Functional relevance of Hif1a for macrophages in the liver:
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
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[2020?]
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| Beschreibung: | X, 71 Seiten Illustrationen, Diagramme 21 cm |
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| 100 | 1 | |a Bach, Katharina Franziska |d 1993- |e Verfasser |0 (DE-588)1211610616 |4 aut | |
| 245 | 1 | 0 | |a Functional relevance of Hif1a for macrophages in the liver |c vorgelegt von Katharina Franziska Bach |
| 264 | 1 | |a Aachen |c [2020?] | |
| 300 | |a X, 71 Seiten |b Illustrationen, Diagramme |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Rheinisch-Westfälische Technische Hochschule Aachen |d 2020 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m B:DE-101 |q application/pdf |u https://d-nb.info/1215769466/04 |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032357643&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-032357643 | ||
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| _version_ | 1804181859413786624 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
....................................................................................................
ILL
LIST
OF
ABBREVIATIONS
..............................................................................................
VII
1
INTRODUCTION
.......................................................................................................
1
1.1
THE
LIVER
....................................................................................................
1
1.1.1
LIVER
ANATOMY
AND
BLOOD
SUPPLY
..........................................................
1
1.1.2
HISTOLOGICAL
STRUCTURE
OF
THE
LIVER
........................................................
1
1.1.3
FUNCTION
OF
THE
LIVER
.............................................................................
2
1.1.3.1
THE
LIVER
AS
AN
IMMUNE
ORGAN
....................................................
4
1.1.4
LIVER
DISEASE
.......................................................................................
5
1.1.4.1
HEPATOCELLULAR
CARCINOMA
............................................................
5
1.1.4.1.1
MOUSE
MODEL
FOR
HCC
............................................................
6
1.2
MACROPHAGES
..............................................................................................
7
1.2.1
ORIGIN
OF
MACROPHAGES
.......................................................................
8
1.2.2
MACROPHAGES
IN
THE
LIVER
....................................................................
9
1.2.3
MACROPHAGE
POLARIZATION
..................................................................
10
1.2.4
MACROPHAGES
AND
CANCER
..................................................................
12
1.3
HYPOXIA-INDUCIBLE
FACTOR
1
.......................................................................
13
1.3.1
HIF-1
A
IN
CANCER
AND
HCC
...............................................................
14
1.3.2
IMPACT
OF
HIF-1
A
ON
MACROPHAGES
...................................................
14
2
AIM
OF
THE
STUDY
..............................................................................................
16
3
MATERIALS
AND
METHODS
...................................................................................
17
3.1
MATERIALS
...................................................................................................
17
3.1.1
MOUSE
STRAINS
....................................................................................
17
3.1.2
CHEMICALS
..........................................................................................
18
3.1.3
KITS
.....................................................................................................20
3.1.4
BUFFERS
................................................................................................
21
3.1.5
MEDIA
FOR
CELL
CULTURE
........................................................................
21
TABLE
OF
CONTENTS
3.1.6
PRIMERS
FOR
REAL-TIME
QUANTITATIVE
POLYMERASE
CHAIN
REACTION
(QPCR)
............................................................................................................22
3.1.7
ANTIBODIES
..........................................................................................
23
3.1.7.1
PRIMARY
ANTIBODIES
.......................................................................23
3.1.7.2
SECONDARY
ANTIBODIES
.................................................................23
3.1.8
EQUIPMENT
..........................................................................................24
3.1.9
CONSUMABLES
.....................................................................................25
3.1.10
SOFTWARE
..........................................................................................26
3.2
METHODS
...................................................................................................28
3.2.1
HISTOLOGY
&
IMMUNOHISTOCHEMISTRY
..................................................28
3.2.1.1
HEMATOXYLIN
AND
EOSIN
STAINING
.................................................28
3.2.1.2
IMMUNOHISTOCHEMISTRY
STAINING
.................................................28
3.2.1.3
IMMUNOFLUORESCENCE
STAINING
WITH
OPAL
4-COLOR
IHC
KIT
........29
3.2.2
NUCLEIC
ACID
ANALYSIS
.........................................................................30
3.2.2.1
GENOMIC
DNA
(GDNA)
ISOLATION
...............................................
30
3.2.2.2
RNA-LSOLATION
FROM
CELLS
.............................................................
31
3.2.2.3
RNA-LSOLATION
FROM
LIVER
TISSUE
..................................................
31
3.2.2
4
COMPLEMENTARY
DNA
(CDNA)
SYNTHESIS
...............................
32
3.2.2.4.1
CDNA
SYNTHESIS
WITH
ISCRIPT*
KIT
.........................................
