The chemical biology of long noncoding RNAs:
This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genome...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cham, Switzerland
Springer
[2020]
|
| Schriftenreihe: | RNA technologies
Volume 11 |
| Schlagworte: | |
| Zusammenfassung: | This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data |
| Beschreibung: | 1.Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans; Gabriela Toomer, Huachen Gan, Joanna Sztuba-Solinska; 2. Evolving Roles of Long Noncoding RNAs; K. Lakshmi Narayanan, Xizi Wu, Haichao Wei and Jiaqian Wu; 3.Biogenesis and Function of the Noncoding Isoform-Type LncRNAs; Yasuhiko Kato and Hajime Watanabe; 4. Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization; Raphael Severino Bonadio, Enrico Alessio, Stefano Cagnin; 5. Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes; Sonam Dhamija and Manoj B. Menon; 6. Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2; Nicholas Delihas ; 7. Long Non-Coding RNAs and Cancer Cells’ Drug Resistance: an Unexpected Connection; Perla Pucci, Erik Venalainen, Wallace Yuen, David Roig Carles, Yuzhuo Wang, Francesco Crea; ; 8. - Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma; Johanna K. DiStefano and Caecilia Sukowati; 9. Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers; Bernadette Neve, Nicolas Jonckheere, Audrey Vincent and Isabelle Van Seuningen; 10. LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer; Yuichi Mitobe, Kazuhiro Ikeda, Kuniko Horie-Inoue and Satoshi Inoue; 11. Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer; Marianna Aprile, George Calin, Amelia Cimmino and Valerio Costa; 12. Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art; Panagiotis Paliogiannis, Valentina Scano, Arduino Aleksander Mangoni, Antonio Cossu, Giuseppe Palmieri; 13. Long Non-Coding RNAs in Cardiovascular Diseases; Laura Schoppe, Tim Meinecke, Patrick Hofmann, Ulrich Laufs, Jes-Niels Boeckel; 14. - Long Non-Coding RNAs in Cardiovascular Development and Diseases; Jiali Deng, Mengying Guo, Junjie Xiao; 15. Long Noncoding RNAs as Players in Breast Tumorigenesis; Cyrinne Achour and Francesca Aguilo; 16. Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders; Yuuka Muraoka, Masamitsu Yamaguchi; 17. Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders; Keisuke Hitachi and Kunihiro Tsuchida; 18. Long Noncoding RNAs in Substance Use Disorders; Changhai Tian and Guoku Hu; 19. The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm; Saumik Biswas and Subrata Chakrabarti; 20. Long Non-Coding RNAs in Diabetes and ß-cell Regulation; Simranjeet Kaur, Caroline Frørup, Verena Hirschberg Jensen, Aashiq H. Mirza, Joana Mendes Lopes de Melo, Reza Yarani, Anne Julie Overgaard, Joachim Størling, Flemming Pociot; |
| Beschreibung: | x, 544, C1 Seiten Illustrationen 1149 grams |
| ISBN: | 9783030447427 |
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| 500 | |a - Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma; Johanna K. DiStefano and Caecilia Sukowati; 9. Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers; Bernadette Neve, Nicolas Jonckheere, Audrey Vincent and Isabelle Van Seuningen; 10. LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer; Yuichi Mitobe, Kazuhiro Ikeda, Kuniko Horie-Inoue and Satoshi Inoue; 11. Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer; Marianna Aprile, George Calin, Amelia Cimmino and Valerio Costa; 12. Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art; Panagiotis Paliogiannis, Valentina Scano, Arduino Aleksander Mangoni, Antonio Cossu, Giuseppe Palmieri; 13. Long Non-Coding RNAs in Cardiovascular Diseases; Laura Schoppe, Tim Meinecke, Patrick Hofmann, Ulrich Laufs, Jes-Niels Boeckel; 14. | ||
| 500 | |a - Long Non-Coding RNAs in Cardiovascular Development and Diseases; Jiali Deng, Mengying Guo, Junjie Xiao; 15. Long Noncoding RNAs as Players in Breast Tumorigenesis; Cyrinne Achour and Francesca Aguilo; 16. Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders; Yuuka Muraoka, Masamitsu Yamaguchi; 17. Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders; Keisuke Hitachi and Kunihiro Tsuchida; 18. Long Noncoding RNAs in Substance Use Disorders; Changhai Tian and Guoku Hu; 19. The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm; Saumik Biswas and Subrata Chakrabarti; 20. Long Non-Coding RNAs in Diabetes and ß-cell Regulation; Simranjeet Kaur, Caroline Frørup, Verena Hirschberg Jensen, Aashiq H. Mirza, Joana Mendes Lopes de Melo, Reza Yarani, Anne Julie Overgaard, Joachim Størling, Flemming Pociot; | ||
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Datensatz im Suchindex
