ruffell Myeloid Cells in Metastasis, 123 Agnieszka Swierczak and Jeffrey W. Pollard Impact of Immunometabolism on Cancer Metastasis: A Focus on T Cells and Macrophages, 145 Nina C. Flerin, Sotiria Pinioti, Alessio Menga, Alessandra Castegna, and Massimiliano Mozzone Extracellular Vesicles and Metastasis, 1 77 Shizhen Emily Wang Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis, 195 Toni Celíà-Terrassa and Mohit Kumar Jolly Clinical Perspectives in Brain Metastasis, 213 Krutika Deshpande, Ian Buchanan, Vahan Martirosian, and Josh Neman v
Contents New Approaches on Cancer Immunotherapy, 227 Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, and Mien-Chie Hung The Etiology and Impact of Muscle Wasting in Metastatic Cancer, 243 Anup K. Biswas and Swarnali Acharyya The Different Facets of Liquid Biopsy: A Kaleidoscopic View, 263 Zuhra Eslami-S, Luis Enrique Cortés-Hernández, Laure Cayrefourcq, and Catherine Alìx-Panabières Zebrafish In Vivo Models of Cancer and Metastasis, 279 Katy R. Asteli and Dirk Sieger Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy, 297 Andreia S. Margarida, Laura Barnes, Claire Vennin, and ]acco van Rheenen Index, 319 VI
Metastasis Mechanism to Therapy Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is respon sible for the majority of cancer deaths and, therefore, is a critical area of research. Work to better understand the metastatic cascade—how cells detach from a primary tumor, migrate through the body, and seed second ary tumors at distant locations—will lead to improved treatment options for patients with cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells. They also consider the selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracel lular vesicles at different steps of the metastatic cascade. Cellular plastic ity—including evidence for metastatic stem cells and the role of tumor cell dormancy in recurrent metastasis—is also covered. In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progres sion and
metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. This volume is therefore a vital reference for all cancer biologists and clinicianscientists concerned with defeating cancer. |
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| spelling | Metastasis mechanism to therapy : a subject collection from Cold Spring Harbor perspectives in medicine edited by Jeffrey W. Pollard, The University of Edinburgh, Yibin Kang, Princeton University Cold Spring Harbor, New York Cold Spring Harbor Laboratory Press [2020] viii, 325 Seiten Illustrationen 26 cm txt rdacontent n rdamedia nc rdacarrier Cold Spring Harbor perspectives in medicine "Metastasis is a critical stage in cancer progression in which cells from the original tumor spread to other locations in the body and seed secondary tumors. This volume examines the molecular mechanisms underlying metastasis, describing how malignant cells change morphology, migrate out of the primary site, and establish new tumors at distant locations. It also discusses ongoing research into how this may be prevented"-- Metastasis / Treatment Neoplasm Metastasis / therapy (DE-588)4143413-4 Aufsatzsammlung gnd-content Pollard, Jeffrey W. edt wpr aut Kang, Yibin edt wpr Erscheint auch als Online-Ausgabe, EPUB 978-1-621823-25-4 Erscheint auch als Online-Ausgabe, kindle edition 978-1-621823-26-1 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032444677&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032444677&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
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| title | Metastasis mechanism to therapy : a subject collection from Cold Spring Harbor perspectives in medicine |
| title_auth | Metastasis mechanism to therapy : a subject collection from Cold Spring Harbor perspectives in medicine |
| title_exact_search | Metastasis mechanism to therapy : a subject collection from Cold Spring Harbor perspectives in medicine |
| title_exact_search_txtP | Metastasis mechanism to therapy : a subject collection from Cold Spring Harbor perspectives in medicine |
| title_full | Metastasis mechanism to therapy : a subject collection from Cold Spring Harbor perspectives in medicine edited by Jeffrey W. Pollard, The University of Edinburgh, Yibin Kang, Princeton University |
| title_fullStr | Metastasis mechanism to therapy : a subject collection from Cold Spring Harbor perspectives in medicine edited by Jeffrey W. Pollard, The University of Edinburgh, Yibin Kang, Princeton University |
| title_full_unstemmed | Metastasis mechanism to therapy : a subject collection from Cold Spring Harbor perspectives in medicine edited by Jeffrey W. Pollard, The University of Edinburgh, Yibin Kang, Princeton University |
| title_short | Metastasis |
| title_sort | metastasis mechanism to therapy a subject collection from cold spring harbor perspectives in medicine |
| title_sub | mechanism to therapy : a subject collection from Cold Spring Harbor perspectives in medicine |
| topic_facet | Aufsatzsammlung |
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