Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine:
This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques,...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer International Publishing
2015
|
| Ausgabe: | 1st ed. 2015 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial. The authors are all members of the French Curie Institute, one of the world's foremost cancer research institutions |
| Beschreibung: | Introduction: Rationale for Precision Medicine Clinical Trials.- The Key Role of Pathology in the Context of Precision Medicine Trials -- Basis for Molecular Genetics in Cancer -- Microarrays Based Molecular Profiling to Identify Genomic Alterations -- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential -- Bioinformatics for Precision Medicine in Oncology -- Assessment of Biomarkers' Predictive Value of Efficacy -- Designs for Evaluating Precision Medicine Trials -- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials |
| Beschreibung: | 1 Online Ressource (X, 144 Seiten, 100 Illustrationen, 50 Illustrationen in Farbe) |
| ISBN: | 9783319221892 |
| DOI: | 10.1007/978-3-319-22189-2 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV046812995 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 200717s2015 |||| o||u| ||||||eng d | ||
| 020 | |a 9783319221892 |9 978-3-319-22189-2 | ||
| 024 | 7 | |a 10.1007/978-3-319-22189-2 |2 doi | |
| 035 | |a (ZDB-2-SME)978-3-319-22189-2 | ||
| 035 | |a (OCoLC)1190907321 | ||
| 035 | |a (DE-599)BVBBV046812995 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 082 | 0 | |a 616.994 | |
| 245 | 1 | 0 | |a Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine |c edited by Christophe Le Tourneau, Maud Kamal |
| 250 | |a 1st ed. 2015 | ||
| 264 | 1 | |a Cham |b Springer International Publishing |c 2015 | |
| 300 | |a 1 Online Ressource (X, 144 Seiten, 100 Illustrationen, 50 Illustrationen in Farbe) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 500 | |a Introduction: Rationale for Precision Medicine Clinical Trials.- The Key Role of Pathology in the Context of Precision Medicine Trials -- Basis for Molecular Genetics in Cancer -- Microarrays Based Molecular Profiling to Identify Genomic Alterations -- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential -- Bioinformatics for Precision Medicine in Oncology -- Assessment of Biomarkers' Predictive Value of Efficacy -- Designs for Evaluating Precision Medicine Trials -- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials | ||
| 520 | |a This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial. The authors are all members of the French Curie Institute, one of the world's foremost cancer research institutions | ||
| 650 | 4 | |a Oncology | |
| 650 | 4 | |a Pathology | |
| 650 | 4 | |a Cancer research | |
| 650 | 4 | |a Molecular biology | |
| 700 | 1 | |a Le Tourneau, Christophe |e Sonstige |4 oth | |
| 700 | 1 | |a Kamal, Maud |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783319221885 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783319221908 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783319371764 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-319-22189-2 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-2-SME | ||
| 940 | 1 | |q ZDB-2-SME_2015 | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-032221508 | ||
| 966 | e | |u https://doi.org/10.1007/978-3-319-22189-2 |l UBR01 |p ZDB-2-SME |q ZDB-2-SME_2015 |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804181620030177280 |
|---|---|
| adam_txt | |
| any_adam_object | |
| any_adam_object_boolean | |
| building | Verbundindex |
| bvnumber | BV046812995 |
| collection | ZDB-2-SME |
| ctrlnum | (ZDB-2-SME)978-3-319-22189-2 (OCoLC)1190907321 (DE-599)BVBBV046812995 |
| dewey-full | 616.994 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.994 |
| dewey-search | 616.994 |
| dewey-sort | 3616.994 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| doi_str_mv | 10.1007/978-3-319-22189-2 |
| edition | 1st ed. 2015 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03076nmm a2200469zc 4500</leader><controlfield tag="001">BV046812995</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">200717s2015 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783319221892</subfield><subfield code="9">978-3-319-22189-2</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-3-319-22189-2</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-2-SME)978-3-319-22189-2</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1190907321</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046812995</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.994</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine</subfield><subfield code="c">edited by Christophe Le Tourneau, Maud Kamal</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1st ed. 2015</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cham</subfield><subfield code="b">Springer International Publishing</subfield><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online Ressource (X, 144 Seiten, 100 Illustrationen, 50 Illustrationen in Farbe)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Introduction: Rationale for Precision Medicine Clinical Trials.