32
3.2.2
4.2
CDNA
SYNTHESIS
WITH
MAXIMA
FIRST
STRAND
KIT
..................
32
3.2.2.5
REAL-TIME
QUANTITATIVE
POLYMERASE
CHAIN
REACTION
AND
DATA
ANALYSIS
.....................................................................................................33
3.2.3
MAGNETIC
ACTIVATED
CELL
SORTING
(MACS)
..........................................
34
3.2.4
CELL
CULTURE
.........................................................................................35
3.2.5
FLOW
CYTOMETRY
...................................................................................
36
3.2.6
STATISTICAL
ANALYSIS
.............................................................................37
4
RESULTS
.............................................................................................................
38
IV
TABLE
OF
CONTENTS
4.1
MYELOID
HIFLA
KNOCKOUT
IS
LESS
EFFICIENT
IN
LIVER
MACROPHAGES
THAN
IN
BMDMS
................................................................................................................
38
4.2
MACROPHAGES
IN
HEALTHY
LIVER
TISSUE
......................................................
39
4.2.1
MACROPHAGE
NUMBER
IS
NOT
REDUCED
IN
LIVERS
OF
HIF1A
MC
MICE
......
39
4.2.2
MACROPHAGE
PROLIFERATION
IN
THE
LIVER
IS
NOT
AFFECTED
BY
HIFLA
.......
40
4.2.3
THE
NUMBER
OF
M2
MACROPHAGES
IN
THE
LIVER
IS
NOT
AFFECTED
BY
HIFLA
DEFICIENCY
........................................................................................................42
4.3
CHARACTERISTICS
OF
MACROPHAGES
IN
MURINE
HCC
...................................
44
4.3.1
MACROPHAGE
NUMBER
IN
HCC
LIVER
IS
NOT
AFFECTED
IN
HIF1A
MC
MICE.
44
4.3.2
M2
MACROPHAGES
ARE
SCARCE
IN
LIVER
TUMORS
AND
ADJACENT
TISSUE
.
46
4.4
MRNA
AND
PROTEIN
LEVELS
OF
F4/80
IN
MACROPHAGES
.............................47
4.4.1
ADGREL
MRNA
LEVELS
DIFFER
IN
BMDMS
OF
DISTINCT
POLARIZATION
......
48
4.4.2
F4/80
EXPRESSION
IN
BMDMS
IS
SIMILAR
REGARDLESS
OF
POLARIZATION..
48
4.4.3
COMPARISON
OF
F4/80
MRNA
AND
PROTEIN
LEVELS
IN
HEALTHY
AND
HCC
LIVER
...........................................................................................................
50
4.4.4
MRNA
LEVELS
DO
NOT
MATCH
F4/80
PROTEIN
LEVELS
IN
LIVER
TISSUE
OF
HEALTHY
AND
CCU-TREATED
MICE
.............................
51
5
DISCUSSION
.......................................................................................................
53
5.1
MYELOID
HIFLA
KNOCKOUT
IS
LESS
EFFICIENT
IN
LIVER
MACROPHAGES
THAN
IN
BMDMS
................................................................................................................
53
5.2
MYELOID
SPECIFIC
HIFLA
DEFICIENCY
DOES
NOT
AFFECT
NUMBER,
SELF-RENEWAL
OR
POLARIZATION
OF
LIVER
MACROPHAGES
.................................................................
54
5.3
ARRANGEMENT
AND
DISTRIBUTION
OF
MACROPHAGES
IN
HCC
LIVER
................
56
5.4
ADGREL
MRNA
AND
F4/80
PROTEIN
LEVELS
LACK
CORRELATION
......................
56
6
SUMMARY
.........................................................................................................
58
7
ZUSAMMENFASSUNG
.........................................................................................
59
8
REFERENCES
......................................................................................................60
ACKNOWLEDGMENTS
..................................................................................................
65
ERKLARUNG
§
5
ABS.
1
ZUR
DATENAUFBEWAHRUNG
....................................................67
V
TABLE
OF
CONTENTS
EIDESSTATTLICHE
ERKLARUNG
GEMAB
§
5
ABS.
(1)
UND
§
11
ABS.
(3)
12.
DER
PROMOTIONSORDNUNG
..............................................................................................
69
CURRICULUM
VITAE
....................................................................................................
71
VI
|
| adam_txt |
TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
.
ILL
LIST
OF
ABBREVIATIONS
.
VII
1
INTRODUCTION
.
1
1.1
THE
LIVER
.
1
1.1.1
LIVER
ANATOMY
AND
BLOOD
SUPPLY
.
