Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Gießen
DVG Service GmbH
2019
|
| Ausgabe: | 1. Auflage |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | VII, 216 Seiten Illustrationen, Diagramme 21 cm |
| ISBN: | 9783863455149 |
Internformat
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| 100 | 1 | |a Wolf, Bettina Julia |e Verfasser |0 (DE-588)141248874 |4 aut | |
| 245 | 1 | 0 | |a Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis |c by Bettina Julia Wolf |
| 250 | |a 1. Auflage | ||
| 264 | 1 | |a Gießen |b DVG Service GmbH |c 2019 | |
| 300 | |a VII, 216 Seiten |b Illustrationen, Diagramme |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Tierärztliche Hochschule Hannover |d 2019 | ||
| 650 | 7 | |a brain diseases |2 cabt | |
| 650 | 7 | |a treatment |2 cabt | |
| 650 | 7 | |a inflammation |2 cabt | |
| 650 | 7 | |a drugs |2 cabt | |
| 650 | 7 | |a behaviour patterns |2 cabt | |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 700 | 1 | |a Beineke, Andreas |0 (DE-588)12869792X |4 dgs | |
| 710 | 2 | |a Tierärztliche Hochschule Hannover |0 (DE-588)2002227-X |4 dgg | |
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Datensatz im Suchindex
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|---|---|
| adam_text | TABLE
OF
CONTENTS
SUMMARY
1
ZUSAMMENFASSUNG
5
1
INTRODUCTION
9
2
STATE
OF
THE
ART
REVIEW
13
2.1
EPILEPSY
13
2.1.1
DEFINITION
AND
SIGNIFICANCE
13
2.1.2
TEMPORAL
LOBE
EPILEPSY
16
2.1.3
EPILEPTOGENESIS
17
2.2
ANTI-EPILEPTOGENESIS
19
2.2.1
DEFINITION
AND
SIGNIFICANCE
19
2.2.2
ANTI-EPILEPTOGENESIS
STUDIES
20
2.2.2.1
ANIMAL
MODELS
OF
EPILEPTOGENESIS
21
2.2.2.1.1
CLASSIFICATION
21
2.2.2.1.2
KAINIC
ACID
MODELS
22
2.2.2.1.3
PILOCARPINE
MODELS
25
2.2.2.2
TREATMENT
SELECTION
27
2.2.2.3
BEHAVIORAL
TEST
FOR
COMORBIDITY
EVALUATION
29
2.2.2
4
CHALLENGES
OF
ANTI-EPILEPTOGENESIS
STUDIES
30
2.3
NEUROINFLAMMATION
31
2.3.1
DEFINITION
AND
SIGNIFICANCE
31
2.3.2
NEUROINFLAMMATION
IN
EPILEPSY
AND
EPILEPTOGENESIS
34
2.4
MOLECULAR
IMAGING
38
2.4.1
DEFINITION
AND
SIGNIFICANCE
38
2.4.2
PRINCIPLE
OF
POSITRON
EMISSION
TOMOGRAPHY
38
2.4.3
PRINCIPLE
OF
MAGNETIC
RESONANCE
IMAGING
42
2.4.4
IMAGING
NEUROINFLAMMATION
43
2.4.5
IMAGING
IN
EPILEPSY
AND
EPILEPTOGENESIS
45
2.5
POTENTIAL
ANTI-EPILEPTOGENIC
TREATMENTS
________________________________
48
2.5.1
ANTI-INFLAMMATORY
TREATMENTS
FOR
ANTI-EPILEPTOGENESIS
48
2.5.1.1.1.1
CURCUMIN
49
2.5.1.1.1.2
FINGOLIMOD
52
2.5.1.1.1.3
MINOCYCLINE
55
2.5.2
TREATMENT
COMBINATIONS
FOR
ANTI-EPILEPTOGENESIS
58
2.5.2.1.1.1
PHENOBARBITAL
58
2.5.3
IMAGING
OF
THERAPY
RESPONSE
60
3
OBJECTIVES
_______________________________________________________
61
4
TSPO
PET
IDENTIFIES
REDUCED
MICROGLIA
ACTIVATION
AFTER
CURCUMIN
TREATMENT
DURING
EXPERIMENTAL
EPILEPTOGENESIS
63
4.1
SUMMARY
64
4.2
INTRODUCTION
64
I
4.3
MATERIALS
AND
METHODS
65
4.4
RESULTS
