Neuroanatomy and Pathology of Sporadic Alzheimer's Disease:
As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. T...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer International Publishing
2015
|
| Ausgabe: | 1st ed. 2015 |
| Schriftenreihe: | Advances in Anatomy, Embryology and Cell Biology
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail |
| Beschreibung: | Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations. |
| Beschreibung: | 1 Online Ressource (XI, 162 Seiten, 48 Illustrationen, 44 Illustrationen in Farbe) |
| ISBN: | 9783319126791 |
| DOI: | 10.1007/978-3-319-12679-1 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV046811927 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 200717s2015 |||| o||u| ||||||eng d | ||
| 020 | |a 9783319126791 |9 978-3-319-12679-1 | ||
| 024 | 7 | |a 10.1007/978-3-319-12679-1 |2 doi | |
| 035 | |a (ZDB-2-SME)978-3-319-12679-1 | ||
| 035 | |a (OCoLC)1190918263 | ||
| 035 | |a (DE-599)BVBBV046811927 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 082 | 0 | |a 612.8 | |
| 100 | 1 | |a Braak, Heiko |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |c by Heiko Braak, Kelly Del Tredici |
| 250 | |a 1st ed. 2015 | ||
| 264 | 1 | |a Cham |b Springer International Publishing |c 2015 | |
| 300 | |a 1 Online Ressource (XI, 162 Seiten, 48 Illustrationen, 44 Illustrationen in Farbe) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Advances in Anatomy, Embryology and Cell Biology | |
| 500 | |a Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations. | ||
| 520 | |a As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail | ||
| 650 | 4 | |a Neurosciences | |
| 650 | 4 | |a Pathology | |
| 650 | 4 | |a Geriatrics | |
| 700 | 1 | |a Del Tredici, Kelly |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783319126784 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783319126807 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-319-12679-1 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-2-SME | ||
| 940 | 1 | |q ZDB-2-SME_2015 | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-032220465 | ||
| 966 | e | |u https://doi.org/10.1007/978-3-319-12679-1 |l UBR01 |p ZDB-2-SME |q ZDB-2-SME_2015 |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804181618144837632 |
|---|---|
| adam_txt | |
| any_adam_object | |
| any_adam_object_boolean | |
| author | Braak, Heiko |
| author_facet | Braak, Heiko |
| author_role | aut |
| author_sort | Braak, Heiko |
| author_variant | h b hb |
| building | Verbundindex |
| bvnumber | BV046811927 |
| collection | ZDB-2-SME |
| ctrlnum | (ZDB-2-SME)978-3-319-12679-1 (OCoLC)1190918263 (DE-599)BVBBV046811927 |
| dewey-full | 612.8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.8 |
| dewey-search | 612.8 |
| dewey-sort | 3612.8 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| doi_str_mv | 10.1007/978-3-319-12679-1 |
| edition | 1st ed. 2015 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03064nmm a2200457zc 4500</leader><controlfield tag="001">BV046811927</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">200717s2015 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783319126791</subfield><subfield code="9">978-3-319-12679-1</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-3-319-12679-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-2-SME)978-3-319-12679-1</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1190918263</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046811927</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">612.8</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Braak, Heiko</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Neuroanatomy and Pathology of Sporadic Alzheimer's Disease</subfield><subfield code="c">by Heiko Braak, Kelly Del Tredici</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1st ed. 2015</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cham</subfield><subfield code="b">Springer International Publishing</subfield><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online Ressource (XI, 162 Seiten, 48 Illustrationen, 44 Illustrationen in Farbe)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Advances in Anatomy, Embryology and Cell Biology</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations. </subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neurosciences</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Geriatrics</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Del Tredici, Kelly</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783319126784</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783319126807</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-3-319-12679-1</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SME</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SME_2015</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-032220465</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-319-12679-1</subfield><subfield code="l">UBR01</subfield><subfield code="p">ZDB-2-SME</subfield><subfield code="q">ZDB-2-SME_2015</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV046811927 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T14:59:04Z |
| indexdate | 2024-07-10T08:54:31Z |
| institution | BVB |
| isbn | 9783319126791 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032220465 |
| oclc_num | 1190918263 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online Ressource (XI, 162 Seiten, 48 Illustrationen, 44 Illustrationen in Farbe) |
| psigel | ZDB-2-SME ZDB-2-SME_2015 ZDB-2-SME ZDB-2-SME_2015 |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Springer International Publishing |
| record_format | marc |
| series2 | Advances in Anatomy, Embryology and Cell Biology |
| spelling | Braak, Heiko Verfasser aut Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak, Kelly Del Tredici 1st ed. 2015 Cham Springer International Publishing 2015 1 Online Ressource (XI, 162 Seiten, 48 Illustrationen, 44 Illustrationen in Farbe) txt rdacontent c rdamedia cr rdacarrier Advances in Anatomy, Embryology and Cell Biology Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations. As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail Neurosciences Pathology Geriatrics Del Tredici, Kelly Sonstige oth Erscheint auch als Druck-Ausgabe 9783319126784 Erscheint auch als Druck-Ausgabe 9783319126807 https://doi.org/10.1007/978-3-319-12679-1 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Braak, Heiko Neuroanatomy and Pathology of Sporadic Alzheimer's Disease Neurosciences Pathology Geriatrics |
| title | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |
| title_auth | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |
| title_exact_search | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |
| title_exact_search_txtP | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |
| title_full | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak, Kelly Del Tredici |
| title_fullStr | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak, Kelly Del Tredici |
| title_full_unstemmed | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak, Kelly Del Tredici |
| title_short | Neuroanatomy and Pathology of Sporadic Alzheimer's Disease |
| title_sort | neuroanatomy and pathology of sporadic alzheimer s disease |
| topic | Neurosciences Pathology Geriatrics |
| topic_facet | Neurosciences Pathology Geriatrics |
| url | https://doi.org/10.1007/978-3-319-12679-1 |
| work_keys_str_mv | AT braakheiko neuroanatomyandpathologyofsporadicalzheimersdisease AT deltredicikelly neuroanatomyandpathologyofsporadicalzheimersdisease |