Cancer cell chemoresistance and chemosensitization:
"Despite the significant advances in cancer therapy made through constant evaluation and analysis of treatment aftereffects, the disease still remains one of the foremost causes of mortality worldwide killing more than 12 million people annually. The prime reason behind the failure of conventio...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Publishing Company Pte Limited
2018
|
| Schlagworte: | |
| Online-Zugang: | UBY01 Volltext |
| Zusammenfassung: | "Despite the significant advances in cancer therapy made through constant evaluation and analysis of treatment aftereffects, the disease still remains one of the foremost causes of mortality worldwide killing more than 12 million people annually. The prime reason behind the failure of conventional chemotherapeutics which are used as the chief regimen in the comprehensive treatment of cancers is the development of chemoresistance. It can be either intrinsic or acquired and is primarily mediated via different key regulators like MDR, MAPK, NF-κB, PI3K/Akt, Wnt signaling pathways etc. Thus, agents which can target these regulatory elements or pathways and in turn sensitize cancer cells to chemotherapy holds immense prospect. However, there is barely such comprehensive work available in scientific literature that explains how chemosensitization of cancer cells functions using different drug combinations and exhibit synergism. This book provides a detailed description of chemoresistance and chemosensitization, targets for chemosensitization and various approaches adapted in the process of chemosensitization. Furthermore, the book explicates the role of various chemosensitizers, both natural and synthetic in sensitizing cancer cells and also details the current research findings on chemosensitization of different cancer types in both pre-clinical and clinical settings."--Publisher's website |
| Beschreibung: | Includes bibliographical references and index Introduction and basic concepts of cancer / Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Nafiseh Mantegh, Ganesan Padmavathi, Ajaikumar B. Kunnumakkara -- Cancer cell chemoresistance : a prime obstacle in cancer therapy -- Javadi Monisha [and 6 others] -- Bladder cancer : chemoresistance and chemosensitization / Nand Kishor Roy, Anand Sharma, Anuj Kumar Singh, Devivasha Bordoloi, Ajaikumar B. Kunnumakkara -- Mechanism of chemoresistance in bone cancer and different chemosensitization approaches / Ganesan Padmavathi, Devivasha Bordoloi, Kishore Banik, Anuj Kumar Singh, Ajaikumar B. Kunnumakkara -- Chemoresistance in brain cancer and different chemosensitization approaches / Amrita Devi Khwairakpam [and 6 others] -- Phytochemicals as chemosensitizers in breast cancer / Madhumita Roy, Ruma Sarkar, Apurba Mukherjee, Sutapa Mukherjee and Jaydip Biswas -- Potential of different chemosensitizers to overcome chemoresistance in cervical cancer / Kishore Banik [and 5 others] -- - Colon cancer chemoresistance and chemosensitization / Muthu K. Shanmugam, Arunasalam Dharmarajan, Frank Arfuso, Gautam Sethi -- Cancer cell chemoresistance and chemosensitization in endometrial cancer / Anuj Kumar Singh [and 5 others] -- Different approaches to overcome chemoresistance in esophageal cancer / Devivasha Bordoloi [and 5 others] -- Different chemosensitization approaches in gastric cancer / Choudhary Harsha [and 5 others] -- Chemoresistance and chemosensitization in haematological malignancies / Ota Fuchs -- Different methods to inhibit chemosresistance in hepatocellular carcinoma / Anuj Kumar Singh [and 6 others] -- Different chemosensitization approaches for the effective management of HNSCC / Krishan K. Thakur, Devivasha Bordoloi, Jai Prakash, Nand Kishor Roy, Ajaikumar B. Kunnumakkara -- Lung cancer chemoresistance and chemosensitization / Kenneth K.W. To -- - Sensitization of chemoresistant melanoma cells to different chemotherapeutic agents / Javadi Monisha [and 5 others] -- Strategies to overcome chemoresistance in ovarian cancer / Choudhary Harsha [and 5 others] -- Molecular alterations involved in pancreatic cancer chemoresistance and chemosensitization strategies / Bethsebie Lalduhsaki Sailo [and 8 others] -- Different chemosensitization approaches to overcome chemoresistance in prostate cancer / Ganesan Padmavathi [and 6 others] -- Therapeutic strategies for chemosensitization of renal cancer / Bethsebie Lalduhsaki Sailo, Devivasha Bordoloi, Kishore Banik, Jai Prakash, Ajaikumar B. Kunnumakkara |
| Beschreibung: | 1 online resource (682 pages) illustrations (some color) |
| ISBN: | 9789813208575 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV046809641 | ||
| 003 | DE-604 | ||