67
4.5
DISCUSSION
70
4.6
REFERENCES
71
5
MOLECULAR
IMAGING
EVALUATION
OF
FTY720
TREATMENT
REVEALS
DIFFERENT
ANTI
INFLAMMATORY
RESPONSE
IN
TWO
POST-STATUS
EPILEPTICUS
ANIMAL
MODELS
OF
EPILEPTOGENESIS
73
5.1
ABSTRACT
74
5.2
INTRODUCTION
75
5.3
MATERIALS
AND
METHODS
76
5.4
RESULTS
83
5.5
DISCUSSION
88
5.6
REFERENCES
91
6
TSPO
PET
IDENTIFIES
DIFFERENT
MINOCYCLINE
TREATMENT
RESPONSE
IN
TWO
RODENT
MODELS
OF
EPILEPTOGENESIS
MINOCYCLINE
95
6.1
ABSTRACT
96
6.2
INTRODUCTION
97
6.3
MATERIALS
AND
METHODS
98
6.4
RESULTS
103
6.5
DISCUSSION
110
6.6
REFERENCES
113
7
MOLECULAR
IMAGING,
BEHAVIORAL
AND
CHRONIC
SEIZURE
EVALUATION
OF
COMBINATORIAL
ANTI-EPILEPTOGENIC
TREATMENT
117
7.1
ABSTRACT
118
7.2
INTRODUCTION
119
7.3
MATERIALS
AND
METHODS
120
7.4
RESULTS
126
7.5
DISCUSSION
135
7.6
REFERENCES
140
8
DISCUSSION
145
8.1
MAIN
FINDINGS
145
8.2
EVALUATION
OF
METHODS
149
8.2.1
ANIMAL
MODELS
149
8.2.1.1
INTRAHIPPOCAMPAL
KAINATE
MOUSE
MODEL
150
II
8.2.1.2
PILOCARPINE
RAT
MODEL
151
8.2.2
TREATMENT
SELECTION
153
8.2.3
IMAGING
MODALITIES
156
8.2.3.1
8.2.32
8.2.33
8.2.34
8.2.3.5
8.2.3.6
8.2.3.7
[18F]GE180
PET
__________________________________________________
156
[18FJGE180
AUTORADIOGRAPHY
________________________________________
158
KINETIC
ANALYSIS
OF
[18F]GE180
PET
___________________________________
159
COMPARING
STATIC
AND
KINETIC
ANALYSIS
OF
[18F]GE180
PET__________________
161
[18F]
FDG
PET
___________________________________________________
163
FURTHER
PET
ANALYSIS
_______________________________________________
163
MRI
____________________________________________________________
166
8.2.4
BEHAVIOR
TEST
167
8.2.5
SEIZURE
EVALUATION
170
8.2.6
HISTOLOGY
170
8.3
COMPARISON
OF
THE
STUDIES
172
8.4
TREATMENT
IMPACT
ON
SEIZURE
DEVELOPMENT
175
8.5
LIMITATIONS
178
8.6
OUTLOOK
179
8.7
CONCLUSION
181
9
REFERENCES
183
10
ACKNOWLEDGEMENTS
215
III
|
| adam_txt |
TABLE
OF
CONTENTS
SUMMARY
1
ZUSAMMENFASSUNG
5
1
INTRODUCTION
9
2
STATE
OF
THE
ART
REVIEW
13
2.1
EPILEPSY
13
2.1.1
DEFINITION
AND
SIGNIFICANCE
13
2.1.2
TEMPORAL
LOBE
EPILEPSY
16
2.1.3
EPILEPTOGENESIS
17
2.2
ANTI-EPILEPTOGENESIS
19
2.2.1
DEFINITION
AND
SIGNIFICANCE
19
2.2.2
ANTI-EPILEPTOGENESIS
STUDIES
20
2.2.2.1
ANIMAL
MODELS
OF
EPILEPTOGENESIS
21
2.2.2.1.1
CLASSIFICATION
21
2.2.2.1.2
KAINIC
ACID
MODELS
22
2.2.2.1.3
PILOCARPINE
MODELS
25
2.2.2.2
TREATMENT
SELECTION
27
2.2.2.3
BEHAVIORAL
TEST
FOR
COMORBIDITY
EVALUATION
29
2.2.2
4
CHALLENGES
OF
ANTI-EPILEPTOGENESIS
STUDIES
30
2.3
NEUROINFLAMMATION
31
2.3.1
DEFINITION
AND
SIGNIFICANCE
31
2.3.2
NEUROINFLAMMATION
IN
EPILEPSY
AND
EPILEPTOGENESIS
34
2.4
MOLECULAR
IMAGING
38
2.4.1
DEFINITION
AND
SIGNIFICANCE
38
2.4.2
PRINCIPLE
OF
POSITRON
EMISSION
TOMOGRAPHY
38
2.4.3
PRINCIPLE
OF
MAGNETIC
RESONANCE
IMAGING
42
2.4.4
IMAGING
NEUROINFLAMMATION
43
2.4.5
IMAGING
IN
EPILEPSY
AND
EPILEPTOGENESIS
45
2.5
POTENTIAL
