Holdings: The genomic & transcriptomic landscape of acute myeloid leukemia

The genomic & transcriptomic landscape of acute myeloid leukemia:

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Bibliographic Details
Main Author:	Blätte, Tamara J. (Author)
Format:	Thesis Book
Language:	English
Published:	Ulm 2019
Subjects:	Bioinformatics Leukemia, Myeloid, Acute Genetics Genomics Sequence alignment Computational biology Hochschulschrift
Online Access:	Inhaltsverzeichnis Inhaltsverzeichnis
Physical Description:	103 Blätter Illustrationen, Diagramme 30 cm

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MARC


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adam_text	CONTENTS CONTENTS CONTENTS 1 MOTIVATION 1 1.1 ACUTE MYELOID LEUKEMIA . 1 1.2 MEASURABLE RESIDUAL DISEASE . 4 1.3 NEXT-GENERATION SEQUENCING . 5 1.4 DATA ANALYSIS. 8 1.5 AIMS. 9 2 METHODS 11 2.1 GENOMICS. 11 2.1.1 SAMPLE PREPARATION FOR TARGETED ENRICHMENT. 11 2.1.2 SAMPLE PREPARATION FOR NAIVE AMPLICONS. 13 2.1.3 SAMPLE PREPARATION FOR BARCODED AMPLICONS . 13 2.1.4 MRD MONITORING OF THE FLT3-ITD. 14 2.2 TRANSCRIPTOMICS. 17 2.2.1 SAMPLE PREPARATION. 17 2.3 SETUP FOR DATA ANALYSIS. 18 2.3.1 THE ENVIRONMENT. 18 2.3.2 NAMING CONVENTIONS . 20 2.3.3 SAMPLE DATABASE. 21 2.3.4 PIPELINE IMPLEMENTATION. 21 2.3.5 THIRD-PARTY TOOLS & SOFTWARE. 22 3 RESULTS 24 3.1 GENOMICS. 24 3.1.1 VARIANT CALLING ON TARGETED ENRICHMENT. 24 3.1.2 VARIANT CALLING ON NAIVE AMPLICONS . 29 3.1.3 VARIANT CALLING ON BARCODED AMPLICONS . 31 3.1.4 MRD MONITORING OF THE FLT3-1TD. 31 3.2 TRANSCRIPTOMICS. 50 3.2.1 QUANTIFICATION OF LINEAR TRANSCRIPTS . 50 3.2.2 QUANTIFICATION OF CIRCULAR TRANSCRIPTS. 57 3.2.3 VARIANT CALLING . 58 I BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1206108894 CONTENTS CONTENTS 3.3 APPLICATION TO AML . 59 4 DISCUSSION 64 4.1 GENOMICS & TRANSCRIPTOMICS. 64 4.2 APPLICATION TO AML . 73 4.3 MRD MONITORING OF THE FLT3-TTD. 75 5 SUMMARY & CONCLUSION 80 6 BIBLIOGRAPHY 82 7 ACKNOWLEDGEMENTS 102 8 STATUTORY DECLARATION 103 II
adam_txt	CONTENTS CONTENTS CONTENTS 1 MOTIVATION 1 1.1 ACUTE MYELOID LEUKEMIA . 1 1.2 MEASURABLE RESIDUAL DISEASE . 4 1.3 NEXT-GENERATION SEQUENCING . 5 1.4 DATA ANALYSIS. 8 1.5 AIMS. 9 2 METHODS 11 2.1 GENOMICS. 11 2.1.1 SAMPLE PREPARATION FOR TARGETED ENRICHMENT. 11 2.1.2 SAMPLE PREPARATION FOR NAIVE AMPLICONS. 13 2.1.3 SAMPLE PREPARATION FOR BARCODED AMPLICONS . 13 2.1.4 MRD MONITORING OF THE FLT3-ITD. 14 2.2 TRANSCRIPTOMICS. 17 2.2.1 SAMPLE PREPARATION. 17 2.3 SETUP FOR DATA ANALYSIS. 18 2.3.1 THE ENVIRONMENT. 18 2.3.2 NAMING CONVENTIONS . 20 2.3.3 SAMPLE DATABASE. 21 2.3.4 PIPELINE IMPLEMENTATION. 21 2.3.5 THIRD-PARTY TOOLS & SOFTWARE. 22 3 RESULTS 24 3.1 GENOMICS. 24 3.1.1 VARIANT CALLING ON TARGETED ENRICHMENT. 24 3.1.2 VARIANT CALLING ON NAIVE AMPLICONS . 29 3.1.3 VARIANT CALLING ON BARCODED AMPLICONS . 31 3.1.4 MRD MONITORING OF THE FLT3-1TD. 31 3.2 TRANSCRIPTOMICS. 50 3.2.1 QUANTIFICATION OF LINEAR TRANSCRIPTS . 50 3.2.2 QUANTIFICATION OF CIRCULAR TRANSCRIPTS. 57 3.2.3 VARIANT CALLING . 58 I BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1206108894 CONTENTS CONTENTS 3.3 APPLICATION TO AML . 59 4 DISCUSSION 64 4.1 GENOMICS & TRANSCRIPTOMICS. 64 4.2 APPLICATION TO AML . 73 4.3 MRD MONITORING OF THE FLT3-TTD. 75 5 SUMMARY & CONCLUSION 80 6 BIBLIOGRAPHY 82 7 ACKNOWLEDGEMENTS 102 8 STATUTORY DECLARATION 103 II
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spelling	Blätte, Tamara J. Verfasser (DE-588)1201331242 aut The genomic & transcriptomic landscape of acute myeloid leukemia by Tamara Jacqueline Blätte Ulm 2019 103 Blätter Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Universität Ulm 2019 Bioinformatics Leukemia, Myeloid, Acute Genetics Genomics Sequence alignment Computational biology (DE-588)4113937-9 Hochschulschrift gnd-content Universität Ulm (DE-588)30607-1 dgg B:DE-101 application/pdf https://d-nb.info/1206108894/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032110759&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Blätte, Tamara J. The genomic & transcriptomic landscape of acute myeloid leukemia Bioinformatics
subject_GND	(DE-588)4113937-9
title	The genomic & transcriptomic landscape of acute myeloid leukemia
title_auth	The genomic & transcriptomic landscape of acute myeloid leukemia
title_exact_search	The genomic & transcriptomic landscape of acute myeloid leukemia
title_exact_search_txtP	The genomic & transcriptomic landscape of acute myeloid leukemia
title_full	The genomic & transcriptomic landscape of acute myeloid leukemia by Tamara Jacqueline Blätte
title_fullStr	The genomic & transcriptomic landscape of acute myeloid leukemia by Tamara Jacqueline Blätte
title_full_unstemmed	The genomic & transcriptomic landscape of acute myeloid leukemia by Tamara Jacqueline Blätte
title_short	The genomic & transcriptomic landscape of acute myeloid leukemia
title_sort	the genomic transcriptomic landscape of acute myeloid leukemia
topic	Bioinformatics
topic_facet	Bioinformatics Hochschulschrift
url	https://d-nb.info/1206108894/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032110759&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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