The human gene editing debate:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford
Oxford University Press
[2020]
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext Inhaltsverzeichnis Klappentext |
| Beschreibung: | vi, 200 Seiten |
| ISBN: | 9780197519561 |
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| adam_text | Contents Acknowledgments 1. Introduction The Importance of Public Bioethical Debate Slippery Slopes The Slope as the Micro-Structure of the HGE Debate Slippery Slopes in the HGE Debate Barriers 2. The First Barriers in the Human Genetic Engineering Debate The First Barriers Why These В arriers Were Strong A Change in the Participants and Their Values Weakening the Somatic/Germline Barrier Weakening the Disease/Enhancement Barrier The Somatic/Germline and Disease/Enhancement Barriers at the End of the 20th Century 3. The CRISPR Era, the National Academies Report, and the Median Trait Barrier The Barriers at the Beginning of the CRISPR Era The NASEM Report Advocates Replacing the Somatic/Germline Barrier The NASEM’s Proposed Barrier The Prevalent Variant Barrier Design Strength of the Barrier Future Polygenic Selection and Modification Designing the Median Trait Barrier Values That Support the Median Trait Barrier Values That Imperil the Median Trait Barrier The Barriers Examined in This Chapter vii 1 5 9 11 15 18 25 29 35 44 46 57 65 67 69 77 85 87 90 94 97 100 103 108
VI CONTENTS 4. Possible Barriers Further Down the Slope The Goals of Medicine Barrier The Family Genes В arrier The Boundary of Humanity Barrier The Liberal Eugenics Barrier Conclusion 111 113 115 122 126 131 5. Conclusion Historical and Future Barriers on the HGE Slope Can Any Barriers Hold? Could Solid Barriers Be Anchored by Authority? Rejecting the Direction of the Slope General Conclusions About Slippery Slopes from the HGE Case What Is to Be Done? 133 134 140 142 143 Notes Bibliography Index 153 181 191 145 150
n 2018 the first genetically modified babies were reportedly born in China, made possible by the invention of CRISPR technology in 2012. This contro versial advancement overturned the pre-existing moral consensus, which had held lor over fifty years before: while gene editing an adult person was morally acceptable, modifying babies, and thus subsequent generations, crossed a signifi cant moral line. It this line is passed over, scientists will be left without an agreedupon ethical limit. What do we do now? I I O H II. 1՛. ѴЛ S here provides a meta-level guide to how these debates move forward and their significance to society. He explains how the bioethical debate has long been charactcrb.ed as a slippery slope, with consensually ethical use at the top, nightmarish dystopia at the bottom, and specific agreed-upon limits in between, which draw the lines between the ethical and the unethical. Kvans frames his analysis around these limits, or barriers. Historically they have existed to guide scientists and to prevent the debate from slipping down the metaphorical slope into unacceptable ettgenicist possibilities, such as in Aidons Huxley’s novel Brave New World or the movie Gtit tacet. Kvans examines the history of how barriers were placed, then fell, then replaced by new ones, and discusses how these insights inform where the debate may head. He evaluates other proposed barriers relevant to where we are now, projects that most of the barriers suggested by scientists and bioethicists will not hold, and cautiously identifies a few that could serve as the moral boundary
for the next generation. At a critical time in this new era of intervention in the human genome, ¡he Питай Gene Editing Debate provides a necessary, comprehensive analysis of the conversation’s direction, past, present, and future.
Contents Acknowledgments 1. Introduction The Importance of Public Bioethical Debate Slippery Slopes The Slope as the Micro-Structure of the HGE Debate Slippery Slopes in the HGE Debate Barriers 2. The First Barriers in the Human Genetic Engineering Debate The First Barriers Why These В arriers Were Strong A Change in the Participants and Their Values Weakening the Somatic/Germline Barrier Weakening the Disease/Enhancement Barrier The Somatic/Germline and Disease/Enhancement Barriers at the End of the 20th Century 3. The CRISPR Era, the National Academies Report, and the Median Trait Barrier The Barriers at the Beginning of the CRISPR Era The NASEM Report Advocates Replacing the Somatic/Germline Barrier The NASEM’s Proposed Barrier The Prevalent Variant Barrier Design Strength of the Barrier Future Polygenic Selection and Modification Designing the Median Trait Barrier Values That Support the Median Trait Barrier Values That Imperil the Median Trait Barrier The Barriers Examined in This Chapter vii 1 5 9 11 15 18 25 29 35 44 46 57 65 67 69 77 85 87 90 94 97 100 103 108
VI CONTENTS 4. Possible Barriers Further Down the Slope The Goals of Medicine Barrier The Family Genes В arrier The Boundary of Humanity Barrier The Liberal Eugenics Barrier Conclusion 111 113 115 122 126 131 5. Conclusion Historical and Future Barriers on the HGE Slope Can Any Barriers Hold? Could Solid Barriers Be Anchored by Authority? Rejecting the Direction of the Slope General Conclusions About Slippery Slopes from the HGE Case What Is to Be Done? 133 134 140 142 143 Notes Bibliography Index 153 181 191 145 150