1
1.1.2
HISTOLOGICAL
STRUCTURE
OF
THE
LIVER
.
1
1.1.3
FUNCTION
OF
THE
LIVER
.
2
1.1.3.1
THE
LIVER
AS
AN
IMMUNE
ORGAN
.
4
1.1.4
LIVER
DISEASE
.
5
1.1.4.1
HEPATOCELLULAR
CARCINOMA
.
5
1.1.4.1.1
MOUSE
MODEL
FOR
HCC
.
6
1.2
MACROPHAGES
.
7
1.2.1
ORIGIN
OF
MACROPHAGES
.
8
1.2.2
MACROPHAGES
IN
THE
LIVER
.
9
1.2.3
MACROPHAGE
POLARIZATION
.
10
1.2.4
MACROPHAGES
AND
CANCER
.
12
1.3
HYPOXIA-INDUCIBLE
FACTOR
1
.
13
1.3.1
HIF-1
A
IN
CANCER
AND
HCC
.
14
1.3.2
IMPACT
OF
HIF-1
A
ON
MACROPHAGES
.
14
2
AIM
OF
THE
STUDY
.
16
3
MATERIALS
AND
METHODS
.
17
3.1
MATERIALS
.
17
3.1.1
MOUSE
STRAINS
.
17
3.1.2
CHEMICALS
.
18
3.1.3
KITS
.20
3.1.4
BUFFERS
.
21
3.1.5
MEDIA
FOR
CELL
CULTURE
.
21
TABLE
OF
CONTENTS
3.1.6
PRIMERS
FOR
REAL-TIME
QUANTITATIVE
POLYMERASE
CHAIN
REACTION
(QPCR)
.22
3.1.7
ANTIBODIES
.
23
3.1.7.1
PRIMARY
ANTIBODIES
.23
3.1.7.2
SECONDARY
ANTIBODIES
.23
3.1.8
EQUIPMENT
.24
3.1.9
CONSUMABLES
.25
3.1.10
SOFTWARE
.26
3.2
METHODS
.28
3.2.1
HISTOLOGY
&
IMMUNOHISTOCHEMISTRY
.28
3.2.1.1
HEMATOXYLIN
AND
EOSIN
STAINING
.28
3.2.1.2
IMMUNOHISTOCHEMISTRY
STAINING
.28
3.2.1.3
IMMUNOFLUORESCENCE
STAINING
WITH
OPAL
4-COLOR
IHC
KIT
.29
3.2.2
NUCLEIC
ACID
ANALYSIS
.30
3.2.2.1
GENOMIC
DNA
(GDNA)
ISOLATION
.
30
3.2.2.2
RNA-LSOLATION
FROM
CELLS
.
31
3.2.2.3
RNA-LSOLATION
FROM
LIVER
TISSUE
.
31
3.2.2
4
COMPLEMENTARY
DNA
(CDNA)
SYNTHESIS
.
32
3.2.2.4.1
CDNA
SYNTHESIS
WITH
ISCRIPT*
KIT
.
32
3.2.2
4.2
CDNA
SYNTHESIS
WITH
MAXIMA
FIRST
STRAND
KIT
.
32
3.2.2.5
REAL-TIME
QUANTITATIVE
POLYMERASE
CHAIN
REACTION
AND
DATA
ANALYSIS
.33
3.2.3
MAGNETIC
ACTIVATED
CELL
SORTING
(MACS)
.
34
3.2.4
CELL
CULTURE
.35
3.2.5
FLOW
CYTOMETRY
.
36
3.2.6
STATISTICAL
ANALYSIS
.37
4
RESULTS
.
38
IV
TABLE
OF
CONTENTS
4.1
MYELOID
HIFLA
KNOCKOUT
IS
LESS
EFFICIENT
IN
LIVER
MACROPHAGES
THAN
IN
BMDMS
.
38
4.2
MACROPHAGES
IN
HEALTHY
LIVER
TISSUE
.
39
4.2.1
MACROPHAGE
NUMBER
IS
NOT
REDUCED
IN
LIVERS
OF
HIF1A
MC
MICE
.
39
4.2.2
MACROPHAGE
PROLIFERATION
IN
THE
LIVER
IS
NOT
AFFECTED
BY
HIFLA
.
40
4.2.3
THE
NUMBER
OF
M2
MACROPHAGES
IN
THE
LIVER
IS
NOT
AFFECTED
BY
HIFLA
DEFICIENCY
.42
4.3
CHARACTERISTICS
OF
MACROPHAGES
IN
MURINE
HCC
.
44
4.3.1
MACROPHAGE
NUMBER
IN
HCC
LIVER
IS
NOT
AFFECTED
IN
HIF1A
MC
MICE.