| 005 | 20201104 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 200716s2018 |||| o||u| ||||||eng d | ||
| 020 | |a 9789813208575 |9 978-981-3208-57-5 | ||
| 024 | 7 | |a 10.1142/10407 |2 doi | |
| 035 | |a (ZDB-124-WOP)00010407 | ||
| 035 | |a (OCoLC)1045420441 | ||
| 035 | |a (DE-599)BVBBV046809641 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-706 | ||
| 082 | 0 | |a 616.99/4061 | |
| 245 | 1 | 0 | |a Cancer cell chemoresistance and chemosensitization |c [edited by] Ajaikumar B. Kunnumakkara, Devivasha Bordoloi, Javadi Monisha |
| 264 | 1 | |a Singapore |b World Scientific Publishing Company Pte Limited |c 2018 | |
| 300 | |a 1 online resource (682 pages) |b illustrations (some color) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Introduction and basic concepts of cancer / Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Nafiseh Mantegh, Ganesan Padmavathi, Ajaikumar B. Kunnumakkara -- Cancer cell chemoresistance : a prime obstacle in cancer therapy -- Javadi Monisha [and 6 others] -- Bladder cancer : chemoresistance and chemosensitization / Nand Kishor Roy, Anand Sharma, Anuj Kumar Singh, Devivasha Bordoloi, Ajaikumar B. Kunnumakkara -- Mechanism of chemoresistance in bone cancer and different chemosensitization approaches / Ganesan Padmavathi, Devivasha Bordoloi, Kishore Banik, Anuj Kumar Singh, Ajaikumar B. Kunnumakkara -- Chemoresistance in brain cancer and different chemosensitization approaches / Amrita Devi Khwairakpam [and 6 others] -- Phytochemicals as chemosensitizers in breast cancer / Madhumita Roy, Ruma Sarkar, Apurba Mukherjee, Sutapa Mukherjee and Jaydip Biswas -- Potential of different chemosensitizers to overcome chemoresistance in cervical cancer / Kishore Banik [and 5 others] -- | ||
| 500 | |a - Colon cancer chemoresistance and chemosensitization / Muthu K. Shanmugam, Arunasalam Dharmarajan, Frank Arfuso, Gautam Sethi -- Cancer cell chemoresistance and chemosensitization in endometrial cancer / Anuj Kumar Singh [and 5 others] -- Different approaches to overcome chemoresistance in esophageal cancer / Devivasha Bordoloi [and 5 others] -- Different chemosensitization approaches in gastric cancer / Choudhary Harsha [and 5 others] -- Chemoresistance and chemosensitization in haematological malignancies / Ota Fuchs -- Different methods to inhibit chemosresistance in hepatocellular carcinoma / Anuj Kumar Singh [and 6 others] -- Different chemosensitization approaches for the effective management of HNSCC / Krishan K. Thakur, Devivasha Bordoloi, Jai Prakash, Nand Kishor Roy, Ajaikumar B. Kunnumakkara -- Lung cancer chemoresistance and chemosensitization / Kenneth K.W. To -- | ||
| 500 | |a - Sensitization of chemoresistant melanoma cells to different chemotherapeutic agents / Javadi Monisha [and 5 others] -- Strategies to overcome chemoresistance in ovarian cancer / Choudhary Harsha [and 5 others] -- Molecular alterations involved in pancreatic cancer chemoresistance and chemosensitization strategies / Bethsebie Lalduhsaki Sailo [and 8 others] -- Different chemosensitization approaches to overcome chemoresistance in prostate cancer / Ganesan Padmavathi [and 6 others] -- Therapeutic strategies for chemosensitization of renal cancer / Bethsebie Lalduhsaki Sailo, Devivasha Bordoloi, Kishore Banik, Jai Prakash, Ajaikumar B. Kunnumakkara | ||
| 520 | |a "Despite the significant advances in cancer therapy made through constant evaluation and analysis of treatment aftereffects, the disease still remains one of the foremost causes of mortality worldwide killing more than 12 million people annually. The prime reason behind the failure of conventional chemotherapeutics which are used as the chief regimen in the comprehensive treatment of cancers is the development of chemoresistance. It can be either intrinsic or acquired and is primarily mediated via different key regulators like MDR, MAPK, NF-κB, PI3K/Akt, Wnt signaling pathways etc. Thus, agents which can target these regulatory elements or pathways and in turn sensitize cancer cells to chemotherapy holds immense prospect. However, there is barely such comprehensive work available in scientific literature that explains how chemosensitization of cancer cells functions using different drug combinations and exhibit synergism. This book provides a detailed description of chemoresistance and chemosensitization, targets for chemosensitization and various approaches adapted in the process of chemosensitization. Furthermore, the book explicates the role of various chemosensitizers, both natural and synthetic in sensitizing cancer cells and also details the current research findings on chemosensitization of different cancer types in both pre-clinical and clinical settings."--Publisher's website | ||