n 2018 the first genetically modified babies were reportedly born in China, made possible by the invention of CRISPR technology in 2012. This contro versial advancement overturned the pre-existing moral consensus, which had held lor over fifty years before: while gene editing an adult person was morally acceptable, modifying babies, and thus subsequent generations, crossed a signifi cant moral line. It this line is passed over, scientists will be left without an agreedupon ethical limit. What do we do now? I I O H II. 1՛. ѴЛ S here provides a meta-level guide to how these debates move forward and their significance to society. He explains how the bioethical debate has long been charactcrb.ed as a slippery slope, with consensually ethical use at the top, nightmarish dystopia at the bottom, and specific agreed-upon limits in between, which draw the lines between the ethical and the unethical. Kvans frames his analysis around these limits, or barriers. Historically they have existed to guide scientists and to prevent the debate from slipping down the metaphorical slope into unacceptable ettgenicist possibilities, such as in Aidons Huxley’s novel Brave New World or the movie Gtit tacet. Kvans examines the history of how barriers were placed, then fell, then replaced by new ones, and discusses how these insights inform where the debate may head. He evaluates other proposed barriers relevant to where we are now, projects that most of the barriers suggested by scientists and bioethicists will not hold, and cautiously identifies a few that could serve as the moral boundary
for the next generation. At a critical time in this new era of intervention in the human genome, ¡he Питай Gene Editing Debate provides a necessary, comprehensive analysis of the conversation’s direction, past, present, and future.
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Contents Acknowledgments 1. Introduction The Importance of Public Bioethical Debate Slippery Slopes The Slope as the Micro-Structure of the HGE Debate Slippery Slopes in the HGE Debate Barriers 2. The First Barriers in the Human Genetic Engineering Debate The First Barriers Why These В arriers Were Strong A Change in the Participants and Their Values Weakening the Somatic/Germline Barrier Weakening the Disease/Enhancement Barrier The Somatic/Germline and Disease/Enhancement Barriers at the End of the 20th Century 3. The CRISPR Era, the National Academies Report, and the Median Trait Barrier The Barriers at the Beginning of the CRISPR Era The NASEM Report Advocates Replacing the Somatic/Germline Barrier The NASEM’s Proposed Barrier The Prevalent Variant Barrier Design Strength of the Barrier Future Polygenic Selection and Modification Designing the Median Trait Barrier Values That Support the Median Trait Barrier Values That Imperil the Median Trait Barrier The Barriers Examined in This Chapter vii 1 5 9 11 15 18 25 29 35 44 46 57 65 67 69 77 85 87 90 94 97 100 103 108
VI CONTENTS 4. Possible Barriers Further Down the Slope The Goals of Medicine Barrier The Family Genes В arrier The Boundary of Humanity Barrier The Liberal Eugenics Barrier Conclusion 111 113 115 122 126 131 5. Conclusion Historical and Future Barriers on the HGE Slope Can Any Barriers Hold? Could Solid Barriers Be Anchored by Authority? Rejecting the Direction of the Slope General Conclusions About Slippery Slopes from the HGE Case What Is to Be Done? 133 134 140 142 143 Notes Bibliography Index 153 181 191 145 150
n 2018 the first genetically modified babies were reportedly born in China, made possible by the invention of CRISPR technology in 2012. This contro versial advancement overturned the pre-existing moral consensus, which had held lor over fifty years before: while gene editing an adult person was morally acceptable, modifying babies, and thus subsequent generations, crossed a signifi cant moral line. It this line is passed over, scientists will be left without an agreedupon ethical limit. What do we do now? I I O H \ II. 1՛. ѴЛ \ S here provides a meta-level guide to how these debates move forward and their significance to society. He explains how the bioethical debate has long been charactcrb.ed as a slippery slope, with consensually ethical use at the top, nightmarish dystopia at the bottom, and specific agreed-upon limits in between, which draw the lines between the ethical and the unethical. Kvans frames his analysis around these limits, or barriers. Historically they have existed to guide scientists and to prevent the debate from slipping down the metaphorical slope into unacceptable ettgenicist possibilities, such as in Aidons Huxley’s novel Brave New World or the movie Gtit tacet. Kvans examines the history of how barriers were placed, then fell, then replaced by new ones, and discusses how these insights inform where the debate may head. He evaluates other proposed barriers relevant to where we are now, projects that most of the barriers suggested by scientists and bioethicists will not hold, and cautiously identifies a few that could serve as the moral boundary
for the next generation. At a critical time in this new era of intervention in the human genome, ¡he Питай Gene Editing Debate provides a necessary, comprehensive analysis of the conversation’s direction, past, present, and future.
