Developmental epilepsy: from clinical medicine to neurobiological mechanisms
"This is a collection of chapters from renowned authors focused on the contemporary issues in developmental epilepsy, from both clinical and basic science perspectives. Developmental epilepsy (or epilepsy syndromes), while receiving much more attention than 20 years ago, is still not well under...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Publishing Company Pte Limited
2019
|
| Schlagworte: | |
| Online-Zugang: | UBY01 Volltext |
| Zusammenfassung: | "This is a collection of chapters from renowned authors focused on the contemporary issues in developmental epilepsy, from both clinical and basic science perspectives. Developmental epilepsy (or epilepsy syndromes), while receiving much more attention than 20 years ago, is still not well understood. This lag in research is reflected in the challenges of treating developmental epilepsy. The book discusses these challenges in the clinic and brings them back to the laboratory bench (and in some cases back to the bedside). This book fills a gap in the literature on developing epilepsy by bridging current clinical knowledge with basic and translational research in the developing brain relevant for developmental epilepsy. The book is introduced by a chapter on brain development to provide a background for understanding when and how seizures and epilepsy can emerge. Recent clinical research indicates strong relationship between childhood epilepsy and developmental cognitive impairment. This connection can be studied in experimental animals and can uncover developmental mechanisms common to both conditions. Targeting those mechanisms might reveal disease-modifying treatments. Febrile seizures are very common in the pediatric population and their impact on further epilepsy development is explored. The link between immunity, inflammation and epileptogenesis in the developing brain is explored. Many developmental epilepsies arise from brain malformations or neuronal migration deficits; some juvenile epilepsies have a clear genetic basis while the etiology of others is less certain. Recently, the involvement of the mTOR pathway in certain childhood epilepsy syndromes was recognized, prompting the repurposing of drugs used in cancer treatment for therapy of these specific epilepsy syndromes. Steroid hormones have significant hormonal effects on neurotransmitter receptors and function, and therefore have an impact on childhood epilepsy; sex steroids may have long term organizational effects on brain structure and epilepsy development. Stress, even early in development, may affect the developing brain and lead to behavioral changes as well as increased susceptibility to seizures."-- |
| Beschreibung: | Mode of access: World Wide Web. - System requirements: Adobe Acrobat Reader |
| Beschreibung: | 1 online resource (xiv, 419 pages) |
| ISBN: | 9789813277731 |
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| 245 | 1 | 0 | |a Developmental epilepsy |b from clinical medicine to neurobiological mechanisms |c editors, Carl E. Stafstrom, Libor Velíšek |
| 264 | 1 | |a Singapore |b World Scientific Publishing Company Pte Limited |c 2019 | |
| 300 | |a 1 online resource (xiv, 419 pages) | ||
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| 505 | 8 | |a Includes bibliographical references and index | |
| 520 | |a "This is a collection of chapters from renowned authors focused on the contemporary issues in developmental epilepsy, from both clinical and basic science perspectives. Developmental epilepsy (or epilepsy syndromes), while receiving much more attention than 20 years ago, is still not well understood. This lag in research is reflected in the challenges of treating developmental epilepsy. The book discusses these challenges in the clinic and brings them back to the laboratory bench (and in some cases back to the bedside). This book fills a gap in the literature on developing epilepsy by bridging current clinical knowledge with basic and translational research in the developing brain relevant for developmental epilepsy. The book is introduced by a chapter on brain development to provide a background for understanding when and how seizures and epilepsy can emerge. Recent clinical research indicates strong relationship between childhood epilepsy and developmental cognitive impairment. | ||
| 520 | |a This connection can be studied in experimental animals and can uncover developmental mechanisms common to both conditions. Targeting those mechanisms might reveal disease-modifying treatments. Febrile seizures are very common in the pediatric population and their impact on further epilepsy development is explored. The link between immunity, inflammation and epileptogenesis in the developing brain is explored. Many developmental epilepsies arise from brain malformations or neuronal migration deficits; some juvenile epilepsies have a clear genetic basis while the etiology of others is less certain. Recently, the involvement of the mTOR pathway in certain childhood epilepsy syndromes was recognized, prompting the repurposing of drugs used in cancer treatment for therapy of these specific epilepsy syndromes. | ||
