Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Elektronisch Software E-Book |
| Sprache: | English |
| Veröffentlicht: |
Leipzig
[2018?]
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| 100 | 1 | |a Nawaz, Hafiz Awais |d 1983- |e Verfasser |0 (DE-588)1171826427 |4 aut | |
| 245 | 1 | 0 | |a Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications |c von Dr. rer. nat. Hafiz Awais Nawaz |
| 264 | 1 | |a Leipzig |c [2018?] | |
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| 502 | |b Dissertation |c Universität Leipzig |d 2018 | ||
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| 347 | |a Textdatei |b PDF | ||
Datensatz im Suchindex
| _version_ | 1804181466285867008 |
|---|---|
| adam_text | TABLE OF CONTENTS
1.
INTRODUCTION............................................................................................................1
1.1 TISSUE
REGENERATION...........................................................................................
2
1.2 TISSUE ENGINEERING SCAFFOLDS AS MECHANICAL SUPPORT STRUCTURES AND
CELL CARRIERS
6
1.3.1 HYDROGELS AS
SCAFFOLDS...............................................................................
10
1.3.2 EXTRACELLULAR
MATRIX.....................................................................................
10
1.3.3 HYDROGELS MIMIC
ECM................................................................................
13
1.3.4 SYNTHETIC AND NATURAL
HYDROGELS.................................................................16
1.3.5 ROLE OF MATRIX STIFFNESS IN CELL LADEN HYDROGELS
..........................................
18
1.3.6 GELATIN BASED
HYDROGELS.............................................................................23
1.3.7 INJECTABLE
HYDROGELS....................................................................................
27
1.4 REACTIVE OLIGOMERS WITH ADDITIONAL FUNCTIONALITIES
............................................
31
1.5 AIMS OF
THESIS....................................................................................................
34
2. MATERIALS AND
METHODS........................................................................................
36
2.1
MATERIALS...........................................................................................................
37
2.1.1
CHEMICALS...................................................................................................
37
2.1.2
LABWARE......................................................................................................
38
2.2
METHODS............................................................................................................
38
2.2.1 OLIGOMER SYNTHESIS
............
.
.......................................................................
38
2.2.2
TITRATIONS.....................................................................................................
39
2.2.2 2 BROWN-FUJIMORI TITRATIONS
(BFT)........................................................... 40
2.2.3 DETERMINATION OF MOLECULAR
WEIGHTS........................................................... 40
2.2.3.1 GEL PERMEATION CHROMATOGRAPHY
(GPC).............................................. 40
2.2.5.2 MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS
SPECTROMETRY (MALDI-TOF
MS)........................................................................41
2.2.4 NUCLEAR MAGNETIC RESONANCE (NMR)
ANALYSIS............................................ 42
2.2.5 DETERMINATION OF OLIGOMER
HYDROPHILICITY.................................................... 42
2.2.6 HYDROGEL
FABRICATION....................................................................................43
2.2.7 RHEOLOGICAL
CHARACTERIZATION.......................................................................44
2.2.8 TNBS
ASSAY................................................................................................
46
2.2.9 CYTOCOMPATIBILITY
STUDIES............................................................................46
2.2.10
WST-ASSAY...............................................................................................
47
2.2.11 GEL
MINERALIZATION.....................................................................................48
2.2.12 CYTOTOXICITY STUDIES FOR SOLVENT AND BASE
MOLECULES................................49
2.2.13 EFFECT OF ULTRASOUND ON MECHANOSENSITIVE OLIGOMER CROSS-LINKED
HYDROGELS
AND RELEASE OF
AMINOPYRENE................................................................................
50
2.2.14 SIRNA/CATIONIC OLIGOMER COMPLEXATION
....................................................
51
2.2.15 STATISTICAL
ANALYSIS....................................................................................
52
3. PEDAS CONTAINING HYDROPHILIC
OLIGOMERS........................................................53
3.1 COMONOMER
SELECTION.......................................................................................
54
3.2 OLIGOMER
SYNTHESIS............................................................................................
55
3.2.1 SYNTHESIS OF
TER-OLIGOMERS..........................................................................56
3.2.2 SYNTHESIS OF QUATER
OLIGOMERS....................................................................57
3.3
TITRATIONS...........................................................................................................
