Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes:
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| 015 | |a 19,H12 |2 dnb | ||
| 016 | 7 | |a 1197539387 |2 DE-101 | |
| 020 | |c Broschur | ||
| 035 | |a (OCoLC)1136986803 | ||
| 035 | |a (DE-599)DNB1197539387 | ||
| 040 | |a DE-604 |b ger |e rda | ||
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| 044 | |a gw |c XA-DE | ||
| 049 | |a DE-355 | ||
| 084 | |a 570 |2 sdnb | ||
| 100 | 1 | |a Russo, Antonella |d 1986- |e Verfasser |0 (DE-588)1196896992 |4 aut | |
| 245 | 1 | 0 | |a Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes |c vorgelegt von Antonella Russo |
| 264 | 1 | |a Münster |c 2019 | |
| 300 | |a 86 Blätter |b Illustrationen |c 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Westfälische Wilhelms-Universität Münster |d 2019 |g Beschränkt für den Austausch | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m B:DE-101 |q application/pdf |u https://d-nb.info/1197539387/04 |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032035833&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-032035833 | ||
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| _version_ | 1804181305375588352 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
1
INTRODUCTION
.....................................................................................................
1
1.1
IMMUNE
SYSTEM
.................................................................................................
1
1.1.1
INNATE
IMMUNITY
..........................................................................................
1
1.1.2
MONOCYTES
AND
MACROPHAGES
..................................................................
1
1.1.3
ER-HOXB8
CELLS
..........................................................................................
2
1.2
CELL
MIGRATION
....................................................................................................
2
1.2.1
STEPS
OF
MIGRATION
......................................................................................
3
1.2.2
AMOEBOID
VERSUS
MESENCHYMAL
MIGRATION
MODE
..................................
4
1.2.3
ROLE
OF
SMALL
RHO
GTPASES
IN
CELL
MIGRATION
.........................................
5
1.2.4
LEUKOCYTE
TRAFFICKING
.................................................................................
7
1.2.5
LEUKOCYTE
EXTRAVASATION
...........................................................................
7
1.3
ALARMINS
.............................................................................................................
8
1.3.1
S100-PROTEINS
............................................................................................
9
1.3.2
INTRACELLULAR
FUNCTIONS
OF
S100A8/S100A9
...............................................
9
1.3.3.
EXTRACELLULAR
FUNCTIONS
OF
S100A8/S100A9
..........................................
10
1.4
AIM
OF
THE
THESIS
..............................................................................................
12
2
MATERIALS
AND
METHODS
............................................................................
13
2.1
MATERIALS
.............................................................................................................
13
2.1.1
MOUSE
STRAINS
..............................................................................................
13
2.1.2
CELL
CULTURE
...................................................................................................
13
2.1.2.1
EQUIPMENT
..............................................................................................
13
2.1.2.2
PLASTIC
MATERIALS
....................................................................................
13
2.1.2.3
CHEMICALS
AND
MEDIA
..........................................................................
13
2.1.2.4
GROW
FACTORS
........................................................................................
14
2.1.2.5
STIMULI
AND
INHIBITORS
............................................................................
14
2.1.2.6
MEDIA
FOR
CELL
CULTURE
AND
CELL
DIFFERENTIATION
..................................
14
2.1.2
CALCIUM
STAINING
.........................................................................................
15
2.1.2.1
EQUIPMENT
AND
MATERIALS
.....................................................................
15
2.1.2.2
CHEMICALS
..............................................................................................
15
2.1.2.3
SOFTWARE
.................................................................................................
15
2.1.3
FLUORESCENCE
ACTIVATED
CELL
SORTING
(FACS)
.............................................
15
2.1.3.1
EQUIPMENT
AND
MATERIALS
.....................................................................
15
TABLE
OF
CONTENTS
2.1.3.2
ANTIBODIES
..............................................................................................
15
2.1.3.2
SOFTWARE
.................................................................................................
16
2.1.3.3
BUFFER
......................................................................................................
16
2.1.4
TRANSMIGRATION
.............................................................................................
16
2.1.4.1
EQUIPMENT
AND
MATERIALS
.....................................................................
16
2.1.4.2
CHEMICALS
..............................................................................................
16
2.1.5
CHEMOTAXIS
..................................................................................................
16
2.1.5.1
EQUIPMENT
AND
MATERIALS
.....................................................................
16
2.1.5.2
CHEMICALS
..............................................................................................
16
2.1.5.3
SOFTWARE
.................................................................................................