| 650 | 4 | |a Cancer / Chemotherapy | |
| 650 | 4 | |a Drug resistance in cancer cells | |
| 650 | 4 | |a Electronic books | |
| 700 | 1 | |a Kunnumakkara, Ajaikumar B. |e Sonstige |4 oth | |
| 700 | 1 | |a Bordoloi, Devivasha |e Sonstige |4 oth | |
| 700 | 1 | |a Monisha, Javadi |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9789813208568 |
| 856 | 4 | 0 | |u http://www.worldscientific.com/worldscibooks/10.1142/10407 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-124-WOP | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-032218231 | ||
| 966 | e | |u http://www.worldscientific.com/worldscibooks/10.1142/10407 |l UBY01 |p ZDB-124-WOP |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804181614114111488 |
|---|---|
| adam_txt | |
| any_adam_object | |
| any_adam_object_boolean | |
| building | Verbundindex |
| bvnumber | BV046809641 |
| collection | ZDB-124-WOP |
| ctrlnum | (ZDB-124-WOP)00010407 (OCoLC)1045420441 (DE-599)BVBBV046809641 |
| dewey-full | 616.99/4061 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/4061 |
| dewey-search | 616.99/4061 |
| dewey-sort | 3616.99 44061 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>05598nmm a2200457zc 4500</leader><controlfield tag="001">BV046809641</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20201104 </controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">200716s2018 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9789813208575</subfield><subfield code="9">978-981-3208-57-5</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1142/10407</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-124-WOP)00010407</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1045420441</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046809641</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-706</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.99/4061</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cancer cell chemoresistance and chemosensitization</subfield><subfield code="c">[edited by] Ajaikumar B. Kunnumakkara, Devivasha Bordoloi, Javadi Monisha</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Singapore</subfield><subfield code="b">World Scientific Publishing Company Pte Limited</subfield><subfield code="c">2018</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (682 pages)</subfield><subfield code="b">illustrations (some color)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Introduction and basic concepts of cancer / Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Nafiseh Mantegh, Ganesan Padmavathi, Ajaikumar B. Kunnumakkara -- Cancer cell chemoresistance : a prime obstacle in cancer therapy -- Javadi Monisha [and 6 others] -- Bladder cancer : chemoresistance and chemosensitization / Nand Kishor Roy, Anand Sharma, Anuj Kumar Singh, Devivasha Bordoloi, Ajaikumar B. Kunnumakkara -- Mechanism of chemoresistance in bone cancer and different chemosensitization approaches / Ganesan Padmavathi, Devivasha Bordoloi, Kishore Banik, Anuj Kumar Singh, Ajaikumar B. Kunnumakkara -- Chemoresistance in brain cancer and different chemosensitization approaches / Amrita Devi Khwairakpam [and 6 others] -- Phytochemicals as chemosensitizers in breast cancer / Madhumita Roy, Ruma Sarkar, Apurba Mukherjee, Sutapa Mukherjee and Jaydip Biswas -- Potential of different chemosensitizers to overcome chemoresistance in cervical cancer / Kishore Banik [and 5 others] -- </subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a"> - Colon cancer chemoresistance and chemosensitization / Muthu K. Shanmugam, Arunasalam Dharmarajan, Frank Arfuso, Gautam Sethi -- Cancer cell chemoresistance and chemosensitization in endometrial cancer / Anuj Kumar Singh [and 5 others] -- Different approaches to overcome chemoresistance in esophageal cancer / Devivasha Bordoloi [and 5 others] -- Different chemosensitization approaches in gastric cancer / Choudhary Harsha [and 5 others] -- Chemoresistance and chemosensitization in haematological malignancies / Ota Fuchs -- Different methods to inhibit chemosresistance in hepatocellular carcinoma / Anuj Kumar Singh [and 6 others] -- Different chemosensitization approaches for the effective management of HNSCC / Krishan K. Thakur, Devivasha Bordoloi, Jai Prakash, Nand Kishor Roy, Ajaikumar B. Kunnumakkara -- Lung cancer chemoresistance and chemosensitization / Kenneth K.W. To -- </subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a"> - Sensitization of chemoresistant melanoma cells to different chemotherapeutic agents / Javadi Monisha [and 5 others] -- Strategies to overcome chemoresistance in ovarian cancer / Choudhary Harsha [and 5 others] -- Molecular alterations involved in pancreatic cancer