60
3.4 MOLECULAR WEIGHT
DETERMINATION........................................................................62
3.5 NUCLEAR MAGNETIC RESONANCE (NMR)
................................................................
64
3.5.1 PROTON NMR
(1H-NMR)...............................................................................64
3.5.2 CARBON NMR
(13C-NMR).............................................................................67
3.6 DETERMINATION OF OLIGOMER HYDROPHILICITY
..........................................................
68
3.6.1
DISSOLUTION..................................................................................................
68
3.6.2 HANSEN*S SOLUBILITY PARAMETERS (HSP)
.......................................................
71
3.7 DEVELOPMENT OF OLIGOMER CROSS-LINKED GELATIN HYDROGEL FORMULATION
..............
74
3.7.1 SELECTION OF GELATIN TYPE AND
CONCENTRATION..............................................74
3.7.1.1 GELATIN TYPE B, 50
BLOOM......................................................................75
3.7.1.2 GELATIN TYPE A, 300 BLOOM AND TYPE B, 225
BLOOM.............................77
3.7.2 OPTIMIZING BASE AND OLIGOMER SOLVENT (TYPE AND CONCENTRATION)
.............
78
3.8 RHEOLOGICAL ASSESSMENT OF TWO COMPONENT (GELATIN/OLIGOMER) HYDROGELS
......
83
3.8.1 GELATION
KINETICS.........................................................................................
84
3.8.2 FREQUENCY SWEEP ASSESSMENT FOR INJECTED HYDROGELS
...............................
87
3.8.3 FREQUENCY SWEEP ASSESSMENT FOR PRE-FABRICATED HYDROGELS
...................
89
3.8.4 STRESS RELAXATION
RHEOLOGY..........................................................................92
3.9 DEGREE OF CROSS-LINKING (TNBS ASSAY)
.............................................................
94
3.10 CYTOCOMPATIBILITY OF OLIGOMER CROSS-LINKED HYDROGELS
.....................................
95
3.11 ASSESSMENT OF CELL
VIABILITY.............................................................................97
3.12 GEL
MINERALIZATION...........................................................................................
99
4. HYDROPHILIC OLIGOMERS WITH VARIABLE HYDROPHOBIC DOMAINS
........................
103
4.1 SPECIFIC AIM AND
MOTIVATION............................................................................104
4.2 OLIGOMER
DESIGN..............................................................................................
105
4.3
TITRATIONS.........................................................................................................
107
4.4 MOLECULAR WEIGHTS DETERMINATION
..............................................
108
4.5 NUCLEAR MAGNETIC RESONANCE
(NMR)...............................................................110
4.6 DETERMINATION OF OLIGOMER
HYDROPHILICITY.........................................................113
4.7 RHEOLOGICAL
ASSESSMENT.................................................................................
116
4.7.1 GELATION KINETICS
...........
............................................................................116
4.7.2 MECHANICAL STIFFNESS OF INJECTED HYDROGELS
..............................................
118
4.7.3 MECHANICAL STIFFNESS OF PRE-FABRICATED HYDROGELS
.....................................
120
4.7.4 STRESS RELAXATION
RHEOLOGY........................................................................122
4.8 DEGREE OF CROSS-LINKING (TNBS
ASSAY)............................................................123
4.9
CYTOCOMPATIBILITY.............................................................................................
125
4.10 ASSESSMENT OF CELL
VIABILITY...........................................................................127
4.11 GEL AND HYDROGEL
MINERALIZATION....................................................................128
5. MULTIFUNCTIONAL MATERIALS FOR REGENERATIVE APPLICATIONS
...............................
133
5.1 MECHANOSENSITIVE
OLIGOMERS...........................................................................134
5.1.1
PERCEPTION................................................................................................
134
5.1.2 OLIGOMER
DESIGN.......................................................................................
136
5.1.3
TITRATIONS....................................................................................................138
5.1.4 MOLECULAR WEIGHTS
DETERMINATION..............................................................139
5.1.5 PROTON NMR
(1H-NMR).............................................................................