17
2.1.6
ADHESION
.......................................................................................................
17
2.1.6.1
EQUIPMENT
AND
MATERIALS
.....................................................................
17
2.1.6.2
CHEMICALS
..............................................................................................
17
2.1.6.3
SOFTWARE
.................................................................................................
17
2.1.7
WESTERN
BLOT
.................................................................................................
17
2.1.7.1
EQUIPMENT
AND
MATERIALS
.....................................................................
17
2.1.7.2
ANTIBODIES
..............................................................................................
18
2.1.7.3
CHEMICALS
..............................................................................................
18
2.1.7.4
SOFTWARE
.................................................................................................
18
2.1.7.5
SOLUTIONS
................................................................................................
19
2.1.8
IMMUNOFLUORESCENCE
STAINING
(IF
STAINING)
...............................................
19
2.1.8.1
EQUIPMENT
AND
MATERIALS
....................
19
2.
1.8.2
CHEMICALS
..............................................................................................
20
2.
1.8.3
ANTIBODIES
..............................................................................................
20
2.1.8.4
SOFTWARE
.................................................................................................
20
2.1.9
TRACTION
FORCE
MICROSCOPY
(TFM)
.............................................................
20
2.
1.9.1
EQUIPMENT
AND
MATERIALS
.....................................................................
20
2.1.9.2
CHEMICALS
..............................................................................................
20
2.1.9.3
SOFTWARE
.................................................................................................
21
2.1.10
IMMUNOPRECIPITATION
(IP)
..........................................................................
21
2.1.10.1
EQUIPMENTS
AND
MATERIALS
................................................................
21
2.1.11
PCR
............................................................................................................
21
2.1.11.1
EQUIPMENT
AND
MATERIALS
..................................................................
21
TABLE
OF
CONTENTS
2.1.11.2
CHEMICALS
............................................................................................
21
2.1.11.3
SOLUTIONS
..............................................................................................
21
2.1.12
ELISA
..........................................................................................................22
2.1.12.1
EQUIPMENT
AND
MATERIALS
...................................................................22
2.1.12.2
CHEMICALS
...........................................................................................
22
2.1.12.3
ANTIBODIES
...........................................................................................
22
2.1.12.5
SOFTWARE
...............................................................................................
22
2.1.12.3
SOLUTIONS
..............................................................................................
22
2.
2
METHODS
.............................................................................................................
23
2.2.1
GENERATION
OF
ER-HOXB8
CELLS
...................................................................
23
2.2.1.1
CULTIVATION
AND
DIFFERENTIATION
OF
ER-HOXB8
CELLS
.............................
23
2.2.
1.2
DETERMINATION
OF
THE
CELL
NUMBER
........................................................
23
2.2.1.2
TREATMENTS
OF
THE
CELLS
.........................................................................
24
2.2.2
WESTERN
BLOT
.................................................................................................24
2.2.2.1
CELL
LYSIS
.................................................................................................
24
2.2.2
2
PROTEIN
CONCENTRATION
AND
SAMPLE
PREPARATION
...............................
25
2.2.2.3
SODIUM-DODECYL-SULFATE-POLYACRYLAMIDE
GEL
ELECTROPHORESIS
(SDS
PAGE)
.................................................................................................................
25
2.2.2.4
WESTERN
BLOT
AND
IMMUNODETECTION
...................................................
26
2.2.2.5
DETECTION
OF
THE
PROTEIN
OF
INTEREST
.....................................................
27
2.2.3
FLUORESCENCE
ACTIVATED
CELL
SORTING
(FACS)
.............................................
27
2.2.5
TRANSMIGRATION
............................................................................................
28
2.2.6
ADHESION
......................................................................................................
28
2.2.7
IMMUNOPRECIPITATION
....................................................................................
29
2.2.8
MICROSCOPY
...................................................................................................
29
2.2.6.
1
SPINNING
DISK
MICROSCOPY
...................................................................
29
2.2.8.2
CALCIUM
STAINING
...................................................................................
29
2.2.9
TRACTION
FORCE
MICROSCOPY
(TFM)
.............................................................30
2.2.9.1
GELS
FOR
THE
TRACTION
FORCE
MICROSCOPY
................................................30
2.2.9.2
IMAGING
..................................................................................................30
2.2.9.3
ANALYSIS
.................................................................................................
31
2.2.10
PCR
............................................................................................................
31
2.2.10.1
1SOLATION
OF
THE
GENOMIC
DNA
(GDNA)
..............................................
