Essential Enzyme Kinetics: A Textbook for Molecular Life Scientists
Essential Enzyme Kinetics: A Textbook for Molecular Life Scientists describes the theoretical basis and best-practice approaches for using initial-rate, fast reaction, and kinetic isotope effect experiments to define enzyme catalysis. Because a detailed knowledge of enzyme transition-states is the m...
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
William Andrew Publishing
2020
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| Schlagworte: | |
| Zusammenfassung: | Essential Enzyme Kinetics: A Textbook for Molecular Life Scientists describes the theoretical basis and best-practice approaches for using initial-rate, fast reaction, and kinetic isotope effect experiments to define enzyme catalysis. Because a detailed knowledge of enzyme transition-states is the main driver for the rational design of slow, tight-binding inhibitors destined to become tomorrow's small-molecule drugs, Essential Enzyme Kinetics is the must-have reference for chemists, biochemists, and pharmacologists intent on pursuing careers in Big Pharma. Given the interdisciplinary nature of contemporary drug development, this book provides a lucid short-course that will also benefit nonspecialists seeking to understand the scope and reach of modern enzyme kinetics. - Provides practical information about how to work with enzymes and design experiments to identify new inhibitors or activators- Includes detailed step-by-step derivations of rate equations, showing tried-and-true ways to confirm that the equations obtained are correct- Arranged for use both as a desk reference (with over 200 equations and more than 400 key references) or as a textbook (with 8-10 problems/exercises at the end of each chapter) |
| Beschreibung: | Approx. 200 illustrations (200 in full color) 1. Introduction 2. Basic Chemical Kinetics 3. Initial-Rate Kinetics of One-Substrate Enzymes 4. Measuring Initial Velocities of Enzyme-catalyzed Reactions 5. Multi-substrate Enzyme Kinetic Mechanisms 6. Fast Kinetic Techniques for Probing Enzyme-Catalyzed Reactions 7. Factors Affecting Enzyme Rates 8. Kinetic Isotope Effects 9. Inhibitor Effects on Enzyme-Catalyzed Reactions 10. Enzyme Cooperativity 11. Kinetics of Force-Generating Enzymes |
| Beschreibung: | 425 p 235 mm |
| ISBN: | 9780128218082 |
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| 500 | |a 1. Introduction 2. Basic Chemical Kinetics 3. Initial-Rate Kinetics of One-Substrate Enzymes 4. Measuring Initial Velocities of Enzyme-catalyzed Reactions 5. Multi-substrate Enzyme Kinetic Mechanisms 6. Fast Kinetic Techniques for Probing Enzyme-Catalyzed Reactions 7. Factors Affecting Enzyme Rates 8. Kinetic Isotope Effects 9. Inhibitor Effects on Enzyme-Catalyzed Reactions 10. Enzyme Cooperativity 11. Kinetics of Force-Generating Enzymes | ||
| 520 | |a Essential Enzyme Kinetics: A Textbook for Molecular Life Scientists describes the theoretical basis and best-practice approaches for using initial-rate, fast reaction, and kinetic isotope effect experiments to define enzyme catalysis. Because a detailed knowledge of enzyme transition-states is the main driver for the rational design of slow, tight-binding inhibitors destined to become tomorrow's small-molecule drugs, Essential Enzyme Kinetics is the must-have reference for chemists, biochemists, and pharmacologists intent on pursuing careers in Big Pharma. Given the interdisciplinary nature of contemporary drug development, this book provides a lucid short-course that will also benefit nonspecialists seeking to understand the scope and reach of modern enzyme kinetics. - Provides practical information about how to work with enzymes and design experiments to identify new inhibitors or activators- Includes detailed step-by-step derivations of rate equations, showing tried-and-true ways to confirm that the equations obtained are correct- Arranged for use both as a desk reference (with over 200 equations and more than 400 key references) or as a textbook (with 8-10 problems/exercises at the end of each chapter) | ||
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Datensatz im Suchindex
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| discipline_str_mv | Biologie Chemie |
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| publisher | William Andrew Publishing |
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| spelling | Purich, Daniel L. Verfasser aut Essential Enzyme Kinetics A Textbook for Molecular Life Scientists William Andrew Publishing 2020 425 p 235 mm txt rdacontent n rdamedia nc rdacarrier Approx. 200 illustrations (200 in full color) 1. Introduction 2. Basic Chemical Kinetics 3. Initial-Rate Kinetics of One-Substrate Enzymes 4. Measuring Initial Velocities of Enzyme-catalyzed Reactions 5. Multi-substrate Enzyme Kinetic Mechanisms 6. Fast Kinetic Techniques for Probing Enzyme-Catalyzed Reactions 7. Factors Affecting Enzyme Rates 8. Kinetic Isotope Effects 9. Inhibitor Effects on Enzyme-Catalyzed Reactions 10. Enzyme Cooperativity 11. Kinetics of Force-Generating Enzymes Essential Enzyme Kinetics: A Textbook for Molecular Life Scientists describes the theoretical basis and best-practice approaches for using initial-rate, fast reaction, and kinetic isotope effect experiments to define enzyme catalysis. Because a detailed knowledge of enzyme transition-states is the main driver for the rational design of slow, tight-binding inhibitors destined to become tomorrow's small-molecule drugs, Essential Enzyme Kinetics is the must-have reference for chemists, biochemists, and pharmacologists intent on pursuing careers in Big Pharma. Given the interdisciplinary nature of contemporary drug development, this book provides a lucid short-course that will also benefit nonspecialists seeking to understand the scope and reach of modern enzyme kinetics. - Provides practical information about how to work with enzymes and design experiments to identify new inhibitors or activators- Includes detailed step-by-step derivations of rate equations, showing tried-and-true ways to confirm that the equations obtained are correct- Arranged for use both as a desk reference (with over 200 equations and more than 400 key references) or as a textbook (with 8-10 problems/exercises at the end of each chapter) bicssc |
| spellingShingle | Purich, Daniel L. Essential Enzyme Kinetics A Textbook for Molecular Life Scientists bicssc |
| title | Essential Enzyme Kinetics A Textbook for Molecular Life Scientists |
| title_auth | Essential Enzyme Kinetics A Textbook for Molecular Life Scientists |
| title_exact_search | Essential Enzyme Kinetics A Textbook for Molecular Life Scientists |
| title_exact_search_txtP | Essential Enzyme Kinetics A Textbook for Molecular Life Scientists |
| title_full | Essential Enzyme Kinetics A Textbook for Molecular Life Scientists |
| title_fullStr | Essential Enzyme Kinetics A Textbook for Molecular Life Scientists |
| title_full_unstemmed | Essential Enzyme Kinetics A Textbook for Molecular Life Scientists |
| title_short | Essential Enzyme Kinetics |
| title_sort | essential enzyme kinetics a textbook for molecular life scientists |
| title_sub | A Textbook for Molecular Life Scientists |
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| topic_facet | bicssc |
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