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| illustrated | Illustrated |
| index_date | 2024-07-03T15:37:57Z |
| indexdate | 2024-07-10T08:58:05Z |
| institution | BVB |
| isbn | 9783030447427 |
| language | English |
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| series2 | RNA technologies |
| spelling | The chemical biology of long noncoding RNAs Stefan Jurga, Jan Barciszewski, editors Cham, Switzerland Springer [2020] x, 544, C1 Seiten Illustrationen 1149 grams txt rdacontent n rdamedia nc rdacarrier RNA technologies Volume 11 1.Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans; Gabriela Toomer, Huachen Gan, Joanna Sztuba-Solinska; 2. Evolving Roles of Long Noncoding RNAs; K. Lakshmi Narayanan, Xizi Wu, Haichao Wei and Jiaqian Wu; 3.Biogenesis and Function of the Noncoding Isoform-Type LncRNAs; Yasuhiko Kato and Hajime Watanabe; 4. Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization; Raphael Severino Bonadio, Enrico Alessio, Stefano Cagnin; 5. Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes; Sonam Dhamija and Manoj B. Menon; 6. Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2; Nicholas Delihas ; 7. Long Non-Coding RNAs and Cancer Cells’ Drug Resistance: an Unexpected Connection; Perla Pucci, Erik Venalainen, Wallace Yuen, David Roig Carles, Yuzhuo Wang, Francesco Crea; ; 8. - Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma; Johanna K. DiStefano and Caecilia Sukowati; 9. Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers; Bernadette Neve, Nicolas Jonckheere, Audrey Vincent and Isabelle Van Seuningen; 10. LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer; Yuichi Mitobe, Kazuhiro Ikeda, Kuniko Horie-Inoue and Satoshi Inoue; 11. Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer; Marianna Aprile, George Calin, Amelia Cimmino and Valerio Costa; 12. Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art; Panagiotis Paliogiannis, Valentina Scano, Arduino Aleksander Mangoni, Antonio Cossu, Giuseppe Palmieri; 13. Long Non-Coding RNAs in Cardiovascular Diseases; Laura Schoppe, Tim Meinecke, Patrick Hofmann, Ulrich Laufs, Jes-Niels Boeckel; 14. - Long Non-Coding RNAs in Cardiovascular Development and Diseases; Jiali Deng, Mengying Guo, Junjie Xiao; 15. Long Noncoding RNAs as Players in Breast Tumorigenesis; Cyrinne Achour and Francesca Aguilo; 16. Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders; Yuuka Muraoka, Masamitsu Yamaguchi; 17. Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders; Keisuke Hitachi and Kunihiro Tsuchida; 18. Long Noncoding RNAs in Substance Use Disorders; Changhai Tian and Guoku Hu; 19. The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm; Saumik Biswas and Subrata Chakrabarti; 20. Long Non-Coding RNAs in Diabetes and ß-cell Regulation; Simranjeet Kaur, Caroline Frørup, Verena Hirschberg Jensen, Aashiq H. Mirza, Joana Mendes Lopes de Melo, Reza Yarani, Anne Julie Overgaard, Joachim Størling, Flemming Pociot; This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data Human genetics Nucleic acids Biomedical engineering Medicine Biochemie (DE-588)4006777-4 gnd rswk-swf Non-coding RNA (DE-588)7650051-2 gnd rswk-swf Hardcover, Softcover / Medizin/Klinische Fächer Non-coding RNA (DE-588)7650051-2 s Biochemie (DE-588)4006777-4 s DE-604 Jurga, Stefan edt Barciszewski, Jan edt Erscheint auch als Online-Ausgabe 978-3-030-44743-4 |
| spellingShingle | The chemical biology of long noncoding RNAs Human genetics Nucleic acids Biomedical engineering Medicine Biochemie (DE-588)4006777-4 gnd Non-coding RNA (DE-588)7650051-2 gnd |
| subject_GND | (DE-588)4006777-4 (DE-588)7650051-2 |
| title | The chemical biology of long noncoding RNAs |
| title_auth | The chemical biology of long noncoding RNAs |
| title_exact_search | The chemical biology of long noncoding RNAs |
| title_exact_search_txtP | The chemical biology of long noncoding RNAs |
| title_full | The chemical biology of long noncoding RNAs Stefan Jurga, Jan Barciszewski, editors |
| title_fullStr | The chemical biology of long noncoding RNAs Stefan Jurga, Jan Barciszewski, editors |
| title_full_unstemmed | The chemical biology of long noncoding RNAs Stefan Jurga, Jan Barciszewski, editors |
| title_short | The chemical biology of long noncoding RNAs |
| title_sort | the chemical biology of long noncoding rnas |
| topic | Human genetics Nucleic acids Biomedical engineering Medicine Biochemie (DE-588)4006777-4 gnd Non-coding RNA (DE-588)7650051-2 gnd |
| topic_facet | Human genetics Nucleic acids Biomedical engineering Medicine Biochemie Non-coding RNA |
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