Contents Acknowledgments 1. Introduction The Importance of Public Bioethical Debate Slippery Slopes The Slope as the Micro-Structure of the HGE Debate Slippery Slopes in the HGE Debate Barriers 2. The First Barriers in the Human Genetic Engineering Debate The First Barriers Why These В arriers Were Strong A Change in the Participants and Their Values Weakening the Somatic/Germline Barrier Weakening the Disease/Enhancement Barrier The Somatic/Germline and Disease/Enhancement Barriers at the End of the 20th Century 3. The CRISPR Era, the National Academies Report, and the Median Trait Barrier The Barriers at the Beginning of the CRISPR Era The NASEM Report Advocates Replacing the Somatic/Germline Barrier The NASEM’s Proposed Barrier The Prevalent Variant Barrier Design Strength of the Barrier Future Polygenic Selection and Modification Designing the Median Trait Barrier Values That Support the Median Trait Barrier Values That Imperil the Median Trait Barrier The Barriers Examined in This Chapter vii 1 5 9 11 15 18 25 29 35 44 46 57 65 67 69 77 85 87 90 94 97 100 103 108
VI CONTENTS 4. Possible Barriers Further Down the Slope The Goals of Medicine Barrier The Family Genes В arrier The Boundary of Humanity Barrier The Liberal Eugenics Barrier Conclusion 111 113 115 122 126 131 5. Conclusion Historical and Future Barriers on the HGE Slope Can Any Barriers Hold? Could Solid Barriers Be Anchored by Authority? Rejecting the Direction of the Slope General Conclusions About Slippery Slopes from the HGE Case What Is to Be Done? 133 134 140 142 143 Notes Bibliography Index 153 181 191 145 150
n 2018 the first genetically modified babies were reportedly born in China, made possible by the invention of CRISPR technology in 2012. This contro versial advancement overturned the pre-existing moral consensus, which had held lor over fifty years before: while gene editing an adult person was morally acceptable, modifying babies, and thus subsequent generations, crossed a signifi cant moral line. It this line is passed over, scientists will be left without an agreedupon ethical limit. What do we do now? I I O H \ II. 1՛. ѴЛ \ S here provides a meta-level guide to how these debates move forward and their significance to society. He explains how the bioethical debate has long been charactcrb.ed as a slippery slope, with consensually ethical use at the top, nightmarish dystopia at the bottom, and specific agreed-upon limits in between, which draw the lines between the ethical and the unethical. Kvans frames his analysis around these limits, or barriers. Historically they have existed to guide scientists and to prevent the debate from slipping down the metaphorical slope into unacceptable ettgenicist possibilities, such as in Aidons Huxley’s novel Brave New World or the movie Gtit tacet. Kvans examines the history of how barriers were placed, then fell, then replaced by new ones, and discusses how these insights inform where the debate may head. He evaluates other proposed barriers relevant to where we are now, projects that most of the barriers suggested by scientists and bioethicists will not hold, and cautiously identifies a few that could serve as the moral boundary
for the next generation. At a critical time in this new era of intervention in the human genome, ¡he Питай Gene Editing Debate provides a necessary, comprehensive analysis of the conversation’s direction, past, present, and future. |
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| spelling | Evans, John Hyde 1965- Verfasser (DE-588)124913504 aut The human gene editing debate John H. Evans Oxford Oxford University Press [2020] © 2020 vi, 200 Seiten txt rdacontent n rdamedia nc rdacarrier Humangenetik (DE-588)4072653-8 gnd rswk-swf Biotechnologie (DE-588)4069491-4 gnd rswk-swf Bioethik (DE-588)4006791-9 gnd rswk-swf Humangenetik (DE-588)4072653-8 s Biotechnologie (DE-588)4069491-4 s Bioethik (DE-588)4006791-9 s DE-604 Erscheint auch als Online-Ausgabe 978-0-19-751959-2 Erscheint auch als Online-Ausgabe, EPUB 978-0-19-751958-5 Erscheint auch als Online-Ausgabe, PDF 978-0-19-751957-8 Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032250385&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032250385&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032250385&sequence=000005&line_number=0003&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032250385&sequence=000007&line_number=0004&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Evans, John Hyde 1965- The human gene editing debate Humangenetik (DE-588)4072653-8 gnd Biotechnologie (DE-588)4069491-4 gnd Bioethik (DE-588)4006791-9 gnd |
| subject_GND | (DE-588)4072653-8 (DE-588)4069491-4 (DE-588)4006791-9 |
| title | The human gene editing debate |
| title_auth | The human gene editing debate |
| title_exact_search | The human gene editing debate |
| title_exact_search_txtP | The human gene editing debate |
| title_full | The human gene editing debate John H. Evans |
| title_fullStr | The human gene editing debate John H. Evans |
| title_full_unstemmed | The human gene editing debate John H. Evans |
| title_short | The human gene editing debate |
| title_sort | the human gene editing debate |
| topic | Humangenetik (DE-588)4072653-8 gnd Biotechnologie (DE-588)4069491-4 gnd Bioethik (DE-588)4006791-9 gnd |
| topic_facet | Humangenetik Biotechnologie Bioethik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032250385&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032250385&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032250385&sequence=000005&line_number=0003&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032250385&sequence=000007&line_number=0004&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT evansjohnhyde thehumangeneeditingdebate |
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