Arylamine n-acetyltransferases in health and disease: from pharmacogenetics to drug discovery and diagnostics
"This book is a fascinating overview of one of the first pharmacogenetic traits to be identified as responsible for genetic variation in response to drugs - the understanding of the arylamine N-acetyltransferases (NATs) is linked to many important therapeutic areas, particularly tuberculosis an...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Publishing Company Pte Limited
2018
|
| Schlagworte: | |
| Online-Zugang: | UBY01 URL des Erstveröffentlichers |
| Zusammenfassung: | "This book is a fascinating overview of one of the first pharmacogenetic traits to be identified as responsible for genetic variation in response to drugs - the understanding of the arylamine N-acetyltransferases (NATs) is linked to many important therapeutic areas, particularly tuberculosis and also cancer. NATs have been important in the metabolism of established anti-tubercular drugs and also in carcinogenesis and susceptibility to bladder cancer. The reach of these enzymes spans pharmacology and therapeutics as well as toxicology and pharmacogenetics. The NAT genes are encoded in a highly polymorphic region of the human genome which has been explored for fine mapping in molecular anthropological studies. The book takes a wide ranging approach covering all aspects of the arylamine N-acetyltransferases from genetics to the chemistry and structural biology of the enzymes in the organisms in which they are found, from humans to bacteria and fungi where they appear to have distinct roles. The coverage is by experts in the field from across the globe."-- |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | 1 online resource (454 pages) illustrations (some color) |
| ISBN: | 9789813232013 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV046809942 | ||
| 003 | DE-604 | ||
| 005 | 20201104 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 200716s2018 |||| o||u| ||||||eng d | ||
| 020 | |a 9789813232013 |9 978-981-3232-01-3 | ||
| 024 | 7 | |a 10.1142/10763 |2 doi | |
| 035 | |a (ZDB-124-WOP)00010763 | ||
| 035 | |a (OCoLC)1045420279 | ||
| 035 | |a (DE-599)BVBBV046809942 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-706 | ||
| 082 | 0 | |a 615.1/9 | |
| 245 | 1 | 0 | |a Arylamine n-acetyltransferases in health and disease |b from pharmacogenetics to drug discovery and diagnostics |c editors, Nicola Laurieri, Edith Sim |
| 264 | 1 | |a Singapore |b World Scientific Publishing Company Pte Limited |c 2018 | |
| 300 | |a 1 online resource (454 pages) |b illustrations (some color) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 520 | |a "This book is a fascinating overview of one of the first pharmacogenetic traits to be identified as responsible for genetic variation in response to drugs - the understanding of the arylamine N-acetyltransferases (NATs) is linked to many important therapeutic areas, particularly tuberculosis and also cancer. NATs have been important in the metabolism of established anti-tubercular drugs and also in carcinogenesis and susceptibility to bladder cancer. The reach of these enzymes spans pharmacology and therapeutics as well as toxicology and pharmacogenetics. The NAT genes are encoded in a highly polymorphic region of the human genome which has been explored for fine mapping in molecular anthropological studies. The book takes a wide ranging approach covering all aspects of the arylamine N-acetyltransferases from genetics to the chemistry and structural biology of the enzymes in the organisms in which they are found, from humans to bacteria and fungi where they appear to have distinct roles. The coverage is by experts in the field from across the globe."-- | ||
| 650 | 4 | |a Acetyltransferases | |
| 650 | 4 | |a Drug development | |
| 650 | 4 | |a Drugs / Metabolism | |
| 650 | 4 | |a Pharmacogenetics | |
| 650 | 4 | |a Enzymes | |
| 650 | 4 | |a Breast / Cancer | |
| 650 | 4 | |a Enzyme inhibitors | |
| 650 | 4 | |a Isoenzymes | |
| 650 | 4 | |a Transferases | |
| 650 | 4 | |a Electronic books | |
| 700 | 1 | |a Laurieri, Nicola |e Sonstige |4 oth | |
| 700 | 1 | |a Sim, E.YYq(Edith) |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9789813232006 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9813232005 |
| 856 | 4 | 0 | |u http://www.worldscientific.com/worldscibooks/10.1142/10763 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-124-WOP | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-032218528 | ||
| 966 | e | |u http://www.worldscientific.com/worldscibooks/10.1142/10763 |l UBY01 |p ZDB-124-WOP |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804181614618476544 |
|---|---|
| adam_txt | |
| any_adam_object | |
| any_adam_object_boolean | |
| building | Verbundindex |
| bvnumber | BV046809942 |
| collection | ZDB-124-WOP |
| ctrlnum | (ZDB-124-WOP)00010763 (OCoLC)1045420279 (DE-599)BVBBV046809942 |
| dewey-full | 615.1/9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.1/9 |
| dewey-search | 615.1/9 |
| dewey-sort | 3615.1 19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02886nmm a2200505zc 4500</leader><controlfield tag="001">BV046809942</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20201104 </controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">200716s2018 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9789813232013</subfield><subfield code="9">978-981-3232-01-3</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1142/10763</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-124-WOP)00010763</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1045420279</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046809942</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-706</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615.1/9</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Arylamine n-acetyltransferases in health and disease</subfield><subfield code="b">from pharmacogenetics to drug discovery and diagnostics</subfield><subfield code="c">editors, Nicola Laurieri, Edith Sim</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Singapore</subfield><subfield code="b">World Scientific Publishing Company Pte Limited</subfield><subfield code="c">2018</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (454 pages)</subfield><subfield code="b">illustrations (some color)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">"This book is a fascinating overview of one of the first pharmacogenetic traits to be identified as responsible for genetic variation in response to drugs - the understanding of the arylamine N-acetyltransferases (NATs) is linked to many important therapeutic areas, particularly tuberculosis and also cancer. NATs have been important in the metabolism of established anti-tubercular drugs and also in carcinogenesis and susceptibility to bladder cancer. The reach of these enzymes spans pharmacology and therapeutics as well as toxicology and pharmacogenetics. The NAT genes are encoded in a highly polymorphic region of the human genome which has been explored for fine mapping in molecular anthropological studies. The book takes a wide ranging approach covering all aspects of the arylamine N-acetyltransferases from genetics to the chemistry and structural biology of the enzymes in the organisms in which they are found, from humans to bacteria and fungi where they appear to have distinct roles. The coverage is by experts in the field from across the globe."