| 520 | |a Steroid hormones have significant hormonal effects on neurotransmitter receptors and function, and therefore have an impact on childhood epilepsy; sex steroids may have long term organizational effects on brain structure and epilepsy development. Stress, even early in development, may affect the developing brain and lead to behavioral changes as well as increased susceptibility to seizures."-- | ||
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| 650 | 4 | |a Brain / Growth | |
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| 700 | 1 | |a Velíšek, Libor |e Sonstige |4 oth | |
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Datensatz im Suchindex
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| discipline | Medizin |
| discipline_str_mv | Medizin |
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| id | DE-604.BV046808746 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T14:58:20Z |
| indexdate | 2024-07-10T08:54:25Z |
| institution | BVB |
| isbn | 9789813277731 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032217351 |
| oclc_num | 1190674955 |
| open_access_boolean | |
| owner | DE-706 |
| owner_facet | DE-706 |
| physical | 1 online resource (xiv, 419 pages) |
| psigel | ZDB-124-WOP |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| publisher | World Scientific Publishing Company Pte Limited |
| record_format | marc |
| spelling | Developmental epilepsy from clinical medicine to neurobiological mechanisms editors, Carl E. Stafstrom, Libor Velíšek Singapore World Scientific Publishing Company Pte Limited 2019 1 online resource (xiv, 419 pages) txt rdacontent c rdamedia cr rdacarrier Mode of access: World Wide Web. - System requirements: Adobe Acrobat Reader Includes bibliographical references and index "This is a collection of chapters from renowned authors focused on the contemporary issues in developmental epilepsy, from both clinical and basic science perspectives. Developmental epilepsy (or epilepsy syndromes), while receiving much more attention than 20 years ago, is still not well understood. This lag in research is reflected in the challenges of treating developmental epilepsy. The book discusses these challenges in the clinic and brings them back to the laboratory bench (and in some cases back to the bedside). This book fills a gap in the literature on developing epilepsy by bridging current clinical knowledge with basic and translational research in the developing brain relevant for developmental epilepsy. The book is introduced by a chapter on brain development to provide a background for understanding when and how seizures and epilepsy can emerge. Recent clinical research indicates strong relationship between childhood epilepsy and developmental cognitive impairment. This connection can be studied in experimental animals and can uncover developmental mechanisms common to both conditions. Targeting those mechanisms might reveal disease-modifying treatments. Febrile seizures are very common in the pediatric population and their impact on further epilepsy development is explored. The link between immunity, inflammation and epileptogenesis in the developing brain is explored. Many developmental epilepsies arise from brain malformations or neuronal migration deficits; some juvenile epilepsies have a clear genetic basis while the etiology of others is less certain. Recently, the involvement of the mTOR pathway in certain childhood epilepsy syndromes was recognized, prompting the repurposing of drugs used in cancer treatment for therapy of these specific epilepsy syndromes. Steroid hormones have significant hormonal effects on neurotransmitter receptors and function, and therefore have an impact on childhood epilepsy; sex steroids may have long term organizational effects on brain structure and epilepsy development. Stress, even early in development, may affect the developing brain and lead to behavioral changes as well as increased susceptibility to seizures."-- Epilepsy Brain / Growth Electronic books Stafstrom, Carl Ernest Sonstige oth Velíšek, Libor Sonstige oth Erscheint auch als Druck-Ausgabe 9789813277724 https://www.worldscientific.com/worldscibooks/10.1142/11198 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Developmental epilepsy from clinical medicine to neurobiological mechanisms Includes bibliographical references and index Epilepsy Brain / Growth |
| title | Developmental epilepsy from clinical medicine to neurobiological mechanisms |
| title_auth | Developmental epilepsy from clinical medicine to neurobiological mechanisms |
| title_exact_search | Developmental epilepsy from clinical medicine to neurobiological mechanisms |
| title_exact_search_txtP | Developmental epilepsy from clinical medicine to neurobiological mechanisms |
| title_full | Developmental epilepsy from clinical medicine to neurobiological mechanisms editors, Carl E. Stafstrom, Libor Velíšek |
| title_fullStr | Developmental epilepsy from clinical medicine to neurobiological mechanisms editors, Carl E. Stafstrom, Libor Velíšek |
| title_full_unstemmed | Developmental epilepsy from clinical medicine to neurobiological mechanisms editors, Carl E. Stafstrom, Libor Velíšek |
| title_short | Developmental epilepsy |
| title_sort | developmental epilepsy from clinical medicine to neurobiological mechanisms |
| title_sub | from clinical medicine to neurobiological mechanisms |
| topic | Epilepsy Brain / Growth |
| topic_facet | Epilepsy Brain / Growth |
| url | https://www.worldscientific.com/worldscibooks/10.1142/11198 |
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