140
5.1.6 FABRICATION OF CROSS-LINKED HYDROGELS WITH MECHANO-SENSITIVE
OLIGOMERS141
5.1.7 EFFECT OF ULTRASOUND ON MECHANO-SENSITIVE OLIGOMER CROSS-LINKED
HYDROGELS
144
5.2 CATIONIC
OLIGOMERS...........................................................................................
147
5.2.1
MOTIVATION.................................................................................................
147
5.2.2 OLIGOMER
DESIGN.......................................................................................
148
5.2.3 MOLECULAR WEIGHTS
DETERMINATION..............................................................149
5.2.4 1H-NMR
ANALYSIS......................................................................................
151
5.2.5 SIRNA/CATIONIC OLIGOMER COMPLEXATION
....................................................
152
6.
DISCUSSION..........................................................................................................154
6.1 PEDAS CONTAINING REACTIVE HYDROPHILIC OLIGOMERS
..........................................
157
6.2 HYDROPHILIC AND REACTIVE OLIGOMERS FOR INJECTABLE HYDROGELS WITH
VARIABLE
HYDROPHOBIC
DOMAINS............................................................................................
174
6.3 MULTIFUNCTIONAL OLIGOMERS FOR BIOMEDICAL APPLICATIONS
....................................
182
6.3.1 MECHANO-SENSITIVE
OLIGOMERS...................................................................182
6.3.2 CATIONIC
OLIGOMERS....................................................................................
183
7.
SUMMARY.............................................................................................................188
8.
ZUSAMMENFASSUNG............................................................................................
195
9.
REFERENCES..........................................................................................................204
10.
APPENDIX.............................................................................................................223
LIST OF
ABBREVIATIONS..............................................................................................
224
LIST OF
FIGURES.......................................................................................................
226
LIST OF
TABLES.........................................................................................................
229
DECLARATION OF
AUTHORSHIP......................................................................................
230
PUBLICATIONS...........................................................................................................
231
CURRICULUM
VITAE...........................................................................................
232
ACKNOWLEDGEMENT.................................................................................................
233
|
| adam_txt |
TABLE OF CONTENTS
1.
INTRODUCTION.1
1.1 TISSUE
REGENERATION.
2
1.2 TISSUE ENGINEERING SCAFFOLDS AS MECHANICAL SUPPORT STRUCTURES AND
CELL CARRIERS
6
1.3.1 HYDROGELS AS
SCAFFOLDS.
10
1.3.2 EXTRACELLULAR
MATRIX.
10
1.3.3 HYDROGELS MIMIC
ECM.
13
1.3.4 SYNTHETIC AND NATURAL
HYDROGELS.16
1.3.5 ROLE OF MATRIX STIFFNESS IN CELL LADEN HYDROGELS
.
18
1.3.6 GELATIN BASED
HYDROGELS.23
1.3.7 INJECTABLE
HYDROGELS.
27
1.4 REACTIVE OLIGOMERS WITH ADDITIONAL FUNCTIONALITIES
.
31
1.5 AIMS OF
THESIS.
34
2. MATERIALS AND
METHODS.
36
2.1
MATERIALS.
37
2.1.1
CHEMICALS.
37
2.1.2
LABWARE.
38
2.2
METHODS.
38
2.2.1 OLIGOMER SYNTHESIS
.
.
.
38
2.2.2
TITRATIONS.
39
2.2.2 2 BROWN-FUJIMORI TITRATIONS
(BFT). 40
2.2.3 DETERMINATION OF MOLECULAR
WEIGHTS. 40
2.2.3.1 GEL PERMEATION CHROMATOGRAPHY
(GPC). 40
2.2.5.2 MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS
SPECTROMETRY (MALDI-TOF
MS).41
2.2.4 NUCLEAR MAGNETIC RESONANCE (NMR)
ANALYSIS. 42
2.2.5 DETERMINATION OF OLIGOMER
HYDROPHILICITY. 42
2.2.6 HYDROGEL
FABRICATION.43
2.2.7 RHEOLOGICAL
CHARACTERIZATION.44
2.2.8 TNBS
ASSAY.
46
2.2.9 CYTOCOMPATIBILITY
STUDIES.46
2.2.10
WST-ASSAY.