ANTI-EPILEPTOGENIC
TREATMENTS
_
48
2.5.1
ANTI-INFLAMMATORY
TREATMENTS
FOR
ANTI-EPILEPTOGENESIS
48
2.5.1.1.1.1
CURCUMIN
49
2.5.1.1.1.2
FINGOLIMOD
52
2.5.1.1.1.3
MINOCYCLINE
55
2.5.2
TREATMENT
COMBINATIONS
FOR
ANTI-EPILEPTOGENESIS
58
2.5.2.1.1.1
PHENOBARBITAL
58
2.5.3
IMAGING
OF
THERAPY
RESPONSE
60
3
OBJECTIVES
_
61
4
TSPO
PET
IDENTIFIES
REDUCED
MICROGLIA
ACTIVATION
AFTER
CURCUMIN
TREATMENT
DURING
EXPERIMENTAL
EPILEPTOGENESIS
63
4.1
SUMMARY
64
4.2
INTRODUCTION
64
I
4.3
MATERIALS
AND
METHODS
65
4.4
RESULTS
67
4.5
DISCUSSION
70
4.6
REFERENCES
71
5
MOLECULAR
IMAGING
EVALUATION
OF
FTY720
TREATMENT
REVEALS
DIFFERENT
ANTI
INFLAMMATORY
RESPONSE
IN
TWO
POST-STATUS
EPILEPTICUS
ANIMAL
MODELS
OF
EPILEPTOGENESIS
73
5.1
ABSTRACT
74
5.2
INTRODUCTION
75
5.3
MATERIALS
AND
METHODS
76
5.4
RESULTS
83
5.5
DISCUSSION
88
5.6
REFERENCES
91
6
TSPO
PET
IDENTIFIES
DIFFERENT
MINOCYCLINE
TREATMENT
RESPONSE
IN
TWO
RODENT
MODELS
OF
EPILEPTOGENESIS
MINOCYCLINE
95
6.1
ABSTRACT
96
6.2
INTRODUCTION
97
6.3
MATERIALS
AND
METHODS
98
6.4
RESULTS
103
6.5
DISCUSSION
110
6.6
REFERENCES
113
7
MOLECULAR
IMAGING,
BEHAVIORAL
AND
CHRONIC
SEIZURE
EVALUATION
OF
COMBINATORIAL
ANTI-EPILEPTOGENIC
TREATMENT
117
7.1
ABSTRACT
118
7.2
INTRODUCTION
119
7.3
MATERIALS
AND
METHODS
120
7.4
RESULTS
126
7.5
DISCUSSION
135
7.6
REFERENCES
140
8
DISCUSSION
145
8.1
MAIN
FINDINGS
145
8.2
EVALUATION
OF
METHODS
149
8.2.1
ANIMAL
MODELS
149
8.2.1.1
INTRAHIPPOCAMPAL
KAINATE
MOUSE
MODEL
150
II
8.2.1.2
PILOCARPINE
RAT
MODEL
151
8.2.2
TREATMENT
SELECTION
153
8.2.3
IMAGING
MODALITIES
156
8.2.3.1
8.2.32
8.2.33
8.2.34
8.2.3.5
8.2.3.6
8.2.3.7
[18F]GE180
PET
_
156
[18FJGE180
AUTORADIOGRAPHY
_
158
KINETIC
ANALYSIS
OF
[18F]GE180
PET
_
159
COMPARING
STATIC
AND
KINETIC
ANALYSIS
OF
[18F]GE180
PET_
161
[18F]
FDG
PET
_
163
FURTHER
PET
ANALYSIS
_
163
MRI
_
166
8.2.4
BEHAVIOR
TEST
167
8.2.5
SEIZURE
EVALUATION
170
8.2.6
HISTOLOGY
170
8.3
COMPARISON
OF
THE
STUDIES
172
8.4
TREATMENT
IMPACT
ON
SEIZURE
DEVELOPMENT
175
8.5
LIMITATIONS
178
8.6
OUTLOOK
179
8.7
CONCLUSION
181
9
REFERENCES
183
10
ACKNOWLEDGEMENTS
215
III |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Wolf, Bettina Julia |
| author_GND | (DE-588)141248874 (DE-588)12869792X |
| author_facet | Wolf, Bettina Julia |
| author_role | aut |
| author_sort | Wolf, Bettina Julia |
| author_variant | b j w bj bjw |
| building | Verbundindex |
| bvnumber | BV046892825 |
| ctrlnum | (OCoLC)1164750991 (DE-599)KXP1701699710 |
| discipline | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau Medizin |
| discipline_str_mv | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau Medizin |
| edition | 1. Auflage |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV046892825 |
| illustrated | Illustrated |
| index_date | 2024-07-03T15:21:56Z |
| indexdate | 2024-07-10T08:56:46Z |
| institution | BVB |
| institution_GND | (DE-588)2002227-X |
