Preventive and Predictive Genetics: Towards Personalised Medicine:
Traditionally, medical research comprised of the identification of the pathological causes of a disease, its epidemiology and empirical investigation of treatment response. Intensive genetic research, marked by the completion of the human genome project in 2003, heralded a new era in medical researc...
Gespeichert in:
Format: | Elektronisch E-Book |
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Sprache: | English |
Veröffentlicht: |
Cham
Springer International Publishing
2015
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Ausgabe: | 1st ed. 2015 |
Schriftenreihe: | Advances in Predictive, Preventive and Personalised Medicine
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Schlagworte: | |
Online-Zugang: | UBR01 URL des Erstveröffentlichers |
Zusammenfassung: | Traditionally, medical research comprised of the identification of the pathological causes of a disease, its epidemiology and empirical investigation of treatment response. Intensive genetic research, marked by the completion of the human genome project in 2003, heralded a new era in medical research. While epidemiology and gross pathology are still mainstay useful tools, genetics and genomics have gradually been shown to increase the resolution of drug response research, showing great potential in also informing and identifying the role of genes and their encoded products in the pathophysiology of diseases. This information is already being applied in the prevention of illness, effective early diagnosis, better risk assessment (prognosis), as well as targeted effective and safe treatment allocation (prediction and monitoring). Genetic testing and genomics support personalised medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalised medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions |
Beschreibung: | Introduction -- Preventive and Predictive Genetics: A perspective -- Roadmap to Drug Development Enabled by Pharmacogenetics -- Preventative and Predictive Genetics: Towards Personalised Medicine -- Pharmacokinetics and Pharmacogenetics: bringing the magic bullet closer to reality -- Pharmacogenetics of Adverse Drug Reactions -- Pharmacogenomics for haemoglobinopathies therapeutics -- Pharmacogenetics of Neurodegenerative Disorders -- Pharmacogenetics of asthma -- Pharmacogenetics and antineoplastic therapies -- Pharmacogenetics of coumarin anticoagulant therapy -- Implementation of Genomic Medicine: tools and challenges -- Ethical Considerations in the Genomic Era -- Index |
Beschreibung: | 1 Online Ressource (XX, 378 Seiten, 18 Illustrationen, 8 Illustrationen in Farbe) |
ISBN: | 9783319153445 |
DOI: | 10.1007/978-3-319-15344-5 |
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520 | |a Traditionally, medical research comprised of the identification of the pathological causes of a disease, its epidemiology and empirical investigation of treatment response. Intensive genetic research, marked by the completion of the human genome project in 2003, heralded a new era in medical research. While epidemiology and gross pathology are still mainstay useful tools, genetics and genomics have gradually been shown to increase the resolution of drug response research, showing great potential in also informing and identifying the role of genes and their encoded products in the pathophysiology of diseases. This information is already being applied in the prevention of illness, effective early diagnosis, better risk assessment (prognosis), as well as targeted effective and safe treatment allocation (prediction and monitoring). Genetic testing and genomics support personalised medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalised medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions | ||
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series2 | Advances in Predictive, Preventive and Personalised Medicine |
spelling | Preventive and Predictive Genetics: Towards Personalised Medicine edited by Godfrey Grech, Iris Grossman 1st ed. 2015 Cham Springer International Publishing 2015 1 Online Ressource (XX, 378 Seiten, 18 Illustrationen, 8 Illustrationen in Farbe) txt rdacontent c rdamedia cr rdacarrier Advances in Predictive, Preventive and Personalised Medicine Introduction -- Preventive and Predictive Genetics: A perspective -- Roadmap to Drug Development Enabled by Pharmacogenetics -- Preventative and Predictive Genetics: Towards Personalised Medicine -- Pharmacokinetics and Pharmacogenetics: bringing the magic bullet closer to reality -- Pharmacogenetics of Adverse Drug Reactions -- Pharmacogenomics for haemoglobinopathies therapeutics -- Pharmacogenetics of Neurodegenerative Disorders -- Pharmacogenetics of asthma -- Pharmacogenetics and antineoplastic therapies -- Pharmacogenetics of coumarin anticoagulant therapy -- Implementation of Genomic Medicine: tools and challenges -- Ethical Considerations in the Genomic Era -- Index Traditionally, medical research comprised of the identification of the pathological causes of a disease, its epidemiology and empirical investigation of treatment response. Intensive genetic research, marked by the completion of the human genome project in 2003, heralded a new era in medical research. While epidemiology and gross pathology are still mainstay useful tools, genetics and genomics have gradually been shown to increase the resolution of drug response research, showing great potential in also informing and identifying the role of genes and their encoded products in the pathophysiology of diseases. This information is already being applied in the prevention of illness, effective early diagnosis, better risk assessment (prognosis), as well as targeted effective and safe treatment allocation (prediction and monitoring). Genetic testing and genomics support personalised medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalised medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions Molecular biology Medical education Systems biology Human genetics Pharmacology Drug resistance Grech, Godfrey Sonstige oth Grossman, Iris Sonstige oth Erscheint auch als Druck-Ausgabe 9783319153452 Erscheint auch als Druck-Ausgabe 9783319153438 Erscheint auch als Druck-Ausgabe 9783319380575 https://doi.org/10.1007/978-3-319-15344-5 Verlag URL des Erstveröffentlichers Volltext |
spellingShingle | Preventive and Predictive Genetics: Towards Personalised Medicine Molecular biology Medical education Systems biology Human genetics Pharmacology Drug resistance |
title | Preventive and Predictive Genetics: Towards Personalised Medicine |
title_auth | Preventive and Predictive Genetics: Towards Personalised Medicine |
title_exact_search | Preventive and Predictive Genetics: Towards Personalised Medicine |
title_exact_search_txtP | Preventive and Predictive Genetics: Towards Personalised Medicine |
title_full | Preventive and Predictive Genetics: Towards Personalised Medicine edited by Godfrey Grech, Iris Grossman |
title_fullStr | Preventive and Predictive Genetics: Towards Personalised Medicine edited by Godfrey Grech, Iris Grossman |
title_full_unstemmed | Preventive and Predictive Genetics: Towards Personalised Medicine edited by Godfrey Grech, Iris Grossman |
title_short | Preventive and Predictive Genetics: Towards Personalised Medicine |
title_sort | preventive and predictive genetics towards personalised medicine |
topic | Molecular biology Medical education Systems biology Human genetics Pharmacology Drug resistance |
topic_facet | Molecular biology Medical education Systems biology Human genetics Pharmacology Drug resistance |
url | https://doi.org/10.1007/978-3-319-15344-5 |
work_keys_str_mv | AT grechgodfrey preventiveandpredictivegeneticstowardspersonalisedmedicine AT grossmaniris preventiveandpredictivegeneticstowardspersonalisedmedicine |