Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials:
This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identifie...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer International Publishing
2015
|
| Ausgabe: | 1st ed. 2015 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (id est chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs. |
| Beschreibung: | Introduction -- Pharmacology of Recommended Antimalarial Agents -- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials -- Pharmacokinetic Drug Interactions Affecting Antimalarials -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials -- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions -- Limitations, Future Directions, and Conclusions |
| Beschreibung: | 1 Online Ressource (VII, 146 Seiten, 1 Illustrationen in Farbe) |
| ISBN: | 9783319105277 |
| DOI: | 10.1007/978-3-319-10527-7 |
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| 520 | |a This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (id est chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs. | ||
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Datensatz im Suchindex
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| author | Kiang, Tony K.L |
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| dewey-full | 616.9883 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.9883 |
| dewey-search | 616.9883 |
| dewey-sort | 3616.9883 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| doi_str_mv | 10.1007/978-3-319-10527-7 |
| edition | 1st ed. 2015 |
| format | Electronic eBook |
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| id | DE-604.BV046811934 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T14:59:04Z |
| indexdate | 2024-07-10T08:54:31Z |
| institution | BVB |
| isbn | 9783319105277 |
| language | English |
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| physical | 1 Online Ressource (VII, 146 Seiten, 1 Illustrationen in Farbe) |
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| spelling | Kiang, Tony K.L. Verfasser aut Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials by Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom 1st ed. 2015 Cham Springer International Publishing 2015 1 Online Ressource (VII, 146 Seiten, 1 Illustrationen in Farbe) txt rdacontent c rdamedia cr rdacarrier Introduction -- Pharmacology of Recommended Antimalarial Agents -- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials -- Pharmacokinetic Drug Interactions Affecting Antimalarials -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials -- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions -- Limitations, Future Directions, and Conclusions This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (id est chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs. Tropical medicine Health promotion Pharmacy Wilby, Kyle John Sonstige oth Ensom, Mary H.H. Sonstige oth Erscheint auch als Druck-Ausgabe 9783319105284 Erscheint auch als Druck-Ausgabe 9783319105260 Erscheint auch als Druck-Ausgabe 9783319381930 https://doi.org/10.1007/978-3-319-10527-7 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Kiang, Tony K.L Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials Tropical medicine Health promotion Pharmacy |
| title | Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials |
| title_auth | Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials |
| title_exact_search | Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials |
| title_exact_search_txtP | Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials |
| title_full | Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials by Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom |
| title_fullStr | Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials by Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom |
| title_full_unstemmed | Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials by Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom |
| title_short | Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials |
| title_sort | clinical pharmacokinetic and pharmacodynamic drug interactions associated with antimalarials |
| topic | Tropical medicine Health promotion Pharmacy |
| topic_facet | Tropical medicine Health promotion Pharmacy |
| url | https://doi.org/10.1007/978-3-319-10527-7 |
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