31
TABLE
OF
CONTENTS
2.2.10.2
PCR
.....................................................................................................
31
2.2.11
MURINE
S100A8/S100A9
ELISA
...............................................................
32
2.2.12
IMMUNOFLUORESCENCE
.................................................................................33
3
RESULTS
...............................................................................................................
34
3.1
CHARACTERIZATION
OF
THE
HOXB8
CELLS
.............................................................. 34
3.2
S100A8/S100A9
AFFECT
MIGRATION
AND
MORPHOLOGY
OF
MONOCYTES
............ 38
3.3
ER-HOXB8
EGFP-LIFEACT
S100A9
KO
MONOCYTES
ARE
PRE-ACTIVATED
.......
40
3.4
TRANSMIGRATION,
ADHESION
AND
TRACTION
FORCES
............................................
42
3.5
GTPASES
ARE
RESPONSIBLE
OF
THE
MORPHOLOGY
AND
MIGRATORY
DIFFERENCES
BETWEEN
ER-HOXB8
WT
AND
ER-HOXB8
S100A9
KO
MONOCYTES
....................
46
3.6
STAT-3
PATHWAY
IS
REGULATED
BY
S100A9
................................................... 50
3.7
EXTRACELLULAR
S100A8/S100A9
IS
THE
KEY
REGULATOR
IN
KEEPING
MONOCYTES
IN
A
RESTING
STATE
....................................................................................................55
3.8
0069
FUNCTIONS
AS
A
NEW
REGULATORY
RECEPTOR
FOR
S100A8/S100A9
TETRAMER-INDUCED
EFFECTS
ON
MONOCYTE
DYNAMICS
..............................................
62
4
DISCUSSION
.........................................................................................................67
4.1
ER-HOXB8
MONOCYTES
....................................................................................
67
4.2
S100A8/S100A9
CONTROLS
MORPHOLOGY
AND
MIGRATORY
BEHAVIOR
OF
MONOCYTES
..............................................................................................................
68
4.3
CELL
MIGRATION
DEPENDS
ON
STAT3
AND
SMALL
GTPASES
FUNCTION
..............
69
4.4
REGULATORS
OF
STAT3
......................................................................................
70
4.5
THE
EARLY
ACTIVATION
MARKER
CD69
................................................................ 72
5
REFERENCES
......................................................................................................
75
6
ABBREVIATIONS
.................................................................................................82
7
CURRICULUM
VITAE
.........................................................................................
85
8
ACKNOWLEDGMENTS
......................................................................................
86
|
| adam_txt |
TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
1
INTRODUCTION
.
1
1.1
IMMUNE
SYSTEM
.
1
1.1.1
INNATE
IMMUNITY
.
1
1.1.2
MONOCYTES
AND
MACROPHAGES
.
1
1.1.3
ER-HOXB8
CELLS
.
2
1.2
CELL
MIGRATION
.
2
1.2.1
STEPS
OF
MIGRATION
.
3
1.2.2
AMOEBOID
VERSUS
MESENCHYMAL
MIGRATION
MODE
.
4
1.2.3
ROLE
OF
SMALL
RHO
GTPASES
IN
CELL
MIGRATION
.
5
1.2.4
LEUKOCYTE
TRAFFICKING
.
7
1.2.5
LEUKOCYTE
EXTRAVASATION
.
7
1.3
ALARMINS
.
8
1.3.1
S100-PROTEINS
.
9
1.3.2
INTRACELLULAR
FUNCTIONS
OF
S100A8/S100A9
.
9
1.3.3.
EXTRACELLULAR
FUNCTIONS
OF
S100A8/S100A9
.
10
1.4
AIM
OF
THE
THESIS
.
12
2
MATERIALS
AND
METHODS
.
13
2.1
MATERIALS
.
13
2.1.1
MOUSE
STRAINS
.
13
2.1.2
CELL
CULTURE
.
13
2.1.2.1
EQUIPMENT
.
13
2.1.2.2
PLASTIC
MATERIALS
.
13
2.1.2.3
CHEMICALS
AND
MEDIA
.
13
2.1.2.4
GROW
FACTORS
.
14
2.1.2.5
STIMULI
AND
INHIBITORS
.
14
2.1.2.6
MEDIA
FOR
CELL
CULTURE
AND
CELL
DIFFERENTIATION
.
14
2.1.2
CALCIUM
STAINING
.
