Genomic uracil: evolution, biology, immunology and disease
"This book describes genomic uracil in evolution, as a DNA constituent in adaptive and innate immune responses and as a mutagenic lesion causing cancer. Genomic uracil is as old as life and may have been a component in self-replicating molecules in the prebiotic era. The first living cells prob...
Saved in:
| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
Singapore
World Scientific Publishing Company Pte Limited
2018
|
| Subjects: | |
| Online Access: | UBY01 Volltext |
| Summary: | "This book describes genomic uracil in evolution, as a DNA constituent in adaptive and innate immune responses and as a mutagenic lesion causing cancer. Genomic uracil is as old as life and may have been a component in self-replicating molecules in the prebiotic era. The first living cells probably contained uracil in DNA, later to be replaced by thymine. The pioneering work of Nobel Laureate, Tomas Lindahl on spontaneous deamination of DNA cytosine to uracil was followed by his discovery of uracil-DNA glycosylase, which initiates repair of genomic uracil in base excision repair (BER). Uracil-DNA glycosylases are found in all forms of life and in DNA viruses, having roles in DNA repair, replication and epigenetics. The surprising discovery of enzymatic DNA cytosine deamination by the AID/APOBEC deaminases subsequently has implicated genomic uracil in the development of human cancer. The aim of the book is to contribute a reference text for graduate students, molecular biologists, immunologists and cancer biologists. Genomic uracil has become a hot research topic of wide interest after the Nobel Prize in Chemistry 2015 was awarded for DNA repair (Paul Modrich, Aziz Sancar and Tomas Lindahl). Furthermore, genomic uracil has received wide interest among both immunologists and cancer biologists due to its unexpected and fundamental role in adaptive immunity. Genomic uracil, thus, is highly relevant to researchers in different areas of research, but to our knowledge there is no published text that treats genomic uracil in an interdisciplinary way. The authors of this book have in the last three decades worked on genomic uracil and its processing and are among the most highly cited authors in the field."--Publisher's website |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | 1 online resource (303 pages) illustrations (some color) |
| ISBN: | 9789813233508 |
Staff View
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| id | DE-604.BV046810069 |
| illustrated | Illustrated |
| index_date | 2024-07-03T14:58:43Z |
| indexdate | 2024-07-10T08:54:28Z |
| institution | BVB |
| isbn | 9789813233508 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032218651 |
| oclc_num | 1191898461 |
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| physical | 1 online resource (303 pages) illustrations (some color) |
| psigel | ZDB-124-WOP |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | World Scientific Publishing Company Pte Limited |
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| spelling | Genomic uracil evolution, biology, immunology and disease editors, Geir Slupphaug, Hans Einar Krokan ; foreword by Tomas Lindahl Singapore World Scientific Publishing Company Pte Limited 2018 1 online resource (303 pages) illustrations (some color) txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references and index "This book describes genomic uracil in evolution, as a DNA constituent in adaptive and innate immune responses and as a mutagenic lesion causing cancer. Genomic uracil is as old as life and may have been a component in self-replicating molecules in the prebiotic era. The first living cells probably contained uracil in DNA, later to be replaced by thymine. The pioneering work of Nobel Laureate, Tomas Lindahl on spontaneous deamination of DNA cytosine to uracil was followed by his discovery of uracil-DNA glycosylase, which initiates repair of genomic uracil in base excision repair (BER). Uracil-DNA glycosylases are found in all forms of life and in DNA viruses, having roles in DNA repair, replication and epigenetics. The surprising discovery of enzymatic DNA cytosine deamination by the AID/APOBEC deaminases subsequently has implicated genomic uracil in the development of human cancer. The aim of the book is to contribute a reference text for graduate students, molecular biologists, immunologists and cancer biologists. Genomic uracil has become a hot research topic of wide interest after the Nobel Prize in Chemistry 2015 was awarded for DNA repair (Paul Modrich, Aziz Sancar and Tomas Lindahl). Furthermore, genomic uracil has received wide interest among both immunologists and cancer biologists due to its unexpected and fundamental role in adaptive immunity. Genomic uracil, thus, is highly relevant to researchers in different areas of research, but to our knowledge there is no published text that treats genomic uracil in an interdisciplinary way. The authors of this book have in the last three decades worked on genomic uracil and its processing and are among the most highly cited authors in the field."--Publisher's website Uracil DNA. Genetics Electronic books Slupphaug, Geir Sonstige oth Krokan, Hans Sonstige oth Erscheint auch als Druck-Ausgabe 9789813233492 http://www.worldscientific.com/worldscibooks/10.1142/10803 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Genomic uracil evolution, biology, immunology and disease Uracil DNA. Genetics Electronic books |
| title | Genomic uracil evolution, biology, immunology and disease |
| title_auth | Genomic uracil evolution, biology, immunology and disease |
| title_exact_search | Genomic uracil evolution, biology, immunology and disease |
| title_exact_search_txtP | Genomic uracil evolution, biology, immunology and disease |
| title_full | Genomic uracil evolution, biology, immunology and disease editors, Geir Slupphaug, Hans Einar Krokan ; foreword by Tomas Lindahl |
| title_fullStr | Genomic uracil evolution, biology, immunology and disease editors, Geir Slupphaug, Hans Einar Krokan ; foreword by Tomas Lindahl |
| title_full_unstemmed | Genomic uracil evolution, biology, immunology and disease editors, Geir Slupphaug, Hans Einar Krokan ; foreword by Tomas Lindahl |
| title_short | Genomic uracil |
| title_sort | genomic uracil evolution biology immunology and disease |
| title_sub | evolution, biology, immunology and disease |
| topic | Uracil DNA. Genetics Electronic books |
| topic_facet | Uracil DNA. Genetics Electronic books |
| url | http://www.worldscientific.com/worldscibooks/10.1142/10803 |
| work_keys_str_mv | AT slupphauggeir genomicuracilevolutionbiologyimmunologyanddisease AT krokanhans genomicuracilevolutionbiologyimmunologyanddisease |