47
2.2.11 GEL
MINERALIZATION.48
2.2.12 CYTOTOXICITY STUDIES FOR SOLVENT AND BASE
MOLECULES.49
2.2.13 EFFECT OF ULTRASOUND ON MECHANOSENSITIVE OLIGOMER CROSS-LINKED
HYDROGELS
AND RELEASE OF
AMINOPYRENE.
50
2.2.14 SIRNA/CATIONIC OLIGOMER COMPLEXATION
.
51
2.2.15 STATISTICAL
ANALYSIS.
52
3. PEDAS CONTAINING HYDROPHILIC
OLIGOMERS.53
3.1 COMONOMER
SELECTION.
54
3.2 OLIGOMER
SYNTHESIS.
55
3.2.1 SYNTHESIS OF
TER-OLIGOMERS.56
3.2.2 SYNTHESIS OF QUATER
OLIGOMERS.57
3.3
TITRATIONS.
60
3.4 MOLECULAR WEIGHT
DETERMINATION.62
3.5 NUCLEAR MAGNETIC RESONANCE (NMR)
.
64
3.5.1 PROTON NMR
(1H-NMR).64
3.5.2 CARBON NMR
(13C-NMR).67
3.6 DETERMINATION OF OLIGOMER HYDROPHILICITY
.
68
3.6.1
DISSOLUTION.
68
3.6.2 HANSEN*S SOLUBILITY PARAMETERS (HSP)
.
71
3.7 DEVELOPMENT OF OLIGOMER CROSS-LINKED GELATIN HYDROGEL FORMULATION
.
74
3.7.1 SELECTION OF GELATIN TYPE AND
CONCENTRATION.74
3.7.1.1 GELATIN TYPE B, 50
BLOOM.75
3.7.1.2 GELATIN TYPE A, 300 BLOOM AND TYPE B, 225
BLOOM.77
3.7.2 OPTIMIZING BASE AND OLIGOMER SOLVENT (TYPE AND CONCENTRATION)
.
78
3.8 RHEOLOGICAL ASSESSMENT OF TWO COMPONENT (GELATIN/OLIGOMER) HYDROGELS
.
83
3.8.1 GELATION
KINETICS.
84
3.8.2 FREQUENCY SWEEP ASSESSMENT FOR INJECTED HYDROGELS
.
87
3.8.3 FREQUENCY SWEEP ASSESSMENT FOR PRE-FABRICATED HYDROGELS
.
89
3.8.4 STRESS RELAXATION
RHEOLOGY.92
3.9 DEGREE OF CROSS-LINKING (TNBS ASSAY)
.
94
3.10 CYTOCOMPATIBILITY OF OLIGOMER CROSS-LINKED HYDROGELS
.
95
3.11 ASSESSMENT OF CELL
VIABILITY.97
3.12 GEL
MINERALIZATION.
99
4. HYDROPHILIC OLIGOMERS WITH VARIABLE HYDROPHOBIC DOMAINS
.
103
4.1 SPECIFIC AIM AND
MOTIVATION.104
4.2 OLIGOMER
DESIGN.
105
4.3
TITRATIONS.
107
4.4 MOLECULAR WEIGHTS DETERMINATION
.
108
4.5 NUCLEAR MAGNETIC RESONANCE
(NMR).110
4.6 DETERMINATION OF OLIGOMER
HYDROPHILICITY.113
4.7 RHEOLOGICAL
ASSESSMENT.
116
4.7.1 GELATION KINETICS
.
.116
4.7.2 MECHANICAL STIFFNESS OF INJECTED HYDROGELS
.
118
4.7.3 MECHANICAL STIFFNESS OF PRE-FABRICATED HYDROGELS
.
120
4.7.4 STRESS RELAXATION
RHEOLOGY.122
4.8 DEGREE OF CROSS-LINKING (TNBS
ASSAY).123
4.9
CYTOCOMPATIBILITY.
125
4.10 ASSESSMENT OF CELL
VIABILITY.127
4.11 GEL AND HYDROGEL
MINERALIZATION.128
5. MULTIFUNCTIONAL MATERIALS FOR REGENERATIVE APPLICATIONS
.
133
5.1 MECHANOSENSITIVE
OLIGOMERS.134
5.1.1
PERCEPTION.