44
4.3.2
M2
MACROPHAGES
ARE
SCARCE
IN
LIVER
TUMORS
AND
ADJACENT
TISSUE
.
46
4.4
MRNA
AND
PROTEIN
LEVELS
OF
F4/80
IN
MACROPHAGES
.47
4.4.1
ADGREL
MRNA
LEVELS
DIFFER
IN
BMDMS
OF
DISTINCT
POLARIZATION
.
48
4.4.2
F4/80
EXPRESSION
IN
BMDMS
IS
SIMILAR
REGARDLESS
OF
POLARIZATION.
48
4.4.3
COMPARISON
OF
F4/80
MRNA
AND
PROTEIN
LEVELS
IN
HEALTHY
AND
HCC
LIVER
.
50
4.4.4
MRNA
LEVELS
DO
NOT
MATCH
F4/80
PROTEIN
LEVELS
IN
LIVER
TISSUE
OF
HEALTHY
AND
CCU-TREATED
MICE
.
51
5
DISCUSSION
.
53
5.1
MYELOID
HIFLA
KNOCKOUT
IS
LESS
EFFICIENT
IN
LIVER
MACROPHAGES
THAN
IN
BMDMS
.
53
5.2
MYELOID
SPECIFIC
HIFLA
DEFICIENCY
DOES
NOT
AFFECT
NUMBER,
SELF-RENEWAL
OR
POLARIZATION
OF
LIVER
MACROPHAGES
.
54
5.3
ARRANGEMENT
AND
DISTRIBUTION
OF
MACROPHAGES
IN
HCC
LIVER
.
56
5.4
ADGREL
MRNA
AND
F4/80
PROTEIN
LEVELS
LACK
CORRELATION
.
56
6
SUMMARY
.
58
7
ZUSAMMENFASSUNG
.
59
8
REFERENCES
.60
ACKNOWLEDGMENTS
.
65
ERKLARUNG
§
5
ABS.
1
ZUR
DATENAUFBEWAHRUNG
.67
V
TABLE
OF
CONTENTS
EIDESSTATTLICHE
ERKLARUNG
GEMAB
§
5
ABS.
(1)
UND
§
11
ABS.
(3)
12.
DER
PROMOTIONSORDNUNG
.
69
CURRICULUM
VITAE
.
71
VI |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Bach, Katharina Franziska 1993- |
| author_GND | (DE-588)1211610616 |
| author_facet | Bach, Katharina Franziska 1993- |
| author_role | aut |
| author_sort | Bach, Katharina Franziska 1993- |
| author_variant | k f b kf kfb |
| building | Verbundindex |
| bvnumber | BV046949090 |
| ctrlnum | (OCoLC)1199740591 (DE-599)DNB1215769466 |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV046949090 |
| illustrated | Illustrated |
| index_date | 2024-07-03T15:40:26Z |
| indexdate | 2024-07-10T08:58:21Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032357643 |
| oclc_num | 1199740591 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | X, 71 Seiten Illustrationen, Diagramme 21 cm |
| publishDate | 2020 |
| publishDateSearch | 2020 |
| publishDateSort | 2020 |
| record_format | marc |
| spelling | Bach, Katharina Franziska 1993- Verfasser (DE-588)1211610616 aut Functional relevance of Hif1a for macrophages in the liver vorgelegt von Katharina Franziska Bach Aachen [2020?] X, 71 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Rheinisch-Westfälische Technische Hochschule Aachen 2020 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1215769466/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032357643&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bach, Katharina Franziska 1993- Functional relevance of Hif1a for macrophages in the liver |
| subject_GND | (DE-588)4113937-9 |
| title | Functional relevance of Hif1a for macrophages in the liver |
| title_auth | Functional relevance of Hif1a for macrophages in the liver |
| title_exact_search | Functional relevance of Hif1a for macrophages in the liver |
| title_exact_search_txtP | Functional relevance of Hif1a for macrophages in the liver |
| title_full | Functional relevance of Hif1a for macrophages in the liver vorgelegt von Katharina Franziska Bach |
| title_fullStr | Functional relevance of Hif1a for macrophages in the liver vorgelegt von Katharina Franziska Bach |
| title_full_unstemmed | Functional relevance of Hif1a for macrophages in the liver vorgelegt von Katharina Franziska Bach |
| title_short | Functional relevance of Hif1a for macrophages in the liver |
| title_sort | functional relevance of hif1a for macrophages in the liver |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1215769466/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032357643&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bachkatharinafranziska functionalrelevanceofhif1aformacrophagesintheliver |
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Inhaltsverzeichnis