The genomic & transcriptomic landscape of acute myeloid leukemia:
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| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Ulm
2019
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| Beschreibung: | 103 Blätter Illustrationen, Diagramme 30 cm |
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| 245 | 1 | 0 | |a The genomic & transcriptomic landscape of acute myeloid leukemia |c by Tamara Jacqueline Blätte |
| 264 | 1 | |a Ulm |c 2019 | |
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| 653 | |a Leukemia, Myeloid, Acute | ||
| 653 | |a Leukemia, Myeloid, Acute | ||
| 653 | |a Genetics | ||
| 653 | |a Genomics | ||
| 653 | |a Sequence alignment | ||
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Datensatz im Suchindex
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| adam_text | CONTENTS CONTENTS
CONTENTS
1 MOTIVATION 1
1.1 ACUTE MYELOID LEUKEMIA . 1
1.2 MEASURABLE RESIDUAL DISEASE . 4
1.3 NEXT-GENERATION SEQUENCING . 5
1.4 DATA ANALYSIS. 8
1.5 AIMS. 9
2 METHODS 11
2.1 GENOMICS. 11
2.1.1 SAMPLE PREPARATION FOR TARGETED ENRICHMENT. 11
2.1.2 SAMPLE PREPARATION FOR NAIVE AMPLICONS. 13
2.1.3 SAMPLE PREPARATION FOR BARCODED AMPLICONS . 13
2.1.4 MRD MONITORING OF THE FLT3-ITD. 14
2.2 TRANSCRIPTOMICS. 17
2.2.1 SAMPLE PREPARATION. 17
2.3 SETUP FOR DATA ANALYSIS. 18
2.3.1 THE ENVIRONMENT. 18
2.3.2 NAMING CONVENTIONS . 20
2.3.3 SAMPLE DATABASE. 21
2.3.4 PIPELINE IMPLEMENTATION. 21
2.3.5 THIRD-PARTY TOOLS & SOFTWARE. 22
3 RESULTS 24
3.1 GENOMICS. 24
3.1.1 VARIANT CALLING ON TARGETED ENRICHMENT. 24
3.1.2 VARIANT CALLING ON NAIVE AMPLICONS . 29
3.1.3 VARIANT CALLING ON BARCODED AMPLICONS . 31
3.1.4 MRD MONITORING OF THE FLT3-1TD. 31
3.2 TRANSCRIPTOMICS. 50
3.2.1 QUANTIFICATION OF LINEAR TRANSCRIPTS . 50
3.2.2 QUANTIFICATION OF CIRCULAR TRANSCRIPTS. 57
3.2.3 VARIANT CALLING . 58
I
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/1206108894
CONTENTS CONTENTS
3.3 APPLICATION TO AML . 59
4 DISCUSSION 64
4.1 GENOMICS & TRANSCRIPTOMICS. 64
4.2 APPLICATION TO AML . 73
4.3 MRD MONITORING OF THE FLT3-TTD. 75
5 SUMMARY & CONCLUSION 80
6 BIBLIOGRAPHY 82
7 ACKNOWLEDGEMENTS 102
8 STATUTORY DECLARATION 103
II
|
| adam_txt |
CONTENTS CONTENTS
CONTENTS
1 MOTIVATION 1
1.1 ACUTE MYELOID LEUKEMIA . 1
1.2 MEASURABLE RESIDUAL DISEASE . 4
1.3 NEXT-GENERATION SEQUENCING . 5
1.4 DATA ANALYSIS. 8
1.5 AIMS. 9
2 METHODS 11
2.1 GENOMICS. 11
2.1.1 SAMPLE PREPARATION FOR TARGETED ENRICHMENT. 11
2.1.2 SAMPLE PREPARATION FOR NAIVE AMPLICONS. 13
2.1.3 SAMPLE PREPARATION FOR BARCODED AMPLICONS . 13
2.1.4 MRD MONITORING OF THE FLT3-ITD. 14
2.2 TRANSCRIPTOMICS. 17
2.2.1 SAMPLE PREPARATION. 17
2.3 SETUP FOR DATA ANALYSIS. 18
2.3.1 THE ENVIRONMENT. 18
2.3.2 NAMING CONVENTIONS . 20
2.3.3 SAMPLE DATABASE. 21
2.3.4 PIPELINE IMPLEMENTATION. 21
2.3.5 THIRD-PARTY TOOLS & SOFTWARE. 22
3 RESULTS 24
3.1 GENOMICS. 24
3.1.1 VARIANT CALLING ON TARGETED ENRICHMENT. 24
3.1.2 VARIANT CALLING ON NAIVE AMPLICONS . 29
3.1.3 VARIANT CALLING ON BARCODED AMPLICONS . 31
3.1.4 MRD MONITORING OF THE FLT3-1TD. 31
3.2 TRANSCRIPTOMICS. 50
3.2.1 QUANTIFICATION OF LINEAR TRANSCRIPTS . 50
3.2.2 QUANTIFICATION OF CIRCULAR TRANSCRIPTS. 57
3.2.3 VARIANT CALLING . 58
I
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/1206108894
CONTENTS CONTENTS
3.3 APPLICATION TO AML . 59
4 DISCUSSION 64
4.1 GENOMICS & TRANSCRIPTOMICS. 64
4.2 APPLICATION TO AML . 73
4.3 MRD MONITORING OF THE FLT3-TTD. 75
5 SUMMARY & CONCLUSION 80
6 BIBLIOGRAPHY 82
7 ACKNOWLEDGEMENTS 102
8 STATUTORY DECLARATION 103
II |
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| spelling | Blätte, Tamara J. Verfasser (DE-588)1201331242 aut The genomic & transcriptomic landscape of acute myeloid leukemia by Tamara Jacqueline Blätte Ulm 2019 103 Blätter Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Universität Ulm 2019 Bioinformatics Leukemia, Myeloid, Acute Genetics Genomics Sequence alignment Computational biology (DE-588)4113937-9 Hochschulschrift gnd-content Universität Ulm (DE-588)30607-1 dgg B:DE-101 application/pdf https://d-nb.info/1206108894/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032110759&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Blätte, Tamara J. The genomic & transcriptomic landscape of acute myeloid leukemia Bioinformatics |
| subject_GND | (DE-588)4113937-9 |
| title | The genomic & transcriptomic landscape of acute myeloid leukemia |
| title_auth | The genomic & transcriptomic landscape of acute myeloid leukemia |
| title_exact_search | The genomic & transcriptomic landscape of acute myeloid leukemia |
| title_exact_search_txtP | The genomic & transcriptomic landscape of acute myeloid leukemia |
| title_full | The genomic & transcriptomic landscape of acute myeloid leukemia by Tamara Jacqueline Blätte |
| title_fullStr | The genomic & transcriptomic landscape of acute myeloid leukemia by Tamara Jacqueline Blätte |
| title_full_unstemmed | The genomic & transcriptomic landscape of acute myeloid leukemia by Tamara Jacqueline Blätte |
| title_short | The genomic & transcriptomic landscape of acute myeloid leukemia |
| title_sort | the genomic transcriptomic landscape of acute myeloid leukemia |
| topic | Bioinformatics |
| topic_facet | Bioinformatics Hochschulschrift |
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