The Black Box of Biology: a history of the molecular revolution
<p><b>In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact.</b></p><p>Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history o...
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| Vorheriger Titel: | Michel Morange A History of Molecular Biology |
|---|---|
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| Weitere Verfasser: | |
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, MA
Harvard University Press
[2020]
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Zusammenfassung: | <p><b>In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact.</b></p><p>Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits <i>A History of Molecular Biology</i> and offers new insights from the past twenty years into his analysis.</p><p><i>The Black Box of Biology</i> shows that what led to the incredible transformation of biology was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the greatest biological achievements of the past few decades should still be understood within the molecular paradigm. What has happened is not the displacement of molecular biology by other techniques and avenues of research, but rather the fusion of molecular principles and concepts with those of other disciplines, including genetics, physics, structural chemistry, and computational biology. This has produced decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific programs such as human genome sequencing, and the emergence of synthetic biology, systems biology, and epigenetics.</p><p>Original, persuasive, and breathtaking in its scope, <i>The Black Box of Biology</i> sets a new standard for the history of the ongoing molecular revolution.</p> |
| Beschreibung: | This volume is revised and expanded from the first English-Language Edition, published as A History of Molecular Biology by Harvard University Press. |
| Beschreibung: | vi, 522 Seiten 235 mm |
| ISBN: | 9780674281363 |
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Contents Introduction 1 PART ONE 1 THE BIRTH OF MOLECULAR BIOLOGY 1 The Roots of the New Science 13 2 The One Gene-One Enzyme Hypothesis 23 3 The Chemical Nature of the Gene 32 4 The Phage Group 41 5 The Birth of Bacterial Genetics 52 6 The Crystallization of the Tobacco Mosaic Virus 63 7 Enter the Physicists 67 8 The Influence of the Rockefeller Foundation 79 9 Physical Techniques in Molecular Biology 88 10 The Role of Physics I PART TWO 99 THE DEVELOPMENT OF MOLECULAR BIOLOGY 11 The Discovery of the Double Helix 105 12 Deciphering the Genetic Code 120 13 138 The Discovery of Messenger RNA 14 The French School 148
Contents vi 1 PART THREE THE EXPANSION OF MOLECULAR BIOLOGY 15 Normal Science 165 16 Genetic Engineering 179 17 Split Genes and Splicing 200 18 211 The Discovery of Oncogenes 19 From DNA Polymerase to the Amplification of DNA 1 PART FOUR 222 BEYOND MOLECULAR BIOLOGY? 20 The Molecularization of Biology and Medicine 235 21 Protein'Structure 251 22 The Rise of Developmental Biology 263 23 Molecular Biology and Evolution 278 24 Gene Therapy 297 25 The Central Place of RNA 311 26 Epigenetics 325 27 Sequencing the Human Genome 340 28 Systems Biology and Synthetic Biology 355 29 Images, Representations, and Metaphors in Molecular Biology 369 General Conclusion 385 Appendix: Definition of Terms 389 Notes 393 Index 503
Since the 1930s, a molecular vision has been transforming biology. Michel Morange pro vides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest tech nologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shov/s that what led to the incredible transformation of bio logy was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the greatest biological achievements of the past few decades should still be understood with in the molecular paradigm. What has hap pened is not the displacement of molecular biology by other techniques and avenues of research, but rather the fusion of molec ular principles and concepts with those of other disciplines, including genetics, physics, structural chemistry, and computational bi ology. This has produced decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific pro grams such as human genome sequencing, and the emergence of synthetic biology, systems biology, and epigenetics. Original, persuasive, and breathtaking in its scope, The Black Box of Biology sets a new standard for the history of the ongoing molecular revolution. |
| adam_txt |
Contents Introduction 1 PART ONE 1 THE BIRTH OF MOLECULAR BIOLOGY 1 The Roots of the New Science 13 2 The One Gene-One Enzyme Hypothesis 23 3 The Chemical Nature of the Gene 32 4 The Phage Group 41 5 The Birth of Bacterial Genetics 52 6 The Crystallization of the Tobacco Mosaic Virus 63 7 Enter the Physicists 67 8 The Influence of the Rockefeller Foundation 79 9 Physical Techniques in Molecular Biology 88 10 The Role of Physics I PART TWO 99 THE DEVELOPMENT OF MOLECULAR BIOLOGY 11 The Discovery of the Double Helix 105 12 Deciphering the Genetic Code 120 13 138 The Discovery of Messenger RNA 14 The French School 148
Contents vi 1 PART THREE THE EXPANSION OF MOLECULAR BIOLOGY 15 Normal Science 165 16 Genetic Engineering 179 17 Split Genes and Splicing 200 18 211 The Discovery of Oncogenes 19 From DNA Polymerase to the Amplification of DNA 1 PART FOUR 222 BEYOND MOLECULAR BIOLOGY? 20 The Molecularization of Biology and Medicine 235 21 Protein'Structure 251 22 The Rise of Developmental Biology 263 23 Molecular Biology and Evolution 278 24 Gene Therapy 297 25 The Central Place of RNA 311 26 Epigenetics 325 27 Sequencing the Human Genome 340 28 Systems Biology and Synthetic Biology 355 29 Images, Representations, and Metaphors in Molecular Biology 369 General Conclusion 385 Appendix: Definition of Terms 389 Notes 393 Index 503
Since the 1930s, a molecular vision has been transforming biology. Michel Morange pro vides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest tech nologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shov/s that what led to the incredible transformation of bio logy was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the greatest biological achievements of the past few decades should still be understood with in the molecular paradigm. What has hap pened is not the displacement of molecular biology by other techniques and avenues of research, but rather the fusion of molec ular principles and concepts with those of other disciplines, including genetics, physics, structural chemistry, and computational bi ology. This has produced decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific pro grams such as human genome sequencing, and the emergence of synthetic biology, systems biology, and epigenetics. Original, persuasive, and breathtaking in its scope, The Black Box of Biology sets a new standard for the history of the ongoing molecular revolution. |
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| spellingShingle | Morange, Michel 1950- The Black Box of Biology a history of the molecular revolution bicssc / Life Sciences: General Issues bicssc / Molecular Biology bisacsh / SCIENCE / History bisacsh / SCIENCE / Life Sciences / General Geschichte (DE-588)4020517-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
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| title | The Black Box of Biology a history of the molecular revolution |
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