| isbn | 9783863455149 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032302608 |
| oclc_num | 1164750991 |
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| owner | DE-188 |
| owner_facet | DE-188 |
| physical | VII, 216 Seiten Illustrationen, Diagramme 21 cm |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| publisher | DVG Service GmbH |
| record_format | marc |
| spelling | Wolf, Bettina Julia Verfasser (DE-588)141248874 aut Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis by Bettina Julia Wolf 1. Auflage Gießen DVG Service GmbH 2019 VII, 216 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Tierärztliche Hochschule Hannover 2019 brain diseases cabt treatment cabt inflammation cabt drugs cabt behaviour patterns cabt (DE-588)4113937-9 Hochschulschrift gnd-content Beineke, Andreas (DE-588)12869792X dgs Tierärztliche Hochschule Hannover (DE-588)2002227-X dgg B:DE-101 application/pdf https://d-nb.info/1215045972/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032302608&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wolf, Bettina Julia Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis brain diseases cabt treatment cabt inflammation cabt drugs cabt behaviour patterns cabt |
| subject_GND | (DE-588)4113937-9 |
| title | Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis |
| title_auth | Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis |
| title_exact_search | Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis |
| title_exact_search_txtP | Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis |
| title_full | Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis by Bettina Julia Wolf |
| title_fullStr | Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis by Bettina Julia Wolf |
| title_full_unstemmed | Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis by Bettina Julia Wolf |
| title_short | Multi-target treatment and molecular imaging of inflammation in preclinical epileptogenesis |
| title_sort | multi target treatment and molecular imaging of inflammation in preclinical epileptogenesis |
| topic | brain diseases cabt treatment cabt inflammation cabt drugs cabt behaviour patterns cabt |
| topic_facet | brain diseases treatment inflammation drugs behaviour patterns Hochschulschrift |
| url | https://d-nb.info/1215045972/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032302608&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT wolfbettinajulia multitargettreatmentandmolecularimagingofinflammationinpreclinicalepileptogenesis AT beinekeandreas multitargettreatmentandmolecularimagingofinflammationinpreclinicalepileptogenesis AT tierarztlichehochschulehannover multitargettreatmentandmolecularimagingofinflammationinpreclinicalepileptogenesis |
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