15
2.1.2.1
EQUIPMENT
AND
MATERIALS
.
15
2.1.2.2
CHEMICALS
.
15
2.1.2.3
SOFTWARE
.
15
2.1.3
FLUORESCENCE
ACTIVATED
CELL
SORTING
(FACS)
.
15
2.1.3.1
EQUIPMENT
AND
MATERIALS
.
15
TABLE
OF
CONTENTS
2.1.3.2
ANTIBODIES
.
15
2.1.3.2
SOFTWARE
.
16
2.1.3.3
BUFFER
.
16
2.1.4
TRANSMIGRATION
.
16
2.1.4.1
EQUIPMENT
AND
MATERIALS
.
16
2.1.4.2
CHEMICALS
.
16
2.1.5
CHEMOTAXIS
.
16
2.1.5.1
EQUIPMENT
AND
MATERIALS
.
16
2.1.5.2
CHEMICALS
.
16
2.1.5.3
SOFTWARE
.
17
2.1.6
ADHESION
.
17
2.1.6.1
EQUIPMENT
AND
MATERIALS
.
17
2.1.6.2
CHEMICALS
.
17
2.1.6.3
SOFTWARE
.
17
2.1.7
WESTERN
BLOT
.
17
2.1.7.1
EQUIPMENT
AND
MATERIALS
.
17
2.1.7.2
ANTIBODIES
.
18
2.1.7.3
CHEMICALS
.
18
2.1.7.4
SOFTWARE
.
18
2.1.7.5
SOLUTIONS
.
19
2.1.8
IMMUNOFLUORESCENCE
STAINING
(IF
STAINING)
.
19
2.1.8.1
EQUIPMENT
AND
MATERIALS
.
19
2.
1.8.2
CHEMICALS
.
20
2.
1.8.3
ANTIBODIES
.
20
2.1.8.4
SOFTWARE
.
20
2.1.9
TRACTION
FORCE
MICROSCOPY
(TFM)
.
20
2.
1.9.1
EQUIPMENT
AND
MATERIALS
.
20
2.1.9.2
CHEMICALS
.
20
2.1.9.3
SOFTWARE
.
21
2.1.10
IMMUNOPRECIPITATION
(IP)
.
21
2.1.10.1
EQUIPMENTS
AND
MATERIALS
.
21
2.1.11
PCR
.
21
2.1.11.1
EQUIPMENT
AND
MATERIALS
.
21
TABLE
OF
CONTENTS
2.1.11.2
CHEMICALS
.
21
2.1.11.3
SOLUTIONS
.
21
2.1.12
ELISA
.22
2.1.12.1
EQUIPMENT
AND
MATERIALS
.22
2.1.12.2
CHEMICALS
.
22
2.1.12.3
ANTIBODIES
.
22
2.1.12.5
SOFTWARE
.
22
2.1.12.3
SOLUTIONS
.
22
2.
2
METHODS
.
23
2.2.1
GENERATION
OF
ER-HOXB8
CELLS
.
23
2.2.1.1
CULTIVATION
AND
DIFFERENTIATION
OF
ER-HOXB8
CELLS
.
23
2.2.
1.2
DETERMINATION
OF
THE
CELL
NUMBER
.
23
2.2.1.2
TREATMENTS
OF
THE
CELLS
.
24
2.2.2
WESTERN
BLOT
.24
2.2.2.1
CELL
LYSIS
.
24
2.2.2
2
PROTEIN
CONCENTRATION
AND
SAMPLE
PREPARATION
.
25
2.2.2.3
SODIUM-DODECYL-SULFATE-POLYACRYLAMIDE
GEL
ELECTROPHORESIS
(SDS
PAGE)
.
25
2.2.2.4
WESTERN
BLOT
AND
IMMUNODETECTION
.
26
2.2.2.5
DETECTION
OF
THE
PROTEIN
OF
INTEREST
.
27
2.2.3
FLUORESCENCE
ACTIVATED
CELL
SORTING
(FACS)
.
27
2.2.5
TRANSMIGRATION
.
28
2.2.6
ADHESION
.
28
2.2.7
IMMUNOPRECIPITATION
.
29
2.2.8
MICROSCOPY
.
29
2.2.6.
1
SPINNING
DISK
MICROSCOPY
.
29
2.2.8.2
CALCIUM
STAINING
.
29
2.2.9
TRACTION
FORCE
MICROSCOPY
(TFM)
.30
2.2.9.1
GELS
FOR
THE
TRACTION
FORCE
MICROSCOPY
.30
2.2.9.2
IMAGING
.30
2.2.9.3
ANALYSIS
.
