The Charnoly body: a novel biomarker of mitochondrial bioenergetics
Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton, FL
CRC Press, Taylor & Francis Group
2019
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| Schlagworte: | |
| Online-Zugang: | URL des Erstveröffentlichers |
| Zusammenfassung: | Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novelcharnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners |
| Beschreibung: | "A Science Publishers book." OCLC-licensed vendor bibliographic record |
| Beschreibung: | 1 online resource |
| ISBN: | 9781315150710 1315150719 9781351366717 1351366718 9781351366700 135136670X 9781351366694 1351366696 |
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| id | DE-604.BV046620848 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T14:08:07Z |
| indexdate | 2024-07-10T08:49:27Z |
| institution | BVB |
| isbn | 9781315150710 1315150719 9781351366717 1351366718 9781351366700 135136670X 9781351366694 1351366696 |
| language | English |
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| spelling | Sharma, Sushil Verfasser aut The Charnoly body a novel biomarker of mitochondrial bioenergetics Sushil Sharma Boca Raton, FL CRC Press, Taylor & Francis Group 2019 1 online resource txt rdacontent c rdamedia cr rdacarrier "A Science Publishers book." OCLC-licensed vendor bibliographic record Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novelcharnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners SCIENCE / Life Sciences / Biochemistry bisacsh MEDICAL / Biochemistry bisacsh SCIENCE / Life Sciences / Cytology bisacsh SCIENCE / Physics bisacsh Metallothionein Biochemical markers https://www.taylorfrancis.com/books/9781315150710 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Sharma, Sushil The Charnoly body a novel biomarker of mitochondrial bioenergetics SCIENCE / Life Sciences / Biochemistry bisacsh MEDICAL / Biochemistry bisacsh SCIENCE / Life Sciences / Cytology bisacsh SCIENCE / Physics bisacsh Metallothionein Biochemical markers |
| title | The Charnoly body a novel biomarker of mitochondrial bioenergetics |
| title_auth | The Charnoly body a novel biomarker of mitochondrial bioenergetics |
| title_exact_search | The Charnoly body a novel biomarker of mitochondrial bioenergetics |
| title_exact_search_txtP | The Charnoly body a novel biomarker of mitochondrial bioenergetics |
| title_full | The Charnoly body a novel biomarker of mitochondrial bioenergetics Sushil Sharma |
| title_fullStr | The Charnoly body a novel biomarker of mitochondrial bioenergetics Sushil Sharma |
| title_full_unstemmed | The Charnoly body a novel biomarker of mitochondrial bioenergetics Sushil Sharma |
| title_short | The Charnoly body |
| title_sort | the charnoly body a novel biomarker of mitochondrial bioenergetics |
| title_sub | a novel biomarker of mitochondrial bioenergetics |
| topic | SCIENCE / Life Sciences / Biochemistry bisacsh MEDICAL / Biochemistry bisacsh SCIENCE / Life Sciences / Cytology bisacsh SCIENCE / Physics bisacsh Metallothionein Biochemical markers |
| topic_facet | SCIENCE / Life Sciences / Biochemistry MEDICAL / Biochemistry SCIENCE / Life Sciences / Cytology SCIENCE / Physics Metallothionein Biochemical markers |
| url | https://www.taylorfrancis.com/books/9781315150710 |
| work_keys_str_mv | AT sharmasushil thecharnolybodyanovelbiomarkerofmitochondrialbioenergetics |