134
5.1.2 OLIGOMER
DESIGN.
136
5.1.3
TITRATIONS.138
5.1.4 MOLECULAR WEIGHTS
DETERMINATION.139
5.1.5 PROTON NMR
(1H-NMR).
140
5.1.6 FABRICATION OF CROSS-LINKED HYDROGELS WITH MECHANO-SENSITIVE
OLIGOMERS141
5.1.7 EFFECT OF ULTRASOUND ON MECHANO-SENSITIVE OLIGOMER CROSS-LINKED
HYDROGELS
144
5.2 CATIONIC
OLIGOMERS.
147
5.2.1
MOTIVATION.
147
5.2.2 OLIGOMER
DESIGN.
148
5.2.3 MOLECULAR WEIGHTS
DETERMINATION.149
5.2.4 1H-NMR
ANALYSIS.
151
5.2.5 SIRNA/CATIONIC OLIGOMER COMPLEXATION
.
152
6.
DISCUSSION.154
6.1 PEDAS CONTAINING REACTIVE HYDROPHILIC OLIGOMERS
.
157
6.2 HYDROPHILIC AND REACTIVE OLIGOMERS FOR INJECTABLE HYDROGELS WITH
VARIABLE
HYDROPHOBIC
DOMAINS.
174
6.3 MULTIFUNCTIONAL OLIGOMERS FOR BIOMEDICAL APPLICATIONS
.
182
6.3.1 MECHANO-SENSITIVE
OLIGOMERS.182
6.3.2 CATIONIC
OLIGOMERS.
183
7.
SUMMARY.188
8.
ZUSAMMENFASSUNG.
195
9.
REFERENCES.204
10.
APPENDIX.223
LIST OF
ABBREVIATIONS.
224
LIST OF
FIGURES.
226
LIST OF
TABLES.
229
DECLARATION OF
AUTHORSHIP.
230
PUBLICATIONS.
231
CURRICULUM
VITAE.
232
ACKNOWLEDGEMENT.
233 |
| any_adam_object | 1 |
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| author | Nawaz, Hafiz Awais 1983- |
| author_GND | (DE-588)1171826427 |
| author_facet | Nawaz, Hafiz Awais 1983- |
| author_role | aut |
| author_sort | Nawaz, Hafiz Awais 1983- |
| author_variant | h a n ha han |
| building | Verbundindex |
| bvnumber | BV046723972 |
| ctrlnum | (OCoLC)1164613208 (DE-599)DNB1171364032 |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Thesis Electronic Software eBook |
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| physical | CD-Rom (234 Blätter) Illustrationen |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| record_format | marc |
| spelling | Nawaz, Hafiz Awais 1983- Verfasser (DE-588)1171826427 aut Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications von Dr. rer. nat. Hafiz Awais Nawaz Leipzig [2018?] CD-Rom (234 Blätter) Illustrationen txt rdacontent c rdamedia cd rdacarrier Dissertation Universität Leipzig 2018 (DE-588)4113937-9 Hochschulschrift gnd-content (DE-588)4139307-7 CD-ROM gnd-carrier B:DE-101 application/pdf http://d-nb.info/1171364032/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032134144&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Textdatei PDF |
| spellingShingle | Nawaz, Hafiz Awais 1983- Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications |
| subject_GND | (DE-588)4113937-9 (DE-588)4139307-7 |
| title | Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications |
| title_auth | Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications |
| title_exact_search | Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications |
| title_exact_search_txtP | Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications |
| title_full | Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications von Dr. rer. nat. Hafiz Awais Nawaz |
| title_fullStr | Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications von Dr. rer. nat. Hafiz Awais Nawaz |
| title_full_unstemmed | Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications von Dr. rer. nat. Hafiz Awais Nawaz |
| title_short | Injectable oligomer-cross-linked gelatin hydrogels for regenerative applications |
| title_sort | injectable oligomer cross linked gelatin hydrogels for regenerative applications |
| topic_facet | Hochschulschrift CD-ROM |
| url | http://d-nb.info/1171364032/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032134144&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT nawazhafizawais injectableoligomercrosslinkedgelatinhydrogelsforregenerativeapplications |
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