- The Key Role of Pathology in the Context of Precision Medicine Trials -- Basis for Molecular Genetics in Cancer -- Microarrays Based Molecular Profiling to Identify Genomic Alterations -- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential -- Bioinformatics for Precision Medicine in Oncology -- Assessment of Biomarkers' Predictive Value of Efficacy -- Designs for Evaluating Precision Medicine Trials -- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial. The authors are all members of the French Curie Institute, one of the world's foremost cancer research institutions</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oncology </subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer research</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Molecular biology</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Le Tourneau, Christophe</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kamal, Maud</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783319221885</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783319221908</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783319371764</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-3-319-22189-2</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SME</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SME_2015</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-032221508</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-319-22189-2</subfield><subfield code="l">UBR01</subfield><subfield code="p">ZDB-2-SME</subfield><subfield code="q">ZDB-2-SME_2015</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV046812995 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T14:59:22Z |
| indexdate | 2024-07-10T08:54:33Z |
| institution | BVB |
| isbn | 9783319221892 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032221508 |
| oclc_num | 1190907321 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online Ressource (X, 144 Seiten, 100 Illustrationen, 50 Illustrationen in Farbe) |
| psigel | ZDB-2-SME ZDB-2-SME_2015 ZDB-2-SME ZDB-2-SME_2015 |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Springer International Publishing |
| record_format | marc |
| spelling | Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine edited by Christophe Le Tourneau, Maud Kamal 1st ed. 2015 Cham Springer International Publishing 2015 1 Online Ressource (X, 144 Seiten, 100 Illustrationen, 50 Illustrationen in Farbe) txt rdacontent c rdamedia cr rdacarrier Introduction: Rationale for Precision Medicine Clinical Trials.- The Key Role of Pathology in the Context of Precision Medicine Trials -- Basis for Molecular Genetics in Cancer -- Microarrays Based Molecular Profiling to Identify Genomic Alterations -- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential -- Bioinformatics for Precision Medicine in Oncology -- Assessment of Biomarkers' Predictive Value of Efficacy -- Designs for Evaluating Precision Medicine Trials -- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial. The authors are all members of the French Curie Institute, one of the world's foremost cancer research institutions Oncology Pathology Cancer research Molecular biology Le Tourneau, Christophe Sonstige oth Kamal, Maud Sonstige oth Erscheint auch als Druck-Ausgabe 9783319221885 Erscheint auch als Druck-Ausgabe 9783319221908 Erscheint auch als Druck-Ausgabe 9783319371764 https://doi.org/10.1007/978-3-319-22189-2 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine Oncology Pathology Cancer research Molecular biology |
| title | Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine |
| title_auth | Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine |
| title_exact_search | Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine |
| title_exact_search_txtP | Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine |
| title_full | Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine edited by Christophe Le Tourneau, Maud Kamal |
| title_fullStr | Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine edited by Christophe Le Tourneau, Maud Kamal |
| title_full_unstemmed | Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine edited by Christophe Le Tourneau, Maud Kamal |
| title_short | Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine |
| title_sort | pan cancer integrative molecular portrait towards a new paradigm in precision medicine |
| topic | Oncology Pathology Cancer research Molecular biology |
| topic_facet | Oncology Pathology Cancer research Molecular biology |
| url | https://doi.org/10.1007/978-3-319-22189-2 |
| work_keys_str_mv | AT letourneauchristophe pancancerintegrativemolecularportraittowardsanewparadigminprecisionmedicine AT kamalmaud pancancerintegrativemolecularportraittowardsanewparadigminprecisionmedicine |