Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method:
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information. The test protocol may al...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2019
|
| Schriftenreihe: | OECD Guidelines for the Testing of Chemicals, Section 4
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information. The test protocol may also provide an indication of the distinction between severe and less severe skin corrosives. This Test Guideline does not require the use of live animals or animal tissue for the assessment of skin corrosivity. The test material (solid or liquid) is applied uniformly and topically to a three-dimensional human skin model, comprising at least a reconstructed epidermis with a functional stratum corneum. Two tissue replicates are used for each treatment (exposure time), and for controls. Corrosive materials are identified by their ability to produce a decrease in cell viability below defined threshold levels at specified exposure periods. Coloured chemicals can also be tested by used of an HPLC procedure. The principle of the human skin model assay is based on the hypothesis that corrosive chemicals are able to penetrate the stratum corneum by diffusion or erosion, and are cytotoxic to the underlying cell layers |
| Beschreibung: | 1 Online-Ressource (26 Seiten) |
| ISBN: | 9789264264618 |
| DOI: | 10.1787/9789264264618-en |
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| id | DE-604.BV046962578 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T15:44:21Z |
| indexdate | 2024-12-17T19:03:25Z |
| institution | BVB |
| isbn | 9789264264618 |
| language | English |
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| series2 | OECD Guidelines for the Testing of Chemicals, Section 4 |
| spelling | Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method Organisation for Economic Co-operation and Development Paris OECD Publishing 2019 1 Online-Ressource (26 Seiten) txt rdacontent c rdamedia cr rdacarrier OECD Guidelines for the Testing of Chemicals, Section 4 The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information. The test protocol may also provide an indication of the distinction between severe and less severe skin corrosives. This Test Guideline does not require the use of live animals or animal tissue for the assessment of skin corrosivity. The test material (solid or liquid) is applied uniformly and topically to a three-dimensional human skin model, comprising at least a reconstructed epidermis with a functional stratum corneum. Two tissue replicates are used for each treatment (exposure time), and for controls. Corrosive materials are identified by their ability to produce a decrease in cell viability below defined threshold levels at specified exposure periods. Coloured chemicals can also be tested by used of an HPLC procedure. The principle of the human skin model assay is based on the hypothesis that corrosive chemicals are able to penetrate the stratum corneum by diffusion or erosion, and are cytotoxic to the underlying cell layers Environment https://doi.org/10.1787/9789264264618-en Verlag kostenfrei Volltext |
| spellingShingle | Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method Environment |
| title | Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method |
| title_auth | Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method |
| title_exact_search | Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method |
| title_exact_search_txtP | Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method |
| title_full | Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method Organisation for Economic Co-operation and Development |
| title_fullStr | Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method Organisation for Economic Co-operation and Development |
| title_full_unstemmed | Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method Organisation for Economic Co-operation and Development |
| title_short | Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method |
| title_sort | test no 431 in vitro skin corrosion reconstructed human epidermis rhe test method |
| topic | Environment |
| topic_facet | Environment |
| url | https://doi.org/10.1787/9789264264618-en |