Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development: A Focus on Early Phase Clinical Studies
This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London
Springer London
2015
|
| Ausgabe: | 1st ed. 2015 |
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development. Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties |
| Beschreibung: | 1. Review of physiology/pathophysiology -- 2. Methods for assessing insulin action in humans -- 3. Assessment of insulin secretion -- 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy -- 5. Isotopic tracers for the measurement of metabolic flux -- 6. Measuring food intake in clinical drug development -- 7. Measurement of energy expenditure -- 8. Assessment of body composition -- 9. Assessment of cardiovascular safety of new diabetes drugs |
| Beschreibung: | 1 Online Ressource (XII, 312 Seiten, 76 Illustrationen, 39 Illustrationen in Farbe) |
| ISBN: | 9781447149200 |
| DOI: | 10.1007/978-1-4471-4920-0 |
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| 520 | |a This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development. Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties | ||
| 650 | 4 | |a Medicine | |
| 650 | 4 | |a Internal medicine | |
| 650 | 4 | |a Diabetes | |
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| 700 | 1 | |a Hompesch, Marcus |e Sonstige |4 oth | |
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| doi_str_mv | 10.1007/978-1-4471-4920-0 |
| edition | 1st ed. 2015 |
| format | Electronic eBook |
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| id | DE-604.BV046815149 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T15:00:01Z |
| indexdate | 2024-07-10T08:54:36Z |
| institution | BVB |
| isbn | 9781447149200 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032223628 |
| oclc_num | 1190912377 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online Ressource (XII, 312 Seiten, 76 Illustrationen, 39 Illustrationen in Farbe) |
| psigel | ZDB-2-SME ZDB-2-SME_2015 ZDB-2-SME ZDB-2-SME_2015 |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Springer London |
| record_format | marc |
| spelling | Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development A Focus on Early Phase Clinical Studies edited by Andrew J. Krentz, Lutz Heinemann, Marcus Hompesch 1st ed. 2015 London Springer London 2015 1 Online Ressource (XII, 312 Seiten, 76 Illustrationen, 39 Illustrationen in Farbe) txt rdacontent c rdamedia cr rdacarrier 1. Review of physiology/pathophysiology -- 2. Methods for assessing insulin action in humans -- 3. Assessment of insulin secretion -- 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy -- 5. Isotopic tracers for the measurement of metabolic flux -- 6. Measuring food intake in clinical drug development -- 7. Measurement of energy expenditure -- 8. Assessment of body composition -- 9. Assessment of cardiovascular safety of new diabetes drugs This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development. Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties Medicine Internal medicine Diabetes Metabolic diseases Pharmacology Pharmaceutical technology Krentz, Andrew J. Sonstige oth Heinemann, Lutz Sonstige oth Hompesch, Marcus Sonstige oth Erscheint auch als Druck-Ausgabe 9781447149217 Erscheint auch als Druck-Ausgabe 9781447149194 Erscheint auch als Druck-Ausgabe 9781447170327 https://doi.org/10.1007/978-1-4471-4920-0 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development A Focus on Early Phase Clinical Studies Medicine Internal medicine Diabetes Metabolic diseases Pharmacology Pharmaceutical technology |
| title | Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development A Focus on Early Phase Clinical Studies |
| title_auth | Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development A Focus on Early Phase Clinical Studies |
| title_exact_search | Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development A Focus on Early Phase Clinical Studies |
| title_exact_search_txtP | Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development A Focus on Early Phase Clinical Studies |
| title_full | Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development A Focus on Early Phase Clinical Studies edited by Andrew J. Krentz, Lutz Heinemann, Marcus Hompesch |
| title_fullStr | Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development A Focus on Early Phase Clinical Studies edited by Andrew J. Krentz, Lutz Heinemann, Marcus Hompesch |
| title_full_unstemmed | Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development A Focus on Early Phase Clinical Studies edited by Andrew J. Krentz, Lutz Heinemann, Marcus Hompesch |
| title_short | Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development |
| title_sort | translational research methods for diabetes obesity and cardiometabolic drug development a focus on early phase clinical studies |
| title_sub | A Focus on Early Phase Clinical Studies |
| topic | Medicine Internal medicine Diabetes Metabolic diseases Pharmacology Pharmaceutical technology |
| topic_facet | Medicine Internal medicine Diabetes Metabolic diseases Pharmacology Pharmaceutical technology |
| url | https://doi.org/10.1007/978-1-4471-4920-0 |
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