Chromosomal Instability in Cancer Cells:
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer International Publishing
2015
|
| Ausgabe: | 1st ed. 2015 |
| Schriftenreihe: | Recent Results in Cancer Research
|
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification |
| Beschreibung: | DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequences of aneuploidy in cancer: transcriptome and beyond |
| Beschreibung: | 1 Online Ressource (VII, 224 Seiten, 39 Illustrationen in Farbe) |
| ISBN: | 9783319202914 |
| DOI: | 10.1007/978-3-319-20291-4 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV046816298 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 200721s2015 |||| o||u| ||||||eng d | ||
| 020 | |a 9783319202914 |9 978-3-319-20291-4 | ||
| 024 | 7 | |a 10.1007/978-3-319-20291-4 |2 doi | |
| 035 | |a (ZDB-2-SME)978-3-319-20291-4 | ||
| 035 | |a (OCoLC)1190923840 | ||
| 035 | |a (DE-599)BVBBV046816298 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 082 | 0 | |a 616.994 | |
| 084 | |a WG 7400 |0 (DE-625)148616: |2 rvk | ||
| 245 | 1 | 0 | |a Chromosomal Instability in Cancer Cells |c edited by B. Michael Ghadimi, Thomas Ried |
| 250 | |a 1st ed. 2015 | ||
| 264 | 1 | |a Cham |b Springer International Publishing |c 2015 | |
| 300 | |a 1 Online Ressource (VII, 224 Seiten, 39 Illustrationen in Farbe) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Recent Results in Cancer Research | |
| 500 | |a DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequences of aneuploidy in cancer: transcriptome and beyond | ||
| 520 | |a This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification | ||
| 650 | 4 | |a Oncology | |
| 650 | 4 | |a Cancer research | |
| 650 | 4 | |a Human genetics | |
| 700 | 1 | |a Ghadimi, B. Michael |e Sonstige |4 oth | |
| 700 | 1 | |a Ried, Thomas |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783319202907 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783319202921 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783319349626 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-319-20291-4 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-2-SME | ||
| 940 | 1 | |q ZDB-2-SME_2015 | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-032224755 | ||
| 966 | e | |u https://doi.org/10.1007/978-3-319-20291-4 |l UBR01 |p ZDB-2-SME |q ZDB-2-SME_2015 |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804181625913737216 |
|---|---|
| adam_txt | |
| any_adam_object | |
| any_adam_object_boolean | |
| building | Verbundindex |
| bvnumber | BV046816298 |
| classification_rvk | WG 7400 |
| collection | ZDB-2-SME |
| ctrlnum | (ZDB-2-SME)978-3-319-20291-4 (OCoLC)1190923840 (DE-599)BVBBV046816298 |
| dewey-full | 616.994 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.994 |
| dewey-search | 616.994 |
| dewey-sort | 3616.994 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| discipline_str_mv | Biologie Medizin |
| doi_str_mv | 10.1007/978-3-319-20291-4 |
| edition | 1st ed. 2015 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03134nmm a2200481zc 4500</leader><controlfield tag="001">BV046816298</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">200721s2015 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783319202914</subfield><subfield code="9">978-3-319-20291-4</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-3-319-20291-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-2-SME)978-3-319-20291-4</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1190923840</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046816298</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.994</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WG 7400</subfield><subfield code="0">(DE-625)148616:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Chromosomal Instability in Cancer Cells</subfield><subfield code="c">edited by B. Michael Ghadimi, Thomas Ried</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1st ed. 2015</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cham</subfield><subfield code="b">Springer International Publishing</subfield><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online Ressource (VII, 224 Seiten, 39 Illustrationen in Farbe)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Recent Results in Cancer Research</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequences of aneuploidy in cancer: transcriptome and beyond</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oncology </subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer research</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human genetics</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ghadimi, B. Michael</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ried, Thomas</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783319202907</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783319202921</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783319349626</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-3-319-20291-4</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SME</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SME_2015</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-032224755</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-319-20291-4</subfield><subfield code="l">UBR01</subfield><subfield code="p">ZDB-2-SME</subfield><subfield code="q">ZDB-2-SME_2015</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV046816298 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T15:00:15Z |
| indexdate | 2024-07-10T08:54:38Z |
| institution | BVB |
| isbn | 9783319202914 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032224755 |
| oclc_num | 1190923840 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online Ressource (VII, 224 Seiten, 39 Illustrationen in Farbe) |
| psigel | ZDB-2-SME ZDB-2-SME_2015 ZDB-2-SME ZDB-2-SME_2015 |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Springer International Publishing |
| record_format | marc |
| series2 | Recent Results in Cancer Research |
| spelling | Chromosomal Instability in Cancer Cells edited by B. Michael Ghadimi, Thomas Ried 1st ed. 2015 Cham Springer International Publishing 2015 1 Online Ressource (VII, 224 Seiten, 39 Illustrationen in Farbe) txt rdacontent c rdamedia cr rdacarrier Recent Results in Cancer Research DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequences of aneuploidy in cancer: transcriptome and beyond This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification Oncology Cancer research Human genetics Ghadimi, B. Michael Sonstige oth Ried, Thomas Sonstige oth Erscheint auch als Druck-Ausgabe 9783319202907 Erscheint auch als Druck-Ausgabe 9783319202921 Erscheint auch als Druck-Ausgabe 9783319349626 https://doi.org/10.1007/978-3-319-20291-4 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Chromosomal Instability in Cancer Cells Oncology Cancer research Human genetics |
| title | Chromosomal Instability in Cancer Cells |
| title_auth | Chromosomal Instability in Cancer Cells |
| title_exact_search | Chromosomal Instability in Cancer Cells |
| title_exact_search_txtP | Chromosomal Instability in Cancer Cells |
| title_full | Chromosomal Instability in Cancer Cells edited by B. Michael Ghadimi, Thomas Ried |
| title_fullStr | Chromosomal Instability in Cancer Cells edited by B. Michael Ghadimi, Thomas Ried |
| title_full_unstemmed | Chromosomal Instability in Cancer Cells edited by B. Michael Ghadimi, Thomas Ried |
| title_short | Chromosomal Instability in Cancer Cells |
| title_sort | chromosomal instability in cancer cells |
| topic | Oncology Cancer research Human genetics |
| topic_facet | Oncology Cancer research Human genetics |
| url | https://doi.org/10.1007/978-3-319-20291-4 |
| work_keys_str_mv | AT ghadimibmichael chromosomalinstabilityincancercells AT riedthomas chromosomalinstabilityincancercells |