31
2.2.10
PCR
.
31
2.2.10.1
1SOLATION
OF
THE
GENOMIC
DNA
(GDNA)
.
31
TABLE
OF
CONTENTS
2.2.10.2
PCR
.
31
2.2.11
MURINE
S100A8/S100A9
ELISA
.
32
2.2.12
IMMUNOFLUORESCENCE
.33
3
RESULTS
.
34
3.1
CHARACTERIZATION
OF
THE
HOXB8
CELLS
. 34
3.2
S100A8/S100A9
AFFECT
MIGRATION
AND
MORPHOLOGY
OF
MONOCYTES
. 38
3.3
ER-HOXB8
EGFP-LIFEACT
S100A9
KO
MONOCYTES
ARE
PRE-ACTIVATED
.
40
3.4
TRANSMIGRATION,
ADHESION
AND
TRACTION
FORCES
.
42
3.5
GTPASES
ARE
RESPONSIBLE
OF
THE
MORPHOLOGY
AND
MIGRATORY
DIFFERENCES
BETWEEN
ER-HOXB8
WT
AND
ER-HOXB8
S100A9
KO
MONOCYTES
.
46
3.6
STAT-3
PATHWAY
IS
REGULATED
BY
S100A9
. 50
3.7
EXTRACELLULAR
S100A8/S100A9
IS
THE
KEY
REGULATOR
IN
KEEPING
MONOCYTES
IN
A
RESTING
STATE
.55
3.8
0069
FUNCTIONS
AS
A
NEW
REGULATORY
RECEPTOR
FOR
S100A8/S100A9
TETRAMER-INDUCED
EFFECTS
ON
MONOCYTE
DYNAMICS
.
62
4
DISCUSSION
.67
4.1
ER-HOXB8
MONOCYTES
.
67
4.2
S100A8/S100A9
CONTROLS
MORPHOLOGY
AND
MIGRATORY
BEHAVIOR
OF
MONOCYTES
.
68
4.3
CELL
MIGRATION
DEPENDS
ON
STAT3
AND
SMALL
GTPASES
FUNCTION
.
69
4.4
REGULATORS
OF
STAT3
.
70
4.5
THE
EARLY
ACTIVATION
MARKER
CD69
. 72
5
REFERENCES
.
75
6
ABBREVIATIONS
.82
7
CURRICULUM
VITAE
.
85
8
ACKNOWLEDGMENTS
.
86 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Russo, Antonella 1986- |
| author_GND | (DE-588)1196896992 |
| author_facet | Russo, Antonella 1986- |
| author_role | aut |
| author_sort | Russo, Antonella 1986- |
| author_variant | a r ar |
| building | Verbundindex |
| bvnumber | BV046624161 |
| ctrlnum | (OCoLC)1136986803 (DE-599)DNB1197539387 |
| discipline | Biologie |
| discipline_str_mv | Biologie |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV046624161 |
| illustrated | Illustrated |
| index_date | 2024-07-03T14:08:51Z |
| indexdate | 2024-07-10T08:49:33Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032035833 |
| oclc_num | 1136986803 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 86 Blätter Illustrationen 30 cm |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| record_format | marc |
| spelling | Russo, Antonella 1986- Verfasser (DE-588)1196896992 aut Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes vorgelegt von Antonella Russo Münster 2019 86 Blätter Illustrationen 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Westfälische Wilhelms-Universität Münster 2019 Beschränkt für den Austausch (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1197539387/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032035833&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Russo, Antonella 1986- Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes |
| subject_GND | (DE-588)4113937-9 |
| title | Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes |
| title_auth | Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes |
| title_exact_search | Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes |
| title_exact_search_txtP | Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes |
| title_full | Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes vorgelegt von Antonella Russo |
| title_fullStr | Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes vorgelegt von Antonella Russo |
| title_full_unstemmed | Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes vorgelegt von Antonella Russo |
| title_short | Tetramers and dimers of the alarmin S100A8/S100A9 exhibit functional different effects on cellular dynamics of monocytes |
| title_sort | tetramers and dimers of the alarmin s100a8 s100a9 exhibit functional different effects on cellular dynamics of monocytes |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1197539387/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032035833&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT russoantonella tetramersanddimersofthealarmins100a8s100a9exhibitfunctionaldifferenteffectsoncellulardynamicsofmonocytes |
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