chemoresistance and chemosensitization strategies / Bethsebie Lalduhsaki Sailo [and 8 others] -- Different chemosensitization approaches to overcome chemoresistance in prostate cancer / Ganesan Padmavathi [and 6 others] -- Therapeutic strategies for chemosensitization of renal cancer / Bethsebie Lalduhsaki Sailo, Devivasha Bordoloi, Kishore Banik, Jai Prakash, Ajaikumar B. Kunnumakkara</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">"Despite the significant advances in cancer therapy made through constant evaluation and analysis of treatment aftereffects, the disease still remains one of the foremost causes of mortality worldwide killing more than 12 million people annually. The prime reason behind the failure of conventional chemotherapeutics which are used as the chief regimen in the comprehensive treatment of cancers is the development of chemoresistance. It can be either intrinsic or acquired and is primarily mediated via different key regulators like MDR, MAPK, NF-κB, PI3K/Akt, Wnt signaling pathways etc. Thus, agents which can target these regulatory elements or pathways and in turn sensitize cancer cells to chemotherapy holds immense prospect. However, there is barely such comprehensive work available in scientific literature that explains how chemosensitization of cancer cells functions using different drug combinations and exhibit synergism. This book provides a detailed description of chemoresistance and chemosensitization, targets for chemosensitization and various approaches adapted in the process of chemosensitization. Furthermore, the book explicates the role of various chemosensitizers, both natural and synthetic in sensitizing cancer cells and also details the current research findings on chemosensitization of different cancer types in both pre-clinical and clinical settings."--Publisher's website</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer / Chemotherapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drug resistance in cancer cells</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Electronic books</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kunnumakkara, Ajaikumar B.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bordoloi, Devivasha</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Monisha, Javadi</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9789813208568</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.worldscientific.com/worldscibooks/10.1142/10407</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-124-WOP</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-032218231</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://www.worldscientific.com/worldscibooks/10.1142/10407</subfield><subfield code="l">UBY01</subfield><subfield code="p">ZDB-124-WOP</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV046809641 |
| illustrated | Illustrated |
| index_date | 2024-07-03T14:58:37Z |
| indexdate | 2024-07-10T08:54:27Z |
| institution | BVB |
| isbn | 9789813208575 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032218231 |
| oclc_num | 1045420441 |
| open_access_boolean | |
| owner | DE-706 |
| owner_facet | DE-706 |
| physical | 1 online resource (682 pages) illustrations (some color) |
| psigel | ZDB-124-WOP |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | World Scientific Publishing Company Pte Limited |
| record_format | marc |
| spelling | Cancer cell chemoresistance and chemosensitization [edited by] Ajaikumar B. Kunnumakkara, Devivasha Bordoloi, Javadi Monisha Singapore World Scientific Publishing Company Pte Limited 2018 1 online resource (682 pages) illustrations (some color) txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references and index Introduction and basic concepts of cancer / Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Nafiseh Mantegh, Ganesan Padmavathi, Ajaikumar B. Kunnumakkara -- Cancer cell chemoresistance : a prime obstacle in cancer therapy -- Javadi Monisha [and 6 others] -- Bladder cancer : chemoresistance and chemosensitization / Nand Kishor Roy, Anand Sharma, Anuj Kumar Singh, Devivasha Bordoloi, Ajaikumar B. Kunnumakkara -- Mechanism of chemoresistance in bone cancer and different chemosensitization approaches / Ganesan Padmavathi, Devivasha Bordoloi, Kishore Banik, Anuj Kumar Singh, Ajaikumar B. Kunnumakkara -- Chemoresistance in brain cancer and different chemosensitization approaches / Amrita Devi Khwairakpam [and 6 others] -- Phytochemicals as chemosensitizers in breast cancer / Madhumita Roy, Ruma Sarkar, Apurba Mukherjee, Sutapa Mukherjee and Jaydip Biswas -- Potential of different chemosensitizers to overcome chemoresistance in cervical cancer / Kishore Banik [and 5 others] -- - Colon cancer