Neuroanatomy and Pathology of Sporadic Alzheimer's Disease:
As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. T...
Saved in:
| Main Author: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cham
Springer International Publishing
2015
|
| Edition: | 1st ed. 2015 |
| Series: | Advances in Anatomy, Embryology and Cell Biology
|
| Subjects: | |
| Online Access: | UBR01 Volltext |
| Summary: | As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail |
| Item Description: | Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations. |
| Physical Description: | 1 Online Ressource (XI, 162 Seiten, 48 Illustrationen, 44 Illustrationen in Farbe) |
| ISBN: | 9783319126791 |
| DOI: | 10.1007/978-3-319-12679-1 |
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| dewey-full | 612.8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
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| id | DE-604.BV046811927 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T14:59:04Z |
| indexdate | 2024-07-10T08:54:31Z |
| institution | BVB |
| isbn | 9783319126791 |
| language | English |
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| physical | 1 Online Ressource (XI, 162 Seiten, 48 Illustrationen, 44 Illustrationen in Farbe) |
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| publisher | Springer International Publishing |
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| series2 | Advances in Anatomy, Embryology and Cell Biology |
| spelling | Braak, Heiko Verfasser aut Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak, Kelly Del Tredici 1st ed. 2015 Cham Springer International Publishing 2015 1 Online Ressource (XI, 162 Seiten, 48 Illustrationen, 44 Illustrationen in Farbe) txt rdacontent c rdamedia cr rdacarrier Advances in Anatomy, Embryology and Cell Biology Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations. As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail Neurosciences Pathology Geriatrics Del Tredici, Kelly Sonstige oth Erscheint auch als Druck-Ausgabe 9783319126784 Erscheint auch als Druck-Ausgabe 9783319126807 https://doi.org/10.1007/978-3-319-12679-1 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Braak, Heiko Neuroanatomy and Pathology of Sporadic Alzheimer's Disease Neurosciences Pathology Geriatrics |
| title | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |
| title_auth | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |
| title_exact_search | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |
| title_exact_search_txtP | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |
| title_full | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak, Kelly Del Tredici |
| title_fullStr | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak, Kelly Del Tredici |
| title_full_unstemmed | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak, Kelly Del Tredici |
| title_short | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |
| title_sort | neuroanatomy and pathology of sporadic alzheimer s disease |
| topic | Neurosciences Pathology Geriatrics |
| topic_facet | Neurosciences Pathology Geriatrics |
| url | https://doi.org/10.1007/978-3-319-12679-1 |
| work_keys_str_mv | AT braakheiko neuroanatomyandpathologyofsporadicalzheimersdisease AT deltredicikelly neuroanatomyandpathologyofsporadicalzheimersdisease |