The molecular switch: signaling and allostery
A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Sw...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
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Princeton, NJ
Princeton University Press
[2020]
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| Online-Zugang: | FAB01 FAW01 FCO01 FHA01 FKE01 FLA01 UPA01 Volltext |
| Zusammenfassung: | A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena.Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons.Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena |
| Beschreibung: | Description based on online resource; title from PDF title page (publisher's Web site, viewed 15. Sep 2020) |
| Beschreibung: | 1 Online-Ressource (440 Seiten) |
| ISBN: | 9780691200255 |
| DOI: | 10.1515/9780691200255 |
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| discipline | Biologie |
| discipline_str_mv | Biologie |
| doi_str_mv | 10.1515/9780691200255 |
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| spelling | Phillips, Rob 1960- Verfasser (DE-588)137096372 aut The molecular switch signaling and allostery Rob Phillips ; illustrated by Nigel Orme Princeton, NJ Princeton University Press [2020] © 2020 1 Online-Ressource (440 Seiten) txt rdacontent c rdamedia cr rdacarrier Description based on online resource; title from PDF title page (publisher's Web site, viewed 15. Sep 2020) A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena.Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons.Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena In English Alexander Gann Bohr effect Bruce Mayer Cell Signaling Genes and Signals MWC enzymes Mark Ptashne Michaelis-Menten Enzymes Tony Pawson Wendell Lim allosterome bacterial aerotaxis cyclic nucleotide gated channels enzyme phenomenology gene expression genome packing glycolosis ligand-receptor binding logic gates membrane receptors nucleosomes phoshofructokinase signal transduction SCIENCE / Life Sciences / Biophysics bisacsh Cellular control mechanisms Cellular signal transduction Molekularer Schalter (DE-588)4444367-5 gnd rswk-swf Molekularer Schalter (DE-588)4444367-5 s DE-604 Orme, Nigel ill Erscheint auch als Druck-Ausgabe 978-0-691-20025-5 https://doi.org/10.1515/9780691200255 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Phillips, Rob 1960- The molecular switch signaling and allostery Alexander Gann Bohr effect Bruce Mayer Cell Signaling Genes and Signals MWC enzymes Mark Ptashne Michaelis-Menten Enzymes Tony Pawson Wendell Lim allosterome bacterial aerotaxis cyclic nucleotide gated channels enzyme phenomenology gene expression genome packing glycolosis ligand-receptor binding logic gates membrane receptors nucleosomes phoshofructokinase signal transduction SCIENCE / Life Sciences / Biophysics bisacsh Cellular control mechanisms Cellular signal transduction Molekularer Schalter (DE-588)4444367-5 gnd |
| subject_GND | (DE-588)4444367-5 |
| title | The molecular switch signaling and allostery |
| title_auth | The molecular switch signaling and allostery |
| title_exact_search | The molecular switch signaling and allostery |
| title_exact_search_txtP | The molecular switch signaling and allostery |
| title_full | The molecular switch signaling and allostery Rob Phillips ; illustrated by Nigel Orme |
| title_fullStr | The molecular switch signaling and allostery Rob Phillips ; illustrated by Nigel Orme |
| title_full_unstemmed | The molecular switch signaling and allostery Rob Phillips ; illustrated by Nigel Orme |
| title_short | The molecular switch |
| title_sort | the molecular switch signaling and allostery |
| title_sub | signaling and allostery |
| topic | Alexander Gann Bohr effect Bruce Mayer Cell Signaling Genes and Signals MWC enzymes Mark Ptashne Michaelis-Menten Enzymes Tony Pawson Wendell Lim allosterome bacterial aerotaxis cyclic nucleotide gated channels enzyme phenomenology gene expression genome packing glycolosis ligand-receptor binding logic gates membrane receptors nucleosomes phoshofructokinase signal transduction SCIENCE / Life Sciences / Biophysics bisacsh Cellular control mechanisms Cellular signal transduction Molekularer Schalter (DE-588)4444367-5 gnd |
| topic_facet | Alexander Gann Bohr effect Bruce Mayer Cell Signaling Genes and Signals MWC enzymes Mark Ptashne Michaelis-Menten Enzymes Tony Pawson Wendell Lim allosterome bacterial aerotaxis cyclic nucleotide gated channels enzyme phenomenology gene expression genome packing glycolosis ligand-receptor binding logic gates membrane receptors nucleosomes phoshofructokinase signal transduction SCIENCE / Life Sciences / Biophysics Cellular control mechanisms Cellular signal transduction Molekularer Schalter |
| url | https://doi.org/10.1515/9780691200255 |
| work_keys_str_mv | AT phillipsrob themolecularswitchsignalingandallostery AT ormenigel themolecularswitchsignalingandallostery |