chemoresistance and chemosensitization / Muthu K. Shanmugam, Arunasalam Dharmarajan, Frank Arfuso, Gautam Sethi -- Cancer cell chemoresistance and chemosensitization in endometrial cancer / Anuj Kumar Singh [and 5 others] -- Different approaches to overcome chemoresistance in esophageal cancer / Devivasha Bordoloi [and 5 others] -- Different chemosensitization approaches in gastric cancer / Choudhary Harsha [and 5 others] -- Chemoresistance and chemosensitization in haematological malignancies / Ota Fuchs -- Different methods to inhibit chemosresistance in hepatocellular carcinoma / Anuj Kumar Singh [and 6 others] -- Different chemosensitization approaches for the effective management of HNSCC / Krishan K. Thakur, Devivasha Bordoloi, Jai Prakash, Nand Kishor Roy, Ajaikumar B. Kunnumakkara -- Lung cancer chemoresistance and chemosensitization / Kenneth K.W. To -- - Sensitization of chemoresistant melanoma cells to different chemotherapeutic agents / Javadi Monisha [and 5 others] -- Strategies to overcome chemoresistance in ovarian cancer / Choudhary Harsha [and 5 others] -- Molecular alterations involved in pancreatic cancer chemoresistance and chemosensitization strategies / Bethsebie Lalduhsaki Sailo [and 8 others] -- Different chemosensitization approaches to overcome chemoresistance in prostate cancer / Ganesan Padmavathi [and 6 others] -- Therapeutic strategies for chemosensitization of renal cancer / Bethsebie Lalduhsaki Sailo, Devivasha Bordoloi, Kishore Banik, Jai Prakash, Ajaikumar B. Kunnumakkara "Despite the significant advances in cancer therapy made through constant evaluation and analysis of treatment aftereffects, the disease still remains one of the foremost causes of mortality worldwide killing more than 12 million people annually. The prime reason behind the failure of conventional chemotherapeutics which are used as the chief regimen in the comprehensive treatment of cancers is the development of chemoresistance. It can be either intrinsic or acquired and is primarily mediated via different key regulators like MDR, MAPK, NF-κB, PI3K/Akt, Wnt signaling pathways etc. Thus, agents which can target these regulatory elements or pathways and in turn sensitize cancer cells to chemotherapy holds immense prospect. However, there is barely such comprehensive work available in scientific literature that explains how chemosensitization of cancer cells functions using different drug combinations and exhibit synergism. This book provides a detailed description of chemoresistance and chemosensitization, targets for chemosensitization and various approaches adapted in the process of chemosensitization. Furthermore, the book explicates the role of various chemosensitizers, both natural and synthetic in sensitizing cancer cells and also details the current research findings on chemosensitization of different cancer types in both pre-clinical and clinical settings."--Publisher's website Cancer / Chemotherapy Drug resistance in cancer cells Electronic books Kunnumakkara, Ajaikumar B. Sonstige oth Bordoloi, Devivasha Sonstige oth Monisha, Javadi Sonstige oth Erscheint auch als Druck-Ausgabe 9789813208568 http://www.worldscientific.com/worldscibooks/10.1142/10407 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Cancer cell chemoresistance and chemosensitization Cancer / Chemotherapy Drug resistance in cancer cells Electronic books |
| title | Cancer cell chemoresistance and chemosensitization |
| title_auth | Cancer cell chemoresistance and chemosensitization |
| title_exact_search | Cancer cell chemoresistance and chemosensitization |
| title_exact_search_txtP | Cancer cell chemoresistance and chemosensitization |
| title_full | Cancer cell chemoresistance and chemosensitization [edited by] Ajaikumar B. Kunnumakkara, Devivasha Bordoloi, Javadi Monisha |
| title_fullStr | Cancer cell chemoresistance and chemosensitization [edited by] Ajaikumar B. Kunnumakkara, Devivasha Bordoloi, Javadi Monisha |
| title_full_unstemmed | Cancer cell chemoresistance and chemosensitization [edited by] Ajaikumar B. Kunnumakkara, Devivasha Bordoloi, Javadi Monisha |
| title_short | Cancer cell chemoresistance and chemosensitization |
| title_sort | cancer cell chemoresistance and chemosensitization |
| topic | Cancer / Chemotherapy Drug resistance in cancer cells Electronic books |
| topic_facet | Cancer / Chemotherapy Drug resistance in cancer cells Electronic books |
| url | http://www.worldscientific.com/worldscibooks/10.1142/10407 |
| work_keys_str_mv | AT kunnumakkaraajaikumarb cancercellchemoresistanceandchemosensitization AT bordoloidevivasha cancercellchemoresistanceandchemosensitization AT monishajavadi cancercellchemoresistanceandchemosensitization |