--</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Acetyltransferases</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drug development</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs / Metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmacogenetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Enzymes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Breast / Cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Enzyme inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Isoenzymes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Transferases</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Electronic books</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Laurieri, Nicola</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sim, E.YYq(Edith)</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9789813232006</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9813232005</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.worldscientific.com/worldscibooks/10.1142/10763</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-124-WOP</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-032218528</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://www.worldscientific.com/worldscibooks/10.1142/10763</subfield><subfield code="l">UBY01</subfield><subfield code="p">ZDB-124-WOP</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV046809942 |
| illustrated | Illustrated |
| index_date | 2024-07-03T14:58:41Z |
| indexdate | 2024-07-10T08:54:27Z |
| institution | BVB |
| isbn | 9789813232013 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032218528 |
| oclc_num | 1045420279 |
| open_access_boolean | |
| owner | DE-706 |
| owner_facet | DE-706 |
| physical | 1 online resource (454 pages) illustrations (some color) |
| psigel | ZDB-124-WOP |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | World Scientific Publishing Company Pte Limited |
| record_format | marc |
| spelling | Arylamine n-acetyltransferases in health and disease from pharmacogenetics to drug discovery and diagnostics editors, Nicola Laurieri, Edith Sim Singapore World Scientific Publishing Company Pte Limited 2018 1 online resource (454 pages) illustrations (some color) txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references and index "This book is a fascinating overview of one of the first pharmacogenetic traits to be identified as responsible for genetic variation in response to drugs - the understanding of the arylamine N-acetyltransferases (NATs) is linked to many important therapeutic areas, particularly tuberculosis and also cancer. NATs have been important in the metabolism of established anti-tubercular drugs and also in carcinogenesis and susceptibility to bladder cancer. The reach of these enzymes spans pharmacology and therapeutics as well as toxicology and pharmacogenetics. The NAT genes are encoded in a highly polymorphic region of the human genome which has been explored for fine mapping in molecular anthropological studies. The book takes a wide ranging approach covering all aspects of the arylamine N-acetyltransferases from genetics to the chemistry and structural biology of the enzymes in the organisms in which they are found, from humans to bacteria and fungi where they appear to have distinct roles. The coverage is by experts in the field from across the globe."-- Acetyltransferases Drug development Drugs / Metabolism Pharmacogenetics Enzymes Breast / Cancer Enzyme inhibitors Isoenzymes Transferases Electronic books Laurieri, Nicola Sonstige oth Sim, E.YYq(Edith) Sonstige oth Erscheint auch als Druck-Ausgabe 9789813232006 Erscheint auch als Druck-Ausgabe 9813232005 http://www.worldscientific.com/worldscibooks/10.1142/10763 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Arylamine n-acetyltransferases in health and disease from pharmacogenetics to drug discovery and diagnostics Acetyltransferases Drug development Drugs / Metabolism Pharmacogenetics Enzymes Breast / Cancer Enzyme inhibitors Isoenzymes Transferases Electronic books |
| title | Arylamine n-acetyltransferases in health and disease from pharmacogenetics to drug discovery and diagnostics |
| title_auth | Arylamine n-acetyltransferases in health and disease from pharmacogenetics to drug discovery and diagnostics |
| title_exact_search | Arylamine n-acetyltransferases in health and disease from pharmacogenetics to drug discovery and diagnostics |
| title_exact_search_txtP | Arylamine n-acetyltransferases in health and disease from pharmacogenetics to drug discovery and diagnostics |
| title_full | Arylamine n-acetyltransferases in health and disease from pharmacogenetics to drug discovery and diagnostics editors, Nicola Laurieri, Edith Sim |
| title_fullStr | Arylamine n-acetyltransferases in health and disease from pharmacogenetics to drug discovery and diagnostics editors, Nicola Laurieri, Edith Sim |
| title_full_unstemmed | Arylamine n-acetyltransferases in health and disease from pharmacogenetics to drug discovery and diagnostics editors, Nicola Laurieri, Edith Sim |
| title_short | Arylamine n-acetyltransferases in health and disease |
| title_sort | arylamine n acetyltransferases in health and disease from pharmacogenetics to drug discovery and diagnostics |
| title_sub | from pharmacogenetics to drug discovery and diagnostics |
| topic | Acetyltransferases Drug development Drugs / Metabolism Pharmacogenetics Enzymes Breast / Cancer Enzyme inhibitors Isoenzymes Transferases Electronic books |
| topic_facet | Acetyltransferases Drug development Drugs / Metabolism Pharmacogenetics Enzymes Breast / Cancer Enzyme inhibitors Isoenzymes Transferases Electronic books |
| url | http://www.worldscientific.com/worldscibooks/10.1142/10763 |
| work_keys_str_mv | AT laurierinicola arylaminenacetyltransferasesinhealthanddiseasefrompharmacogeneticstodrugdiscoveryanddiagnostics AT simeyyqedith arylaminenacetyltransferasesinhealthanddiseasefrompharmacogeneticstodrugdiscoveryanddiagnostics |